Product References
Intra-pituitary follicle-stimulating hormone signaling regulates hepatic lipid metabolism in mice.
Nature communications
Qiao S,Alasmi S,Wyatt A,Wartenberg P,Wang H,Candlish M,Das D,Aoki M,Grünewald R,Zhou Z,Tian Q,Yu Q,Götz V,Belkacemi A,Raza A,Ectors F,Kattler K,Gasparoni G,Walter J,Lipp P,Mollard P,Bernard DJ,Karatayli E,Karatayli SC,Lammert F,Boehm U
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to demonstrate that functional communication of two distinct hormone-secreting cell populations in the pituitary regulates hepatic lipid metabolism.
Sat Feb 25 00:00:00 EST 2023
Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson's Model.
International journal of molecular sciences
Lai JI,Porcu A,Romoli B,Keisler M,Manfredsson FP,Powell SB,Dulcis D
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to reveal the mechanism of nicotine-induced dopaminergic (DA) plasticity protecting substantia nigra (SN) neurons against nigrostriatal damage could contribute to developing new strategies for neurotransmitter replacement in Parkinson's disease (PD).
Mon Feb 20 00:00:00 EST 2023
An updated suite of viral vectors for in vivo calcium imaging using intracerebral and retro-orbital injections in male mice.
Nature communications
Grødem S,Nymoen I,Vatne GH,Rogge FS,Björnsdóttir V,Lensjø KK,Fyhn M
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to explore the use of systemically administered PHP.eB AAVs for brain-wide expression of GECIs and show that systemic administration is a promising strategy for imaging neural activity.
Sat Feb 04 00:00:00 EST 2023
Investigating cell-specific effects of FMRP deficiency on spiny projection neurons in a mouse model of Fragile X syndrome.
Frontiers in cellular neuroscience
Giua G,Lassalle O,Makrini-Maleville L,Valjent E,Chavis P,Manzoni OJJ
A10262 was used in Immunohistochemistry - Free Floating to suggest that the absence of Fragile X Messenger Ribonucleoprotein (FMRP) disrupts the standard dichotomy characterizing nucleus accumbens (NAc) D1- and D2-spiny projection neurons (SPNs), resulting in a homogenous phenotype.
Mon Jun 19 00:00:00 EDT 2023
Rgp1 contributes to craniofacial cartilage development and Rab8a-mediated collagen II secretion.
Frontiers in endocrinology
Ritter DJ,Choudhary D,Unlu G,Knapik EW
A10262 was used in Immunohistochemistry (Frozen) to propose that an Rgp1-regulated Rab6a-Rab8a pathway directs secretion of ECM cargoes such as collagen II, a pathway that may also be utilized in other tissues where coordinated trafficking and secretion of collagens and other large cargoes is required for normal development and tissue function.
Tue Feb 28 00:00:00 EST 2023
Region-selective control of the thalamic reticular nucleus via cortical layer 5 pyramidal cells.
Nature neuroscience
Hádinger N,Bősz E,Tóth B,Vantomme G,Lüthi A,Acsády L
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to show that frontal cortex functions require a highly specialized cortical control over intrathalamic inhibitory processes.
Sun Jan 01 00:00:00 EST 2023
Multiplex translaminar imaging in the spinal cord of behaving mice.
Nature communications
Shekhtmeyster P,Carey EM,Duarte D,Ngo A,Gao G,Nelson NA,Clark CL,Nimmerjahn A
A10262 was used in Immunohistochemistry (Frozen) to show that tachykinin precursor 1 (Tac1)-expressing neurons exhibit translaminar activity to acute mechanical pain but not locomotion.
Tue Mar 21 00:00:00 EDT 2023
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth.
Nature genetics
Abby E,Dentro SC,Hall MWJ,Fowler JC,Ong SH,Sood R,Herms A,Piedrafita G,Abnizova I,Siebel CW,Gerstung M,Hall BA,Jones PH
A10262 was used in Immunohistochemistry to conclude that Notch1 mutations in normal epithelium are beneficial as wild-type Notch1 favors tumor expansion.
