Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-87432
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 700-806 of human FGFR3
Conjugate
Form
Liquid
Concentration
1.36 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804142
Product Specific Information
Positive Samples: U-87MG, A-549, A-431; Cellular Location: Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Single-pass type I membrane protein
Immunogen sequence: VEELFKLLKE GHRMDKPANC THDLYMIMRE CWHAAPSQRP TFKQLVEDLD RVLTVTSTDE YLDLSAPFEQ YSPGGQDTPS SSSSGDDSVF AHDLLPPAPP SSGGSRT
Target Information
FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: CD333; FGF Receptor; FGFR; FGFR-3; FGFR3deltaTM; Fibroblast growth factor receptor 3; fibroblast growth factor receptor 3 variant 4; hydroxyaryl-protein kinase; tyrosine kinase JTK4
Gene Aliases: ACH; CD333; CEK2; FGFR3; HSFGFR3EX; JTK4
UniProt ID: (Human) P22607
Entrez Gene ID: (Human) 2261
protein tyrosine kinase activity
fibroblast growth factor-activated receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
1-phosphatidylinositol-3-kinase activity
fibroblast growth factor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
transmembrane signal receptor
MAPK cascade
skeletal system development
endochondral ossification
chondrocyte differentiation
endochondral bone growth
JAK-STAT cascade
cell-cell signaling
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
positive regulation of phospholipase activity
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
bone mineralization
chondrocyte proliferation
phosphatidylinositol-3-phosphate biosynthetic process
positive regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of MAPK cascade
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
protein autophosphorylation
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
negative regulation of developmental growth
bone morphogenesis
positive regulation of ERK1 and ERK2 cascade
bone maturation
fibroblast growth factor receptor apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support