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Product Details
10966-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FH Fusion Protein Ag1437 (1-510 aa encoded by BC017444)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MYRALRLLA RSRPLVRAPA AALASAPGLG GAAVPSFWPP NAARMASQNS FRIEYDTFGE LKVPNDKYYG AQTVRSTMNF KIGGVTERMP TPVIKAFGIL KRAAAEVNQD YGLDPKIANA IMKAADEVAE GKLNDHFPLV VWQTGSGTQT NMNVNEVISN RAIEMLGGEL GSKIPVHPND HVNKSQSSND TFPTAMHIAA AIEVHEVLLP GLQKLHDALD AKSKEFAQII KIGRTHTQDA VPLTLGQEFS GYVQQVKYAM TRIKAAMPRI YELAAGGTAV GTGLNTRIGF AEKVAAKVAA LTGLPFVTAP NKFEALAAHD ALVELSGAMN TTACSLMKIA NDIRFLGSGP RSGLGELILP ENEPGSSIMP GKVNPTQCEA MTMVAAQVMG NHVAVTVGGS NGHFELNVFK PMMIKNVLHS ARLLGDASVS FTENCVVGIQ ANTERINKLM NESLMLVTAL NPHIGYDKAA KIAKTAHKNG STLKETAIEL GYLTAEQFDE WVKPKDMLGP K (1-510 aa encoded by BC017444)
Target Information
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EF-3; Fumarase; fumarate hydratase 1; Fumarate hydratase, mitochondrial
Gene Aliases: FH; Fh-1; Fh1; FMRD; HLRCC; LRCC; MCL; MCUL1
UniProt ID: (Human) P07954, (Rat) P14408, (Mouse) P97807
Entrez Gene ID: (Human) 2271, (Rat) 24368, (Mouse) 14194
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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