Wed Feb 01 00:00:00 EST 2023
Deficiency in hereditary hemorrhagic telangiectasia-associated Endoglin elicits hypoxia-driven heart failure in zebrafish.
Disease models & mechanisms
Lelièvre E,Bureau C,Bordat Y,Frétaud M,Langevin C,Jopling C,Kissa K
A10262 was used in Immunohistochemistry to characterize the zebrafish endoglin locus and demonstrated that it produces two phylogenetically conserved protein isoforms.
Mon May 01 00:00:00 EDT 2023
D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase.
Cell reports
Liu Y,Wang M,Guo Y,Wang L,Guo W
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to study the exact metabolic program governs the balance between quiescent and activated RGLs.
Tue Feb 28 00:00:00 EST 2023
Sensitive multicolor indicators for monitoring norepinephrine in vivo.
Nature methods
Kagiampaki Z,Rohner V,Kiss C,Curreli S,Dieter A,Wilhelm M,Harada M,Duss SN,Dernic J,Bhat MA,Zhou X,Ravotto L,Ziebarth T,Wasielewski LM,Sönmez L,Benke D,Weber B,Bohacek J,Reiner A,Wiegert JS,Fellin T,Patriarchi T
A10262 was used in Immunohistochemistry to introduce a family of sensitive multicolor norepinephrine (NE) indicators, which includes nLightG (green) and nLightR (red).
Fri Sep 01 00:00:00 EDT 2023
Matriptase-dependent epidermal pre-neoplasm in zebrafish embryos caused by a combination of hypotonic stress and epithelial polarity defects.
PLoS genetics
Hatzold J,Nett V,Brantsch S,Zhang JL,Armistead J,Wessendorf H,Stephens R,Humbert PO,Iden S,Hammerschmidt M
A10262 was used in Western Blotting to identify epithelial polarity defects and systemic hypotonic stress as another mode of aberrant Matriptase activation in the embryonic zebrafish epidermis in vivo.
Tue Aug 01 00:00:00 EDT 2023
Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions.
The Journal of experimental medicine
Császár E,Lénárt N,Cserép C,Környei Z,Fekete R,Pósfai B,Balázsfi D,Hangya B,Schwarcz AD,Szabadits E,Szöllősi D,Szigeti K,Máthé D,West BL,Sviatkó K,Brás AR,Mariani JC,Kliewer A,Lenkei Z,Hricisák L,Benyó Z,Baranyi M,Sperlágh B,Menyhárt Á,Farkas E,Dénes Á
A10262 was used in Immunohistochemistry to reveal a previously unrecognized role for microglia in CBF regulation, with broad implications for common neurological diseases.
Mon Mar 07 00:00:00 EST 2022
Hypothalamic Galanin-producing neurons regulate stress in zebrafish through a peptidergic, self-inhibitory loop.
Current biology : CB
Corradi L,Bruzzone M,Maschio MD,Sawamiphak S,Filosa A
A10262 was used in Immunohistochemistry to describe a neuronal circuit in the hypothalamus of zebrafish larvae that inhibits stress-related behaviors and prevents excessive activation of the neuroendocrine pathway hypothalamic-pituitary-interrenal axis.
Mon Apr 11 00:00:00 EDT 2022
The Neurotrophic Receptor Tyrosine Kinase in MEC-mPFC Neurons Contributes to Remote Memory Consolidation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hong J,Jeong Y,Heo WD
A10262 was used in Immunohistochemistry to suggest that TrkB in intercortical circuits functions in remote memory consolidation.
Wed Jul 20 00:00:00 EDT 2022
Gli1 Regulates the Postnatal Acquisition of Peripheral Nerve Architecture.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zotter B,Dagan O,Brady J,Baloui H,Samanta J,Salzer JL
A10262 was used in Immunohistochemistry-immunofluorescence to delineate how peripheral nerves acquire their distinctive organization during normal development, and highlight mechanisms that may regulate their reorganization in pathologic settings, including peripheral neuropathies and nerve injury.
Wed Jan 12 00:00:00 EST 2022
Bisphenol-A impairs synaptic formation and function by RGS4-mediated regulation of BDNF signaling in the cerebral cortex.
