Proteintech

FTO Polyclonal Antibody

FTO Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 9

FTO Antibody (27226-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Mouse testis tissue slide using (Product # 27226-1-AP) FTO antibody at dilution of 1:2,000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

FTO Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

FTO Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

27226-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 73 publications 73 publications

Immunohistochemistry (IHC)

View 17 publications 17 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:2,000

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Immunoprecipitation (IP)

1:1,000

View 1 publication 1 publication

RNA Immunoprecipitation (RIP)

View 7 publications 7 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FTO Fusion Protein Ag26095 (400-505 aa encoded by NM_001080432)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAQLEALWK KMEGVTNAVL HEVKREGLPV EQRNEILTAI LASLTARQNL RREWHARCQS RIARTLPADQ KPECRPYWEK DDASMPLPFD LTDIVSELRG QLLEAKP (400-505 aa encoded by NM_001080432)

Target Information

FTO is a novel protein and a member of the non-heme dioxygenase (Fe(II)-and 2-oxoglutarate-dependent dioxygenases) superfamily. Amino acid conservation patterns support this hypothesis and indicates that both 2-oxoglutarate and iron should be important for FTO function. Though not much is yet known about FTO, it is thought that the protein may somehow modify the activity of genes involved in metabolism and fat storage, which in turn may influence a person's risk of obesity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The m6A demethylase FTO promotes keloid formation by up-regulating COL1A1.

Annals of translational medicine

Ren S,Ji Y,Wang M,Ye M,Huang L,Cai X

Sun Jan 15 00:00:00 EST 2023

The m6A demethylase FTO promotes keloid formation by up-regulating COL1A1.

Annals of translational medicine

Ren S,Ji Y,Wang M,Ye M,Huang L,Cai X

Sun Jan 15 00:00:00 EST 2023

m⁶ A demethylase Fto regulates the TNF-α-induced inflammatory response in cementoblasts.

Oral diseases

Li B,Du M,Sun Q,Cao Z,He H

Sun Oct 01 00:00:00 EDT 2023

FTO regulates the DNA damage response via effects on cell-cycle progression.

Mutation research. Genetic toxicology and environmental mutagenesis

Liu W,Yasui M,Sassa A,You X,Wan J,Cao Y,Xi J,Zhang X,Honma M,Luan Y

Sat Apr 01 00:00:00 EDT 2023

Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.

Molecular medicine (Cambridge, Mass.)

Chen Y,Liu X,Li L,He X,Zheng F,Zhang Y,Gao H,Jin Z,Wu D,Wang Q,Tao H,Zhao Y,Liu W,Zou L

Mon Feb 06 00:00:00 EST 2023

Comprehensive analyses of molecular features, prognostic values, and regulatory functionalities of m⁶A-modified long non-coding RNAs in lung adenocarcinoma.

Clinical epigenetics

Ping Y,Huang J,Zhu J,Sun Z,Shang A,Chen C,Liu W,Li D

Fri Apr 07 00:00:00 EDT 2023

m6A demethylase FTO renders radioresistance of nasopharyngeal carcinoma via promoting OTUB1-mediated anti-ferroptosis.

Translational oncology

Huang WM,Li ZX,Wu YH,Shi ZL,Mi JL,Hu K,Wang RS

Sun Jan 01 00:00:00 EST 2023

m6A demethylase FTO renders radioresistance of nasopharyngeal carcinoma via promoting OTUB1-mediated anti-ferroptosis.

Translational oncology

Huang WM,Li ZX,Wu YH,Shi ZL,Mi JL,Hu K,Wang RS

Sun Jan 01 00:00:00 EST 2023

Epitranscriptic regulation of HRAS by N⁶-methyladenosine drives tumor progression.

Proceedings of the National Academy of Sciences of the United States of America

Pan Y,Gu Y,Liu T,Zhang Q,Yang F,Duan L,Cheng S,Zhu X,Xi Y,Chang X,Ye Q,Gao S

Tue Apr 04 00:00:00 EDT 2023

Epitranscriptic regulation of HRAS by N⁶-methyladenosine drives tumor progression.

