Proteintech

FIS1 Polyclonal Antibody

FIS1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 21

FIS1 Antibody (10956-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using (Product # 10956-1-AP) (FIS1 antibody) at dilution of 1:100 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

FIS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIS1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10956-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:16,000

View 211 publications 211 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:100

Immunocytochemistry (ICC/IF)

1:50-1:200

View 27 publications 27 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 3 publications 3 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Published species

Human, Mouse, Rat, Rodent

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FIS1 Fusion Protein Ag1409 (1-152 aa encoded by BC009428)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody was raised against the full-length of human Fis1 protein, and recognizes endogenous Fis1 protein in various lysates.

Immunogen sequence: MEAVLNELV SVEDLLKFEK KFQSEKAAGS VSKSTQFEYA WCLVRSKYND DIRKGIVLLE ELLPKGSKEE QRDYVFYLAV GNYRLKEYEK ALKYVRGLLQ TEPQNNQAKE LERLIDKAMK KDGLVGMAIV GGMALGVAGL AGLIGLAVSK SKS (1-152 aa encoded by BC009428)

Target Information

Fis1, a 17KDa integral membrane protein, is a novel member of mitochondrial fission machinery. It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-terminal transmembrane domain. It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane. Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission. It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functional fission complex, thereby inducing apoptosis. Role of Fis1 has also been implicated in growth and division of peroxisomes. Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhang R,Hou X,Wang C,Li J,Zhu J,Jiang Y,Hou F

Tue Nov 01 00:00:00 EDT 2022

PINK1 regulates mitochondrial fission/fusion and neuroinflammation in β-amyloid-induced Alzheimer's disease models.

Neurochemistry international

Wang X,Xue Y,Yao Y,Li Y,Ji X,Chi T,Liu P,Zou L

Tue Mar 01 00:00:00 EST 2022

PINK1 regulates mitochondrial fission/fusion and neuroinflammation in β-amyloid-induced Alzheimer's disease models.

Neurochemistry international

Wang X,Xue Y,Yao Y,Li Y,Ji X,Chi T,Liu P,Zou L

Tue Mar 01 00:00:00 EST 2022

Generation of a homozygous FIS1 knockout human embryonic stem cell line GIBHe015-B by CRISPR/Cas9 system.

Stem cell research

Wang M,Tang J,Zhou T,Mai Y,Zhu Y

Thu Dec 01 00:00:00 EST 2022

Myricetin Restores Aβ-Induced Mitochondrial Impairments in N2a-SW Cells.

ACS chemical neuroscience

Yao X,Zhang J,Lu Y,Deng Y,Zhao R,Xiao S

Wed Feb 16 00:00:00 EST 2022

Dihydromyricetin contributes to weight loss via pro-browning mediated by mitochondrial fission in white adipose.

European journal of pharmacology

Xiong X,Xia M,Niu A,Zhang Y,Yin T,Huang Q

Tue Nov 15 00:00:00 EST 2022

Intracellular Ca²⁺ Signaling and Calcium Release-Activated Calcium Modulator ORAI1 Are Associated With CD4⁺ T Lymphocytes in Dairy Cows.

Frontiers in immunology

Li M,Zhang B,Yin Y,Wen J,Wang J,He Y,Jiang Q,Loor JJ,Wang S,Yang W,Xu C

Wed Jun 08 00:00:00 EDT 2022

ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.

Human molecular genetics

Lin BC,Phung TH,Higgins NR,Greenslade JE,Prado MA,Finley D,Karbowski M,Polster BM,Monteiro MJ

Thu Jun 17 00:00:00 EDT 2021

Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells.

Experimental and therapeutic medicine

Zhang L,Cao H,Tao H,Yang J,Gong W,Hu Q

Thu Jul 01 00:00:00 EDT 2021

Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.

Theranostics

Luo Q,Xian P,Wang T,Wu S,Sun T,Wang W,Wang B,Yang H,Yang Y,Wang H,Liu W,Long Q

Fri Jul 30 00:00:00 EDT 2021

Chronic hypoxia alters cardiac mitochondrial complex protein expression and activity in fetal guinea pigs in a sex-selective manner.

American journal of physiology. Regulatory, integrative and comparative physiology

Song H,Polster BM,Thompson LP

Wed Dec 01 00:00:00 EST 2021

Effects of photoperiod on morphology and function in testis and epididymis of Cricetulus barabensis.

Journal of cellular physiology

Mou J,Xu J,Wang Z,Wang C,Yang X,Wang X,Xue H,Wu M,Xu L

Mon Mar 01 00:00:00 EST 2021

Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation.

Development (Cambridge, England)

Varuzhanyan G,Ladinsky MS,Yamashita SI,Abe M,Sakimura K,Kanki T,Chan DC

Sun Aug 15 00:00:00 EDT 2021

Elevated Lactate by High-Intensity Interval Training Regulates the Hippocampal BDNF Expression and the Mitochondrial Quality Control System.

Frontiers in physiology

Hu J,Cai M,Shang Q,Li Z,Feng Y,Liu B,Xue X,Lou S

Tue Mar 16 00:00:00 EDT 2021

Dihydromyricetin attenuates heat stress-induced apoptosis in dairy cow mammary epithelial cells through suppressing mitochondrial dysfunction.

Ecotoxicology and environmental safety

Wang HL,Xing GD,Qian Y,Sun XF,Zhong JF,Chen KL

Sat May 01 00:00:00 EDT 2021

The detrimental effect of iron on OA chondrocytes: Importance of pro-inflammatory cytokines induced iron influx and oxidative stress.

Journal of cellular and molecular medicine

Jing X,Du T,Li T,Yang X,Wang G,Liu X,Jiang Z,Cui X

Tue Jun 01 00:00:00 EDT 2021

Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.

Nature communications

Xiao X,Yeghiazaryan G,Hess S,Klemm P,Sieben A,Kleinridders A,Morgan DA,Wunderlich FT,Rahmouni K,Kong D,Scammell TE,Lowell BB,Kloppenburg P,Brüning JC,Hausen AC

Thu Sep 02 00:00:00 EDT 2021

Targeting P2RX1 alleviates renal ischemia/reperfusion injury by preserving mitochondrial dynamics.

Pharmacological research

Zhuang S,Xia S,Huang P,Wu J,Qu J,Chen R,Sun N,Li D,Wu H,Zhang M,Zhang J,Yuan X,Wang X

Sun Aug 01 00:00:00 EDT 2021

Extract of Cynomorium songaricum ameliorates mitochondrial ultrastructure impairments and dysfunction in two different in vitro models of Alzheimer's disease.

BMC complementary medicine and therapies

Cheng D,Su L,Wang X,Li X,Li L,Hu M,Lu Y

Mon Aug 09 00:00:00 EDT 2021

Restoring metabolism of myeloid cells reverses cognitive decline in ageing.

Nature

Minhas PS,Latif-Hernandez A,McReynolds MR,Durairaj AS,Wang Q,Rubin A,Joshi AU,He JQ,Gauba E,Liu L,Wang C,Linde M,Sugiura Y,Moon PK,Majeti R,Suematsu M,Mochly-Rosen D,Weissman IL,Longo FM,Rabinowitz JD,Andreasson KI

Mon Feb 01 00:00:00 EST 2021

Intranasal administration of DHED protects against exhaustive exercise-induced brain injury in rats.

Brain research

Peng G,Zheng H,Wu C,Wu C,Ma X,Xiong J,Hou J,Zhang L,Yang L,Pan H

Wed Dec 01 00:00:00 EST 2021

Distinct fission signatures predict mitochondrial degradation or biogenesis.

Nature

Kleele T,Rey T,Winter J,Zaganelli S,Mahecic D,Perreten Lambert H,Ruberto FP,Nemir M,Wai T,Pedrazzini T,Manley S

Sat May 01 00:00:00 EDT 2021

Distinct fission signatures predict mitochondrial degradation or biogenesis.

Nature

Kleele T,Rey T,Winter J,Zaganelli S,Mahecic D,Perreten Lambert H,Ruberto FP,Nemir M,Wai T,Pedrazzini T,Manley S

Sat May 01 00:00:00 EDT 2021

Mesenchymal stem cells ameliorate lipid metabolism through reducing mitochondrial damage of hepatocytes in the treatment of post-hepatectomy liver failure.

