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Product Details
PA5-68947
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide corresponding to a region of mouse FOXJ1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2689236
Product Specific Information
This target displays homology in the following species: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 93%; Mouse: 100%; Rabbit: 100%; Rat: 93%
Target Information
Forkhead-box J1 (FOXJ1) is a 421-amino acid transcription factor that suppresses T cell activity and spontaneous autoimmunity, through the repression of NF B activity. FOXJ1 also inhibits the humoral immune response in B cells. FOXJ1 deficiency in B cells results in spontaneous and accentuated germinal center formation and is implicated in the development of pathogenic autoantibodies and accentuated responses to immunizations. Abnormal expression of FOXJ1 may be associated with autoimmune diseases and/or other inflammatory diseases. FOXJ1 is also required for cilia formation and left-right axis determination because it increases calpastatin expression, a protein necessary for the ability of basal bodies to anchor to the apical cytoskeleton. FOXJ1 expression may function as an early marker of epithelial cell differentiation, recovery, and function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Forkhead box protein J1; forkhead-related protein FKHL13; Hepatocyte nuclear factor 3 forkhead homolog 4; HFH-4; HNF-3/forkhead homolog 4; MGC35202
Gene Aliases: FKHL-13; Foxj1; HFH-4; Hfh4
UniProt ID: (Mouse) Q61660
Entrez Gene ID: (Mouse) 15223
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
central tolerance induction
negative regulation of germinal center formation
positive regulation of central B cell tolerance induction
negative regulation of humoral immune response mediated by circulating immunoglobulin
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
humoral immune response
cell projection organization
actin cytoskeleton organization
cell differentiation
regulation of epithelial cell differentiation
negative regulation of NF-kappaB transcription factor activity
negative regulation of T cell differentiation in thymus
establishment of apical/basal cell polarity
negative regulation of T cell proliferation
cilium assembly
negative regulation of interleukin-6 biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
negative regulation of B cell activation
leukocyte migration
cilium morphogenesis
left/right pattern formation
activation of GTPase activity
positive regulation of lung ciliated cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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