Proceedings of the National Academy of Sciences of the United States of America

Pan Y,Gu Y,Liu T,Zhang Q,Yang F,Duan L,Cheng S,Zhu X,Xi Y,Chang X,Ye Q,Gao S

Tue Apr 04 00:00:00 EDT 2023

Epitranscriptic regulation of HRAS by N⁶-methyladenosine drives tumor progression.

Proceedings of the National Academy of Sciences of the United States of America

Pan Y,Gu Y,Liu T,Zhang Q,Yang F,Duan L,Cheng S,Zhu X,Xi Y,Chang X,Ye Q,Gao S

Tue Apr 04 00:00:00 EDT 2023

METTL3-mediated m6A mRNA modification was involved in cadmium-induced liver injury.

Environmental pollution (Barking, Essex : 1987)

Li W,Tan M,Wang H,Wang Z,Pang Y,Yang R,Zhong S,Pan X,Chen S,Wang Q,Li D,Xiao Y,Chen W,Chen L

Tue Aug 15 00:00:00 EDT 2023

The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.

Acta biochimica et biophysica Sinica

Du P,Meng L,Liao X,Liu Y,Mo X,Gong M,Liao Y

Wed Jan 25 00:00:00 EST 2023

The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.

Acta biochimica et biophysica Sinica

Du P,Meng L,Liao X,Liu Y,Mo X,Gong M,Liao Y

Wed Jan 25 00:00:00 EST 2023

FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner.

Cellular signalling

Yu Z,Zheng L,Geng Y,Zhang Y,Wang Y,You G,Cai M,Li M,Cheng X,Zan J

Fri Sep 01 00:00:00 EDT 2023

FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner.

Cellular signalling

Yu Z,Zheng L,Geng Y,Zhang Y,Wang Y,You G,Cai M,Li M,Cheng X,Zan J

Fri Sep 01 00:00:00 EDT 2023

ALKBH1-mediated m¹ A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression.

Molecular oncology

Chen W,Wang H,Mi S,Shao L,Xu Z,Xue M

Wed Feb 01 00:00:00 EST 2023

Demethylase FTO enhances the PI3K/Akt signaling to promote gastric cancer malignancy.

Medical oncology (Northwood, London, England)

Zhu Y,Yang J,Li Y,Xu J,Fang Z

Mon Mar 27 00:00:00 EDT 2023

Demethylase FTO enhances the PI3K/Akt signaling to promote gastric cancer malignancy.

Medical oncology (Northwood, London, England)

Zhu Y,Yang J,Li Y,Xu J,Fang Z

Mon Mar 27 00:00:00 EDT 2023

Demethylase FTO enhances the PI3K/Akt signaling to promote gastric cancer malignancy.

Medical oncology (Northwood, London, England)

Zhu Y,Yang J,Li Y,Xu J,Fang Z

Mon Mar 27 00:00:00 EDT 2023

Demethylase FTO enhances the PI3K/Akt signaling to promote gastric cancer malignancy.

Medical oncology (Northwood, London, England)

Zhu Y,Yang J,Li Y,Xu J,Fang Z

Mon Mar 27 00:00:00 EDT 2023

Differential epitranscriptome and proteome modulation in the brain of neonatal mice exposed to isoflurane or sevoflurane.

Cell biology and toxicology

Wu Y,Yang Z,Su S,Xu X,Li Y,Li X,Gao Y,Sun D,Wan S,Pen M,Jin W,Ke C

Sun Oct 01 00:00:00 EDT 2023

Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer.

Oncology letters

Gui S,Wang Q,Bao L,He X,Wang Z,Liu L,Wu L,Zhao Y,Zhou J,Xie Y

Sat Apr 01 00:00:00 EDT 2023

Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer.

Oncology letters

Gui S,Wang Q,Bao L,He X,Wang Z,Liu L,Wu L,Zhao Y,Zhou J,Xie Y

Sat Apr 01 00:00:00 EDT 2023

Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer.

Oncology letters

Gui S,Wang Q,Bao L,He X,Wang Z,Liu L,Wu L,Zhao Y,Zhou J,Xie Y

Sat Apr 01 00:00:00 EDT 2023

Hypericin Ameliorates Depression-like Behaviors via Neurotrophin Signaling Pathway Mediating m6A Epitranscriptome Modification.

Molecules (Basel, Switzerland)

Lei C,Li N,Chen J,Wang Q

Wed May 03 00:00:00 EDT 2023

Newcastle disease virus activates methylation-related enzymes to reprogram m⁶A methylation in infected cells.

