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Product Details
68111-1-IG150UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1E8B1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
FTO is a novel protein and a member of the non-heme dioxygenase (Fe(II)-and 2-oxoglutarate-dependent dioxygenases) superfamily. Amino acid conservation patterns support this hypothesis and indicates that both 2-oxoglutarate and iron should be important for FTO function. Though not much is yet known about FTO, it is thought that the protein may somehow modify the activity of genes involved in metabolism and fat storage, which in turn may influence a person's risk of obesity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AlkB homolog 9; Alpha-ketoglutarate-dependent dioxygenase FTO; fat mass and obesity associated protein; Fat mass and obesity-associated protein; fatso; m6A(m)-demethylase FTO; MGC5149; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; mRNA N(6)-methyladenosine demethylase FTO; Protein fatso; protein fto; tRNA N1-methyl adenine demethylase FTO; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
Gene Aliases: ALKBH9; AW743446; BMIQ14; FTO; GDFD; KIAA1752; mKIAA1752
UniProt ID: (Human) Q9C0B1, (Mouse) Q8BGW1
Entrez Gene ID: (Pig) 100127165, (Human) 79068, (Mouse) 26383
ferrous iron binding
oxidative RNA demethylase activity
oxidative DNA demethylase activity
DNA-N1-methyladenine dioxygenase activity
RNA N6-methyladenosine dioxygenase activity
sulfonate dioxygenase activity
oxidoreductase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
metal ion binding
dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
oxygenase
temperature homeostasis
DNA dealkylation involved in DNA repair
regulation of lipid storage
oxidative single-stranded DNA demethylation
oxidative single-stranded RNA demethylation
regulation of multicellular organism growth
RNA repair
regulation of respiratory system process
adipose tissue development
regulation of white fat cell proliferation
oxidative demethylation
DNA demethylation
regulation of brown fat cell differentiation
DNA repair
cellular response to DNA damage stimulus
oxidation-reduction process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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