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Product Details
H00002658-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4D2
Immunogen
GDF2 (NP_057288, 320 a.a. approximately 419 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: SAGAGSHCQK TSLRVNFEDI GWDSWIIAPK EYEAYECKGG CFFPLADDVT PTKHAIVQTL VHLKFPTKVG KACCVPTKLS PISVLYKDDM GVPTLKYHYE
Target Information
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP; BMP-9; Bone morphogenetic protein; Bone morphogenetic protein 9; GDF-2; Growth/differentiation factor 2
Gene Aliases: BMP-9; BMP9; GDF2; HHT5
UniProt ID: (Human) Q9UK05
Entrez Gene ID: (Human) 2658
ossification
angiogenesis
patterning of blood vessels
vasculogenesis
osteoblast differentiation
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
cellular iron ion homeostasis
negative regulation of DNA replication
negative regulation of endothelial cell migration
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of angiogenesis
negative regulation of cell growth
BMP signaling pathway
positive regulation of BMP signaling pathway
positive regulation of interleukin-8 production
activin receptor signaling pathway
growth
regulation of apoptotic process
regulation of MAPK cascade
negative regulation of blood vessel endothelial cell migration
positive regulation of endothelial cell differentiation
positive regulation of osteoblast differentiation
positive regulation of angiogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell development
blood vessel morphogenesis
cartilage development
pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
positive regulation of cartilage development
cellular response to BMP stimulus
negative regulation of DNA biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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