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Product Details
H00025793-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4G8
Immunogen
FBXO7 (NP_036311, 357 a.a. approximately 455 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: AVCRDLFTAS NDPLLWRFLY LRDFRDNTVR VQDTDWKELY RKRHIQRKES PKGRFVMLLP SSTHTIPFYP NPLHPRPFPS SRLPPGIIGG EYDQRPTLP
Target Information
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686B08113; F-box only protein 7
Gene Aliases: FBX; FBX07; FBX7; FBXO7; PARK15; PKPS
UniProt ID: (Human) Q9Y3I1
Entrez Gene ID: (Human) 25793
mitophagy
ubiquitin-dependent protein catabolic process
protein targeting to mitochondrion
protein ubiquitination
regulation of protein stability
negative regulation of lymphocyte differentiation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of G1/S transition of mitotic cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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