Product References
Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress.
Science advances
Jiang L,Chakraborty P,Zhang L,Wong M,Hill SE,Webber CJ,Libera J,Blair LJ,Wolozin B,Zweckstetter M
Published figure using FKBP12 polyclonal antibody (Product # PA1-026A) in Western Blot
Fri Feb 03 00:00:00 EST 2023
Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress.
Science advances
Jiang L,Chakraborty P,Zhang L,Wong M,Hill SE,Webber CJ,Libera J,Blair LJ,Wolozin B,Zweckstetter M
Published figure using FKBP12 polyclonal antibody (Product # PA1-026A) in Western Blot
Fri Feb 03 00:00:00 EST 2023
Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress.
Science advances
Jiang L,Chakraborty P,Zhang L,Wong M,Hill SE,Webber CJ,Libera J,Blair LJ,Wolozin B,Zweckstetter M
Published figure using FKBP12 polyclonal antibody (Product # PA1-026A) in Western Blot
Fri Feb 03 00:00:00 EST 2023
A Proximal-to-Distal Survey of Healthy Adult Human Small Intestine and Colon Epithelium by Single-Cell Transcriptomics.
Cellular and molecular gastroenterology and hepatology
Burclaff J,Bliton RJ,Breau KA,Ok MT,Gomez-Martinez I,Ranek JS,Bhatt AP,Purvis JE,Woosley JT,Magness ST
Published figure using FKBP12 polyclonal antibody (Product # PA1-026A) in Immunohistochemistry
Mon Apr 18 00:00:00 EDT 2022
ADAR1 mutation causes ZBP1-dependent immunopathology.
Nature
Hubbard NW,Ames JM,Maurano M,Chu LH,Somfleth KY,Gokhale NS,Werner M,Snyder JM,Lichauco K,Savan R,Stetson DB,Oberst A
PA1-026A was used in Immunoprecipitation to indicate that ADAR1 is a negative regulator of sterile ZBP1 activation, and that ZBP1-dependent signalling underlies the autoinflammatory pathology caused by alteration of ADAR1.
Fri Jul 01 00:00:00 EDT 2022
Interplay between Triadin and Calsequestrin in the Pathogenesis of CPVT in the Mouse.
Molecular therapy : the journal of the American Society of Gene Therapy
Cacheux M,Fauconnier J,Thireau J,Osseni A,Brocard J,Roux-Buisson N,Brocard J,Fauré J,Lacampagne A,Marty I
PA1-026A was used in Western Blotting to study the mechanisms of triadin-induced catecholaminergic polymorphic ventricular tachycardia(CPVT) and assay multiple therapeutic interventions by using a triadin knockout mouse model presenting a CPVT-like phenotype associated with a decrease in calsequestrin protein level.
Wed Jan 08 00:00:00 EST 2020
The mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation.
Glia
Ornelas IM,Khandker L,Wahl SE,Hashimoto H,Macklin WB,Wood TL
PA1-026A was used in Western Blot to conclude that mTOR promotes early oligodendrocyte differentiation by suppressing BMP signaling in OPCs.
Mon Jun 01 00:00:00 EDT 2020
Calcineurin phosphatase activity regulates Varicella-Zoster Virus induced cell-cell fusion.
PLoS pathogens
Zhou M,Kamarshi V,Arvin AM,Oliver SL
Published figure using FKBP12 polyclonal antibody (Product # PA1-026A) in Western Blot
Sun Nov 01 00:00:00 EDT 2020
Calcineurin phosphatase activity regulates Varicella-Zoster Virus induced cell-cell fusion.
PLoS pathogens
Zhou M,Kamarshi V,Arvin AM,Oliver SL
Published figure using FKBP12 polyclonal antibody (Product # PA1-026A) in Western Blot
Sun Nov 01 00:00:00 EDT 2020
Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection.
Journal of immunology (Baltimore, Md. : 1950)
Aaes TL,Verschuere H,Kaczmarek A,Heyndrickx L,Wiernicki B,Delrue I,De Craene B,Taminau J,Delvaeye T,Bertrand MJM,Declercq W,Berx G,Krysko DV,Adjemian S,Vandenabeele P
PA1-026A was used in Western Blotting to highlight necroptosis as a possible preferred ICD form over apoptosis in the treatment of cancer.
Sat Feb 15 00:00:00 EST 2020
Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes.
eLife
Tammineni ER,Kraeva N,Figueroa L,Manno C,Ibarra CA,Klip A,Riazi S,Rios E
Published figure using FKBP12 polyclonal antibody (Product # PA1-026A) in Western Blot
Mon May 04 00:00:00 EDT 2020
Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes.
eLife
Tammineni ER,Kraeva N,Figueroa L,Manno C,Ibarra CA,Klip A,Riazi S,Rios E
Published figure using FKBP12 polyclonal antibody (Product # PA1-026A) in Western Blot
Mon May 04 00:00:00 EDT 2020
FKBP52 regulates TRPC3-dependent Ca2+ signals and the hypertrophic growth of cardiomyocyte cultures.