Disease models & mechanisms
Hyun SA,Ko MY,Jang S,Lee BS,Rho J,Kim KK,Kim WY,Ka M
A10262 was used in Immunohistochemistry to provide molecular mechanistic insights into anatomical and physiological neurotoxic consequences related to a potent endocrine modifier.
Fri Jul 01 00:00:00 EDT 2022
Long-Term Cultures of Spinal Cord Interneurons.
Frontiers in cellular neuroscience
Vargova I,Kriska J,Kwok JCF,Fawcett JW,Jendelova P
A10262 was used in Immunocytochemistry to demonstrate distinct morphologies and some form perineuronal nets in long-term cultivation.
Wed Nov 15 00:00:00 EST 2023
Determinants of synapse diversity revealed by super-resolution quantal transmission and active zone imaging.
Nature communications
Newman ZL,Bakshinskaya D,Schultz R,Kenny SJ,Moon S,Aghi K,Stanley C,Marnani N,Li R,Bleier J,Xu K,Isacoff EY
A10262 was used in Immunohistochemistry to find that Pr varies greatly between synapses made by a single axon, quantify the contribution of key AZ proteins to Pr diversity and find that one of these, Complexin, suppresses spontaneous and evoked transmission differentially, thereby generating a spatial and quantitative mismatch between release modes.
Tue Jan 11 00:00:00 EST 2022
PYK2 senses calcium through a disordered dimerization and calmodulin-binding element.
Communications biology
Momin AA,Mendes T,Barthe P,Faure C,Hong S,Yu P,Kadaré G,Jaremko M,Girault JA,Jaremko Ł,Arold ST
A10262 was used in Western Blotting to investigate the mechanism by which the protein tyrosine kinase 2-beta (PYK2) functions as a sensor and effector of cellular calcium influx.
Tue Aug 09 00:00:00 EDT 2022
Whole-body analysis of TRPML3 (MCOLN3) expression using a GFP-reporter mouse model reveals widespread expression in secretory cells and endocrine glands.
PloS one
Spix B,Castiglioni AJ,Remis NN,Flores EN,Wartenberg P,Wyatt A,Boehm U,Gudermann T,Biel M,García-Añoveros J,Grimm C
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to uncover TRPML3 expression in several organs and distinct cell types, using a τGFP reporter mouse model for TRPML3.
Mon Dec 19 00:00:00 EST 2022
Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer.
Cell reports
Jahid S,Ortega JA,Vuong LM,Acquistapace IM,Hachey SJ,Flesher JL,La Serra MA,Brindani N,La Sala G,Manigrasso J,Arencibia JM,Bertozzi SM,Summa M,Bertorelli R,Armirotti A,Jin R,Liu Z,Chen CF,Edwards R,Hughes CCW,De Vivo M,Ganesan AK
A10262 was used in Immunocytochemistry-immunofluorescence to identify a class of therapeutic agents that influence tumor growth by modulating CDC42 signaling in both the tumor cell and its microenvironment.
Tue Apr 05 00:00:00 EDT 2022
Serotonergic neurons translate taste detection into internal nutrient regulation.
Neuron
Yao Z,Scott K
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to demonstrate that 5-HT neurons relay acute gustatory detection to divergent pathways for longer-term stabilization of circulating nutrients.
Wed Mar 16 00:00:00 EDT 2022
Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment.
Cell stem cell
Sun C,Kannan S,Choi IY,Lim H,Zhang H,Chen GS,Zhang N,Park SH,Serra C,Iyer SR,Lloyd TE,Kwon C,Lovering RM,Lim SB,Andersen P,Wagner KR,Lee G
A10262 was used in Flow Cytometry to demonstrate that a subset of PAX7::GFP MPCs engraft within the basal lamina of regenerated myofibers, adopt a quiescent state, and contribute to regeneration upon reinjury and in mdx mouse models.
Thu Apr 07 00:00:00 EDT 2022
Periosteal stem cells control growth plate stem cells during postnatal skeletal growth.
