Invitrogen

GATA4 Recombinant Rabbit Monoclonal Antibody (1M2E4)

View all (29) GATA4 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-38112

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

1M2E4

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 343-442 of human GATA4 (NP_0020432)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.55 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2898030

Product Specific Information

Positive Samples: HepG2, SKOV3, Mouse liver, Mouse testis, Rat testis

Immunogen sequence: ASGASSNSSN ATTSSSEEMR PIKTEPGLSS HYGHSSSVSQ TFSVSAMSGH GPSIHPVLSA LKLSPQGYAS PVSQSPQTSS KQDSWNSLVL ADSHGDIITA

Target Information

GATA4 is a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in the gene encoding GATA4 have been associated with cardiac septal defects.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DNA-binding protein GATA-GT2; GAT4; GATA-binding factor 4; GATA-binding protein 4; MGC126629; Transcription factor GATA-4

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Gene Aliases: Gata-4; Gata4

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UniProt ID: (Mouse) Q08369, (Rat) P46152

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Entrez Gene ID: (Mouse) 14463, (Rat) 54254

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor binding enhancer sequence-specific DNA binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription coactivator activity protein binding transcription factor binding zinc ion binding protein kinase binding activating transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding metal ion binding NFAT protein binding co-SMAD binding DNA-binding transcription factor
Process(es)
in utero embryonic development gastrulation with mouth forming second endoderm formation heart looping heart morphogenesis outflow tract morphogenesis atrioventricular valve morphogenesis atrioventricular valve formation mitral valve formation tricuspid valve formation endocardial cushion development cardiac right ventricle morphogenesis ventricular cardiac muscle tissue development cardiac septum development ventricular septum development atrial septum primum morphogenesis atrial septum secundum morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cell-cell signaling spermatogenesis heart development male gonad development response to mechanical stimulus regulation of gene expression negative regulation of autophagy positive regulation of vascular endothelial growth factor production cardiac muscle hypertrophy in response to stress signal transduction involved in regulation of gene expression BMP signaling pathway positive regulation of BMP signaling pathway response to retinoic acid embryonic heart tube development embryonic heart tube anterior/posterior pattern specification tube morphogenesis skeletal muscle cell differentiation atrioventricular canal development response to drug response to estrogen positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic digestive tract morphogenesis embryonic morphogenesis embryonic foregut morphogenesis cardiac muscle tissue development cardiac muscle cell differentiation Sertoli cell differentiation regulation of cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation canonical Wnt signaling pathway transdifferentiation SMAD protein signal transduction atrial septum morphogenesis lung morphogenesis lung lobe formation diaphragm morphogenesis intestinal epithelial cell differentiation vasculogenesis involved in coronary vascular morphogenesis cell growth involved in cardiac muscle cell development cellular response to gonadotropin stimulus cellular response to follicle-stimulating hormone stimulus epithelial cell fate commitment seminiferous tubule development regulation of cardiac muscle cell contraction response to vitamin A positive regulation of cardioblast differentiation cellular response to glucose stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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