Veterinary microbiology

Yuan W,Hou Y,Wang Q,Lv T,Ren J,Fan L,Cai J,Xiang B,Lin Q,Liao M,Ding C,Chen L,Ren T

Thu Jun 01 00:00:00 EDT 2023

Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Ai S,Li D,Gu X,Xu Y,Wang Y,Wang HL,Chen XT

Tue Aug 01 00:00:00 EDT 2023

Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis.

Immunology

Gou Y,Wang H,Wang T,Wang H,Wang B,Jiao N,Yu Y,Cao Y,Wang H,Zhang Z

Wed Mar 01 00:00:00 EST 2023

RNA binding protein YTHDF1 mediates bisphenol S-induced Leydig cell damage by regulating the mitochondrial pathway of BCL2 and the expression of CDK2-CyclinE1.

Environmental pollution (Barking, Essex : 1987)

Li JZ,Zhou SM,Yuan WB,Chen HQ,Zeng Y,Fan J,Zhang Z,Wang N,Cao J,Liu WB

Wed Mar 15 00:00:00 EDT 2023

Cross-Talk between N6-Methyladenosine and Their Related RNAs Defined a Signature and Confirmed m6A Regulators for Diagnosis of Endometriosis.

International journal of molecular sciences

Wang X,Zhao X,Wang J,Wu H,Cheng Y,Guo Q,Liang T,Zhang G

Sat Jan 14 00:00:00 EST 2023

FTO demethylates m6A modifications in CDKAL1 mRNA and promotes gastric cancer chemoresistance by altering mitochondrial dynamics.

Clinical and experimental pharmacology & physiology

Liu N,Liu C,Wang Z,Wang L,Wang J,Kong J

Sat Apr 01 00:00:00 EDT 2023

A druggable copper-signalling pathway that drives inflammation.

Nature

Solier S,Müller S,Cañeque T,Versini A,Mansart A,Sindikubwabo F,Baron L,Emam L,Gestraud P,Pantoș GD,Gandon V,Gaillet C,Wu TD,Dingli F,Loew D,Baulande S,Durand S,Sencio V,Robil C,Trottein F,Péricat D,Näser E,Cougoule C,Meunier E,Bègue AL,Salmon H,Manel N,Puisieux A,Watson S,Dawson MA,Servant N,Kroemer G,Annane D,Rodriguez R

Mon May 01 00:00:00 EDT 2023

Maternal tamoxifen exposure leads to abnormal primordial follicle assembly.

Histochemistry and cell biology

Zhao J,Zhang J,Sun Y,Wang R,Shi D,Shen W,Sun X

Tue Aug 01 00:00:00 EDT 2023

Novel RNA N6-methyladenosine regulator related signature for predicting clinical and immunological characteristics in breast cancer.

Gene

Zhang J,Liu G,Dai Z,Xie F,Zheng R,Yuan B,Guo L

Wed Feb 15 00:00:00 EST 2023

AS3MT facilitates NLRP3 inflammasome activation by m⁶A modification during arsenic-induced hepatic insulin resistance.

Cell biology and toxicology

Qiu T,Wu C,Yao X,Han Q,Wang N,Yuan W,Zhang J,Shi Y,Jiang L,Liu X,Yang G,Sun X

Sun Oct 01 00:00:00 EDT 2023

The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Wang X,Li X,Yang P,Qin X,Yu J,Cheng Y,Zhang G,Tang L

Thu Jun 01 00:00:00 EDT 2023

5'-tRF-GlyGCC promotes breast cancer metastasis by increasing fat mass and obesity-associated protein demethylase activity.

International journal of biological macromolecules

Chen F,Song C,Meng F,Zhu Y,Chen X,Fang X,Ma D,Wang Y,Zhang C

Tue Jan 31 00:00:00 EST 2023

5'-tRF-GlyGCC promotes breast cancer metastasis by increasing fat mass and obesity-associated protein demethylase activity.

International journal of biological macromolecules

Chen F,Song C,Meng F,Zhu Y,Chen X,Fang X,Ma D,Wang Y,Zhang C

Tue Jan 31 00:00:00 EST 2023

ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.

