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Invitrogen
FceR1 alpha Chimeric Recombinant Rabbit Monoclonal Antibody (IB10)
FIGURE: 1 / 1
FceR1 alpha Chimeric Antibody (MA5-48232) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of FceR1 alpha in U937 cells using FceR1 alpha Chimeric Monoclonal Antibody (Product # MA5-48232). Paraformaldehyde-fixed cells were immobilized on cover slips and stained with FceR1 alpha Chimeric Monoclonal Antibody at 10 µg/mL followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing diffuse membrane staining. The nuclear stain is DAPI (blue). Panel... View More
Product Details
MA5-48232
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
IB10
Immunogen
Recombinant human protein, N-terminus.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3074675
Product Specific Information
Specificity: This antibody binds to human Fc epsilon receptor and competes with IgE binding.
Target Information
FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE. Fc epsilonR1 alpha is a tetrameric complex consisting of one alpha, one ß and two additional subunits. The latter two are required for signal transduction activity. The Fc epsilonR1 complex plays an important role in triggering allergic responses, and the immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine, which are responsible for allergy symptoms, are released. The IgE receptor couples allergen and mast cells to initiate the inflammatory responses that are characteristic of disorders such as hay fever and asthma. The release of histamine and proteases leads to the synthesis of prostaglandins and leukotrienes-potent effectors of the hypersensitivity response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fc epsilon r1; Fc epsilon receptor Ia; Fc epsilon RI alpha-chain; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc IgE receptor, alpha polypeptide; Fc-epsilon RI-alpha; FcERI; high affinity immunoglobulin epsilon receptor alpha-subunit; High affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor subunit alpha; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; RP11-550P17.3
Gene Aliases: FCE1A; FCER1A; FcERI
UniProt ID: (Human) P12319
Entrez Gene ID: (Human) 2205
positive regulation of type I hypersensitivity
serotonin secretion
activation of JUN kinase activity
leukotriene biosynthetic process
Fc-epsilon receptor signaling pathway
positive regulation of mast cell degranulation
positive regulation of interleukin-3 biosynthetic process
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of calcium-mediated signaling
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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