Cell death & disease

Wang JL,Ding HR,Pan CY,Shi XL,Ren HZ

Thu Jan 21 00:00:00 EST 2021

Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial.

Experimental gerontology

Harper SA,Bassler JR,Peramsetty S,Yang Y,Roberts LM,Drummer D,Mankowski RT,Leeuwenburgh C,Ricart K,Patel RP,Bamman MM,Anton SD,Jaeger BC,Buford TW

Fri Jan 01 00:00:00 EST 2021

KCa3.1 Mediates Dysregulation of Mitochondrial Quality Control in Diabetic Kidney Disease.

Frontiers in cell and developmental biology

Huang C,Yi H,Shi Y,Cao Q,Shi Y,Cheng D,Braet F,Chen XM,Pollock CA

Wed Mar 10 00:00:00 EST 2021

PP2 Ameliorates Renal Fibrosis by Regulating the NF-κB/COX-2 and PPARγ/UCP2 Pathway in Diabetic Mice.

Oxidative medicine and cellular longevity

Wei J,Deng X,Li Y,Li R,Yang Z,Li X,Song S,Shi Y,Duan H,Wu H

Mon Jan 31 00:00:00 EST 2022

Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer's disease.

Human molecular genetics

Reddy AP,Yin X,Sawant N,Reddy PH

Sat May 29 00:00:00 EDT 2021

Tortoise Plastron and Deer Antler Gelatin Prevents Against Neuronal Mitochondrial Dysfunction In Vitro: Implication for a Potential Therapy of Alzheimer's Disease.

Frontiers in pharmacology

Cheng D,Yang XJ,Zhang L,Qin ZS,Li WQ,Xu HC,Zhang ZJ

Tue Jun 01 00:00:00 EDT 2021

SIRT3 protects bovine mammary epithelial cells from heat stress damage by activating the AMPK signaling pathway.

Cell death discovery

Sun XC,Wang Y,Zeng HF,Xi YM,Lin H,Han ZY,Chen KL

Thu Oct 21 00:00:00 EDT 2021

Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3.

Toxicology and applied pharmacology

Geng Y,Wang Y,Sun R,Kang X,Zhao H,Zhu M,Sun Y,Hu Y,Wang Z,Tian X,Zhao Y,Yao J

Wed Dec 01 00:00:00 EST 2021

Selonsertib, a potential drug for liver failure therapy by rescuing the mitochondrial dysfunction of macrophage via ASK1-JNK-DRP1 pathway.

Cell & bioscience

Lou G,Li A,Cen Y,Yang Q,Zhang T,Qi J,Chen Z,Liu Y

Thu Jan 07 00:00:00 EST 2021

RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats.

Evidence-based complementary and alternative medicine : eCAM

He H,Li C,Lu X,Li Y,Li X,Sun X,Tang B,Wu Y,Li C

Tue Jan 11 00:00:00 EST 2022

Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.

Nature communications

Hu D,Sun X,Magpusao A,Fedorov Y,Thompson M,Wang B,Lundberg K,Adams DJ,Qi X

Mon Sep 06 00:00:00 EDT 2021

Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.

Mitochondrion

Xie QE,Wang MY,Cao ZP,Du X,Ji DM,Liang D,Cao YX,Liu YJ

Mon Nov 01 00:00:00 EDT 2021

Mechanisms of impaired mitochondrial homeostasis and NAD⁺ metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation.

Redox biology

Chiang S,Braidy N,Maleki S,Lal S,Richardson DR,Huang ML

Fri Oct 01 00:00:00 EDT 2021

Mechanisms of impaired mitochondrial homeostasis and NAD⁺ metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation.

Redox biology

Chiang S,Braidy N,Maleki S,Lal S,Richardson DR,Huang ML

Fri Oct 01 00:00:00 EDT 2021

The XBP1‒MARCH5‒MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma.

The Journal of investigative dermatology

Wang H,Yi X,Guo S,Wang S,Ma J,Zhao T,Shi Q,Tian Y,Wang H,Jia L,Gao T,Li C,Guo W

Wed Dec 01 00:00:00 EST 2021

ATPIF1 maintains normal mitochondrial structure which is impaired by CCM3 deficiency in endothelial cells.

Cell & bioscience

Wang K,Chen H,Zhou Z,Zhang H,Zhou HJ,Min W

Sat Jan 09 00:00:00 EST 2021

Haemodynamic-directed cardiopulmonary resuscitation promotes mitochondrial fusion and preservation of mitochondrial mass after successful resuscitation in a pediatric porcine model.

Resuscitation plus

Senthil K,Morgan RW,Hefti MM,Karlsson M,Lautz AJ,Mavroudis CD,Ko T,Nadkarni VM,Ehinger J,Berg RA,Sutton RM,McGowan FX,Kilbaugh TJ

Tue Jun 01 00:00:00 EDT 2021

Change on apoptosis, autophagy and mitochondria of the Harderian gland in Cricetulus barabensis during age.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology

Kong XT,Wang Z,Mou JJ,Li CS,Xue HL,Wu M,Chen L,Xu JH,Xu LX

Mon Jun 28 00:00:00 EDT 2021

CHIP protects against MPP⁺/MPTP-induced damage by regulating Drp1 in two models of Parkinson's disease.

Aging

Hu Z,Mao C,Wang H,Zhang Z,Zhang S,Luo H,Tang M,Yang J,Yuan Y,Wang Y,Liu Y,Fan L,Zhang Q,Yao D,Liu F,Schisler JC,Shi C,Xu Y

Sat Jan 02 00:00:00 EST 2021

LKB1/AMPKα signaling pathway and mitochondrial fission/fusion dynamics regulate apoptosis induced by 3-chlorpropane-1,2-diol in HEK293 cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Jin C,Xue W,Liu Q,Han J,Luo R,Feng J,Liu J,Guo T,Peng X,Hu T

Sun Aug 01 00:00:00 EDT 2021

Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca²⁺ homeostasis.

Cell biology and toxicology

Zhong Y,Jin C,Han J,Zhu J,Liu Q,Sun D,Xia X,Peng X

Fri Oct 01 00:00:00 EDT 2021

Protective effects of a mitochondria-targeted small peptide SS31 against hyperglycemia-induced mitochondrial abnormalities in the liver tissues of diabetic mice, Tallyho/JngJ mice.

Mitochondrion

Bhatti JS,Tamarai K,Kandimalla R,Manczak M,Yin X,Ramasubramanian B,Sawant N,Pradeepkiran JA,Vijayan M,Kumar S,Reddy PH

Sat May 01 00:00:00 EDT 2021

Effects of andrographolide on renal tubulointersticial injury and fibrosis. Evidence of its mechanism of action.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Liu W,Liang L,Zhang Q,Li Y,Yan S,Tang T,Ren Y,Mo J,Liu F,Chen X,Lan T

Fri Oct 01 00:00:00 EDT 2021

Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia.

Frontiers in cell and developmental biology

Mao X,Gu Y,Sui X,Shen L,Han J,Wang H,Xi Q,Zhuang Q,Meng Q,Wu G

Tue Apr 26 00:00:00 EDT 2022

Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72.

Brain research

Chai N,Haney MS,Couthouis J,Morgens DW,Benjamin A,Wu K,Ousey J,Fang S,Finer S,Bassik MC,Gitler AD

Sat Feb 01 00:00:00 EST 2020

Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72.

Brain research

Chai N,Haney MS,Couthouis J,Morgens DW,Benjamin A,Wu K,Ousey J,Fang S,Finer S,Bassik MC,Gitler AD

Sat Feb 01 00:00:00 EST 2020

Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72.

Brain research

Chai N,Haney MS,Couthouis J,Morgens DW,Benjamin A,Wu K,Ousey J,Fang S,Finer S,Bassik MC,Gitler AD

Sat Feb 01 00:00:00 EST 2020

Hypoxia induces pulmonary artery smooth muscle dysfunction through mitochondrial fragmentation-mediated endoplasmic reticulum stress.

