Proteintech

FSHR Polyclonal Antibody

FSHR Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 8

FSHR Antibody (22665-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 22665-1-AP (FSHR antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

FSHR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

22665-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 32 publications 32 publications

Immunohistochemistry (IHC)

View 11 publications 11 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 33 publications 33 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Sheep

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FSHR Fusion Protein Ag18158 (18-352 aa encoded by BC118548)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: CHHRICHCS NRVFLCQESK VTEIPSDLPR NAIELRFVLT KLRVIQKGAF SGFGDLEKIE ISQNDVLEVI EADVFSNLPK LHEIRIEKAN NLLYINPEAF QNLPNLQYLL ISNTGIKHLP DVHKIHSLQK VLLDIQDNIN IHTIERNSFV GLSFESVILW LNKNGIQEIH NCAFNGTQLD ELNLSDNNNL EELPNDVFHG ASGPVILDIS RTRIHSLPSY GLENLKKLRA RSTYNLKKLP TLEKLVALME ASLTYPSHCC AFANWRRQIS ELHPICNKSI LRQEVDYMTQ TRGQRSSLAE DNESSYSRGF DMTYTEFDYD LCNEVVDVTC SPKPDA (18-352 aa encoded by BC118548)

Target Information

Follicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Sat Jan 21 00:00:00 EST 2023

Exploration the role of INHBA in Hu sheep granulosa cells using RNA-Seq.

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Iron overload modulates follicular microenvironment via ROS/HIF-1α/FSHR signaling.

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Iron overload modulates follicular microenvironment via ROS/HIF-1α/FSHR signaling.

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Wu Y,Yang R,Lan J,Wu Y,Huang J,Fan Q,You Y,Lin H,Jiao X,Chen H,Cao C,Zhang Q

Mon Feb 20 00:00:00 EST 2023

Iron overload modulates follicular microenvironment via ROS/HIF-1α/FSHR signaling.

Free radical biology & medicine

Wu Y,Yang R,Lan J,Wu Y,Huang J,Fan Q,You Y,Lin H,Jiao X,Chen H,Cao C,Zhang Q

Mon Feb 20 00:00:00 EST 2023

Cytosine-phosphate-guanine oligodeoxynucleotides regulate the cell cycle, apoptosis, and steroidogenesis of mouse ovarian granulosa cells by targeting inhibin alpha (1 ~ 32) fragments.

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MiR-34c-5p promotes granulosa cells apoptosis by targeting Bcl2 in broody goose (Anser cygnoides).

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Ubiquitin-like modifier 1 ligating enzyme 1 relieves cisplatin-induced premature ovarian failure by reducing endoplasmic reticulum stress in granulosa cells.

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Fri Sep 16 00:00:00 EDT 2022

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Wu T,Gao YY,Tang XN,Li Y,Dai J,Zhou S,Wu M,Zhang JJ,Wang SX

Thu Nov 24 00:00:00 EST 2022

The Role of Inactivated NF-κB in Premature Ovarian Failure.

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Luo X,Xu J,Zhao R,Qin J,Wang X,Yan Y,Wang LJ,Wang G,Yang X

Tue Mar 01 00:00:00 EST 2022

The Role of Inactivated NF-κB in Premature Ovarian Failure.

The American journal of pathology

Luo X,Xu J,Zhao R,Qin J,Wang X,Yan Y,Wang LJ,Wang G,Yang X

Tue Mar 01 00:00:00 EST 2022

Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells.

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Miao Y,Wan W,Zhu K,Pan M,Zhao X,Ma B,Wei Q

Tue Mar 01 00:00:00 EST 2022

Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells.

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Liu J,Li L,Zhu J,Luo L,Li Y,Zhang C,Zhang W

Fri Apr 15 00:00:00 EDT 2022

Yangjing Zhongyu decoction facilitates mitochondrial activity, estrogenesis, and energy metabolism in H₂O₂-induced human granulosa cell line KGN.

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Smad4 mediates Bmf involvement in sheep granulosa cell apoptosis.

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Tue Apr 05 00:00:00 EDT 2022

Acute hypoxia induced dysregulation of clock-controlled ovary functions.

