Proteintech

FGFR1 Monoclonal Antibody (10F12E7)

FGFR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

FGFR1 Antibody (60325-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 60325-1-IG ( FGFR1 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

60325-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:3,000

View 20 publications 20 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Mouse / IgG2c

Class

Monoclonal

Type

Antibody

Clone

10F12E7

Immunogen

FGFR1 Fusion Protein Ag3646 (471-821 aa encoded by BC018128)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.12 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LPRDRLVLG KPLGEGCFGQ VVLAEAIGLD KDKPNRVTKV AVKMLKSDAT EKDLSDLISE MEMMKMIGKH KNIINLLGAC TQDGPLYVIV EYASKGNLRE YLQARRPPGL EYCYNPSHNP EEQLSSKDLV SCAYQVARGM EYLASKKCIH RDLAARNVLV TEDNVMKIAD FGLARDIHHI DYYKKTTNGR LPVKWMAPEA LFDRIYTHQS DVWSFGVLLW EIFTLGGSPY PGVPVEELFK LLKEGHRMDK PSNCTNELYM MMRDCWHAVP SQRPTFKQLV EDLDRIVALT SNQEYLDLSM PLDQYSPSFP DTRSSTCSSG EDSVFSHEPL PEEPCLPRHP AQLANGGLKR R (471-821 aa encoded by BC018128)

Target Information

FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that constitute a family of four membrane-spanning tyrosine kinases (FGFR1-4) which serve as high-affinity receptors for 17 growth factors (FGF1-17). The FGF Receptor family plays an important role in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth. FGFR1 is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body. Other defects in FGFR1 are responsible for several diseases which include Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, Antley-Bixler syndrome. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Journal of ophthalmology

Cao X,Li T,Tian Y,Tian Y,Gao C,Zhang D,Song Y

Tue May 09 00:00:00 EDT 2023

The UCMSC-bFGF/Scaffold System Accelerates the Healing of the Uterine Full-Thickness Injury.

Tissue engineering. Part A

Wang L,Yao S,Huang F,Lv H,Liu D,Gao T,Wang B,Zhou Z,Cao C,Zhu Q,Weng Q,Zhao G,Hu Y

Wed Feb 01 00:00:00 EST 2023

Intracellular FGF1 promotes invasion and migration in thyroid carcinoma via HMGA1 independent of FGF receptors.

Endocrine connections

Chen Z,Zhong X,Tang W,Xia M,Liu C,Guo Y,Yi Y,Jiang Q,Zu X,Zhong J

Mon May 01 00:00:00 EDT 2023

LncRNA SNHG1 Promotes the Progression of Pancreatic Cancer by Regulating FGFR1 Expression via Competitively Binding to miR-497.

Frontiers in oncology

Chen S,Guo W,Meng M,Wu D,Zhou T,Wang L,Xu J

Sun May 01 00:00:00 EDT 2022

Blockade of phosphotyrosine pathways suggesting SH2 superbinder as a novel therapy for pulmonary fibrosis.

Theranostics

Wang M,Liu AD,Niu Q,Feng X,Zheng YY,Chen SJ,Xu H,Li Q,Hou GQ,Bi XY,Lu YZ,Cheng PP,Liang LM,Jiang YH,Zhao LQ,Liu F,Song LJ,Zhou LL,Xiao LY,Chen F,Li SS,Ma WL,Cao X,Ye H

Fri Jul 15 00:00:00 EDT 2022

DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma.

Oxidative medicine and cellular longevity

Chen X,Yang G,Guo X,Zhang J,Sun W,Liu D,Wang H,Liu S

Fri Jul 01 00:00:00 EDT 2022

Effects of Infrared Combined with Methylcobalamin on the Vibratory Sensory Threshold and Nerve Conduction Velocity of the Lower Extremity in Patients with Diabetic Foot Treatment.

Disease markers

Wang Y,Lin S,Chen Z,Chen Q,Fu M

Fri Sep 09 00:00:00 EDT 2022

Bevacizumab is an Efficient Therapeutic Approach with Low Side Effects in Patient-Derived Xenografts of Adenoid Cystic Carcinoma of the Lacrimal Gland.