Aging

Zhuan B,Wang X,Wang MD,Li ZC,Yuan Q,Xie J,Yang Z

Wed Nov 18 00:00:00 EST 2020

ChREBP-β regulates thermogenesis in brown adipose tissue.

The Journal of endocrinology

Wei C,Ma X,Su K,Qi S,Zhu Y,Lin J,Wang C,Yang R,Chen X,Wang W,Zhang WJ

Mon Jun 01 00:00:00 EDT 2020

Heat stress induces apoptosis through disruption of dynamic mitochondrial networks in dairy cow mammary epithelial cells.

In vitro cellular & developmental biology. Animal

Chen KL,Wang HL,Jiang LZ,Qian Y,Yang CX,Chang WW,Zhong JF,Xing GD

Wed Apr 01 00:00:00 EDT 2020

Exercise enhances mitochondrial fission and mitophagy to improve myopathy following critical limb ischemia in elderly mice via the PGC1a/FNDC5/irisin pathway.

Skeletal muscle

He W,Wang P,Chen Q,Li C

Tue Sep 15 00:00:00 EDT 2020

Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.

Science advances

Zhang X,Wang R,Hu D,Sun X,Fujioka H,Lundberg K,Chan ER,Wang Q,Xu R,Flanagan ME,Pieper AA,Qi X

Tue Dec 01 00:00:00 EST 2020

Exogenous H₂S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.

Aging and disease

Sun Y,Lu F,Yu X,Wang B,Chen J,Lu F,Peng S,Sun X,Yu M,Chen H,Wang Y,Zhang L,Liu N,Du H,Zhao D,Zhang W

Wed Apr 01 00:00:00 EDT 2020

The effect of autophagy and mitochondrial fission on Harderian gland is greater than apoptosis in male hamsters during different photoperiods.

PloS one

Xu JH,Wang Z,Mou JJ,Zhao XY,Geng XC,Wu M,Xue HL,Chen L,Xu LX

Thu Dec 24 00:00:00 EST 2020

PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission.

Aging

Guo J,Ren R,Yao X,Ye Y,Sun K,Lin J,Wang G,Guo F,Xiao J,Xu T

Tue Feb 25 00:00:00 EST 2020

Photoperiod Affects Harderian Gland Morphology and Secretion in Female Cricetulus barabensis: Autophagy, Apoptosis, and Mitochondria.

Frontiers in physiology

Wang Z,Xu JH,Mou JJ,Kong XT,Wu M,Xue HL,Xu LX

Mon Sep 28 00:00:00 EDT 2020

Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation.

The EMBO journal

Murata D,Yamada T,Tokuyama T,Arai K,Quirós PM,López-Otín C,Iijima M,Sesaki H

Tue Dec 15 00:00:00 EST 2020

Drp1/Mff signaling pathway is involved in fluoride-induced abnormal fission of hepatocyte mitochondria in mice.

The Science of the total environment

Zhou BH,Wei SS,Jia LS,Zhang Y,Miao CY,Wang HW

Fri Jul 10 00:00:00 EDT 2020

HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.

Cell proliferation

Jiang N,Zhao H,Han Y,Li L,Xiong S,Zeng L,Xiao Y,Wei L,Xiong X,Gao P,Yang M,Liu Y,Sun L

Sun Nov 01 00:00:00 EDT 2020

HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.

Cell proliferation

Jiang N,Zhao H,Han Y,Li L,Xiong S,Zeng L,Xiao Y,Wei L,Xiong X,Gao P,Yang M,Liu Y,Sun L

Sun Nov 01 00:00:00 EDT 2020

HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.

Cell proliferation

Jiang N,Zhao H,Han Y,Li L,Xiong S,Zeng L,Xiao Y,Wei L,Xiong X,Gao P,Yang M,Liu Y,Sun L

Sun Nov 01 00:00:00 EDT 2020

HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.

Cell proliferation

Jiang N,Zhao H,Han Y,Li L,Xiong S,Zeng L,Xiao Y,Wei L,Xiong X,Gao P,Yang M,Liu Y,Sun L

Sun Nov 01 00:00:00 EDT 2020

High-Intensity Interval Training Restores Glycolipid Metabolism and Mitochondrial Function in Skeletal Muscle of Mice With Type 2 Diabetes.

Frontiers in endocrinology

Zheng L,Rao Z,Guo Y,Chen P,Xiao W

Wed May 19 00:00:00 EDT 2021

Proteomic Profile of Mouse Brain Aging Contributions to Mitochondrial Dysfunction, DNA Oxidative Damage, Loss of Neurotrophic Factor, and Synaptic and Ribosomal Proteins.

Oxidative medicine and cellular longevity

Li Y,Yu H,Chen C,Li S,Zhang Z,Xu H,Zhu F,Liu J,Spencer PS,Dai Z,Yang X

Fri Feb 05 00:00:00 EST 2021

PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.

Stem cell research & therapy

Yao X,Yu S,Jing X,Guo J,Sun K,Guo F,Ye Y

Mon Mar 30 00:00:00 EDT 2020

Formation of colorectal liver metastases induces musculoskeletal and metabolic abnormalities consistent with exacerbated cachexia.

JCI insight

Huot JR,Novinger LJ,Pin F,Narasimhan A,Zimmers TA,O'Connell TM,Bonetto A

Thu May 07 00:00:00 EDT 2020

USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.

Life science alliance

Rusilowicz-Jones EV,Jardine J,Kallinos A,Pinto-Fernandez A,Guenther F,Giurrandino M,Barone FG,McCarron K,Burke CJ,Murad A,Martinez A,Marcassa E,Gersch M,Buckmelter AJ,Kayser-Bricker KJ,Lamoliatte F,Gajbhiye A,Davis S,Scott HC,Murphy E,England K,Mortiboys H,Komander D,Trost M,Kessler BM,Ioannidis S,Ahlijanian MK,Urbé S,Clague MJ

Sat Aug 01 00:00:00 EDT 2020

Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons.

The Science of the total environment

Zhang C,Wang J,Zhu J,Chen Y,Han X

Mon Feb 10 00:00:00 EST 2020

Novel ultrastructural findings on cardiac mitochondria of huddling Brandt's voles in mild cold environment.

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

Wang Z,Xu JH,Mou JJ,Kong XT,Zou JW,Xue HL,Wu M,Xu LX

Sun Nov 01 00:00:00 EDT 2020

Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.

PLoS biology

Ma D,Zheng B,Liu HL,Zhao YB,Liu X,Zhang XH,Li Q,Shi WB,Suzuki T,Wen JK

Sat Aug 01 00:00:00 EDT 2020

Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.

PLoS biology

Ma D,Zheng B,Liu HL,Zhao YB,Liu X,Zhang XH,Li Q,Shi WB,Suzuki T,Wen JK

Sat Aug 01 00:00:00 EDT 2020

Desferoxamine protects against glucocorticoid-induced osteonecrosis of the femoral head via activating HIF-1α expression.

Journal of cellular physiology

Jing X,Du T,Yang X,Zhang W,Wang G,Liu X,Li T,Jiang Z

Tue Dec 01 00:00:00 EST 2020

DsbA-L deficiency exacerbates mitochondrial dysfunction of tubular cells in diabetic kidney disease.

Clinical science (London, England : 1979)

Gao P,Yang M,Chen X,Xiong S,Liu J,Sun L

Fri Apr 17 00:00:00 EDT 2020

Bu-Yin-Qian-Zheng Formula Ameliorates MPP⁺-Induced Mitochondrial Dysfunction in Parkinson's Disease via Parkin.

Frontiers in pharmacology

Ma HJ,Gai C,Chai Y,Feng WD,Cheng CC,Zhang JK,Zhang YX,Yang LP,Guo ZY,Gao YS,Sun HM

Tue Jan 12 00:00:00 EST 2021

PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.

Nature communications

Guo L,Cui C,Wang J,Yuan J,Yang Q,Zhang P,Su W,Bao R,Ran J,Wu C

Thu Oct 01 00:00:00 EDT 2020

Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients.