Translational research : the journal of laboratory and clinical medicine

An X,Wu W,Yang L,Dong J,Liu B,Guo J,Chen J,Guo B,Cao W,Jiang Q

Fri Sep 01 00:00:00 EDT 2023

Fat mass and obesity-associated factor (FTO)-mediated N6-methyladenosine regulates spermatogenesis in an age-dependent manner.

The Journal of biological chemistry

Wu Y,Li J,Li C,Lu S,Wei X,Li Y,Xia W,Qian C,Wang Z,Liu M,Gu Y,Huang B,Tan Y,Hu Z

Thu Jun 01 00:00:00 EDT 2023

FTO-dependent m⁶A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.

Nature communications

Li B,Xi W,Bai Y,Liu X,Zhang Y,Li L,Bian L,Liu C,Tang Y,Shen L,Yang L,Gu X,Xie J,Zhou Z,Wang Y,Yu X,Wang J,Chao J,Han B,Yao H

Mon Jan 30 00:00:00 EST 2023

FTO-dependent m⁶A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.

Nature communications

Li B,Xi W,Bai Y,Liu X,Zhang Y,Li L,Bian L,Liu C,Tang Y,Shen L,Yang L,Gu X,Xie J,Zhou Z,Wang Y,Yu X,Wang J,Chao J,Han B,Yao H

Mon Jan 30 00:00:00 EST 2023

FTO-dependent m⁶A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.

Nature communications

Li B,Xi W,Bai Y,Liu X,Zhang Y,Li L,Bian L,Liu C,Tang Y,Shen L,Yang L,Gu X,Xie J,Zhou Z,Wang Y,Yu X,Wang J,Chao J,Han B,Yao H

Mon Jan 30 00:00:00 EST 2023

FTO-dependent m⁶A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.

Nature communications

Li B,Xi W,Bai Y,Liu X,Zhang Y,Li L,Bian L,Liu C,Tang Y,Shen L,Yang L,Gu X,Xie J,Zhou Z,Wang Y,Yu X,Wang J,Chao J,Han B,Yao H

Mon Jan 30 00:00:00 EST 2023

Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism.

Journal of hazardous materials

Qi Z,Wang S,Li J,Wen Y,Cui R,Zhang K,Liu Y,Yang X,Zhang L,Xu B,Liu W,Xu Z,Deng Y

Tue Mar 15 00:00:00 EDT 2022

Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism.

Journal of hazardous materials

Qi Z,Wang S,Li J,Wen Y,Cui R,Zhang K,Liu Y,Yang X,Zhang L,Xu B,Liu W,Xu Z,Deng Y

Tue Mar 15 00:00:00 EDT 2022

Long noncoding RNA lnc-H2AFV-1 promotes cell growth by regulating aberrant m6A RNA modification in head and neck squamous cell carcinoma.

Cancer science

Chen X,Liu Y,Sun D,Sun R,Wang X,Li M,Song N,Ying J,Guo T,Jiang Y

Wed Jun 01 00:00:00 EDT 2022

GSK3β Exacerbates Myocardial Ischemia/Reperfusion Injury by Inhibiting Myc.

Oxidative medicine and cellular longevity

Wen C,Lan M,Tan X,Wang X,Zheng Z,Lv M,Zhao X,Luo H,Liu Y,Wei P,Yue R,Hu H,Guo L

Tue May 10 00:00:00 EDT 2022

GSK3β Exacerbates Myocardial Ischemia/Reperfusion Injury by Inhibiting Myc.

Oxidative medicine and cellular longevity

Wen C,Lan M,Tan X,Wang X,Zheng Z,Lv M,Zhao X,Luo H,Liu Y,Wei P,Yue R,Hu H,Guo L

Tue May 10 00:00:00 EDT 2022

m⁶A mRNA Methylation Was Associated With Gene Expression and Lipid Metabolism in Liver of Broilers Under Lipopolysaccharide Stimulation.

Frontiers in genetics

Guo F,Zhang Y,Ma J,Yu Y,Wang Q,Gao P,Wang L,Xu Z,Wei X,Jing M

Wed Mar 16 00:00:00 EDT 2022

PIKE-A Modulates Mitochondrial Metabolism through Increasing SDHA Expression Mediated by STAT3/FTO Axis.