Journal of cell science
Bandleon S,Strunz PP,Pickel S,Tiapko O,Cellini A,Miranda-Laferte E,Eder-Negrin P
PA1-026A was used in Western Blotting to identify FK506-binding protein 52 as a novel interaction partner of TRPC3 in the heart.
Wed Oct 23 00:00:00 EDT 2019
FKBP12.6 protects heart from AngII-induced hypertrophy through inhibiting Ca2+ /calmodulin-mediated signalling pathways in vivo and in vitro.
Journal of cellular and molecular medicine
Xiao YF,Zeng ZX,Guan XH,Wang LF,Wang CJ,Shi H,Shou W,Deng KY,Xin HB
PA1-026A was used in Western Blotting to demonstrate that FKBP12.6 protects heart from AngII-induced cardiac hypertrophy through inhibiting Ca2+ /calmodulin-mediated signalling pathways.
Sun Jul 01 00:00:00 EDT 2018
Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells.
Nature communications
Chopard C,Tong PBV,Tóth P,Schatz M,Yezid H,Debaisieux S,Mettling C,Gross A,Pugnière M,Tu A,Strub JM,Mesnard JM,Vitale N,Beaumelle B
Published figure using FKBP12 polyclonal antibody (Product # PA1-026A) in Western Blot
Fri Jun 08 00:00:00 EDT 2018
RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation.
Cell
Daniels BP,Snyder AG,Olsen TM,Orozco S,Oguin TH,Tait SWG,Martinez J,Gale M,Loo YM,Oberst A
PA1026A was used in western blot to identify pleiotropic functions for RIPK3 using a mouse model of West Nile virus encephalitis
Thu Apr 06 00:00:00 EDT 2017
MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D.
Journal of immunology (Baltimore, Md. : 1950)
Gutierrez KD,Davis MA,Daniels BP,Olsen TM,Ralli-Jain P,Tait SW,Gale M,Oberst A
PA1026A was used in immunocytochemistry and western blot to report a role for MLKL in NLRP3 inflammasome activation
Wed Mar 01 00:00:00 EST 2017
Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity.
Cell reports
Aaes TL,Kaczmarek A,Delvaeye T,De Craene B,De Koker S,Heyndrickx L,Delrue I,Taminau J,Wiernicki B,De Groote P,Garg AD,Leybaert L,Grooten J,Bertrand MJ,Agostinis P,Berx G,Declercq W,Vandenabeele P,Krysko DV
PA1-026A was used in western blot to analyze induction of efficient anti-tumor immunity by vaccination with necroptotic cancer cells
Tue Apr 12 00:00:00 EDT 2016
Pancreatic endoplasmic reticulum kinase activation promotes medulloblastoma cell migration and invasion through induction of vascular endothelial growth factor A.
PloS one
Jamison S,Lin Y,Lin W
PA1-026A was used in Western Blotting to suggest that moderate pancreatic endoplasmic reticulum kinase activation promotes medulloblastoma cell migration and invasion through enhancement of vascular endothelial growth factor (VEGF)-A /VEGF receptor 2 signalling.
Tue Feb 09 00:00:00 EST 2016
Pancreatic endoplasmic reticulum kinase activation promotes medulloblastoma cell migration and invasion through induction of vascular endothelial growth factor A.
PloS one
Jamison S,Lin Y,Lin W
PA1-026A was used in Western Blotting to suggest that moderate pancreatic endoplasmic reticulum kinase activation promotes medulloblastoma cell migration and invasion through enhancement of vascular endothelial growth factor (VEGF)-A /VEGF receptor 2 signalling.
Tue Feb 09 00:00:00 EST 2016
The composition of EphB2 clusters determines the strength in the cellular repulsion response.
The Journal of cell biology
Schaupp A,Sabet O,Dudanova I,Ponserre M,Bastiaens P,Klein R
PA1-026A was used in western blot to study the relationship between the strength of the cellular repulsion response and the composition of EphB2 clusters
Mon Feb 03 00:00:00 EST 2014
Bone morphogenetic protein 7 regulates reactive gliosis in retinal astrocytes and Müller glia.
Molecular vision
Dharmarajan S,Gurel Z,Wang S,Sorenson CM,Sheibani N,Belecky-Adams TL
PA1-026A was used in immunohistochemistry - frozen section to test if bone morphogenetic proteins trigger reactive gliosis in retinal astrocytes and Muller glial cells
Tue Dec 08 00:00:00 EST 2015
Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity.