Nature communications
Tsukasaki M,Komatsu N,Negishi-Koga T,Huynh NC,Muro R,Ando Y,Seki Y,Terashima A,Pluemsakunthai W,Nitta T,Nakamura T,Nakashima T,Ohba S,Akiyama H,Okamoto K,Baron R,Takayanagi H
A10262 was used in Immunohistochemistry to show that PSCs are not only required for intramembranous bone formation, but also for the growth plate maintenance and prolonged longitudinal bone growth.
Mon Jul 18 00:00:00 EDT 2022
A viral toolbox for conditional and transneuronal gene expression in zebrafish.
eLife
Satou C,Neve RL,Oyibo HK,Zmarz P,Huang KH,Arn Bouldoires E,Mori T,Higashijima SI,Keller GB,Friedrich RW
A10262 was used in Immunohistochemistry to develop methods for efficient gene transfer and retrograde tracing in adult and larval zebrafish by herpes simplex viruses (HSV1).
Fri Jul 22 00:00:00 EDT 2022
Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer.
Nature cell biology
Cockburn K,Annusver K,Gonzalez DG,Ganesan S,May DP,Mesa KR,Kawaguchi K,Kasper M,Greco V
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to show that differentiation, from commitment to exit from the stem cell layer, is a multi-day process wherein cells transit through a continuum of transcriptional changes with upregulation of differentiation genes preceding downregulation of typical stemness genes.
Thu Dec 01 00:00:00 EST 2022
Taste quality and hunger interactions in a feeding sensorimotor circuit.
eLife
Shiu PK,Sterne GR,Engert S,Dickson BJ,Scott K
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to reveal central mechanisms for the integration of external taste detection and internal nutritive state to flexibly execute a critical feeding decision.
Wed Jul 06 00:00:00 EDT 2022
Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21.
Nature metabolism
Pena-Leon V,Folgueira C,Barja-Fernández S,Pérez-Lois R,Da Silva Lima N,Martin M,Heras V,Martinez-Martinez S,Valero P,Iglesias C,Duquenne M,Al-Massadi O,Beiroa D,Souto Y,Fidalgo M,Sowmyalakshmi R,Guallar D,Cunarro J,Castelao C,Senra A,González-Saenz P,Vázquez-Cobela R,Leis R,Sabio G,Mueller-Fielitz H,Schwaninger M,López M,Tovar S,Casanueva FF,Valjent E,Diéguez C,Prevot V,Nogueiras R,Seoane LM
A10262 was used in Immunohistochemistry-immunofluorescence to investigate the effects of breastfeeding by the infant on the reprogramming of energy balance in childhood and throughout adulthood.
Fri Jul 01 00:00:00 EDT 2022
Evidence for oligodendrocyte progenitor cell heterogeneity in the adult mouse brain.
Scientific reports
Beiter RM,Rivet-Noor C,Merchak AR,Bai R,Johanson DM,Slogar E,Sol-Church K,Overall CC,Gaultier A
A10262 was used in Immunohistochemistry-immunofluorescence to investigate the exact mechanisms through which Oligodendrocyte progenitor cells might influence brain function.
Thu Jul 28 00:00:00 EDT 2022
Drosophila gustatory projections are segregated by taste modality and connectivity.
eLife
Engert S,Sterne GR,Bock DD,Scott K
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to resolve the anatomy of labellar gustatory projections, reveals that gustatory projections are segregated based on taste modality, and uncovers synaptic connections that may alter the transmission of gustatory signals.
Wed May 25 00:00:00 EDT 2022
An exon junction complex-independent function of Barentsz in neuromuscular synapse growth.
EMBO reports
Ho CH,Paolantoni C,Bawankar P,Tang Z,Brown S,Roignant JY,Treisman JE
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to show that a fourth subunit, Barentsz, has distinct functions within and separate from the exon junction complex in Drosophila neuromuscular development.
Wed Jan 05 00:00:00 EST 2022
WDR5-HOTTIP Histone Modifying Complex Regulates Neural Migration and Dendrite Polarity of Pyramidal Neurons via Reelin Signaling.
Molecular neurobiology
Ka M,Kim HG,Kim WY
A10262 was used in Immunocytochemistry to demonstrate a novel role for WDR5 in neuronal development and provide mechanistic insights into the neuropathology associated with histone methyltransferase dysfunction.