International journal of molecular sciences

Sun M,Yan Q,Qiao Y,Zhao H,Wang Y,Shan C,Zhang S

Sun Sep 25 00:00:00 EDT 2022

FTO/RUNX2 signaling axis promotes cementoblast differentiation under normal and inflammatory condition.

Biochimica et biophysica acta. Molecular cell research

Sun Q,Zhao T,Li B,Li M,Luo P,Zhang C,Chen G,Cao Z,Li Y,Du M,He H

Thu Dec 01 00:00:00 EST 2022

FTO/RUNX2 signaling axis promotes cementoblast differentiation under normal and inflammatory condition.

Biochimica et biophysica acta. Molecular cell research

Sun Q,Zhao T,Li B,Li M,Luo P,Zhang C,Chen G,Cao Z,Li Y,Du M,He H

Thu Dec 01 00:00:00 EST 2022

FTO/RUNX2 signaling axis promotes cementoblast differentiation under normal and inflammatory condition.

Biochimica et biophysica acta. Molecular cell research

Sun Q,Zhao T,Li B,Li M,Luo P,Zhang C,Chen G,Cao Z,Li Y,Du M,He H

Thu Dec 01 00:00:00 EST 2022

Increased m6A-RNA methylation and FTO suppression is associated with myocardial inflammation and dysfunction during endotoxemia in mice.

Molecular and cellular biochemistry

Dubey PK,Patil M,Singh S,Dubey S,Ahuja P,Verma SK,Krishnamurthy P

Sat Jan 01 00:00:00 EST 2022

FTO Inhibits Epithelial Ovarian Cancer Progression by Destabilising SNAI1 mRNA through IGF2BP2.

Cancers

Sun M,Zhang X,Bi F,Wang D,Zhou X,Li X,Yang Q

Tue Oct 25 00:00:00 EDT 2022

FTO Inhibits Epithelial Ovarian Cancer Progression by Destabilising SNAI1 mRNA through IGF2BP2.

Cancers

Sun M,Zhang X,Bi F,Wang D,Zhou X,Li X,Yang Q

Tue Oct 25 00:00:00 EDT 2022

MiR-155 regulates m⁶A level and cell progression by targeting FTO in clear cell renal cell carcinoma.

Cellular signalling

Yang W,Xie L,Wang P,Zhuang C

Tue Mar 01 00:00:00 EST 2022

The Maternal Microbiome Programs the m⁶A Epitranscriptome of the Mouse Fetal Brain and Intestine.

Frontiers in cell and developmental biology

Xiao Z,Liu S,Li Z,Cui J,Wang H,Wang Z,Ren Q,Xia L,Wang Z,Li Y

Tue Jul 26 00:00:00 EDT 2022

FTO mediated ERBB2 demethylation promotes tumor progression in esophageal squamous cell carcinoma cells.

Clinical & experimental metastasis

Zhao F,Ge F,Xie M,Li Z,Zang C,Kong L,Pu Y,Zheng X,Tan Y

Mon Aug 01 00:00:00 EDT 2022

The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.

Brain research

Li M,Zhong X,Zhao Z,Zeng Z,Yuan Q,Xiao X,Zu X,Liu J

Tue Feb 15 00:00:00 EST 2022

m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.

The Journal of biological chemistry

Suphakhong K,Terashima M,Wanna-Udom S,Takatsuka R,Ishimura A,Takino T,Suzuki T

Tue Nov 01 00:00:00 EDT 2022

PDGF signaling inhibits mitophagy in glioblastoma stem cells through N⁶-methyladenosine.

Developmental cell

Lv D,Gimple RC,Zhong C,Wu Q,Yang K,Prager BC,Godugu B,Qiu Z,Zhao L,Zhang G,Dixit D,Lee D,Shen JZ,Li X,Xie Q,Wang X,Agnihotri S,Rich JN

Mon Jun 20 00:00:00 EDT 2022

Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma.

Discover. Oncology

Kong F,Wang K,Wang L

Fri Nov 25 00:00:00 EST 2022

m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer.

Cell & bioscience

Duan X,Yang L,Wang L,Liu Q,Zhang K,Liu S,Liu C,Gao Q,Li L,Qin G,Zhang Y

Sat May 14 00:00:00 EDT 2022

N6-methyladenosine reader YTHDF3 regulates melanoma metastasis via its 'executor'LOXL3.

