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Product Details
BS-1256R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human FGF4, amino acids 101-206.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Fibroblast growth factor 4 (FGF4) is a member of the fibroblast growth factor (FGF) family that possess broad mitogenic and cell survival activities and play key roles in growth and survival of stem cells during embryogenesis, tissue regeneration, and carcinogenesis. FGF4 was identified by its strong oncogenic transforming activity and is a potent angiogenic factor, expressed in several highly vascularized tumors and also in adult mouse testis, intestine, and brain. Studies on the mouse homolog suggests a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. Furthermore, FGF4 regulates neural progenitor cell proliferation and neuronal differentiation. Recent studies show a growth-promoting role for FGF4 in human embryonic stem cells and a putative feedback inhibition mechanism by a novel FGF4 splice isoform that may serve to promote differentiation at a later stages of development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGF; FGF-4; Fibroblast growth factor; Fibroblast growth factor 4; fibroblast growth factor 4 splice isoform; HBGF-4; heparin secretory transforming protein 1; Heparin secretory-transforming protein 1; heparin-binding growth factor 1; Heparin-binding growth factor 4; HST; HSTF-1; human stomach cancer, transforming factor from FGF-related oncogene; K-fibroblast growth factor; kaposi sarcoma oncogene; oncogene HST; Transforming protein KS3
Gene Aliases: Fgf-4; FGF4; Fgfk; HBGF-4; HST; HST-1; Hst1; Hstf-1; HSTF1; K-FGF; KFGF; KS3
UniProt ID: (Human) P08620, (Mouse) P11403
Entrez Gene ID: (Human) 2249, (Rat) 116499, (Mouse) 14175
protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
fibroblast growth factor receptor binding
growth factor activity
heparin binding
1-phosphatidylinositol-3-kinase activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
receptor binding
protein binding
growth factor
intercellular signal molecule
MAPK cascade
cartilage condensation
signal transduction
cell-cell signaling
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
mesenchymal cell proliferation
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
stem cell population maintenance
embryonic hindlimb morphogenesis
phosphatidylinositol-3-phosphate biosynthetic process
odontogenesis of dentin-containing tooth
negative regulation of apoptotic process
positive regulation of GTPase activity
positive regulation of transcription from RNA polymerase II promoter
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of cell division
cranial suture morphogenesis
apoptotic process involved in morphogenesis
chondroblast differentiation
positive regulation of ERK1 and ERK2 cascade
regulation of endothelial cell chemotaxis to fibroblast growth factor
positive regulation of protein phosphorylation
regulation of gene expression
positive regulation of gene expression
embryonic limb morphogenesis
multicellular organism development
cell differentiation
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