Cancer management and research

Zhang J,Yan X,Liu R,Wu S,Liu Q,Li J,Ma J

Wed Mar 16 00:00:00 EDT 2022

Upregulated insulin receptor tyrosine kinase substrate promotes the proliferation of colorectal cancer cells via the bFGF/AKT signaling pathway.

Gastroenterology report

Wang S,Liu Z,Ma YM,Guan X,Jiang Z,Sun P,Liu ER,Zhang YK,Wang HY,Wang XS

Thu Apr 01 00:00:00 EDT 2021

Fisetin attenuates periodontitis through FGFR1/TLR4/NLRP3 inflammasome pathway.

International immunopharmacology

Huang X,Shen H,Liu Y,Qiu S,Guo Y

Tue Jun 01 00:00:00 EDT 2021

The FGFR Family Inhibitor AZD4547 Exerts an Antitumor Effect in Ovarian Cancer Cells.

International journal of molecular sciences

Na YR,Kim JY,Song CH,Kim M,Do YT,Vo TTL,Choi E,Ha E,Seo JH,Shin SJ

Wed Oct 06 00:00:00 EDT 2021

Fibroblast Growth Factor 21 Protects Against Atrial Remodeling via Reducing Oxidative Stress.

Frontiers in cardiovascular medicine

Chen M,Zhong J,Wang Z,Xu H,Chen H,Sun X,Lu Y,Chen L,Xie X,Zheng L

Sat Oct 30 00:00:00 EDT 2021

Fibroblast Growth Factor 21 Protects Against Atrial Remodeling via Reducing Oxidative Stress.

Frontiers in cardiovascular medicine

Chen M,Zhong J,Wang Z,Xu H,Chen H,Sun X,Lu Y,Chen L,Xie X,Zheng L

Sat Oct 30 00:00:00 EDT 2021

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.

Nature communications

Wang C,Li Y,Yan S,Wang H,Shao X,Xiao M,Yang B,Qin G,Kong R,Chen R,Zhang N

Mon Jun 22 00:00:00 EDT 2020

LncRNA AGAP2-AS1 augments cell viability and mobility, and confers gemcitabine resistance by inhibiting miR-497 in colorectal cancer.

Aging

Hong S,Yan Z,Song Y,Bi M,Li S

Mon Mar 23 00:00:00 EDT 2020

Brivanib, a multitargeted small-molecule tyrosine kinase inhibitor, suppresses laser-induced CNV in a mouse model of neovascular AMD.

Journal of cellular physiology

Li L,Zhu M,Wu W,Qin B,Gu J,Tu Y,Chen J,Liu D,Shi Y,Liu X,Sang A,Ding D

Sat Feb 01 00:00:00 EST 2020

Human-like collagen promotes the healing of acetic acid-induced gastric ulcers in rats by regulating NOS and growth factors.

Food & function

Xing M,Fu R,Liu Y,Wang P,Ma P,Zhu C,Fan D

Fri May 01 00:00:00 EDT 2020

Dl-3-N-butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats.

CNS neuroscience & therapeutics

Zhou PT,Wang LP,Qu MJ,Shen H,Zheng HR,Deng LD,Ma YY,Wang YY,Wang YT,Tang YH,Tian HL,Zhang ZJ,Yang GY

Sat Jun 01 00:00:00 EDT 2019

Synergistic protection of tetramethylpyrazine phosphate and borneol on brain microvascular endothelium cells injured by hypoxia.

American journal of translational research

Yu B,Zhong FM,Yao Y,Deng SQ,Xu HQ,Lu JF,Ruan M,Shen XC

Thu Oct 01 00:00:00 EDT 2020

Toxicity Effects of Methylene Blue on Rat Intervertebral Disc Annulus Fibrosus Cells.

Pain physician

Zhang L,Liu Y,Huang Z,Nan L,Wang F,Zhou S,Wang J,Feng X

Fri Mar 01 00:00:00 EST 2019

Long non-coding RNA PVT1 promotes malignancy in human endometrial carcinoma cells through negative regulation of miR-195-5p.