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Ding M,Lu Y,Huang X,Xing C,Hou S,Wang D,Zhang Y,Wang W,Zhang C,Zhang M,Meng F,Liu K,Liu G,Zhao J,Song L

Wed Jan 11 00:00:00 EST 2023

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Tan D,Zhao Y,Ma D,Tong F

Thu Apr 01 00:00:00 EDT 2021

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Thu Apr 01 00:00:00 EDT 2021

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Thu Sep 09 00:00:00 EDT 2021

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Fri Oct 01 00:00:00 EDT 2021

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Fri Feb 05 00:00:00 EST 2021

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Mon Feb 01 00:00:00 EST 2021

FSH directly regulates chondrocyte dedifferentiation and cartilage development.

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Mon Feb 01 00:00:00 EST 2021

FSH directly regulates chondrocyte dedifferentiation and cartilage development.

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Mon Feb 01 00:00:00 EST 2021

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FSH modulated cartilage ECM metabolism by targeting the PKA/CREB/SOX9 pathway.

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FSH modulated cartilage ECM metabolism by targeting the PKA/CREB/SOX9 pathway.

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Wed Sep 01 00:00:00 EDT 2021

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Mon Nov 15 00:00:00 EST 2021

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Wed Jun 02 00:00:00 EDT 2021

After cyclophosphamide exposure, granulosa cells recover their anti-müllerian hormone-producing ability but not their numbers.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

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The function of BAP18 on modulation of androgen receptor action in luteinized granulosa cells from normal weight women with and without PCOS.

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Tang T,Jiao J,Li D,Sun G,Lin L,Wang C,Wang S,Zou R,Liu W,Zhao Y,Wang X

Sat May 01 00:00:00 EDT 2021

CXCL12 and its receptors regulate granulosa cell apoptosis in PCOS rats and human KGN tumor cells.

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Effects of Osthole on Progesterone Secretion in Chicken Preovulatory Follicles Granulosa Cells.

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Thu Oct 01 00:00:00 EDT 2020

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Sat Apr 16 00:00:00 EDT 2022

Synergistic effect of Huyang Yangkun Formula and embryonic stem cells on 4-vinylcyclohexene diepoxide induced premature ovarian insufficiency in mice.

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Sat Apr 16 00:00:00 EDT 2022

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Tue Feb 04 00:00:00 EST 2020

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Stem cell research & therapy

Liu M,Qiu Y,Xue Z,Wu R,Li J,Niu X,Yuan J,Wang Y,Wu Q

Fri Jan 03 00:00:00 EST 2020

Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol.

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Guo Y,Zhao M,Bo T,Ma S,Yuan Z,Chen W,He Z,Hou X,Liu J,Zhang Z,Zhu Q,Wang Q,Lin X,Yang Z,Cui M,Liu L,Li Y,Yu C,Qi X,Wang Q,Zhang H,Guan Q,Zhao L,Xuan S,Yan H,Lin Y,Wang L,Li Q,Song Y,Gao L,Zhao J

Fri Feb 01 00:00:00 EST 2019

Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol.

Cell research

Guo Y,Zhao M,Bo T,Ma S,Yuan Z,Chen W,He Z,Hou X,Liu J,Zhang Z,Zhu Q,Wang Q,Lin X,Yang Z,Cui M,Liu L,Li Y,Yu C,Qi X,Wang Q,Zhang H,Guan Q,Zhao L,Xuan S,Yan H,Lin Y,Wang L,Li Q,Song Y,Gao L,Zhao J

Fri Feb 01 00:00:00 EST 2019

Follicular fluid humanin concentration is related to ovarian reserve markers and clinical pregnancy after IVF-ICSI: a pilot study.

Reproductive biomedicine online

Rao M,Zhou F,Tang L,Zeng Z,Hu S,Wang Y,Ke D,Cheng G,Xia W,Zhang L,Zhu C

Tue Jan 01 00:00:00 EST 2019

Follicular fluid humanin concentration is related to ovarian reserve markers and clinical pregnancy after IVF-ICSI: a pilot study.

Reproductive biomedicine online

Rao M,Zhou F,Tang L,Zeng Z,Hu S,Wang Y,Ke D,Cheng G,Xia W,Zhang L,Zhu C

Tue Jan 01 00:00:00 EST 2019

Silencing of LncRNA steroid receptor RNA activator attenuates polycystic ovary syndrome in mice.

