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FOXC1 Antibody (A303-520A) in IHC
Detection of human FOXC1 by immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti- FOXC1 (Cat. No. A303-520A Lot1) used at a dilution of 1:200 (1µg/ml). Detection: DAB. Counterstain: hematoxylin (blue).
Product Details
A303-520A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 375 and 425 of human Forkhead Box C1.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
FOXC1 is a protein belonging to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this protein is not known, however, it plays a role in the regulation of FGF19-FGFR4-MAPK pathway to promote both the development and maintenance of anterior segment structures within the eye. Mutations in this gene cause various glaucoma, iridogoniodysgenesis anomaly, Peters anomaly that includes central corneal leukoma, absence of the posterior corneal stroma and Descemetmembrane and Axenfeld-Rieger anomaly characterized by posterior corneal embryotoxon, iris adhesion to the Schwalbe line, hypertelorism, hypoplasia of the malar bones, congenital absence of some teeth and mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: forkhead box C1 protein; Forkhead box protein C1; forkhead, drosophila, homolog-like 7; forkhead-related activator 3; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7; FREAC-3; HGNC:3800; myeloid factor-delta
Gene Aliases: ARA; FKHL7; FOXC1; FREAC-3; FREAC3; IGDA; IHG1; IRID1; RIEG3
UniProt ID: (Human) Q12948
Entrez Gene ID: (Human) 2296
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
DNA binding, bending
sequence-specific DNA binding
transcription regulatory region DNA binding
winged helix/forkhead transcription factor
skeletal system development
ossification
ovarian follicle development
eye development
ureteric bud development
in utero embryonic development
somitogenesis
lymph vessel development
blood vessel remodeling
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
Notch signaling pathway
brain development
heart development
cell proliferation
germ cell migration
mesenchymal cell development
neural crest cell development
cell migration
negative regulation of angiogenesis
collagen fibril organization
glycosaminoglycan metabolic process
lacrimal gland development
embryonic heart tube development
maintenance of lens transparency
vascular endothelial growth factor signaling pathway
odontogenesis of dentin-containing tooth
camera-type eye development
positive regulation of transcription, DNA-templated
negative regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
regulation of organ growth
vascular endothelial growth factor receptor signaling pathway
paraxial mesoderm formation
artery morphogenesis
regulation of blood vessel size
ventricular cardiac muscle tissue morphogenesis
cardiac muscle cell proliferation
negative regulation of lymphangiogenesis
positive regulation of hematopoietic progenitor cell differentiation
positive regulation of hematopoietic stem cell differentiation
negative regulation of apoptotic process involved in outflow tract morphogenesis
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