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FGF21 Antibody (BS-2318R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded rat liver; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with FGF21 Polyclonal Antibody, Unconjugated (bs-2318R)at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining.
Product Details
BS-2318R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human FGF21, amino acids 29-120.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGF; FGF-21; FGFL; Fibroblast growth factor; Fibroblast growth factor 21; PRO10196
Gene Aliases: FGF21; UNQ3115/PRO10196
UniProt ID: (Human) Q9NSA1, (Mouse) Q9JJN1
Entrez Gene ID: (Human) 26291, (Rat) 170580, (Mouse) 56636
signal transduction
cell-cell signaling
positive regulation of cell proliferation
regulation of low-density lipoprotein particle clearance
response to activity
endoplasmic reticulum unfolded protein response
response to nutrient levels
cellular response to drug
positive regulation of low-density lipoprotein particle receptor biosynthetic process
positive regulation of glucose import
positive regulation of ERK1 and ERK2 cascade
cellular response to glucose stimulus
cellular response to low-density lipoprotein particle stimulus
endothelial cell apoptotic process
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
negative regulation of endothelial cell apoptotic process
fibroblast growth factor receptor signaling pathway
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