Mon Aug 01 00:00:00 EDT 2022
Adult Born Dentate Granule Cell Mediated Upregulation of Feedback Inhibition in a Mouse Model of Traumatic Brain Injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kang YJ,Lee SH,Boychuk JA,Butler CR,Juras JA,Cloyd RA,Smith BN
A10262 was used in Immunohistochemistry to support that DGC birth date-related increased feedback inhibition in of DGCs may contribute to altered excitability after TBI.SIGNIFICANCE STATEMENT Dentate granule cells (DGCs) control excitability of the dentate gyrus through synaptic interactions with inhibitory GABAergic interneurons.
Wed Sep 14 00:00:00 EDT 2022
Hippocampal-amygdala memory circuits govern experience-dependent observational fear.
Neuron
Terranova JI,Yokose J,Osanai H,Marks WD,Yamamoto J,Ogawa SK,Kitamura T
A10262 was used in Immunohistochemistry to provide new insights into the memory engram-dependent perception-action coupling that underlies empathic behaviors like experience-dependent observational fear.
Wed Apr 20 00:00:00 EDT 2022
Microglial control of neuronal development via somatic purinergic junctions.
Cell reports
Cserép C,Schwarcz AD,Pósfai B,László ZI,Kellermayer A,Környei Z,Kisfali M,Nyerges M,Lele Z,Katona I
A10262 was used in Immunohistochemistry to propose that early developmental formation of somatic purinergic junctions represents an important interface for microglia to monitor the status of immature neurons and control neurodevelopment.
Tue Sep 20 00:00:00 EDT 2022
Developmental, neurochemical, and behavioral analyses of ErbB4 Cyt-1 knockout mice.
Journal of neurochemistry
Erben L,Welday JP,Cronin ME,Murphy R,Skirzewski M,Vullhorst D,Carroll SL,Buonanno A
A10262 was used in Immunocytochemistry-immunofluorescence to indicate that ErbB4 Cyt-1 function in vivo is important for DA balance and behaviors in adults.
Wed Jun 01 00:00:00 EDT 2022
Combining mass spectrometry and genetic labeling in mice to report TRP channel expression.
MethodsX
Wartenberg P,Lux F,Busch K,Fecher-Trost C,Wyatt A,Flockerzi V,Krasteva-Christ G,Boehm U,Weissgerber P
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to present an optimized method to visualize primary TRP-expressing cells with single cell resolution throughout the entire organism.
Tue Dec 27 00:00:00 EST 2022
Systematic expression profiling of Dpr and DIP genes reveals cell surface codes in Drosophila larval motor and sensory neurons.
Development (Cambridge, England)
Wang Y,Lobb-Rabe M,Ashley J,Chatterjee P,Anand V,Bellen HJ,Kanca O,Carrillo RA
A10262 was used in Immunohistochemistry to investigate expression of Dpr and DIP genes, two CSP subfamilies belonging to the immunoglobulin superfamily, in Drosophila larval motor neurons (MNs), muscles, glia and sensory neurons (SNs) using a collection of GAL4 driver lines.
Sun May 15 00:00:00 EDT 2022
Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish.
G3 (Bethesda, Md.)
Casey MA,Hill JT,Hoshijima K,Bryan CD,Gribble SL,Brown JT,Chien CB,Yost HJ,Kwan KM
A10262 was used in Immunohistochemistry to study the factors regulating eye development in zebrafish.
Fri Mar 04 00:00:00 EST 2022
Reactivating hippocampal-mediated memories during reconsolidation to disrupt fear.
Nature communications
Grella SL,Fortin AH,Ruesch E,Bladon JH,Reynolds LF,Gross A,Shpokayte M,Cincotta C,Zaki Y,Ramirez S
A10262 was used in Immunohistochemistry to implicate the dorsal dentate gyrus as a potential therapeutic node for modulating memories to suppress fear.
Mon Sep 12 00:00:00 EDT 2022
Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina.