Biomolecules

Tokuyama T,Hirai A,Shiiba I,Ito N,Matsuno K,Takeda K,Saito K,Mii K,Matsushita N,Fukuda T,Inatome R,Yanagi S

Fri Mar 13 00:00:00 EDT 2020

Mst1 Knockout Alleviates Mitochondrial Fission and Mitigates Left Ventricular Remodeling in the Development of Diabetic Cardiomyopathy.

Frontiers in cell and developmental biology

Feng X,Wang S,Yang X,Lin J,Man W,Dong Y,Zhang Y,Zhao Z,Wang H,Sun D

Wed Feb 10 00:00:00 EST 2021

Deletion of Bmal1 Impairs Pancreatic β-Cell Function via Mitochondrial Signaling Pathway.

BioMed research international

Ye L,Wu H,Xu W

Mon Apr 26 00:00:00 EDT 2021

Promotion of mitochondrial fusion protects against developmental PBDE-47 neurotoxicity by restoring mitochondrial homeostasis and suppressing excessive apoptosis.

Theranostics

Dong L,Li P,Yang K,Liu L,Gao H,Zhou G,Zhao Q,Xia T,Wang A,Zhang S

Thu Apr 08 00:00:00 EDT 2021

AIM2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics.

Oncogene

Qi M,Dai D,Liu J,Li Z,Liang P,Wang Y,Cheng L,Zhan Y,An Z,Song Y,Yang Y,Yan X,Xiao H,Shao H

Sun Mar 01 00:00:00 EST 2020

Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.

International journal of biological sciences

Deng X,Liu J,Liu L,Sun X,Huang J,Dong J

Mon Sep 27 00:00:00 EDT 2021

An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Dasgupta A,Chen KH,Wu D,Hoskin V,Mewburn J,Lima PDA,Parlow LRG,Hindmarch CCT,Martin A,Sykes EA,Tayade C,Lightbody ED,Madarnas Y,SenGupta SK,Elliott BE,Nicol CJB,Archer SL

Wed Apr 01 00:00:00 EDT 2020

FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Yoo SM,Yamashita SI,Kim H,Na D,Lee H,Kim SJ,Cho DH,Kanki T,Jung YK

Sat Feb 01 00:00:00 EST 2020

PRCC-TFE3 regulates migration and invasion of translocation renal cell carcinomas via activation of Drp1-dependent mitochondrial fission.

Cell biology international

Wang B,Gan W,Han X,Li D

Sat Aug 01 00:00:00 EDT 2020

Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.

Cell metabolism

Zhong X,Cui P,Cai Y,Wang L,He X,Long P,Lu K,Yan R,Zhang Y,Pan X,Zhao X,Li W,Zhang H,Zhou Q,Gao P

Tue Apr 02 00:00:00 EDT 2019

Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.

Cell metabolism

Zhong X,Cui P,Cai Y,Wang L,He X,Long P,Lu K,Yan R,Zhang Y,Pan X,Zhao X,Li W,Zhang H,Zhou Q,Gao P

Tue Apr 02 00:00:00 EDT 2019

Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy.

EMBO molecular medicine

Sprenger HG,Wani G,Hesseling A,König T,Patron M,MacVicar T,Ahola S,Wai T,Barth E,Rugarli EI,Bergami M,Langer T

Tue Jan 01 00:00:00 EST 2019

Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy.

EMBO molecular medicine

Sprenger HG,Wani G,Hesseling A,König T,Patron M,MacVicar T,Ahola S,Wai T,Barth E,Rugarli EI,Bergami M,Langer T

Tue Jan 01 00:00:00 EST 2019

Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.

Autophagy

Li H,Ham A,Ma TC,Kuo SH,Kanter E,Kim D,Ko HS,Quan Y,Sardi SP,Li A,Arancio O,Kang UJ,Sulzer D,Tang G

Tue Jan 01 00:00:00 EST 2019

Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.

Autophagy

Li H,Ham A,Ma TC,Kuo SH,Kanter E,Kim D,Ko HS,Quan Y,Sardi SP,Li A,Arancio O,Kang UJ,Sulzer D,Tang G

Tue Jan 01 00:00:00 EST 2019

Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder.

Proceedings of the National Academy of Sciences of the United States of America

Chen CW,Wang HL,Huang CW,Huang CY,Lim WK,Tu IC,Koorapati A,Hsieh ST,Kan HW,Tzeng SR,Liao JC,Chong WM,Naroditzky I,Kidron D,Eran A,Nijim Y,Sela E,Feldman HB,Kalfon L,Raveh-Barak H,Falik-Zaccai TC,Elpeleg O,Mandel H,Chang ZF

Tue Jan 08 00:00:00 EST 2019

Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission.

Pharmacological research

Yao X,Zhang J,Jing X,Ye Y,Guo J,Sun K,Guo F

Tue Jan 01 00:00:00 EST 2019

Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission.

Pharmacological research

Yao X,Zhang J,Jing X,Ye Y,Guo J,Sun K,Guo F

Tue Jan 01 00:00:00 EST 2019

Novel findings on ultrastructural protection of skeletal muscle fibers during hibernation of Daurian ground squirrels: Mitochondria, nuclei, cytoskeleton, glycogen.

Journal of cellular physiology

Wang Z,Jiang SF,Cao J,Liu K,Xu SH,Arfat Y,Guo QL,Chang H,Goswami N,Hinghofer-Szalkay H,Gao YF

Thu Aug 01 00:00:00 EDT 2019

Novel findings on ultrastructural protection of skeletal muscle fibers during hibernation of Daurian ground squirrels: Mitochondria, nuclei, cytoskeleton, glycogen.

Journal of cellular physiology

Wang Z,Jiang SF,Cao J,Liu K,Xu SH,Arfat Y,Guo QL,Chang H,Goswami N,Hinghofer-Szalkay H,Gao YF

Thu Aug 01 00:00:00 EDT 2019

Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children.

Archives of toxicology

Zhao Q,Niu Q,Chen J,Xia T,Zhou G,Li P,Dong L,Xu C,Tian Z,Luo C,Liu L,Zhang S,Wang A

Fri Mar 01 00:00:00 EST 2019

Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children.

Archives of toxicology

Zhao Q,Niu Q,Chen J,Xia T,Zhou G,Li P,Dong L,Xu C,Tian Z,Luo C,Liu L,Zhang S,Wang A

Fri Mar 01 00:00:00 EST 2019

Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children.

Archives of toxicology

Zhao Q,Niu Q,Chen J,Xia T,Zhou G,Li P,Dong L,Xu C,Tian Z,Luo C,Liu L,Zhang S,Wang A

Fri Mar 01 00:00:00 EST 2019

Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children.

Archives of toxicology

Zhao Q,Niu Q,Chen J,Xia T,Zhou G,Li P,Dong L,Xu C,Tian Z,Luo C,Liu L,Zhang S,Wang A

Fri Mar 01 00:00:00 EST 2019

Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity.

Human molecular genetics

Manczak M,Kandimalla R,Yin X,Reddy PH

Tue Jan 15 00:00:00 EST 2019

Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity.

Human molecular genetics

Manczak M,Kandimalla R,Yin X,Reddy PH

Tue Jan 15 00:00:00 EST 2019

Hepatic HKDC1 Expression Contributes to Liver Metabolism.

Endocrinology

Pusec CM,De Jesus A,Khan MW,Terry AR,Ludvik AE,Xu K,Giancola N,Pervaiz H,Daviau Smith E,Ding X,Harrison S,Chandel NS,Becker TC,Hay N,Ardehali H,Cordoba-Chacon J,Layden BT

Fri Feb 01 00:00:00 EST 2019

Hepatic HKDC1 Expression Contributes to Liver Metabolism.

Endocrinology

Pusec CM,De Jesus A,Khan MW,Terry AR,Ludvik AE,Xu K,Giancola N,Pervaiz H,Daviau Smith E,Ding X,Harrison S,Chandel NS,Becker TC,Hay N,Ardehali H,Cordoba-Chacon J,Layden BT

Fri Feb 01 00:00:00 EST 2019

Proteomic Analysis and Biochemical Correlates of Mitochondrial Dysfunction after Low-Intensity Primary Blast Exposure.

