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Fibrinogen-like protein 2 (Fgl2), also known as fibroleukin, is secreted by T cells and is involved in diseases in which thrombosis plays a pivotal role, such as virus-induced fulminant hepatitis, fetal loss syndrome and xenograft rejection. Constitutively expressed in cytotoxic T cells, Fgl2 exerts immunosuppressive effects on both T cell proliferation and dendritic cell maturation. Fgl2 is a serine protease and directly cleaves prothrombin to thrombin. Fgl2 functions in the pathogenesis of diseases including viral-induced hepatitis and Th1 cytokine-induced fetal loss syndrome.
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Protein Aliases: associated with MHV-3 induced prothrombinase activity; Cytotoxic T-lymphocyte-specific protein; Fibrinogen-like protein 2; Fibroleukin; Prothrombinase
Gene Aliases: AI385601; Fgl2; Fiblp; musfiblp
UniProt ID: (Mouse) P12804
Entrez Gene ID: (Mouse) 14190, (Rat) 84586
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