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Product Details
PA5-142461
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-KIRSNLQKDGTKT.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2933109
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
FZD4 is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. Frizzled 4 is widely expressed, particularly in heart, skeletal muscle, ovary, and fetal kidney. Transcripts have also been identified in liver, kidney, pancreas, spleen, and fetal lung, and in smaller amounts in placenta, adult lung, prostate, testis, colon, and fetal brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD344; CD344 antigen; frizzled 4, seven transmembrane spanning receptor; frizzled family receptor 4; frizzled homolog 4; Frizzled-4; Fz-4; FzE4; MGC34390; WNT receptor frizzled-4
Gene Aliases: CD344; EVR1; FEVR; Fz-4; Fz4; FZD4; FZD4S; FzE4; GPCR; hFz4
UniProt ID: (Human) Q9ULV1
Entrez Gene ID: (Human) 8322
vasculogenesis
G-protein coupled receptor signaling pathway
Wnt signaling pathway, calcium modulating pathway
sensory perception of sound
negative regulation of cell-substrate adhesion
Wnt signaling pathway
neuron differentiation
regulation of vascular endothelial growth factor receptor signaling pathway
locomotion involved in locomotory behavior
substrate adhesion-dependent cell spreading
extracellular matrix-cell signaling
progesterone secretion
positive regulation of JUN kinase activity
positive regulation of transcription, DNA-templated
positive regulation of sequence-specific DNA binding transcription factor activity
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
retina vasculature morphogenesis in camera-type eye
cerebellum vasculature morphogenesis
retinal blood vessel morphogenesis
cellular response to retinoic acid
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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