Journal of neurotrauma

Song H,Chen M,Chen C,Cui J,Johnson CE,Cheng J,Wang X,Swerdlow RH,DePalma RG,Xia W,Gu Z

Wed May 15 00:00:00 EDT 2019

Proteomic Analysis and Biochemical Correlates of Mitochondrial Dysfunction after Low-Intensity Primary Blast Exposure.

Journal of neurotrauma

Song H,Chen M,Chen C,Cui J,Johnson CE,Cheng J,Wang X,Swerdlow RH,DePalma RG,Xia W,Gu Z

Wed May 15 00:00:00 EDT 2019

Pyridostigmine regulates glucose metabolism and mitochondrial homeostasis to reduce myocardial vulnerability to injury in diabetic mice.

American journal of physiology. Endocrinology and metabolism

Yang Y,Zhao M,Yu XJ,Liu LZ,He X,Deng J,Zang WJ

Thu Aug 01 00:00:00 EDT 2019

Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae.

Cell metabolism

Yuan J,Chen C,Cui J,Lu J,Yan C,Wei X,Zhao X,Li N,Li S,Xue G,Cheng W,Li B,Li H,Lin W,Tian C,Zhao J,Han J,An D,Zhang Q,Wei H,Zheng M,Ma X,Li W,Chen X,Zhang Z,Zeng H,Ying S,Wu J,Yang R,Liu D

Tue Oct 01 00:00:00 EDT 2019

Oxidative pathophysiology following volumetric muscle loss injury in a porcine model.

Journal of applied physiology (Bethesda, Md. : 1985)

Chao T,Burmeister DM,Corona BT,Greising SM

Sat Jun 01 00:00:00 EDT 2019

SS-31 reduces inflammation and oxidative stress through the inhibition of Fis1 expression in lipopolysaccharide-stimulated microglia.

Biochemical and biophysical research communications

Mo Y,Deng S,Zhang L,Huang Y,Li W,Peng Q,Liu Z,Ai Y

Tue Nov 26 00:00:00 EST 2019

Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff).

PloS one

Lee L,Seager R,Nakamura Y,Wilkinson KA,Henley JM

Tue Jan 14 00:00:00 EST 2020

Da-Bu-Yin-Wan and Qian-Zheng-San Ameliorate Mitochondrial Dynamics in the Parkinson's Disease Cell Model Induced by MPP.

Frontiers in pharmacology

Gai C,Feng WD,Qiang TY,Ma HJ,Chai Y,Zhang SJ,Guo ZY,Hu JH,Sun HM

Wed Sep 30 00:00:00 EDT 2020

Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells.

Oxidative medicine and cellular longevity

Zeng Y,Pan Q,Wang X,Li D,Lin Y,Man F,Xiao F,Guo L

Fri Dec 13 00:00:00 EST 2019

Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation.

Oxidative medicine and cellular longevity

Chai N,Zhang H,Li L,Yu X,Liu Y,Lin Y,Wang L,Yan J,Nikolaevna SE,Zhao Y

Fri Dec 13 00:00:00 EST 2019

Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways.

Frontiers in pharmacology

Yao X,Jing X,Guo J,Sun K,Deng Y,Zhang Y,Guo F,Ye Y

Thu Oct 01 00:00:00 EDT 2020

Propofol Ameliorates H9c2 Cells Apoptosis Induced by Oxygen Glucose Deprivation and Reperfusion Injury via Inhibiting High Levels of Mitochondrial Fusion and Fission.

Frontiers in pharmacology

Zhao L,Zhuang J,Wang Y,Zhou D,Zhao D,Zhu S,Pu J,Zhang H,Yin M,Zhao W,Wang Z,Hong J

Thu Oct 01 00:00:00 EDT 2020

Burn-induced reductions in mitochondrial abundance and efficiency are more pronounced with small volumes of colloids in swine.

American journal of physiology. Cell physiology

Chao T,Gómez BI,Heard TC,Smith BW,Dubick MA,Burmeister DM

Sun Dec 01 00:00:00 EST 2019

ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.

Nature communications

Zhao Y,Sun X,Hu D,Prosdocimo DA,Hoppel C,Jain MK,Ramachandran R,Qi X

Tue Mar 26 00:00:00 EDT 2019

Mitochondrial dysfunction in endothelial cells induced by airborne fine particulate matter (<2.5 μm).

Journal of applied toxicology : JAT

Miao X,Li W,Niu B,Li J,Sun J,Qin M,Zhou Z

Tue Oct 01 00:00:00 EDT 2019

Angiotensin II suppresses autophagy and disrupts ultrastructural morphology and function of mitochondria in mouse skeletal muscle.

Journal of applied physiology (Bethesda, Md. : 1985)

Silva KAS,Ghiarone T,Schreiber K,Grant D,White T,Frisard MI,Sukhanov S,Chandrasekar B,Delafontaine P,Yoshida T

Sat Jun 01 00:00:00 EDT 2019

Low-dose oral copper treatment changes the hippocampal phosphoproteomic profile and perturbs mitochondrial function in a mouse model of Alzheimer's disease.

Free radical biology & medicine

Chen C,Jiang X,Li Y,Yu H,Li S,Zhang Z,Xu H,Yang Y,Liu G,Zhu F,Ren X,Zou L,Xu B,Liu J,Spencer PS,Yang X

Wed May 01 00:00:00 EDT 2019

SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo.

Theranostics

Yi X,Guo W,Shi Q,Yang Y,Zhang W,Chen X,Kang P,Chen J,Cui T,Ma J,Wang H,Guo S,Chang Y,Liu L,Jian Z,Wang L,Xiao Q,Li S,Gao T,Li C

Mon Mar 16 00:00:00 EDT 2020

AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells.

Cell stem cell

Pei S,Minhajuddin M,Adane B,Khan N,Stevens BM,Mack SC,Lai S,Rich JN,Inguva A,Shannon KM,Kim H,Tan AC,Myers JR,Ashton JM,Neff T,Pollyea DA,Smith CA,Jordan CT

Thu Jul 05 00:00:00 EDT 2018

AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells.

Cell stem cell

Pei S,Minhajuddin M,Adane B,Khan N,Stevens BM,Mack SC,Lai S,Rich JN,Inguva A,Shannon KM,Kim H,Tan AC,Myers JR,Ashton JM,Neff T,Pollyea DA,Smith CA,Jordan CT

Thu Jul 05 00:00:00 EDT 2018

AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells.

Cell stem cell

Pei S,Minhajuddin M,Adane B,Khan N,Stevens BM,Mack SC,Lai S,Rich JN,Inguva A,Shannon KM,Kim H,Tan AC,Myers JR,Ashton JM,Neff T,Pollyea DA,Smith CA,Jordan CT

Thu Jul 05 00:00:00 EDT 2018

AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells.

Cell stem cell

Pei S,Minhajuddin M,Adane B,Khan N,Stevens BM,Mack SC,Lai S,Rich JN,Inguva A,Shannon KM,Kim H,Tan AC,Myers JR,Ashton JM,Neff T,Pollyea DA,Smith CA,Jordan CT

Thu Jul 05 00:00:00 EDT 2018

INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division.

The Journal of cell biology

Chakrabarti R,Ji WK,Stan RV,de Juan Sanz J,Ryan TA,Higgs HN

Tue Jan 02 00:00:00 EST 2018

INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division.

The Journal of cell biology

Chakrabarti R,Ji WK,Stan RV,de Juan Sanz J,Ryan TA,Higgs HN

Tue Jan 02 00:00:00 EST 2018

GLUT10 maintains the integrity of major arteries through regulation of redox homeostasis and mitochondrial function.

Human molecular genetics

Syu YW,Lai HW,Jiang CL,Tsai HY,Lin CC,Lee YC

Mon Jan 15 00:00:00 EST 2018

GLUT10 maintains the integrity of major arteries through regulation of redox homeostasis and mitochondrial function.

Human molecular genetics

Syu YW,Lai HW,Jiang CL,Tsai HY,Lin CC,Lee YC

Mon Jan 15 00:00:00 EST 2018

Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.

