Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
H00002660-M07
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
3E7
Immunogen
GDF8 (NP_005250, 241 a.a. approximately 310 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: GPGEDGLNPF LEVKVTDTPK RSRRDFGLDC DEHSTESRCC RYPLTVDFEA FGWDWIIAPK RYKANYCS
Target Information
The protein encoded by this gene is a member of the bone morphogenetic protein family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: GDF-8; Growth/differentiation factor 8; H-Myo-Propeptide; H-Myostatin; Myostatin
Gene Aliases: GDF8; MSLHP; MSTN
UniProt ID: (Human) O14793
Entrez Gene ID: (Human) 2660
positive regulation of defense response to virus by host
transforming growth factor beta receptor signaling pathway
muscle organ development
response to heat
response to gravity
positive regulation of pathway-restricted SMAD protein phosphorylation
skeletal muscle atrophy
negative regulation of muscle hypertrophy
response to muscle activity
ovulation cycle process
response to testosterone
negative regulation of kinase activity
regulation of apoptotic process
skeletal muscle tissue regeneration
regulation of MAPK cascade
response to estrogen
response to ethanol
negative regulation of myoblast differentiation
positive regulation of transcription, DNA-templated
negative regulation of insulin receptor signaling pathway
muscle cell cellular homeostasis
cell development
negative regulation of skeletal muscle tissue growth
response to electrical stimulus
negative regulation of protein kinase B signaling
SMAD protein signal transduction
cellular response to dexamethasone stimulus
mitophagy in response to mitochondrial depolarization
xenophagy
negative regulation of skeletal muscle satellite cell proliferation
negative regulation of satellite cell differentiation
negative regulation of myoblast proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support