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Immunogen sequence: STDGHQPLF PKPIYSYSIL IFMALKNSKT GSLPVSEIYN FMTEHFPYFK TAPDGWKNSV RHNLSLNKCF EKVENKSGSS SRKGCLWALN PAKIDKMQEE LQKWKRKDPI AVRKSMAKPE ELDSLIGDKR EKLGSPLLGC PPPGLSGSGP IRPLAPPAGL SPPLHSLHPA PGPIPGKNPL QDLLMGHTPS CYGQTYLHLS PGLAPPGPPQ PLFPQPDGHL ELRAQPGTPQ DSPLPAHTPP SHSAKLLAEP SPARTMHDTL LPDGDLGTDL DAINPSLTDF DFQGNLWEQL KDDSLALDPL VLVTSSPTSS SMPPPQPPPH CFPPGPCLTE TGSGAGDLAA PGSGGSGALG DLHLTTLYSA FMELEPTPPT APAGPSVYLS PSSKPVALA (261-648 aa encoded by BC146539)
FOXN1 is a 648 amino acid protein belonging to the winged helix/forkhead family It contains 1 fork-head DNA-binding domain and is a transcriptional regulator involved in development. FOXN1 is involved in directing lineage choices of multi-potential progenitor epithelial cells and controls important regulating genes of lympho-epithelial interactions. It modulates keratinocyte differentiation in hair follicles and nail apparatus and its defects lead to T-cell immunodeficiency congenital alopecia, nail dystrophy, macroscopic nudity and an inborn dysgenesis of the thymus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Forkhead box protein N1; JTK1; Rowett nude; winged helix nude; winged-helix nude; Winged-helix transcription factor nude
Gene Aliases: FKHL20; FOXN1; RONU; WHN
UniProt ID: (Human) O15353
Entrez Gene ID: (Human) 8456
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