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Product Details
PA5-56268
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GADD45B. Recombinant protein control fragment (Product #RP-90634).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2641817
Product Specific Information
Immunogen sequence: AVEELLVAAQ RQDRLTVGVY ESAKLMNVDP DSVVLCLLAI DEEEEDDIAL QIHFTLIQSF CCDNDINIVR VSGMQRLAQL LGEPAETQGT TEARDLHCLL VTNPHTDAWK SHGLVEVASY CEESRGNNQW VPY
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 94%.
Target Information
Cellcycle progression issubject to arrest at G1 and G2 checkpointsin response to DNA damage, presumablyto allow time for DNA repair prior to entryinto S andMphase, respectively. The p53 tumorsuppressor isrequired for one such G1 checkpoint and functionsto upregulate expression of GADD 45 and p21. GADD 45 binds both Cdks and PCNA, a protein involved in DNA replication and repair. GADD 45 stimulates DNA excision repair in vitro and inhibits entry ofcellsinto S phase. Thus, it has been suggested that GADD 45 mayserve as a link between the p53-dependentcellcycle checkpoint and DNA repair. GADD 45-like proteins, GADD 45 beta and GADD 45 gamma, have been shown to be induced by environmentalstresses. GADD 45 beta and GADD 45 gamma are thought to induce p38/JNK activation via MEKK4 activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZP566B133; Growth arrest and DNA damage-inducible protein GADD45 beta; growth arrest and DNA-damage-inducible, beta; Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118
Gene Aliases: GADD45B; GADD45BETA; MYD118
UniProt ID: (Human) O75293
Entrez Gene ID: (Human) 4616
activation of MAPKKK activity
activation of MAPKK activity
negative regulation of protein kinase activity
apoptotic process
response to stress
multicellular organism development
cell differentiation
positive regulation of apoptotic process
positive regulation of JNK cascade
regulation of cell cycle
positive regulation of p38MAPK cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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