Product References
Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease.
Cell reports. Medicine
Zhao R,Cao L,Gu WJ,Li L,Chen ZZ,Xiang J,Zhou ZY,Xu B,Zang WD,Zhou XY,Cao J,Sun K,Zhao JY
MA5-15532 was used in Chromatin immunoprecipitation to find that PA promotes methionyl-tRNA synthetase (MARS) expression and protein lysine homocysteinylation (K-Hcy) of GATA4 and results in GATA4 inhibition and abnormal heart development.
Tue Mar 21 00:00:00 EDT 2023
Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease.
Cell reports. Medicine
Zhao R,Cao L,Gu WJ,Li L,Chen ZZ,Xiang J,Zhou ZY,Xu B,Zang WD,Zhou XY,Cao J,Sun K,Zhao JY
MA5-15532 was used in Chromatin immunoprecipitation to find that PA promotes methionyl-tRNA synthetase (MARS) expression and protein lysine homocysteinylation (K-Hcy) of GATA4 and results in GATA4 inhibition and abnormal heart development.
Tue Mar 21 00:00:00 EDT 2023
A common variant in 11q23.3 associated with hyperlipidemia is mediated by the binding and regulation of GATA4.
NPJ genomic medicine
Chou WC,Chen WT,Shen CY
MA5-15532 was used in Western Blot, ChIP assay to suggest elevating GATA4 activity could provide a therapeutic potential for treating the development of hyperlipidemia.
Wed Jan 19 00:00:00 EST 2022
A common variant in 11q23.3 associated with hyperlipidemia is mediated by the binding and regulation of GATA4.
NPJ genomic medicine
Chou WC,Chen WT,Shen CY
MA5-15532 was used in Western Blot, ChIP assay to suggest elevating GATA4 activity could provide a therapeutic potential for treating the development of hyperlipidemia.
Wed Jan 19 00:00:00 EST 2022
Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells.
Nature communications
Low BSJ,Lim CS,Ding SSL,Tan YS,Ng NHJ,Krishnan VG,Ang SF,Neo CWY,Verma CS,Hoon S,Lim SC,Tai ES,Teo AKK
MA5-15532 was used in Flow Cytometry to reveal the importance of HNF1A in regulating GLUT2 and several genes involved in insulin secretion that can account for the insulin secretory defect clinically observed in MODY3 patients.
Tue May 25 00:00:00 EDT 2021
Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells.
Nature communications
Low BSJ,Lim CS,Ding SSL,Tan YS,Ng NHJ,Krishnan VG,Ang SF,Neo CWY,Verma CS,Hoon S,Lim SC,Tai ES,Teo AKK
MA5-15532 was used in Flow Cytometry to reveal the importance of HNF1A in regulating GLUT2 and several genes involved in insulin secretion that can account for the insulin secretory defect clinically observed in MODY3 patients.
Tue May 25 00:00:00 EDT 2021
Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas.
Cancer research
Pan J,Silva TC,Gull N,Yang Q,Plummer JT,Chen S,Daigo K,Hamakubo T,Gery S,Ding LW,Jiang YY,Hu S,Xu LY,Li EM,Ding Y,Klempner SJ,Gayther SA,Berman BP,Koeffler HP,Lin DC
MA5-15532 was used in Western Blotting to show that gastrointestinal adenocarcinomas (GIAC)-specific master regulatory transcription factors control HNF4A via three distal enhancers to promote GIAC cell proliferation and survival.
Wed Jul 01 00:00:00 EDT 2020
BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells.
Cell death & disease
Loo LSW,Soetedjo AAP,Lau HH,Ng NHJ,Ghosh S,Nguyen L,Krishnan VG,Choi H,Roca X,Hoon S,Teo AKK
MA5-15532 was used in Immunocytochemistry-immunoflourescence to profile the expression of BCL-2 family of proteins during pancreatic specification and observed an upregulation of BCL-xL, downregulation of BAK and corresponding downregulation of cleaved CASP3 representative of apoptosis.
Mon May 18 00:00:00 EDT 2020
BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells.
Cell death & disease
Loo LSW,Soetedjo AAP,Lau HH,Ng NHJ,Ghosh S,Nguyen L,Krishnan VG,Choi H,Roca X,Hoon S,Teo AKK
MA5-15532 was used in Immunocytochemistry-immunoflourescence to profile the expression of BCL-2 family of proteins during pancreatic specification and observed an upregulation of BCL-xL, downregulation of BAK and corresponding downregulation of cleaved CASP3 representative of apoptosis.
Mon May 18 00:00:00 EDT 2020
HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells.
iScience
Ng NHJ,Jasmen JB,Lim CS,Lau HH,Krishnan VG,Kadiwala J,Kulkarni RN,Ræder H,Vallier L,Hoon S,Teo AKK
MA5-15532 was used in Immunocytochemistry-immunoflourescence to suggest that in MODY1, liver and pancreas development is perturbed early on, contributing to altered hepatic proteins and Β cell defects in patients.
Fri Jun 28 00:00:00 EDT 2019