Proteintech

FOXO3A Polyclonal Antibody

FOXO3A Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 12

FOXO3A Antibody (10849-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed SH-SY5Y cells using 10849-1-AP (FOXO3A antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

FOXO3A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

10849-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 67 publications 67 publications

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 12 publications 12 publications

Immunoprecipitation (IP)

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FOXO3A Fusion Protein Ag1289 (325-673 aa encoded by BC021224)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The calculated molecular weight of FOXO3 is 71 kDa, but some experiments using a FOXO3a specific antibody showed the expression of a 90 kDa full-length FOXO3a protein (Full) and a 40 kDa processed FOXO3a product (Short).

Immunogen sequence: SPIMASTEL DEVQDDDAPL SPMLYSSSAS LSPSVSKPCT VELPRLTDMA GTMNLNDGLT ENLMDDLLDN ITLPPSQPSP TGGLMQRSSS FPYTTKGSGL GSPTSSFNST VFGPSSLNSL RQSPMQTIQE NKPATFSSMS HYGNQTLQDL LTSDSLSHSD VMMTQSDPLM SQASTAVSAQ NSRRNVMLRN DPMMSFAAQP NQGSLVNQNL LHHQHQTQGA LGGSRALSNS VSNMGLSESS SLGSAKHQQQ SPVSQSMQTL SDSLSGSSLY STSANLPVMG HEKFPSDLDL DMFNGSLECD MESIIRSELM DADGLDFNFD SLISTQNVVG LNVGNFTGAK QASSQSWVPG (325-673 aa encoded by BC021224)

Target Information

USP48 is a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Wang Y,Liu M,Johnson SB,Yuan G,Arriba AK,Zubizarreta ME,Chatterjee S,Nagarkatti M,Nagarkatti P,Xiao S

Tue Oct 15 00:00:00 EDT 2019

Casticin prevents DSS induced ulcerative colitis in mice through inhibitions of NF-κB pathway and ROS signaling.

Phytotherapy research : PTR

Ma J,Yin G,Lu Z,Xie P,Zhou H,Liu J,Yu L

Sat Sep 01 00:00:00 EDT 2018

Casticin prevents DSS induced ulcerative colitis in mice through inhibitions of NF-κB pathway and ROS signaling.

Phytotherapy research : PTR

Ma J,Yin G,Lu Z,Xie P,Zhou H,Liu J,Yu L

Sat Sep 01 00:00:00 EDT 2018

Casticin prevents DSS induced ulcerative colitis in mice through inhibitions of NF-κB pathway and ROS signaling.

Phytotherapy research : PTR

Ma J,Yin G,Lu Z,Xie P,Zhou H,Liu J,Yu L

Sat Sep 01 00:00:00 EDT 2018

Casticin prevents DSS induced ulcerative colitis in mice through inhibitions of NF-κB pathway and ROS signaling.

Phytotherapy research : PTR

Ma J,Yin G,Lu Z,Xie P,Zhou H,Liu J,Yu L

Sat Sep 01 00:00:00 EDT 2018

Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.

Journal of agricultural and food chemistry

Yang S,Zhao N,Yang Y,Hu Y,Dong H,Zhao R

Wed Mar 21 00:00:00 EDT 2018

Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.

Journal of agricultural and food chemistry

Yang S,Zhao N,Yang Y,Hu Y,Dong H,Zhao R

Wed Mar 21 00:00:00 EDT 2018

Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy.

Theranostics

Li YF,Ouyang SH,Tu LF,Wang X,Yuan WL,Wang GE,Wu YP,Duan WJ,Yu HM,Fang ZZ,Kurihara H,Zhang Y,He RR

Wed Sep 04 00:00:00 EDT 2019

Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy.

Theranostics

Li YF,Ouyang SH,Tu LF,Wang X,Yuan WL,Wang GE,Wu YP,Duan WJ,Yu HM,Fang ZZ,Kurihara H,Zhang Y,He RR

Wed Sep 04 00:00:00 EDT 2019

Nuclear forkhead box O3a accumulation contributing to the proliferative suppression in liver cancer cells by PI3K/Akt signaling pathway.

Journal of cancer research and therapeutics

Hou Y,Sun G,Jiang X,Zhu Z,Yang J

Sat Dec 01 00:00:00 EST 2018

Nuclear forkhead box O3a accumulation contributing to the proliferative suppression in liver cancer cells by PI3K/Akt signaling pathway.

Journal of cancer research and therapeutics

Hou Y,Sun G,Jiang X,Zhu Z,Yang J

Sat Dec 01 00:00:00 EST 2018

Expression of PIM-1 in salivary gland adenoid cystic carcinoma: Association with tumor progression and patients' prognosis.

Oncology letters

Zhu X,Yu Y,Hou X,Xu J,Tan Z,Nie X,Ling Z,Ge M

Mon Jan 01 00:00:00 EST 2018

Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways.

Scientific reports

Zhang C,Li C,Chen S,Li Z,Ma L,Jia X,Wang K,Bao J,Liang Y,Chen M,Li P,Su H,Lee SM,Liu K,Wan JB,He C

Mon Jan 23 00:00:00 EST 2017

Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways.

