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Invitrogen
Fra1 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 5
Fra1 Antibody (PA5-66880) in ICC/IF
Immunofluorescence analysis of Fra1 was performed using 70% confluent log phase PC-3 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Fra1 Polyclonal Antibody (Product # PA5-66880) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Goat anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32731),... View More
Product Details
PA5-66880
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Fra1
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2662584
Product Specific Information
Immunogen sequence: LVPSINTMSGS QELQWMVQPH FLGPSSYPRP LTYPQYSPPQ PRPGVIRALG PPPGVRRRPC EQISPE
Highest antigen sequence identity to the following orthologs - mouse 88%, rat 96%.
Target Information
The v-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. Members of the c-Fos gene family, including c-Fos, Fos B, Fra-1 and Fra-2, encode nuclear phosphoproteins that are rapidly and transiently induced by a variety of agents and function as transcriptional regulators for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers that bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FOS like 1, AP-1 trancription factor subunit; FOS like antigen 1; FOS-like antigen 1; FOS-like antigen-1; Fos-related antigen 1; FRA-1; HGNC:13718
Gene Aliases: FOSL1; FRA; fra-1; FRA1
UniProt ID: (Human) P15407
Entrez Gene ID: (Human) 8061
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
basic leucine zipper transcription factor
in utero embryonic development
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
chemotaxis
cellular defense response
vitellogenesis
female pregnancy
learning
positive regulation of cell proliferation
negative regulation of cell proliferation
response to mechanical stimulus
response to virus
response to gravity
cellular response to extracellular stimulus
response to progesterone
response to cytokine
response to drug
response to hydrogen peroxide
positive regulation of apoptotic process
positive regulation of cell cycle
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
response to corticosterone
response to cAMP
placenta blood vessel development
pri-miRNA transcription from RNA polymerase II promoter
positive regulation of DNA-templated transcription, initiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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