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Product Details
66428-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1F12D11
Immunogen
FOXO3A Fusion Protein Ag1289 (325-673 aa encoded by BC021224)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The calculated molecular weight of FOXO3 is 71 kDa, but some experiments using a FOXO3a specific antibody showed the expression of a 90 kDa full-length FOXO3a protein (Full) and a 40 kDa processed FOXO3a product (Short).
Immunogen sequence: SPIMASTEL DEVQDDDAPL SPMLYSSSAS LSPSVSKPCT VELPRLTDMA GTMNLNDGLT ENLMDDLLDN ITLPPSQPSP TGGLMQRSSS FPYTTKGSGL GSPTSSFNST VFGPSSLNSL RQSPMQTIQE NKPATFSSMS HYGNQTLQDL LTSDSLSHSD VMMTQSDPLM SQASTAVSAQ NSRRNVMLRN DPMMSFAAQP NQGSLVNQNL LHHQHQTQGA LGGSRALSNS VSNMGLSESS SLGSAKHQQQ SPVSQSMQTL SDSLSGSSLY STSANLPVMG HEKFPSDLDL DMFNGSLECD MESIIRSELM DADGLDFNFD SLISTQNVVG LNVGNFTGAK QASSQSWVPG (325-673 aa encoded by BC021224)
Target Information
USP48 is a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AF6q21 protein; forkhead box O3A; Forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma-like 1; forkhead protein FKHR2; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
Gene Aliases: 1110048B16Rik; 2010203A17Rik; AF6q21; C76856; Fkhr2; FKHRL1; FKHRL1P2; FOXO2; FOXO3; FOXO3A
UniProt ID: (Human) O43524, (Mouse) Q9WVH4
Entrez Gene ID: (Human) 2309, (Mouse) 56484, (Rat) 294515
core promoter binding
transcription cofactor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
protein kinase binding
chromatin DNA binding
sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
ovulation from ovarian follicle
initiation of primordial ovarian follicle growth
antral ovarian follicle growth
oocyte maturation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
regulation of translation
apoptotic process
anatomical structure morphogenesis
cell differentiation
DNA damage response, signal transduction by p53 class mediator
cellular response to oxidative stress
glucose homeostasis
positive regulation of neuron apoptotic process
positive regulation of erythrocyte differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of canonical Wnt signaling pathway
neuronal stem cell population maintenance
extrinsic apoptotic signaling pathway in absence of ligand
regulation of neural precursor cell proliferation
regulation of reactive oxygen species metabolic process
tumor necrosis factor-mediated signaling pathway
positive regulation of apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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