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Invitrogen
Filamin A Recombinant Rabbit Monoclonal Antibody (SA30-08)
FIGURE: 1 / 7
Filamin A Antibody (MA5-31975) in ICC/IF
Immunocytochemical analysis of Filamin A in Hela cells using a Filamin A Monoclonal antibody (Product # MA5-31975) as seen in green. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Product Details
MA5-31975
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SA30-08
Immunogen
Synthetic peptide within Human Filamin A aa 2,598-2,647
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2809269
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Filamin functions as a crosslinking protein forming a flexible link between two actin filaments. It is composed of two identical polypeptide chains each joined to the other at one end, with an actin binding site at the other. It is present in human platelets, lymphocytes, fibroblasts and smooth muscle actin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABP-280; actin binding protein 280; Actin-binding protein 280; alpha filamin; Alpha-filamin; dilated pupils 2; Endothelial actin-binding protein; Endothelial actin-binding protein 280); filamin 1; filamin A, alpha; filamin, alpha; Filamin-1; Filamin-A; FilaminA; FLN-A; Non-muscle filamin
Gene Aliases: ABP-280; ABPX; CSBS; CVD1; Dilp2; F730004A14Rik; filamin-1; FLN; FLN-A; FLN1; FLNA; FMD; GENA 379; MNS; NHBP; OPD; OPD1; OPD2; RGD1560614; XLVD; XMVD
UniProt ID: (Human) P21333
Entrez Gene ID: (Human) 2316, (Rat) 293860, (Mouse) 192176
G-protein coupled receptor binding
glycoprotein binding
signal transducer activity
protein binding
transcription factor binding
Rho GTPase binding
Ral GTPase binding
kinase binding
small GTPase binding
mu-type opioid receptor binding
Fc-gamma receptor I complex binding
protein homodimerization activity
poly(A) RNA binding
SMAD binding
Rac GTPase binding
actin filament binding
GTPase binding
cadherin binding involved in cell-cell adhesion
protein kinase C binding
protein complex binding
actin binding
epithelial to mesenchymal transition
adenylate cyclase-inhibiting dopamine receptor signaling pathway
biological_process
actin cytoskeleton organization
actin cytoskeleton reorganization
protein localization to cell surface
negative regulation of protein catabolic process
cilium assembly
mRNA transcription from RNA polymerase II promoter
positive regulation of transcription factor import into nucleus
receptor clustering
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of sequence-specific DNA binding transcription factor activity
early endosome to late endosome transport
establishment of protein localization
protein stabilization
cytoplasmic sequestering of protein
actin crosslink formation
platelet aggregation
mitotic spindle assembly
negative regulation of transcription from RNA polymerase I promoter
cell projection organization
negative regulation of apoptotic process
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of integrin-mediated signaling pathway
platelet degranulation
platelet activation
regulation of cell migration
cell junction assembly
wound healing, spreading of cells
semaphorin-plexin signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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