Clinical and translational medicine

Shi HZ,Xiong JS,Gan L,Zhang Y,Zhang CC,Kong YQ,Miao QJ,Tian CC,Li R,Liu JQ,Zhang EJ,Bu WB,Wang Y,Cheng XF,Sun JF,Chen H

Tue Nov 01 00:00:00 EDT 2022

Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis.

Frontiers in physiology

Tian C,Chai J,Liu W,Zhang X,Li Y,Zuo H,Yuan G,Zhang H,Liu H,Chen Z

Sat Jul 16 00:00:00 EDT 2022

Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.

Cancer letters

Yan R,Dai W,Wu R,Huang H,Shu M

Sat May 28 00:00:00 EDT 2022

Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.

Journal of clinical laboratory analysis

Li Z,Xu Q,Huangfu N,Chen X,Zhu J

Sat Jan 01 00:00:00 EST 2022

The landscape of m6A regulators in esophageal cancer: molecular characteristics, immuno-oncology features, and clinical relevance.

Annals of translational medicine

Li Z,Zheng C,Huang L,Yin X,Wang Z,Liu C,Li B

Thu Dec 01 00:00:00 EST 2022

Identification and experimental validation of key m6A modification regulators as potential biomarkers of osteoporosis.

Frontiers in genetics

Qiao Y,Li J,Liu D,Zhang C,Liu Y,Zheng S

Thu Feb 02 00:00:00 EST 2023

PGE₂ -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.

The EMBO journal

Tao X,Du R,Guo S,Feng X,Yu T,OuYang Q,Chen Q,Fan X,Wang X,Guo C,Li X,Xue F,Chen S,Tong M,Lazarus M,Zuo S,Yu Y,Shen Y

Tue Aug 16 00:00:00 EDT 2022

Fat mass and obesity associated (FTO)-mediated N6-methyladenosine modification of Krüppel-like factor 3 (KLF3) promotes osteosarcoma progression.

Bioengineered

Shan HJ,Gu WX,Duan G,Chen HL

Fri Apr 01 00:00:00 EDT 2022

Fat mass and obesity associated (FTO)-mediated N6-methyladenosine modification of Krüppel-like factor 3 (KLF3) promotes osteosarcoma progression.

Bioengineered

Shan HJ,Gu WX,Duan G,Chen HL

Fri Apr 01 00:00:00 EDT 2022

Fusobacterium nucleatum reduces METTL3-mediated m⁶A modification and contributes to colorectal cancer metastasis.

Nature communications

Chen S,Zhang L,Li M,Zhang Y,Sun M,Wang L,Lin J,Cui Y,Chen Q,Jin C,Li X,Wang B,Chen H,Zhou T,Wang L,Hsu CH,Zhuo W

Thu Mar 10 00:00:00 EST 2022

Intermittent Fasting Improves High-Fat Diet-Induced Obesity Cardiomyopathy via Alleviating Lipid Deposition and Apoptosis and Decreasing m6A Methylation in the Heart.

Nutrients

Xu Z,Qin Y,Lv B,Tian Z,Zhang B

Fri Jan 07 00:00:00 EST 2022

The N⁶-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression.

Biochemical pharmacology

Ondo K,Isono M,Nakano M,Hashiba S,Fukami T,Nakajima M

Thu Jul 01 00:00:00 EDT 2021

Identification of a robust signature for clinical outcomes and immunotherapy response in gastric cancer: based on N6-methyladenosine related long noncoding RNAs.

Cancer cell international

Han T,Xu D,Zhu J,Li J,Liu L,Deng Y

Mon Aug 16 00:00:00 EDT 2021

Increased m6A modification of RNA methylation related to the inhibition of demethylase FTO contributes to MEHP-induced Leydig cell injury^¿.

Environmental pollution (Barking, Essex : 1987)

Zhao T,Wang J,Wu Y,Han L,Chen J,Wei Y,Shen L,Long C,Wu S,Wei G

Fri Jan 01 00:00:00 EST 2021

METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial-mesenchymal transition of renal tubular cells in diabetic kidney disease.

Cell death & disease

Xu Z,Jia K,Wang H,Gao F,Zhao S,Li F,Hao J

Mon Jan 04 00:00:00 EST 2021

m⁶A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2.