Development (Cambridge, England)
Chen H,Zhang W,Sun X,Yoshimoto M,Chen Z,Zhu W,Liu J,Shen Y,Yong W,Li D,Zhang J,Lin Y,Li B,VanDusen NJ,Snider P,Schwartz RJ,Conway SJ,Field LJ,Yoder MC,Firulli AB,Carlesso N,Towbin JA,Shou W
PA1-026A was used in immunohistochemistry to study the role of Fbbp1a-mediated regulation of Notch1 activity in ventricular myocardial trabeculation and compaction
Wed May 01 00:00:00 EDT 2013
Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity.
Development (Cambridge, England)
Chen H,Zhang W,Sun X,Yoshimoto M,Chen Z,Zhu W,Liu J,Shen Y,Yong W,Li D,Zhang J,Lin Y,Li B,VanDusen NJ,Snider P,Schwartz RJ,Conway SJ,Field LJ,Yoder MC,Firulli AB,Carlesso N,Towbin JA,Shou W
PA1-026A was used in immunohistochemistry to study the role of Fbbp1a-mediated regulation of Notch1 activity in ventricular myocardial trabeculation and compaction
Wed May 01 00:00:00 EDT 2013
mTOR pathway and Ca²⁺ stores mobilization in aged smooth muscle cells.
Aging
Martín-Cano FE,Camello-Almaraz C,Hernandez D,Pozo MJ,Camello PJ
Published figure using FKBP12 polyclonal antibody (Product # PA1-026A) in Western Blot
Wed May 01 00:00:00 EDT 2013
Targeting colorectal cancer stem cells with inducible caspase-9.
Apoptosis : an international journal on programmed cell death
Kemper K,Rodermond H,Colak S,Grandela C,Medema JP
PA1-026A was used in immunohistochemistry to investigate the influence of dimerization of inducible caspase-9 in colorectal cancer stem cells
Tue May 01 00:00:00 EDT 2012
Relieving autophagy and 4EBP1 from rapamycin resistance.
Molecular and cellular biology
Nyfeler B,Bergman P,Triantafellow E,Wilson CJ,Zhu Y,Radetich B,Finan PM,Klionsky DJ,Murphy LO
PA1-026A was used in western blot to investigate the regulation of autophagy by rapamycin in different cell lines
Fri Jul 01 00:00:00 EDT 2011
Reduced gain of excitation-contraction coupling in triadin-null myotubes is mediated by the disruption of FKBP12/RyR1 interaction.
Cell calcium
Eltit JM,Szpyt J,Li H,Allen PD,Perez CF
Published figure using FKBP12 polyclonal antibody (Product # PA1-026A) in Western Blot
Tue Feb 01 00:00:00 EST 2011
Prevention of ventricular arrhythmia and calcium dysregulation in a catecholaminergic polymorphic ventricular tachycardia mouse model carrying calsequestrin-2 mutation.
Journal of cardiovascular electrophysiology
Alcalai R,Wakimoto H,Arad M,Planer D,Konno T,Wang L,Seidman JG,Seidman CE,Berul CI
PA1-026A was used in western blot to identify therapeutic targets in ventricular arrhythmia and calcium dysregulation
Tue Mar 01 00:00:00 EST 2011
Transgenic analysis of the role of FKBP12.6 in cardiac function and intracellular calcium release.
Assay and drug development technologies
Liu Y,Chen H,Ji G,Li B,Mohler PJ,Zhu Z,Yong W,Chen Z,Xu X,Xin H,Shou W
PA1-026A was used in western blot to investigate the role of FK506 binding protein12.6 FKBP12 in intracellular calcium release and heart function
Thu Dec 01 00:00:00 EST 2011
Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor.
The Journal of biological chemistry
Wang R,Zhong X,Meng X,Koop A,Tian X,Jones PP,Fruen BR,Wagenknecht T,Liu Z,Chen SR
PA1-026A was used in western blot to investigate the interaction between dantrolene and ryanodine receptor
Fri Apr 08 00:00:00 EDT 2011
Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor.
The Journal of biological chemistry
Wang R,Zhong X,Meng X,Koop A,Tian X,Jones PP,Fruen BR,Wagenknecht T,Liu Z,Chen SR
PA1-026A was used in western blot to investigate the interaction between dantrolene and ryanodine receptor
Fri Apr 08 00:00:00 EDT 2011
Organelle-specific, rapid induction of molecular activities and membrane tethering.
Nature methods
Komatsu T,Kukelyansky I,McCaffery JM,Ueno T,Varela LC,Inoue T
PA1-026A was used in western blot to develop a new method of targeting proteins to individual intracellular organelles
Mon Mar 01 00:00:00 EST 2010
Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gerard M,Deleersnijder A,Daniëls V,Schreurs S,Munck S,Reumers V,Pottel H,Engelborghs Y,Van den Haute C,Taymans JM,Debyser Z,Baekelandt V
PA1-026A was used in western blot to study the role of FKBPs in aggregation and apoptosis
Wed Feb 17 00:00:00 EST 2010
Differential protein profiling as a potential multi-marker approach for TSE diagnosis.
