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Product Details
H00002253-M01
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2A10
Immunogen
FGF8 (NP_149354, 65 a.a. approximately 133 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: SRRLIRTYQL YSRTSGKHVQ VLANKRINAM AEDGDPFAKL IVETDTFGSR VRVRGAETGL YICMNKKGK
Target Information
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AIGF; androgen-induced; Androgen-induced growth factor; FGF; FGF-8; Fibroblast growth factor; Fibroblast growth factor 8; fibroblast growth factor 8 (androgen-induced); HBGF-8; Heparin-binding growth factor 8; MGC149376
Gene Aliases: AIGF; FGF-8; FGF8; HBGF-8; HH6; KAL6
UniProt ID: (Human) P55075, (Mouse) P37237
Entrez Gene ID: (Human) 2253, (Rat) 29349, (Mouse) 14179
protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
fibroblast growth factor receptor binding
growth factor activity
1-phosphatidylinositol-3-kinase activity
chemoattractant activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
type 1 fibroblast growth factor receptor binding
type 2 fibroblast growth factor receptor binding
receptor binding
growth factor
intercellular signal molecule
MAPK cascade
patterning of blood vessels
metanephros development
branching involved in ureteric bud morphogenesis
organ induction
mesonephros development
neural plate morphogenesis
heart looping
blood vessel remodeling
outflow tract septum morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
apoptotic process
response to oxidative stress
gastrulation
motor neuron axon guidance
mesodermal cell migration
positive regulation of cell proliferation
gonad development
fibroblast growth factor receptor signaling pathway
anatomical structure morphogenesis
positive regulation of gene expression
regulation of phosphatidylinositol 3-kinase signaling
response to organic cyclic compound
peptidyl-tyrosine phosphorylation
pallium development
subpallium development
forebrain dorsal/ventral pattern formation
cell proliferation in forebrain
forebrain neuron development
signal transduction involved in regulation of gene expression
BMP signaling pathway
male genitalia development
thyroid gland development
otic vesicle formation
midbrain-hindbrain boundary development
dorsal/ventral axon guidance
embryonic hindlimb morphogenesis
aorta morphogenesis
phosphatidylinositol-3-phosphate biosynthetic process
odontogenesis
regulation of odontogenesis of dentin-containing tooth
response to drug
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
cell fate commitment
positive regulation of mitotic nuclear division
positive regulation of organ growth
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
forebrain morphogenesis
positive chemotaxis
positive regulation of cell division
negative regulation of cardiac muscle tissue development
pharyngeal system development
canonical Wnt signaling pathway
corticotropin hormone secreting cell differentiation
thyroid-stimulating hormone-secreting cell differentiation
bone development
lung morphogenesis
branching involved in salivary gland morphogenesis
neuroepithelial cell differentiation
positive regulation of ERK1 and ERK2 cascade
dopaminergic neuron differentiation
cell migration involved in mesendoderm migration
kidney development
heart morphogenesis
outflow tract morphogenesis
determination of left/right symmetry
heart development
embryo development ending in birth or egg hatching
telencephalon development
central nervous system neuron development
lung development
embryonic heart tube development
limb morphogenesis
inner ear morphogenesis
negative regulation of apoptotic process
generation of neurons
multicellular organism development
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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