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Product Details
MA5-25875
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI4F1
Immunogen
Full length human recombinant protein of PPP1R15A produced in HEK293T cell
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2723205
Target Information
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Growth arrest and DNA damage-inducible protein GADD34; growth arrest and DNA-damage-inducible 34; Myeloid differentiation primary response protein MyD116 homolog; PR15A; Protein phosphatase 1 regulatory subunit 15A; protein phosphatase 1, regulatory (inhibitor) subunit 15A; protein phosphatase 1, regulatory subunit 15A
Gene Aliases: GADD34; PPP1R15A
UniProt ID: (Human) O75807
Entrez Gene ID: (Human) 23645
positive regulation of protein phosphorylation
apoptotic process
cellular response to DNA damage stimulus
cell cycle arrest
aging
negative regulation of cell proliferation
negative regulation of peptidyl-threonine phosphorylation
negative regulation of protein processing
endoplasmic reticulum unfolded protein response
positive regulation of translational initiation in response to stress
negative regulation of phosphoprotein phosphatase activity
positive regulation of phosphoprotein phosphatase activity
cellular response to UV
response to endoplasmic reticulum stress
negative regulation of protein dephosphorylation
cellular response to drug
response to immobilization stress
regulation of translational initiation by eIF2 alpha dephosphorylation
response to cocaine
positive regulation of apoptotic process
regulation of angiogenesis
negative regulation of cell death
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
peptidyl-serine dephosphorylation
protein localization to endoplasmic reticulum
cellular response to antibiotic
cellular response to carbohydrate stimulus
cellular response to methyl methanesulfonate
cellular response to calcium ion starvation
response to environmental enrichment
cellular response to oxygen-glucose deprivation
positive regulation of peptidyl-serine dephosphorylation
negative regulation of PERK-mediated unfolded protein response
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
cellular response to desipramine
cellular response to cordycepin
cellular response to gold(3+)
cellular response to methamphetamine hydrochloride
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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