BMC infectious diseases
Barr JB,Watson M,Head MW,Ironside JW,Harris N,Hogarth C,Fraser JR,Barron R
PA1-026A was used in immunocytochemistry to study differential protein profiling as a potential multi-marker approach for transmissible spongiform encephalopathy diagnosis
Fri Nov 27 00:00:00 EST 2009
Expression levels of RyR1 and RyR3 control resting free Ca2+ in skeletal muscle.
American journal of physiology. Cell physiology
Perez CF,López JR,Allen PD
PA1-026A was used in western blot to investigate the effect of the transient expression of ryanodine receptor (RyR) type 3 and 1 on calcium homeostasis in skeletal muscle
Tue Mar 01 00:00:00 EST 2005
Gene silencing in androgen-responsive prostate cancer cells from the tissue-specific prostate-specific antigen promoter.
Cancer research
Song J,Pang S,Lu Y,Yokoyama KK,Zheng JY,Chiu R
PA1-026A was used in western blot to study the gene silencing in androgen-responsive prostate cancer cells with a prostate-specific antigen promoter.
Mon Nov 01 00:00:00 EST 2004
The 12 kDa FK506-binding protein, FKBP12, modulates the Ca(2+)-flux properties of the type-3 ryanodine receptor.
Journal of cell science
Van Acker K,Bultynck G,Rossi D,Sorrentino V,Boens N,Missiaen L,De Smedt H,Parys JB,Callewaert G
PA1-026A was used in western blot to study the effect of FKBP12 on the activity of the type-3 ryanodine receptor.
Mon Mar 01 00:00:00 EST 2004
Protection against ischemic brain damage in rats by immunophilin ligand GPI-1046.
Journal of neuroscience research
Li F,Omori N,Hayashi T,Jin G,Sato K,Nagano I,Shoji M,Abe K
PA1-026A was used in immunohistochemistry to evaluate the protective effect of immunophilin ligand GPI-1046 against ischemic brain damage in rats
Sat May 01 00:00:00 EDT 2004
Increased sensitivity of the ryanodine receptor to halothane-induced oligomerization in malignant hyperthermia-susceptible human skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985)
Glover L,Heffron JJ,Ohlendieck K
PA1-026A was used in western blot to investigate the importance of RyR2 complex formation in the development of a metabolic crisis in malignant hyperthermia
Thu Jan 01 00:00:00 EST 2004
Cyclophilin A is required for retinoic acid-induced neuronal differentiation in p19 cells.
The Journal of biological chemistry
Song J,Lu YC,Yokoyama K,Rossi J,Chiu R
PA1-026A was used in western blot to investigate the role of cyclophilin A in the retinoic acid-induced p19 cell differentiation.
Fri Jun 04 00:00:00 EDT 2004
Early decrease of the immunophilin FKBP 52 in the spinal cord of a transgenic model for amyotrophic lateral sclerosis.
Brain research
Manabe Y,Warita H,Murakami T,Shiote M,Hayashi T,Omori N,Nagano I,Shoji M,Abe K
PA1-026A was used in immunohistochemistry to investigate the effect of the downregulation of FKBP-52 on the pathogenesis of amyotrophic lateral sclerosis
Fri May 10 00:00:00 EDT 2002
Transport activity and surface expression of the Na+-Ca2+ exchanger NCX1 are inhibited by the immunosuppressive agent cyclosporin A and by the nonimmunosuppressive agent PSC833.
The Journal of biological chemistry
Kimchi-Sarfaty C,Kasir J,Ambudkar SV,Rahamimoff H
PA1-026A was used in western blot to study the effects of cyclosporin A and PSC833 on the sodium/calcium exchanger NCX1 expression and activity
Fri Jan 25 00:00:00 EST 2002
Effects of the immunosuppressant FK506 on intracellular Ca2+ release and Ca2+ accumulation mechanisms.
The Journal of physiology
Bultynck G,De Smet P,Weidema AF,Ver Heyen M,Maes K,Callewaert G,Missiaen L,Parys JB,De Smedt H
PA1-026A was used in western blot to study the effects of immunosuppressant FK506 on calcium homeostasis.
Thu Jun 15 00:00:00 EDT 2000
Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp).
The Journal of biological chemistry
Wesselborg S,Fruman DA,Sagoo JK,Bierer BE,Burakoff SJ
PA1-026A was used in western blot to investigate the interaction between calcineurin and NFATp
Fri Jan 19 00:00:00 EST 1996