Biochemical pharmacology

Takemoto S,Nakano M,Fukami T,Nakajima M

Mon Nov 01 00:00:00 EDT 2021

The tumor-suppressive effects of alpha-ketoglutarate-dependent dioxygenase FTO via N6-methyladenosine RNA methylation on bladder cancer patients.

Bioengineered

Yi W,Yu Y,Li Y,Yang J,Gao S,Xu L

Wed Dec 01 00:00:00 EST 2021

The tumor-suppressive effects of alpha-ketoglutarate-dependent dioxygenase FTO via N6-methyladenosine RNA methylation on bladder cancer patients.

Bioengineered

Yi W,Yu Y,Li Y,Yang J,Gao S,Xu L

Wed Dec 01 00:00:00 EST 2021

Exploration of the potential roles of m6A regulators in the uterus in pregnancy and infertility.

Journal of reproductive immunology

Zhao S,Lu J,Chen Y,Wang Z,Cao J,Dong Y

Sun Aug 01 00:00:00 EDT 2021

Exploration of the potential roles of m6A regulators in the uterus in pregnancy and infertility.

Journal of reproductive immunology

Zhao S,Lu J,Chen Y,Wang Z,Cao J,Dong Y

Sun Aug 01 00:00:00 EDT 2021

Decreased expression of m⁶A demethylase FTO in ovarian aging.

Archives of gynecology and obstetrics

Sun X,Zhang Y,Hu Y,An J,Li L,Wang Y,Zhang X

Sat May 01 00:00:00 EDT 2021

Decreased expression of m⁶A demethylase FTO in ovarian aging.

Archives of gynecology and obstetrics

Sun X,Zhang Y,Hu Y,An J,Li L,Wang Y,Zhang X

Sat May 01 00:00:00 EDT 2021

Downregulated fat mass and obesity-associated protein inhibits bone resorption and osteoclastogenesis by nuclear factor-kappa B inactivation.

Cellular signalling

Zhuang J,Ning H,Wang M,Zhao W,Jing Y,Liu X,Zu J,Kong P,Wang X,Sun C,Yan J

Mon Nov 01 00:00:00 EDT 2021

AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.

Clinical and translational medicine

Bian X,Shi D,Xing K,Zhou H,Lu L,Yu D,Wu W

Mon Mar 01 00:00:00 EST 2021

Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression.

Human cell

Cheng L,Yu P,Li F,Jiang X,Jiao X,Shen Y,Lai X

Mon Nov 01 00:00:00 EDT 2021

mTORC1 stimulates cell growth through SAM synthesis and m⁶A mRNA-dependent control of protein synthesis.

Molecular cell

Villa E,Sahu U,O'Hara BP,Ali ES,Helmin KA,Asara JM,Gao P,Singer BD,Ben-Sahra I

Thu May 20 00:00:00 EDT 2021

Upregulation of METTL3 expression and m6A RNA methylation in placental trophoblasts in preeclampsia.

Placenta

Gu Y,Chu X,Morgan JA,Lewis DF,Wang Y

Fri Jan 01 00:00:00 EST 2021

Upregulation of METTL3 expression and m6A RNA methylation in placental trophoblasts in preeclampsia.

Placenta

Gu Y,Chu X,Morgan JA,Lewis DF,Wang Y

Fri Jan 01 00:00:00 EST 2021

FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy.

Pathology, research and practice

Zhao L,Kong X,Zhong W,Wang Y,Li P

Tue Sep 01 00:00:00 EDT 2020

FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy.

Pathology, research and practice

Zhao L,Kong X,Zhong W,Wang Y,Li P

Tue Sep 01 00:00:00 EDT 2020

Resveratrol Attenuates Aflatoxin B₁-Induced ROS Formation and Increase of m⁶A RNA Methylation.

Animals : an open access journal from MDPI

Wu J,Gan Z,Zhuo R,Zhang L,Wang T,Zhong X

Mon Apr 13 00:00:00 EDT 2020

Resveratrol Attenuates High-Fat Diet Induced Hepatic Lipid Homeostasis Disorder and Decreases m⁶A RNA Methylation.