Biochimie

Li Y,Zhao W,Wang H,Chen C,Zhou D,Li S,Zhang X,Zhao H,Zhou D,Chen B

Fri Feb 01 00:00:00 EST 2019

Silencing of LncRNA steroid receptor RNA activator attenuates polycystic ovary syndrome in mice.

Biochimie

Li Y,Zhao W,Wang H,Chen C,Zhou D,Li S,Zhang X,Zhao H,Zhou D,Chen B

Fri Feb 01 00:00:00 EST 2019

miR-323-3p regulates the steroidogenesis and cell apoptosis in polycystic ovary syndrome (PCOS) by targeting IGF-1.

Gene

Wang T,Liu Y,Lv M,Xing Q,Zhang Z,He X,Xu Y,Wei Z,Cao Y

Wed Jan 30 00:00:00 EST 2019

miR-323-3p regulates the steroidogenesis and cell apoptosis in polycystic ovary syndrome (PCOS) by targeting IGF-1.

Gene

Wang T,Liu Y,Lv M,Xing Q,Zhang Z,He X,Xu Y,Wei Z,Cao Y

Wed Jan 30 00:00:00 EST 2019

HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress.

Aging

Wang Y,Yang C,Elsheikh NAH,Li C,Yang F,Wang G,Li L

Mon Aug 12 00:00:00 EDT 2019

Novel FSHR mutations in Han Chinese women with sporadic premature ovarian insufficiency.

Molecular and cellular endocrinology

Liu H,Guo T,Gong Z,Yu Y,Zhang Y,Zhao S,Qin Y

Mon Jul 15 00:00:00 EDT 2019

Novel FSHR mutations in Han Chinese women with sporadic premature ovarian insufficiency.

Molecular and cellular endocrinology

Liu H,Guo T,Gong Z,Yu Y,Zhang Y,Zhao S,Qin Y

Mon Jul 15 00:00:00 EDT 2019

Role of nuclear factor-κB pathway in the transition of mouse secondary follicles to antral follicles.

Journal of cellular physiology

Xu JJ,Wang G,Luo X,Wang LJ,Bao Y,Yang X

Sun Dec 01 00:00:00 EST 2019

Role of nuclear factor-κB pathway in the transition of mouse secondary follicles to antral follicles.

Journal of cellular physiology

Xu JJ,Wang G,Luo X,Wang LJ,Bao Y,Yang X

Sun Dec 01 00:00:00 EST 2019

Melatonin alleviates β-zearalenol and HT-2 toxin-induced apoptosis and oxidative stress in bovine ovarian granulosa cells.

Environmental toxicology and pharmacology

Yang F,Li L,Chen K,Li C,Wang Y,Wang G

Wed May 01 00:00:00 EDT 2019

Estrogen receptor β upregulates CCL2 via NF-κB signaling in endometriotic stromal cells and recruits macrophages to promote the pathogenesis of endometriosis.

Human reproduction (Oxford, England)

Gou Y,Li X,Li P,Zhang H,Xu T,Wang H,Wang B,Ma X,Jiang X,Zhang Z

Mon Apr 01 00:00:00 EDT 2019

Molecular mechanism of FSHR expression induced by BMP15 in human granulosa cells.

Journal of assisted reproduction and genetics

Shimizu K,Nakamura T,Nakanishi N,Kasahara Y,Nagai T,Murase T,Osuka S,Goto M,Iwase A,Kikkawa F

Sat Jun 01 00:00:00 EDT 2019

Role of RAB5A in FSHR-mediated signal transduction in human granulosa cells.

Reproduction (Cambridge, England)

Zhu K,Li S,Liu J,Hong Y,Chen ZJ,Du Y

Fri Jun 01 00:00:00 EDT 2018

Role of RAB5A in FSHR-mediated signal transduction in human granulosa cells.

Reproduction (Cambridge, England)

Zhu K,Li S,Liu J,Hong Y,Chen ZJ,Du Y

Fri Jun 01 00:00:00 EDT 2018

Role of RAB5A in FSHR-mediated signal transduction in human granulosa cells.