Human molecular genetics

Reddy PH,Yin X,Manczak M,Kumar S,Pradeepkiran JA,Vijayan M,Reddy AP

Sun Jul 15 00:00:00 EDT 2018

Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.

Human molecular genetics

Reddy PH,Yin X,Manczak M,Kumar S,Pradeepkiran JA,Vijayan M,Reddy AP

Sun Jul 15 00:00:00 EDT 2018

Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease.

Human molecular genetics

Kandimalla R,Manczak M,Yin X,Wang R,Reddy PH

Mon Jan 01 00:00:00 EST 2018

Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease.

Human molecular genetics

Kandimalla R,Manczak M,Yin X,Wang R,Reddy PH

Mon Jan 01 00:00:00 EST 2018

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease.

Human molecular genetics

Manczak M,Kandimalla R,Yin X,Reddy PH

Sun Apr 15 00:00:00 EDT 2018

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease.

Human molecular genetics

Manczak M,Kandimalla R,Yin X,Reddy PH

Sun Apr 15 00:00:00 EDT 2018

A high-fat diet impairs mitochondrial biogenesis, mitochondrial dynamics, and the respiratory chain complex in rat myocardial tissues.

Journal of cellular biochemistry

Chen D,Li X,Zhang L,Zhu M,Gao L

Thu Nov 01 00:00:00 EDT 2018

A high-fat diet impairs mitochondrial biogenesis, mitochondrial dynamics, and the respiratory chain complex in rat myocardial tissues.

Journal of cellular biochemistry

Chen D,Li X,Zhang L,Zhu M,Gao L

Thu Nov 01 00:00:00 EDT 2018

In Vivo Deletion of β-Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption.

Endocrinology

Hennings TG,Chopra DG,DeLeon ER,VanDeusen HR,Sesaki H,Merrins MJ,Ku GM

Sat Sep 01 00:00:00 EDT 2018

Polybrene induces neural degeneration by bidirectional Ca²⁺ influx-dependent mitochondrial and ER-mitochondrial dynamics.

Cell death & disease

Bao F,Shi H,Gao M,Yang L,Zhou L,Zhao Q,Wu Y,Chen K,Xiang G,Long Q,Guo J,Zhang J,Liu X

Thu Sep 20 00:00:00 EDT 2018

Polybrene induces neural degeneration by bidirectional Ca²⁺ influx-dependent mitochondrial and ER-mitochondrial dynamics.

Cell death & disease

Bao F,Shi H,Gao M,Yang L,Zhou L,Zhao Q,Wu Y,Chen K,Xiang G,Long Q,Guo J,Zhang J,Liu X

Thu Sep 20 00:00:00 EDT 2018

Aerobic Exercise Preconception and During Pregnancy Enhances Oxidative Capacity in the Hindlimb Muscles of Mice Offspring.

Journal of strength and conditioning research

Liu J,Lee I,Feng HZ,Galen SS,Hüttemann PP,Perkins GA,Jin JP,Hüttemann M,Malek MH

Tue May 01 00:00:00 EDT 2018

Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.

The EMBO journal

Wang L,Zhang T,Wang L,Cai Y,Zhong X,He X,Hu L,Tian S,Wu M,Hui L,Zhang H,Gao P

Mon May 15 00:00:00 EDT 2017

Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.

The EMBO journal

Wang L,Zhang T,Wang L,Cai Y,Zhong X,He X,Hu L,Tian S,Wu M,Hui L,Zhang H,Gao P

Mon May 15 00:00:00 EDT 2017

Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.

The EMBO journal

Wang L,Zhang T,Wang L,Cai Y,Zhong X,He X,Hu L,Tian S,Wu M,Hui L,Zhang H,Gao P

Mon May 15 00:00:00 EDT 2017

Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.

The EMBO journal

Wang L,Zhang T,Wang L,Cai Y,Zhong X,He X,Hu L,Tian S,Wu M,Hui L,Zhang H,Gao P

Mon May 15 00:00:00 EDT 2017

Receptor-mediated Drp1 oligomerization on endoplasmic reticulum.

The Journal of cell biology

Ji WK,Chakrabarti R,Fan X,Schoenfeld L,Strack S,Higgs HN

Mon Dec 04 00:00:00 EST 2017

Receptor-mediated Drp1 oligomerization on endoplasmic reticulum.

The Journal of cell biology

Ji WK,Chakrabarti R,Fan X,Schoenfeld L,Strack S,Higgs HN

Mon Dec 04 00:00:00 EST 2017

Receptor-mediated Drp1 oligomerization on endoplasmic reticulum.

The Journal of cell biology

Ji WK,Chakrabarti R,Fan X,Schoenfeld L,Strack S,Higgs HN

Mon Dec 04 00:00:00 EST 2017

Receptor-mediated Drp1 oligomerization on endoplasmic reticulum.

The Journal of cell biology

Ji WK,Chakrabarti R,Fan X,Schoenfeld L,Strack S,Higgs HN

Mon Dec 04 00:00:00 EST 2017

Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension.

Journal of molecular medicine (Berlin, Germany)

Tian L,Neuber-Hess M,Mewburn J,Dasgupta A,Dunham-Snary K,Wu D,Chen KH,Hong Z,Sharp WW,Kutty S,Archer SL

Sat Apr 01 00:00:00 EDT 2017

Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.

Journal of cellular and molecular medicine

Liu N,Wu J,Zhang L,Gao Z,Sun Y,Yu M,Zhao Y,Dong S,Lu F,Zhang W

Fri Dec 01 00:00:00 EST 2017

Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.

Journal of cellular and molecular medicine

Liu N,Wu J,Zhang L,Gao Z,Sun Y,Yu M,Zhao Y,Dong S,Lu F,Zhang W

Fri Dec 01 00:00:00 EST 2017

Low-level laser therapy for beta amyloid toxicity in rat hippocampus.

Neurobiology of aging

Lu Y,Wang R,Dong Y,Tucker D,Zhao N,Ahmed ME,Zhu L,Liu TC,Cohen RM,Zhang Q

Sun Jan 01 00:00:00 EST 2017

Low-level laser therapy for beta amyloid toxicity in rat hippocampus.

Neurobiology of aging

Lu Y,Wang R,Dong Y,Tucker D,Zhao N,Ahmed ME,Zhu L,Liu TC,Cohen RM,Zhang Q

Sun Jan 01 00:00:00 EST 2017

p62-Mediated mitochondrial clustering attenuates apoptosis induced by mitochondrial depolarization.

Biochimica et biophysica acta. Molecular cell research

Xiao B,Deng X,Lim GGY,Zhou W,Saw WT,Zhou ZD,Lim KL,Tan EK

Sat Jul 01 00:00:00 EDT 2017

p62-Mediated mitochondrial clustering attenuates apoptosis induced by mitochondrial depolarization.

Biochimica et biophysica acta. Molecular cell research

Xiao B,Deng X,Lim GGY,Zhou W,Saw WT,Zhou ZD,Lim KL,Tan EK

Sat Jul 01 00:00:00 EDT 2017

Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation.

Biochimica et biophysica acta. Molecular cell research

Guedouari H,Daigle T,Scorrano L,Hebert-Chatelain E

Sun Jan 01 00:00:00 EST 2017

Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation.

Biochimica et biophysica acta. Molecular cell research

Guedouari H,Daigle T,Scorrano L,Hebert-Chatelain E

Sun Jan 01 00:00:00 EST 2017

Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease.

PPAR research

Wang Y,Zhao W,Li G,Chen J,Guan X,Chen X,Guan Z

Thu Oct 01 00:00:00 EDT 2020

Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease.

PPAR research

Wang Y,Zhao W,Li G,Chen J,Guan X,Chen X,Guan Z

Thu Oct 01 00:00:00 EDT 2020

Phosphorylation of dynamin-related protein 1 at Ser616 regulates mitochondrial fission and is involved in mitochondrial calcium uniporter-mediated neutrophil polarization and chemotaxis.

Molecular immunology

Zheng X,Chen M,Meng X,Chu X,Cai C,Zou F

Sat Jul 01 00:00:00 EDT 2017

Phosphorylation of dynamin-related protein 1 at Ser616 regulates mitochondrial fission and is involved in mitochondrial calcium uniporter-mediated neutrophil polarization and chemotaxis.

