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Invitrogen
GFAP Monoclonal Antibody (131-17719), Alexa Fluor™ 594
FIGURE: 1 / 4
GFAP Antibody (A-21295) in IHC (F)
Immunohistochemistry using NMDA Receptor Subunit 2A Polyclonal Antibody, Rabbit: Rat brain cryosections labeled with anti-NMDA receptor, subunit 2A (rat), rabbit IgG fraction (Product # A-6473) and detected using Alexa Fluor® 488 goat anti-rabbit IgG antibody (Product # A-11008). The tissue was also labeled with Alexa Fluor® 594 anti-glial fibrillary acidic protein antibody (Product # A-21295) and counterst... View More
Product Details
A-21295
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
131-17719
Immunogen
protein glial fibrillary acidic protein
Conjugate
Excitation/Emission Max
590/618 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
5mM sodium azide
Storage conditions
4° C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2535832
Target Information
GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. GFAP is heavily and specifically expressed in astrocytes and certain astroglia of the central nervous system, in satellite cells of peripheral ganglia, and in non-myelinating Schwann cells of peripheral nerves. In addition, neural stem cells strongly express GFAP. Antibodies to GFAP are very useful as markers of astrocytic cells. In addition, many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. GFAP is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Astrocyte or Intermediate Filament Protein; FLJ45472; GFAP; GFAP epsilon; Glial fibrillary acidic protein; Glial Fibrillary Acidic Protein (GFAP)
Gene Aliases: ALXDRD; GFAP
UniProt ID: (Human) E9PAX3
Entrez Gene ID: (Human) 2670
response to wounding
positive regulation of Schwann cell proliferation
negative regulation of neuron projection development
astrocyte development
extracellular matrix organization
neuron projection regeneration
regulation of protein complex assembly
intermediate filament organization
regulation of neurotransmitter uptake
Bergmann glial cell differentiation
long-term synaptic potentiation
regulation of chaperone-mediated autophagy
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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