Biochimica et biophysica acta. Molecular cell research

Kong F,Ma J,Yang H,Yang D,Wang C,Ma X

Thu Jul 19 00:00:00 EDT 2018

Long non-coding RNA PVT1 promotes malignancy in human endometrial carcinoma cells through negative regulation of miR-195-5p.

Biochimica et biophysica acta. Molecular cell research

Kong F,Ma J,Yang H,Yang D,Wang C,Ma X

Thu Jul 19 00:00:00 EDT 2018

Long non-coding RNA PVT1 promotes malignancy in human endometrial carcinoma cells through negative regulation of miR-195-5p.

Biochimica et biophysica acta. Molecular cell research

Kong F,Ma J,Yang H,Yang D,Wang C,Ma X

Thu Jul 19 00:00:00 EDT 2018

Long non-coding RNA PVT1 promotes malignancy in human endometrial carcinoma cells through negative regulation of miR-195-5p.

Biochimica et biophysica acta. Molecular cell research

Kong F,Ma J,Yang H,Yang D,Wang C,Ma X

Thu Jul 19 00:00:00 EDT 2018

Spiroplasma eriocheiris induces mouse 3T6-Swiss albino cell apoptosis that associated with the infection mechanism.

Molecular immunology

Hou L,Gu W,Zhu H,Yao W,Wang W,Meng Q

Wed Nov 01 00:00:00 EDT 2017

Spiroplasma eriocheiris induces mouse 3T6-Swiss albino cell apoptosis that associated with the infection mechanism.

Molecular immunology

Hou L,Gu W,Zhu H,Yao W,Wang W,Meng Q

Wed Nov 01 00:00:00 EDT 2017

The expression and function of miR-424 in infantile skin hemangioma and its mechanism.

Scientific reports

Yang L,Dai J,Li F,Cheng H,Yan D,Ruan Q

Tue Sep 19 00:00:00 EDT 2017

The expression and function of miR-424 in infantile skin hemangioma and its mechanism.

Scientific reports

Yang L,Dai J,Li F,Cheng H,Yan D,Ruan Q

Tue Sep 19 00:00:00 EDT 2017

The expression and function of miR-424 in infantile skin hemangioma and its mechanism.

Scientific reports

Yang L,Dai J,Li F,Cheng H,Yan D,Ruan Q

Tue Sep 19 00:00:00 EDT 2017

The expression and function of miR-424 in infantile skin hemangioma and its mechanism.

Scientific reports

Yang L,Dai J,Li F,Cheng H,Yan D,Ruan Q

Tue Sep 19 00:00:00 EDT 2017

Alpaca fiber growth is mediated by microRNA let-7b via down-regulation of target gene FGF5.

Genetics and molecular research : GMR

Wang T,Zhang Y,Wang HD,Shen Y,Liu N,Cao J,Yu XJ,Dong CS,He XY

Thu Oct 29 00:00:00 EDT 2015

Alpaca fiber growth is mediated by microRNA let-7b via down-regulation of target gene FGF5.

Genetics and molecular research : GMR

Wang T,Zhang Y,Wang HD,Shen Y,Liu N,Cao J,Yu XJ,Dong CS,He XY

Thu Oct 29 00:00:00 EDT 2015

Bioinformatics

Protein Aliases: 2.7.10.1; Basic fibroblast growth factor receptor 1; BFGFR; CD331; CD331 antigen; FGF Receptor; FGFR; fgfr 1; FGFR-1; FGFR1/PLAG1 fusion; Fibroblast growth factor receptor 1; FLT-2; FMS-like tyrosine kinase 2; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; N-sam; Proto-oncogene c-Fgr

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Gene Aliases: bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR; FGFR-1; FGFR1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM; OGD

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UniProt ID: (Human) P11362

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Entrez Gene ID: (Human) 2260

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Function(s)

glycoprotein binding protein tyrosine kinase activity fibroblast growth factor-activated receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding heparin binding 1-phosphatidylinositol-3-kinase activity fibroblast growth factor binding protein complex binding identical protein binding protein homodimerization activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity cell adhesion molecule binding transmembrane signal receptor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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FGFR1 Monoclonal Antibody (10F12E7)

FGFR1 Antibody (60325-1-IG) in IHC (P)

Product Details

60325-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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