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OriGene
G protein alpha inhibitor 1 (GNAI1) Monoclonal Antibody (OTI2D1), TrueMAB™
Product Details
CF811907
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI2D1
Immunogen
Human recombinant protein fragment corresponding to amino acids 1-354 of human GNAI1 (NP_002060) produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
See Label
Purification
Protein A/G
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Target Information
Guanine nucleotide-binding proteins (G proteins) form a large family of signal-transducing molecules. They are found as heterotrimers made up of alpha, beta, and gamma subunits. Members of the G protein family have been characterized most extensively on the basis of the alpha subunit, which binds guanine nucleotide, is capable of hydrolyzing GTP, and interacts with specific receptor and effector molecules. The G protein family includes Gs and Gi, the stimulatory and inhibitory GTP-binding regulators of adenylate cyclase; Go, a protein abundant in brain; and transducin-1 and transducin-2, proteins involved in phototransduction in retinal rods and cones, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adenylate cyclase-inhibiting G alpha protein; Gi1 protein alpha subunit; guanine nucleotide binding protein (G protein), alpha inhibiting 1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; guanine nucleotide binding protein, alpha inhibiting 1; Guanine nucleotide-binding protein G(i) subunit alpha-1; guanine nucleotide-binding protein G(i), alpha-1 subunit
Gene Aliases: AU046200; BPGTPB; Gi; Gialpha1; Gnai-1; GNAI1
UniProt ID: (Human) P63096, (Rat) P10824, (Mouse) B2RSH2
Entrez Gene ID: (Human) 2770, (Rat) 25686, (Mouse) 14677
magnesium ion binding
G-protein coupled receptor binding
GTPase activity
signal transducer activity
protein binding
GTP binding
GDP binding
G-protein beta/gamma-subunit complex binding
G-protein coupled serotonin receptor binding
GTPase activating protein binding
metal ion binding
nucleotide binding
guanyl nucleotide binding
heterotrimeric G-protein
protein folding
cell cycle
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
response to peptide hormone
regulation of cAMP-mediated signaling
negative regulation of synaptic transmission
cell division
cellular response to forskolin
metabolic process
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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