Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Sequence of this protein is as follows: MDLLWILPSL WLLLLGGPAC LKTQEHPSCP GPRELEASKV VLLPSCPGAP GSPGEKGAPG PQGPPGPPGK MGPKGEPGPR NCRELLSQGA TLSGWYHLCL PEGRALPVFC DMDTEGGGWL VFQRRQDGSV DFFRSWSSYR AGFGNQESEF WLGNENLHQL TLQGNWELRV ELEDFNGNRT FAHYATFRLL GEVDHYQLAL GKFSEGTAGD SLSLHSGRPL TTYDADHDSS NSNCAVIVHG AWWYASCYRS NLNGRYAVSE AAAHKYGIDW ASGRGVGHPY RRVRMMLR
H-Ficolin (Hakata antigen, Ficolin-3) is an innate immunity pattern recognition molecule found in human serum. H-Ficolin binds to distinct pathogen-associated molecular patterns (PAMP) formed by carbohydrates (GlcNAc, GalNAc and fucose) activating complement through the lectin pathway by means of the associated MASPs ((MBL)-associated serine proteases). H-Ficolin consists of 35 kDa protein chains associated in triplet subunits which are again associated in high molecular weight oligomers by means of disulfide bonds at the N-terminal region.
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Protein Aliases: Collagen/fibrinogen domain-containing lectin 3 p35; Collagen/fibrinogen domain-containing protein 3; Ficolin-3; Hakata antigen; MGC22543
Gene Aliases: FCN3; FCNH; HAKA1
UniProt ID: (Human) O75636
Entrez Gene ID: (Human) 8547
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