Frontiers in pharmacology

Wu J,Li Y,Yu J,Gan Z,Wei W,Wang C,Zhang L,Wang T,Zhong X

Tue Feb 02 00:00:00 EST 2021

N⁶-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2.

Nature genetics

Li Y,Xia L,Tan K,Ye X,Zuo Z,Li M,Xiao R,Wang Z,Liu X,Deng M,Cui J,Yang M,Luo Q,Liu S,Cao X,Zhu H,Liu T,Hu J,Shi J,Xiao S,Xia L

Tue Sep 01 00:00:00 EDT 2020

Alteration of N⁶-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy.

Epigenomics

Li X,Fan X,Yin X,Liu H,Yang Y

Wed Jul 01 00:00:00 EDT 2020

The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N⁶-methyladenosine methylation of Parp10 mRNA.

Nature cell biology

Gao XQ,Zhang YH,Liu F,Ponnusamy M,Zhao XM,Zhou LY,Zhai M,Liu CY,Li XM,Wang M,Shan C,Shan PP,Wang Y,Dong YH,Qian LL,Yu T,Ju J,Wang T,Wang K,Chen XZ,Wang YH,Zhang J,Li PF,Wang K

Sun Nov 01 00:00:00 EDT 2020

The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N⁶-methyladenosine methylation of Parp10 mRNA.

Nature cell biology

Gao XQ,Zhang YH,Liu F,Ponnusamy M,Zhao XM,Zhou LY,Zhai M,Liu CY,Li XM,Wang M,Shan C,Shan PP,Wang Y,Dong YH,Qian LL,Yu T,Ju J,Wang T,Wang K,Chen XZ,Wang YH,Zhang J,Li PF,Wang K

Sun Nov 01 00:00:00 EDT 2020

FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13.

Experimental cell research

Liu S,Huang M,Chen Z,Chen J,Chao Q,Yin X,Quan M

Wed Apr 01 00:00:00 EDT 2020

FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13.

Experimental cell research

Liu S,Huang M,Chen Z,Chen J,Chao Q,Yin X,Quan M

Wed Apr 01 00:00:00 EDT 2020

YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.

Carcinogenesis

Sheng H,Li Z,Su S,Sun W,Zhang X,Li L,Li J,Liu S,Lu B,Zhang S,Shan C

Fri Jul 10 00:00:00 EDT 2020

Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5.

Frontiers in cardiovascular medicine

Ma D,Liu X,Zhang JJ,Zhao JJ,Xiong YJ,Chang Q,Wang HY,Su P,Meng J,Zhao YB

Fri Dec 18 00:00:00 EST 2020

Glucose Is Involved in the Dynamic Regulation of m6A in Patients With Type 2 Diabetes.

The Journal of clinical endocrinology and metabolism

Yang Y,Shen F,Huang W,Qin S,Huang JT,Sergi C,Yuan BF,Liu SM

Fri Mar 01 00:00:00 EST 2019

Bioinformatics

Protein Aliases: AlkB homolog 9; Alpha-ketoglutarate-dependent dioxygenase FTO; Fat mass and obesity-associated protein; fatso; m6A(m)-demethylase FTO; MGC5149; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; mRNA N(6)-methyladenosine demethylase FTO; Protein fatso; protein fto; tRNA N1-methyl adenine demethylase FTO; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO

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Gene Aliases: ALKBH9; AW743446; BMIQ14; FTO; GDFD; KIAA1752; mKIAA1752

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UniProt ID: (Human) Q9C0B1, (Mouse) Q8BGW1

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Entrez Gene ID: (Human) 79068, (Mouse) 26383

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Function(s)

Process(es)

temperature homeostasis DNA dealkylation involved in DNA repair regulation of lipid storage oxidative single-stranded DNA demethylation oxidative single-stranded RNA demethylation regulation of multicellular organism growth RNA repair regulation of respiratory system process adipose tissue development regulation of white fat cell proliferation oxidative demethylation DNA demethylation regulation of brown fat cell differentiation DNA repair cellular response to DNA damage stimulus oxidation-reduction process

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FTO Polyclonal Antibody

FTO Antibody (27226-1-AP) in IHC (P)

Product Details

27226-1-AP

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Immunohistochemistry (Paraffin) (IHC (P))

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RNA Immunoprecipitation (RIP)

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