Reproduction (Cambridge, England)

Zhu K,Li S,Liu J,Hong Y,Chen ZJ,Du Y

Fri Jun 01 00:00:00 EDT 2018

Role of RAB5A in FSHR-mediated signal transduction in human granulosa cells.

Reproduction (Cambridge, England)

Zhu K,Li S,Liu J,Hong Y,Chen ZJ,Du Y

Fri Jun 01 00:00:00 EDT 2018

Up-Regulation of Long Noncoding RNA SRA Promotes Cell Growth, Inhibits Cell Apoptosis, and Induces Secretion of Estradiol and Progesterone in Ovarian Granular Cells of Mice.

Medical science monitor : international medical journal of experimental and clinical research

Li Y,Wang H,Zhou D,Shuang T,Zhao H,Chen B

Fri Apr 20 00:00:00 EDT 2018

Up-Regulation of Long Noncoding RNA SRA Promotes Cell Growth, Inhibits Cell Apoptosis, and Induces Secretion of Estradiol and Progesterone in Ovarian Granular Cells of Mice.

Medical science monitor : international medical journal of experimental and clinical research

Li Y,Wang H,Zhou D,Shuang T,Zhao H,Chen B

Fri Apr 20 00:00:00 EDT 2018

Vitamin D receptor expression and potential role of vitamin D on cell proliferation and steroidogenesis in goat ovarian granulosa cells.

Theriogenology

Yao X,Zhang G,Guo Y,Ei-Samahy M,Wang S,Wan Y,Han L,Liu Z,Wang F,Zhang Y

Sun Oct 15 00:00:00 EDT 2017

Vitamin D receptor expression and potential role of vitamin D on cell proliferation and steroidogenesis in goat ovarian granulosa cells.

Theriogenology

Yao X,Zhang G,Guo Y,Ei-Samahy M,Wang S,Wan Y,Han L,Liu Z,Wang F,Zhang Y

Sun Oct 15 00:00:00 EDT 2017

Vitamin D receptor expression and potential role of vitamin D on cell proliferation and steroidogenesis in goat ovarian granulosa cells.

Theriogenology

Yao X,Zhang G,Guo Y,Ei-Samahy M,Wang S,Wan Y,Han L,Liu Z,Wang F,Zhang Y

Sun Oct 15 00:00:00 EDT 2017

Vitamin D receptor expression and potential role of vitamin D on cell proliferation and steroidogenesis in goat ovarian granulosa cells.

Theriogenology

Yao X,Zhang G,Guo Y,Ei-Samahy M,Wang S,Wan Y,Han L,Liu Z,Wang F,Zhang Y

Sun Oct 15 00:00:00 EDT 2017

A novel homozygous mutation in the FSHR gene is causative for primary ovarian insufficiency.

Fertility and sterility

Liu H,Xu X,Han T,Yan L,Cheng L,Qin Y,Liu W,Zhao S,Chen ZJ

Fri Dec 01 00:00:00 EST 2017

Novel WT1 Missense Mutations in Han Chinese Women with Premature Ovarian Failure.

Scientific reports

Wang H,Li G,Zhang J,Gao F,Li W,Qin Y,Chen ZJ

Fri Sep 11 00:00:00 EDT 2015

Novel WT1 Missense Mutations in Han Chinese Women with Premature Ovarian Failure.

Scientific reports

Wang H,Li G,Zhang J,Gao F,Li W,Qin Y,Chen ZJ

Fri Sep 11 00:00:00 EDT 2015

Bioinformatics

Protein Aliases: Follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; FSH-R

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Gene Aliases: FSHR; FSHR1; FSHRO; LGR1; ODG1

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UniProt ID: (Human) P23945, (Rat) P20395, (Mouse) P35378

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Entrez Gene ID: (Human) 2492, (Rat) 25449, (Mouse) 14309

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Function(s)

follicle-stimulating hormone receptor activity protein binding G-protein coupled peptide receptor activity G-protein coupled receptor activity peptide hormone binding signal transducer activity protein-hormone receptor activity G-protein coupled receptor

Process(es)

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FSHR Polyclonal Antibody

FSHR Antibody (22665-1-AP) in ICC/IF

Product Details

22665-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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