Proteintech

FcRn Polyclonal Antibody

FcRn Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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FcRn Antibody (16190-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using (Product # 16190-1-AP) (FcRn-Specific antibody) at dilution of 1:1,000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

16190-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000

Immunocytochemistry (ICC/IF)

Assay-dependent

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Dog, Guinea pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.28 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

FCGRT binds to the Fc region of monomeric immunoglobulins gamma. It mediates the uptake of IgG from milk. It plays a possible role in transfer of immunoglobulin G from mother to fetus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Recombinant Humanized IgG1 Antibody Promotes Reverse Cholesterol Transport through FcRn-ERK1/2-PPARα Pathway in Hepatocytes.

International journal of molecular sciences

Li Z,Zhang Q,Liu X,Zhao M

Wed Nov 23 00:00:00 EST 2022

Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B.

Cell

Zhao X,Zhang G,Liu S,Chen X,Peng R,Dai L,Qu X,Li S,Song H,Gao Z,Yuan P,Liu Z,Li C,Shang Z,Li Y,Zhang M,Qi J,Wang H,Du N,Wu Y,Bi Y,Gao S,Shi Y,Yan J,Zhang Y,Xie Z,Wei W,Gao GF

Thu May 30 00:00:00 EDT 2019

Gestation age dependent transfer of human immunoglobulins across placenta in timed-pregnant guinea pigs.

Placenta

Xu Y,Ma L,Norton MG,Stuart C,Zhao Z,Toibero D,Dahlen S,Zhong L,Zhang P,Struble EB

Tue Dec 01 00:00:00 EST 2015

Gestation age dependent transfer of human immunoglobulins across placenta in timed-pregnant guinea pigs.

Placenta

Xu Y,Ma L,Norton MG,Stuart C,Zhao Z,Toibero D,Dahlen S,Zhong L,Zhang P,Struble EB

Tue Dec 01 00:00:00 EST 2015

Gestation age dependent transfer of human immunoglobulins across placenta in timed-pregnant guinea pigs.

Placenta

Xu Y,Ma L,Norton MG,Stuart C,Zhao Z,Toibero D,Dahlen S,Zhong L,Zhang P,Struble EB

Tue Dec 01 00:00:00 EST 2015

Gestation age dependent transfer of human immunoglobulins across placenta in timed-pregnant guinea pigs.

Placenta

Xu Y,Ma L,Norton MG,Stuart C,Zhao Z,Toibero D,Dahlen S,Zhong L,Zhang P,Struble EB

Tue Dec 01 00:00:00 EST 2015

Human antibodies can cross guinea pig placenta and bind its neonatal Fc Receptor: implications for studying immune prophylaxis and therapy during pregnancy.

Clinical & developmental immunology

Struble EB,Ma L,Zhong L,Lesher A,Beren J,Zhang P

Thu Jan 31 00:00:00 EST 2013

Human antibodies can cross guinea pig placenta and bind its neonatal Fc Receptor: implications for studying immune prophylaxis and therapy during pregnancy.

Clinical & developmental immunology

Struble EB,Ma L,Zhong L,Lesher A,Beren J,Zhang P

Thu Jan 31 00:00:00 EST 2013

Bioinformatics

Protein Aliases: Fc fragment of IgG, receptor, transporter, alpha; FcRn; FcRn alpha chain; heavy chain of the major histocompatibility complex class I-like Fc receptor; IgG Fc fragment receptor transporter alpha chain; IgG receptor FcRn large subunit p51; immunoglobulin receptor, intestinal, heavy chain; major histocompatibility complex class I-like Fc receptor; Neonatal Fc receptor; neonatal Fc-receptor for Ig; transmembrane alpha chain of the neonatal receptor

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Gene Aliases: alpha-chain; FCGRT; FCRN

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UniProt ID: (Human) P55899

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Entrez Gene ID: (Human) 2217

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Function(s)

antigen binding IgG receptor activity IgG binding beta-2-microglobulin binding peptide antigen binding major histocompatibility complex protein

Process(es)

IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor immune response antigen processing and presentation Fc-gamma receptor signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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FcRn Polyclonal Antibody

FcRn Antibody (16190-1-AP) in IHC (P)

Product Details

16190-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

Bioinformatics

Performance Guarantee

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