Scientific reports

Zhang C,Li C,Chen S,Li Z,Ma L,Jia X,Wang K,Bao J,Liang Y,Chen M,Li P,Su H,Lee SM,Liu K,Wan JB,He C

Mon Jan 23 00:00:00 EST 2017

High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells.

Oncotarget

Zhang XQ,Dong JJ,Cai T,Shen X,Zhou XJ,Liao L

Tue Apr 11 00:00:00 EDT 2017

High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells.

Oncotarget

Zhang XQ,Dong JJ,Cai T,Shen X,Zhou XJ,Liao L

Tue Apr 11 00:00:00 EDT 2017

Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway.

The international journal of biochemistry & cell biology

Yang Y,Li X,Sun Q,He B,Jia Y,Cai D,Zhao R

Sat Oct 01 00:00:00 EDT 2016

Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway.

The international journal of biochemistry & cell biology

Yang Y,Li X,Sun Q,He B,Jia Y,Cai D,Zhao R

Sat Oct 01 00:00:00 EDT 2016

Low-protein diet fed to crossbred sows during pregnancy and lactation enhances myostatin gene expression through epigenetic regulation in skeletal muscle of weaning piglets.

European journal of nutrition

Jia Y,Gao G,Song H,Cai D,Yang X,Zhao R

Fri Apr 01 00:00:00 EDT 2016

Low-protein diet fed to crossbred sows during pregnancy and lactation enhances myostatin gene expression through epigenetic regulation in skeletal muscle of weaning piglets.

European journal of nutrition

Jia Y,Gao G,Song H,Cai D,Yang X,Zhao R

Fri Apr 01 00:00:00 EDT 2016

CHIP promotes thyroid cancer proliferation via activation of the MAPK and AKT pathways.

Biochemical and biophysical research communications

Zhang L,Liu L,He X,Shen Y,Liu X,Wei J,Yu F,Tian J

Fri Aug 26 00:00:00 EDT 2016

CHIP promotes thyroid cancer proliferation via activation of the MAPK and AKT pathways.

Biochemical and biophysical research communications

Zhang L,Liu L,He X,Shen Y,Liu X,Wei J,Yu F,Tian J

Fri Aug 26 00:00:00 EDT 2016

Rictor/mTORC2 pathway in oocytes regulates folliculogenesis, and its inactivation causes premature ovarian failure.

The Journal of biological chemistry

Chen Z,Kang X,Wang L,Dong H,Wang C,Xiong Z,Zhao W,Jia C,Lin J,Zhang W,Yuan W,Zhong M,Du H,Bai X

Fri Mar 06 00:00:00 EST 2015

Rictor/mTORC2 pathway in oocytes regulates folliculogenesis, and its inactivation causes premature ovarian failure.

The Journal of biological chemistry

Chen Z,Kang X,Wang L,Dong H,Wang C,Xiong Z,Zhao W,Jia C,Lin J,Zhang W,Yuan W,Zhong M,Du H,Bai X

Fri Mar 06 00:00:00 EST 2015

miRNA-155 modulates the malignant biological characteristics of NK/T-cell lymphoma cells by targeting FOXO3a gene.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban

Ji WG,Zhang XD,Sun XD,Wang XQ,Chang BP,Zhang MZ

Mon Dec 01 00:00:00 EST 2014

miRNA-155 modulates the malignant biological characteristics of NK/T-cell lymphoma cells by targeting FOXO3a gene.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban

Ji WG,Zhang XD,Sun XD,Wang XQ,Chang BP,Zhang MZ

Mon Dec 01 00:00:00 EST 2014

Bioinformatics

Protein Aliases: AF6q21 protein; forkhead box O3A; Forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma-like 1; forkhead protein FKHR2; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1

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Gene Aliases: 1110048B16Rik; 2010203A17Rik; AF6q21; C76856; Fkhr2; FKHRL1; FKHRL1P2; FOXO2; FOXO3; FOXO3A

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UniProt ID: (Human) O43524, (Mouse) Q9WVH4

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Entrez Gene ID: (Human) 2309, (Mouse) 56484, (Rat) 294515

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Function(s)

core promoter binding transcription cofactor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding protein kinase binding chromatin DNA binding sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding

Process(es)

negative regulation of transcription from RNA polymerase II promoter ovulation from ovarian follicle initiation of primordial ovarian follicle growth antral ovarian follicle growth oocyte maturation transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter regulation of translation apoptotic process anatomical structure morphogenesis cell differentiation DNA damage response, signal transduction by p53 class mediator cellular response to oxidative stress glucose homeostasis positive regulation of neuron apoptotic process positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance extrinsic apoptotic signaling pathway in absence of ligand regulation of neural precursor cell proliferation regulation of reactive oxygen species metabolic process tumor necrosis factor-mediated signaling pathway positive regulation of apoptotic process

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FOXO3A Polyclonal Antibody

FOXO3A Antibody (10849-1-AP) in ICC/IF

Product Details

10849-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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