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Product Details
CL55566373100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2A7B12
Conjugate
Excitation/Emission Max
555/570 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Target Information
This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G6PD; Glucose-6-phosphate 1-dehydrogenase; Glucose-6-phosphate 1-dehydrogenase X; glucose-6-phosphate dehydrogenase X-linked
Gene Aliases: G28A; G6PD; G6pd-1; G6PD1; G6pdx; Gpdx
UniProt ID: (Human) P11413, (Rat) P05370, (Mouse) Q00612
Entrez Gene ID: (Human) 2539, (Rat) 24377, (Mouse) 14381
glucose metabolic process
pentose-phosphate shunt
lipid metabolic process
cholesterol biosynthetic process
NADP metabolic process
NADPH regeneration
glutathione metabolic process
pentose-phosphate shunt, oxidative branch
negative regulation of protein glutathionylation
response to organic cyclic compound
pentose biosynthetic process
substantia nigra development
response to food
cellular response to oxidative stress
erythrocyte maturation
regulation of neuron apoptotic process
response to ethanol
ribose phosphate biosynthetic process
glucose 6-phosphate metabolic process
oxidation-reduction process
cytokine production
angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
NADP biosynthetic process
response to oxidative stress
interleukin-10 production
interleukin-12 production
regulation of multicellular organism growth
erythrocyte development
carbohydrate metabolic process
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