Molecular immunology

Zheng X,Chen M,Meng X,Chu X,Cai C,Zou F

Sat Jul 01 00:00:00 EDT 2017

Mitochondrial dynamics changes with age in an APPsw/PS1dE9 mouse model of Alzheimer's disease.

Neuroreport

Xu LL,Shen Y,Wang X,Wei LF,Wang P,Yang H,Wang CF,Xie ZH,Bi JZ

Wed Mar 01 00:00:00 EST 2017

Mitochondrial dynamics changes with age in an APPsw/PS1dE9 mouse model of Alzheimer's disease.

Neuroreport

Xu LL,Shen Y,Wang X,Wei LF,Wang P,Yang H,Wang CF,Xie ZH,Bi JZ

Wed Mar 01 00:00:00 EST 2017

Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin.

Scientific reports

Liu Y,Hu Y,E Q,Zuo J,Yang L,Liu W

Thu Mar 02 00:00:00 EST 2017

Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin.

Scientific reports

Liu Y,Hu Y,E Q,Zuo J,Yang L,Liu W

Thu Mar 02 00:00:00 EST 2017

FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.

The EMBO journal

Wu W,Lin C,Wu K,Jiang L,Wang X,Li W,Zhuang H,Zhang X,Chen H,Li S,Yang Y,Lu Y,Wang J,Zhu R,Zhang L,Sui S,Tan N,Zhao B,Zhang J,Li L,Feng D

Fri Jul 01 00:00:00 EDT 2016

FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.

The EMBO journal

Wu W,Lin C,Wu K,Jiang L,Wang X,Li W,Zhuang H,Zhang X,Chen H,Li S,Yang Y,Lu Y,Wang J,Zhu R,Zhang L,Sui S,Tan N,Zhao B,Zhang J,Li L,Feng D

Fri Jul 01 00:00:00 EDT 2016

Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease.

Molecular psychiatry

Sharoar MG,Shi Q,Ge Y,He W,Hu X,Perry G,Zhu X,Yan R

Thu Sep 01 00:00:00 EDT 2016

Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease.

Molecular psychiatry

Sharoar MG,Shi Q,Ge Y,He W,Hu X,Perry G,Zhu X,Yan R

Thu Sep 01 00:00:00 EDT 2016

Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.

The Journal of cell biology

Korwitz A,Merkwirth C,Richter-Dennerlein R,Tröder SE,Sprenger HG,Quirós PM,López-Otín C,Rugarli EI,Langer T

Mon Jan 18 00:00:00 EST 2016

Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.

The Journal of cell biology

Korwitz A,Merkwirth C,Richter-Dennerlein R,Tröder SE,Sprenger HG,Quirós PM,López-Otín C,Rugarli EI,Langer T

Mon Jan 18 00:00:00 EST 2016

AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer's Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons.

Oxidative medicine and cellular longevity

Zhao FL,Fang F,Qiao PF,Yan N,Gao D,Yan Y

Mon Dec 26 00:00:00 EST 2016

AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer's Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons.

Oxidative medicine and cellular longevity

Zhao FL,Fang F,Qiao PF,Yan N,Gao D,Yan Y

Mon Dec 26 00:00:00 EST 2016

Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission.

Journal of agricultural and food chemistry

Wu H,Wang Y,Wu C,Yang P,Li H,Li Z

Wed Dec 14 00:00:00 EST 2016

Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission.

Journal of agricultural and food chemistry

Wu H,Wang Y,Wu C,Yang P,Li H,Li Z

Wed Dec 14 00:00:00 EST 2016

Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology.

Journal of cell science

Zhang C,Shi Z,Zhang L,Zhou Z,Zheng X,Liu G,Bu G,Fraser PE,Xu H,Zhang YW

Tue Mar 01 00:00:00 EST 2016

Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology.

Journal of cell science

Zhang C,Shi Z,Zhang L,Zhou Z,Zheng X,Liu G,Bu G,Fraser PE,Xu H,Zhang YW

Tue Mar 01 00:00:00 EST 2016

Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.

Human molecular genetics

Manczak M,Kandimalla R,Fry D,Sesaki H,Reddy PH

Thu Dec 01 00:00:00 EST 2016

Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.

Human molecular genetics

Manczak M,Kandimalla R,Fry D,Sesaki H,Reddy PH

Thu Dec 01 00:00:00 EST 2016

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.

Human molecular genetics

Yin X,Manczak M,Reddy PH

Sun May 01 00:00:00 EDT 2016

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.

Human molecular genetics

Yin X,Manczak M,Reddy PH

Sun May 01 00:00:00 EDT 2016

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.

Human molecular genetics

Yin X,Manczak M,Reddy PH

Sun May 01 00:00:00 EDT 2016

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.

Human molecular genetics

Yin X,Manczak M,Reddy PH

Sun May 01 00:00:00 EDT 2016

Autophagy plays a role in skeletal muscle mitochondrial biogenesis in an endurance exercise-trained condition.

The journal of physiological sciences : JPS

Ju JS,Jeon SI,Park JY,Lee JY,Lee SC,Cho KJ,Jeong JM

Thu Sep 01 00:00:00 EDT 2016

Autophagy plays a role in skeletal muscle mitochondrial biogenesis in an endurance exercise-trained condition.

The journal of physiological sciences : JPS

Ju JS,Jeon SI,Park JY,Lee JY,Lee SC,Cho KJ,Jeong JM

Thu Sep 01 00:00:00 EDT 2016

Quantification and Characterization of UVB-Induced Mitochondrial Fragmentation in Normal Primary Human Keratinocytes.

Scientific reports

Jugé R,Breugnot J,Da Silva C,Bordes S,Closs B,Aouacheria A

Wed Oct 12 00:00:00 EDT 2016

Quantification and Characterization of UVB-Induced Mitochondrial Fragmentation in Normal Primary Human Keratinocytes.

Scientific reports

Jugé R,Breugnot J,Da Silva C,Bordes S,Closs B,Aouacheria A

Wed Oct 12 00:00:00 EDT 2016

Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease.

Human molecular genetics

Manczak M,Reddy PH

Sun Dec 20 00:00:00 EST 2015

Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease.

Human molecular genetics

Manczak M,Reddy PH

Sun Dec 20 00:00:00 EST 2015

Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease.

Human molecular genetics

Manczak M,Reddy PH

Sun Dec 20 00:00:00 EST 2015

Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease.

Human molecular genetics

Manczak M,Reddy PH

Sun Dec 20 00:00:00 EST 2015

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.

Nature immunology

Wang X,Jiang W,Yan Y,Gong T,Han J,Tian Z,Zhou R

Mon Dec 01 00:00:00 EST 2014

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.

Nature immunology

Wang X,Jiang W,Yan Y,Gong T,Han J,Tian Z,Zhou R

Mon Dec 01 00:00:00 EST 2014

PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation.

Autophagy

Furuya N,Ikeda S,Sato S,Soma S,Ezaki J,Oliva Trejo JA,Takeda-Ezaki M,Fujimura T,Arikawa-Hirasawa E,Tada N,Komatsu M,Tanaka K,Kominami E,Hattori N,Ueno T

Tue Apr 01 00:00:00 EDT 2014

PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation.

Autophagy

Furuya N,Ikeda S,Sato S,Soma S,Ezaki J,Oliva Trejo JA,Takeda-Ezaki M,Fujimura T,Arikawa-Hirasawa E,Tada N,Komatsu M,Tanaka K,Kominami E,Hattori N,Ueno T

Tue Apr 01 00:00:00 EDT 2014

The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.

The Journal of cell biology

Anand R,Wai T,Baker MJ,Kladt N,Schauss AC,Rugarli E,Langer T

Mon Mar 17 00:00:00 EDT 2014

The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.

The Journal of cell biology

Anand R,Wai T,Baker MJ,Kladt N,Schauss AC,Rugarli E,Langer T

Mon Mar 17 00:00:00 EDT 2014

Mutations in Fis1 disrupt orderly disposal of defective mitochondria.

