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Product Details
H00010220-M06
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4F7
Immunogen
GDF11 (NP_005802, 310 a.a. approximately 407 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: ESRCCRYPLT VDFEAFGWDW IIAPKRYKAN YCSGQCEYMF MQKYPHTHLV QQANPRGSAG PCCTPTKMSP INMLYFNDKQ QIIYGKIPGM VVDRCGCS
Target Information
GDF11 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP-11; Bone morphogenetic protein 11; GDF-11; Growth/differentiation factor 11
Gene Aliases: BMP-11; BMP11; GDF11
UniProt ID: (Human) O95390
Entrez Gene ID: (Human) 10220
skeletal system development
metanephros development
ureteric bud development
nervous system development
mesoderm development
negative regulation of cell proliferation
positive regulation of pathway-restricted SMAD protein phosphorylation
spinal cord anterior/posterior patterning
pancreas development
growth
regulation of apoptotic process
regulation of MAPK cascade
negative regulation of neuron differentiation
cell development
cell maturation
camera-type eye morphogenesis
palate development
SMAD protein signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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