Proteintech

FUCA1 Polyclonal Antibody

FUCA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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FUCA1 Antibody (16420-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver cancer using 16420-1-AP (FUCA1 antibody) at dilution of 1:50 (under 40x lens).

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Product Details

16420-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FUCA1 Fusion Protein Ag9612 (113-461 aa encoded by BC017338)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EEWADLFQA AGAKYVVLTT KHHEGFTNWP SPVSWNWNSK DVGPHRDLVG ELGTALRKRN IRYGLYHSLL EWFHPLYLLD KKNGFKTQHF VSAKTMPELY DLVNSYKPDL IWSDGEWECP DTYWNSTNFL SWLYNDSPVK DEVVVNDRWG QNCSCHHGGY YNCEDKFKPQ SLPDHKWEMC TSIDKFSWGY RRDMALSDVT EESEIISELV QTVSLGGNYL LNIGPTKDGL IVPIFQERLL AVGKWLSING EAIYASKPWR VQWEKNTTSV WYTSKGSAVY AIFLHWPENG VLNLESPITT STTKITMLGI QGDLKWSTDP DKGLFISLPQ LPPSAVPAEF AWTIKLTGVK (113-461 aa encoded by BC017338)

Target Information

Alpha-L-fucosidase (EC 3.2.1.51) is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids (Occhiodoro et al., 1989 [PubMed 2803312]). At least 2 separate polymorphic alpha-L-fucosidases are recognized in man: that in tissues, FUCA1, which is deficient in fucosidosis (MIM 230000), and that in plasma, FUCA2 (MIM 136820).[supplied by OMIM].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

USP35 promotes cell proliferation and chemotherapeutic resistance through stabilizing FUCA1 in colorectal cancer.

Oncogenesis

Xiao Y,Jiang X,Yin K,Miao T,Lu H,Wang W,Ma L,Zhao Y,Liu C,Qiao Y,Zhang P

Fri Mar 03 00:00:00 EST 2023

Alpha-L-fucosidase-1 is a diagnostic marker that distinguishes mucoepidermoid carcinoma from squamous cell carcinoma.

Pathology international

Ishida S,Kayamori K,Sakamoto K,Yukimori A,Kugimoto T,Harada H,Ikeda T

Fri Feb 01 00:00:00 EST 2019

Reduced expression of α-L-Fucosidase-1 (FUCA-1) predicts recurrence and shorter cancer specific survival in luminal B LN+ breast cancer patients.

Oncotarget

Bonin S,Parascandolo A,Aversa C,Barbazza R,Tsuchida N,Castellone MD,Stanta G,Vecchio G

Fri Mar 16 00:00:00 EDT 2018

Reduced expression of α-L-Fucosidase-1 (FUCA-1) predicts recurrence and shorter cancer specific survival in luminal B LN+ breast cancer patients.

Oncotarget

Bonin S,Parascandolo A,Aversa C,Barbazza R,Tsuchida N,Castellone MD,Stanta G,Vecchio G

Fri Mar 16 00:00:00 EDT 2018

Reduced expression of α-L-Fucosidase-1 (FUCA-1) predicts recurrence and shorter cancer specific survival in luminal B LN+ breast cancer patients.

Oncotarget

Bonin S,Parascandolo A,Aversa C,Barbazza R,Tsuchida N,Castellone MD,Stanta G,Vecchio G

Fri Mar 16 00:00:00 EDT 2018

Reduced expression of α-L-Fucosidase-1 (FUCA-1) predicts recurrence and shorter cancer specific survival in luminal B LN+ breast cancer patients.

Oncotarget

Bonin S,Parascandolo A,Aversa C,Barbazza R,Tsuchida N,Castellone MD,Stanta G,Vecchio G

Fri Mar 16 00:00:00 EDT 2018

High Resolution Proteomic Analysis of the Cervical Cancer Cell Lines Secretome Documents Deregulation of Multiple Proteases.

Cancer genomics & proteomics

Pappa KI,Kontostathi G,Makridakis M,Lygirou V,Zoidakis J,Daskalakis G,Anagnou NP

Tue Jul 03 00:00:00 EDT 2018

High Resolution Proteomic Analysis of the Cervical Cancer Cell Lines Secretome Documents Deregulation of Multiple Proteases.

Cancer genomics & proteomics

Pappa KI,Kontostathi G,Makridakis M,Lygirou V,Zoidakis J,Daskalakis G,Anagnou NP

Tue Jul 03 00:00:00 EDT 2018

Proteomics analysis of bladder cancer invasion: Targeting EIF3D for therapeutic intervention.

Oncotarget

Latosinska A,Mokou M,Makridakis M,Mullen W,Zoidakis J,Lygirou V,Frantzi M,Katafigiotis I,Stravodimos K,Hupe MC,Dobrzynski M,Kolch W,Merseburger AS,Mischak H,Roubelakis MG,Vlahou A

Tue Sep 19 00:00:00 EDT 2017

Human a-L-fucosidase-1 attenuates the invasive properties of thyroid cancer.

Oncotarget

Vecchio G,Parascandolo A,Allocca C,Ugolini C,Basolo F,Moracci M,Strazzulli A,Cobucci-Ponzano B,Laukkanen MO,Castellone MD,Tsuchida N

Tue Apr 18 00:00:00 EDT 2017

Human a-L-fucosidase-1 attenuates the invasive properties of thyroid cancer.

Oncotarget

Vecchio G,Parascandolo A,Allocca C,Ugolini C,Basolo F,Moracci M,Strazzulli A,Cobucci-Ponzano B,Laukkanen MO,Castellone MD,Tsuchida N

Tue Apr 18 00:00:00 EDT 2017

Human a-L-fucosidase-1 attenuates the invasive properties of thyroid cancer.

Oncotarget

Vecchio G,Parascandolo A,Allocca C,Ugolini C,Basolo F,Moracci M,Strazzulli A,Cobucci-Ponzano B,Laukkanen MO,Castellone MD,Tsuchida N

Tue Apr 18 00:00:00 EDT 2017

Human a-L-fucosidase-1 attenuates the invasive properties of thyroid cancer.

Oncotarget

Vecchio G,Parascandolo A,Allocca C,Ugolini C,Basolo F,Moracci M,Strazzulli A,Cobucci-Ponzano B,Laukkanen MO,Castellone MD,Tsuchida N

Tue Apr 18 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: A L fucosidase I; A L fucoside fucohydrolase 1; Alpha-L-fucosidase 1; Alpha-L-fucosidase I; Alpha-L-fucoside fucohydrolase 1; EC 3.2.1; EC 3.2.1.51; Fucosidase alpha-L-1 tissue; Fucosidase, alpha-L-1, tissue; Tissue alpha-L-fucosidase; Tissue α L fucosidase; α L fucosidase 1; α L fucosidase I; α L fucoside fucohydrolase 1

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Gene Aliases: 0610006A03Rik; 9530055J05Rik; Afuc; FUCA; FUCA1; Nbla10230

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UniProt ID: (Human) P04066, (Rat) P17164, (Mouse) Q3UAH8

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Entrez Gene ID: (Human) 2517, (Rat) 24375, (Mouse) 71665

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Function(s)

alpha-L-fucosidase activity carbohydrate binding fucosidase activity fucose binding hydrolase activity hydrolase activity, acting on glycosyl bonds glycosidase

Process(es)

fucose metabolic process glycosaminoglycan catabolic process glycoside catabolic process biological_process carbohydrate metabolic process metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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FUCA1 Polyclonal Antibody

FUCA1 Antibody (16420-1-AP) in IHC (P)

Product Details

16420-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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