Molecular biology of the cell

Shen Q,Yamano K,Head BP,Kawajiri S,Cheung JT,Wang C,Cho JH,Hattori N,Youle RJ,van der Bliek AM

Wed Jan 01 00:00:00 EST 2014

Mutations in Fis1 disrupt orderly disposal of defective mitochondria.

Molecular biology of the cell

Shen Q,Yamano K,Head BP,Kawajiri S,Cheung JT,Wang C,Cho JH,Hattori N,Youle RJ,van der Bliek AM

Wed Jan 01 00:00:00 EST 2014

Mutations in Fis1 disrupt orderly disposal of defective mitochondria.

Molecular biology of the cell

Shen Q,Yamano K,Head BP,Kawajiri S,Cheung JT,Wang C,Cho JH,Hattori N,Youle RJ,van der Bliek AM

Wed Jan 01 00:00:00 EST 2014

Mutations in Fis1 disrupt orderly disposal of defective mitochondria.

Molecular biology of the cell

Shen Q,Yamano K,Head BP,Kawajiri S,Cheung JT,Wang C,Cho JH,Hattori N,Youle RJ,van der Bliek AM

Wed Jan 01 00:00:00 EST 2014

Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.

The Journal of clinical investigation

Guo X,Disatnik MH,Monbureau M,Shamloo M,Mochly-Rosen D,Qi X

Sun Dec 01 00:00:00 EST 2013

Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.

The Journal of clinical investigation

Guo X,Disatnik MH,Monbureau M,Shamloo M,Mochly-Rosen D,Qi X

Sun Dec 01 00:00:00 EST 2013

Mitochondrial abnormalities in temporal lobe of autistic brain.

Neurobiology of disease

Tang G,Gutierrez Rios P,Kuo SH,Akman HO,Rosoklija G,Tanji K,Dwork A,Schon EA,Dimauro S,Goldman J,Sulzer D

Sat Jun 01 00:00:00 EDT 2013

Mitochondrial abnormalities in temporal lobe of autistic brain.

Neurobiology of disease

Tang G,Gutierrez Rios P,Kuo SH,Akman HO,Rosoklija G,Tanji K,Dwork A,Schon EA,Dimauro S,Goldman J,Sulzer D

Sat Jun 01 00:00:00 EDT 2013

Mitochondrial abnormalities in temporal lobe of autistic brain.

Neurobiology of disease

Tang G,Gutierrez Rios P,Kuo SH,Akman HO,Rosoklija G,Tanji K,Dwork A,Schon EA,Dimauro S,Goldman J,Sulzer D

Sat Jun 01 00:00:00 EDT 2013

Mitochondrial abnormalities in temporal lobe of autistic brain.

Neurobiology of disease

Tang G,Gutierrez Rios P,Kuo SH,Akman HO,Rosoklija G,Tanji K,Dwork A,Schon EA,Dimauro S,Goldman J,Sulzer D

Sat Jun 01 00:00:00 EDT 2013

A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.

Journal of cell science

Qi X,Qvit N,Su YC,Mochly-Rosen D

Fri Feb 01 00:00:00 EST 2013

A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.

Journal of cell science

Qi X,Qvit N,Su YC,Mochly-Rosen D

Fri Feb 01 00:00:00 EST 2013

A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.

Journal of cell science

Qi X,Qvit N,Su YC,Mochly-Rosen D

Fri Feb 01 00:00:00 EST 2013

A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.

Journal of cell science

Qi X,Qvit N,Su YC,Mochly-Rosen D

Fri Feb 01 00:00:00 EST 2013

Loss of Yme1L perturbates mitochondrial dynamics.

Cell death & disease

Ruan Y,Li H,Zhang K,Jian F,Tang J,Song Z

Thu Oct 31 00:00:00 EDT 2013

Loss of Yme1L perturbates mitochondrial dynamics.

Cell death & disease

Ruan Y,Li H,Zhang K,Jian F,Tang J,Song Z

Thu Oct 31 00:00:00 EDT 2013

Biochimica et biophysica acta

Manczak M,Sesaki H,Kageyama Y,Reddy PH

Fri Jun 01 00:00:00 EDT 2012

Biochimica et biophysica acta

Manczak M,Sesaki H,Kageyama Y,Reddy PH

Fri Jun 01 00:00:00 EDT 2012

Biochimica et biophysica acta

Manczak M,Sesaki H,Kageyama Y,Reddy PH

Fri Jun 01 00:00:00 EDT 2012

Biochimica et biophysica acta

Manczak M,Sesaki H,Kageyama Y,Reddy PH

Fri Jun 01 00:00:00 EDT 2012

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease.

Human molecular genetics

Calkins MJ,Manczak M,Mao P,Shirendeb U,Reddy PH

Thu Dec 01 00:00:00 EST 2011

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease.

Human molecular genetics

Calkins MJ,Manczak M,Mao P,Shirendeb U,Reddy PH

Thu Dec 01 00:00:00 EST 2011

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage.

Human molecular genetics

Shirendeb U,Reddy AP,Manczak M,Calkins MJ,Mao P,Tagle DA,Reddy PH

Fri Apr 01 00:00:00 EDT 2011

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage.

Human molecular genetics

Shirendeb U,Reddy AP,Manczak M,Calkins MJ,Mao P,Tagle DA,Reddy PH

Fri Apr 01 00:00:00 EDT 2011

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage.

Human molecular genetics

Shirendeb U,Reddy AP,Manczak M,Calkins MJ,Mao P,Tagle DA,Reddy PH

Fri Apr 01 00:00:00 EDT 2011

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage.

Human molecular genetics

Shirendeb U,Reddy AP,Manczak M,Calkins MJ,Mao P,Tagle DA,Reddy PH

Fri Apr 01 00:00:00 EDT 2011

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.

Human molecular genetics

Manczak M,Calkins MJ,Reddy PH

Fri Jul 01 00:00:00 EDT 2011

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.

Human molecular genetics

Manczak M,Calkins MJ,Reddy PH

Fri Jul 01 00:00:00 EDT 2011

Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons.

Journal of Alzheimer's disease : JAD

Manczak M,Mao P,Calkins MJ,Cornea A,Reddy AP,Murphy MP,Szeto HH,Park B,Reddy PH

Mon Sep 13 00:00:00 EDT 2010

Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons.

Journal of Alzheimer's disease : JAD

Manczak M,Mao P,Calkins MJ,Cornea A,Reddy AP,Murphy MP,Szeto HH,Park B,Reddy PH

Mon Sep 13 00:00:00 EDT 2010

Bioinformatics

Protein Aliases: FIS1 homolog; fis1 {ECO:0000250|UniProtKB:Q9Y3D6}; fission 1 (mitochondrial outer membrane) homolog; H_NH0132A01.6; hFis1; Mitochondrial fission 1 protein; mitochondrial fission molecule; rFis1; tetratricopeptide repeat domain 11; Tetratricopeptide repeat protein 11; TPR repeat protein 11

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Gene Aliases: 2010003O14Rik; CGI-135; FIS1; TTC11

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UniProt ID: (Human) Q9Y3D6, (Rat) P84817, (Mouse) Q9CQ92

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Entrez Gene ID: (Pig) 100622909, (Human) 51024, (Rat) 288584, (Mouse) 66437

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Function(s)

receptor binding protein binding

Process(es)

mitochondrial fission mitophagy release of cytochrome c from mitochondria protein targeting to mitochondrion positive regulation of cytosolic calcium ion concentration mitochondrial fusion regulation of mitochondrion organization peroxisome fission negative regulation of endoplasmic reticulum calcium ion concentration calcium-mediated signaling using intracellular calcium source positive regulation of cysteine-type endopeptidase activity involved in apoptotic process mitochondrial fragmentation involved in apoptotic process protein homooligomerization positive regulation of mitochondrial calcium ion concentration mitochondrion morphogenesis positive regulation of mitochondrial fission positive regulation of protein targeting to membrane positive regulation of intrinsic apoptotic signaling pathway apoptotic process

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FIS1 Polyclonal Antibody

FIS1 Antibody (10956-1-AP) in ICC/IF

Product Details

10956-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

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Contains

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Target Information

Bioinformatics

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