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Product Details
MA5-23861
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
117611
Immunogen
E. coli-derived recombinant human FGF-19 Phe27-Lys216
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2609888
Product Specific Information
This antibody shows approximately 10% cross-reactivity with recombinant human (rh) FGF-3 and rhFGF-5 and no cross-reactivity with rhFGF-4, rhFGF-6, rhFGF-7, rhFGF-9, rhFGF-10, rhFGF-13, rhFGF-16, rhFGF-17, rhFGF-18, rhFGF acidic, and rhFGF basic.
Reconstitute at 0.5 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
FGF19, Fibroblast growth factor 19, is a protein that in humans is encoded by the FGF19 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. The FGF19 gene is mapped to 11q13.3. The deduced 216-amino acid FGF19 protein contains asignal sequence and 2 cysteine residues that are conserved in the FGF family. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. FGF19 stimulates hepatic protein and glycogen synthesis but does not induce lipogenesis. The effects of FGF19 are independent of the activity of either insulin or the protein kinase Akt and, instead, are mediated through a mitogen-activated protein kinase signaling pathway that activates components of the protein translation machinery and stimulates glycogen synthase activity. The orthologous protein in mouse is FGF15, which shares about 50% amino acid identity and has similar functions. Together they are often referred to as FGF15/19.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGF; FGF-19; Fibroblast growth factor; Fibroblast growth factor 19
Gene Aliases: FGF19; UNQ334/PRO533
UniProt ID: (Human) O95750
Entrez Gene ID: (Human) 9965
MAPK cascade
neural crest cell migration
positive regulation of protein phosphorylation
nervous system development
heart development
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
negative regulation of gene expression
regulation of phosphatidylinositol 3-kinase signaling
phosphatidylinositol-3-phosphate biosynthetic process
positive regulation of GTPase activity
positive regulation of glucose import
positive regulation of JNK cascade
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of ERK1 and ERK2 cascade
negative regulation of bile acid biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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