Frontiers in cell and developmental biology
Le N,Appel H,Pannullo N,Hoang T,Blackshaw S
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to demonstrate strong insert-dependent effects on AAV-based GFAP mini promoter specificity that preclude its use in inferring cell lineage relationships when studying glia-to-neuron conversion in retina.
Fri Apr 21 00:00:00 EDT 2023
Distinct effects of volatile and intravenous anaesthetics on presynaptic calcium dynamics in mouse hippocampal GABAergic neurones.
British journal of anaesthesia
Speigel IA,Patel K,Hemmings HC
A10262 was used in Immunocytochemistry to show that anaesthetic-agent-selective effects on presynaptic Ca2+ entry have functional implications for hippocampal circuit function during i.v. or volatile anaesthetic-mediated anaesthesia. Hippocampal interneurones have distinct subtype-specific sensitivities to volatile anaesthetic actions on presynaptic Ca2+, which are similar between isoflurane and sevoflurane.
Wed Jun 01 00:00:00 EDT 2022
Endophilin-B regulates autophagy during synapse development and neurodegeneration.
Neurobiology of disease
Hernandez-Diaz S,Ghimire S,Sanchez-Mirasierra I,Montecinos-Oliva C,Swerts J,Kuenen S,Verstreken P,Soukup SF
A10262 was used in Immunohistochemistry (Frozen) to show that EndoB is required to prevent neuronal loss.
Tue Feb 01 00:00:00 EST 2022
Huygens synchronization of medial septal pacemaker neurons generates hippocampal theta oscillation.
Cell reports
Kocsis B,Martínez-Bellver S,Fiáth R,Domonkos A,Sviatkó K,Schlingloff D,Barthó P,Freund TF,Ulbert I,Káli S,Varga V,Hangya B
A10262 was used in Immunohistofluorescence to show that medial septum pacemakers synchronize their individual rhythmicity frequencies.
Tue Aug 02 00:00:00 EDT 2022
Posteromedial thalamic nucleus activity significantly contributes to perceptual discrimination.
PLoS biology
Qi J,Ye C,Naskar S,Inácio AR,Lee S
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to study the role of POm in sensory perception.
Tue Nov 01 00:00:00 EDT 2022
Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2.
Matrix biology : journal of the International Society for Matrix Biology
Zhang JL,Richetti S,Ramezani T,Welcker D,Lütke S,Pogoda HM,Hatzold J,Zaucke F,Keene DR,Bloch W,Sengle G,Hammerschmidt M
A10262 was used in Immunohistochemistry to suggest that despite their mutually exclusive physical binding, hemicentins, nidogens, and laminins tightly cooperate and support each other during formation, maintenance, and function of basement membranes to confer tissue linkage.
Thu Sep 01 00:00:00 EDT 2022
Activity-dependent endoplasmic reticulum Ca2+ uptake depends on Kv2.1-mediated endoplasmic reticulum/plasma membrane junctions to promote synaptic transmission.
Proceedings of the National Academy of Sciences of the United States of America
Panzera LC,Johnson B,Quinn JA,Cho IH,Tamkun MM,Hoppa MB
A10262 was used in Immunocytochemistry-immunofluorescence to reveal an essential nonclassical role for both Kv2.1 and the ER-PM junctions in synaptic transmission.
Tue Jul 26 00:00:00 EDT 2022
Isolation of mouse pancreatic islet Procr+ progenitors and long-term expansion of islet organoids in vitro.
Nature protocols
Wang J,Wang D,Chen X,Yuan S,Bai L,Liu C,Zeng YA
A10262 was used in Immunocytochemistry to study islet regeneration and diseases.
Sun May 01 00:00:00 EDT 2022
Pairing of segmentation clock genes drives robust pattern formation.
Nature
Zinani OQH,Keseroğlu K,Ay A,Özbudak EM
A10262 was used in Immunohistochemistry to show that gene pairing boosts correlated transcription and provides phenotypic robustness for the formation of developmental patterns.
Fri Jan 01 00:00:00 EST 2021
Food cue regulation of AGRP hunger neurons guides learning.
Nature
Berrios J,Li C,Madara JC,Garfield AS,Steger JS,Krashes MJ,Lowell BB
A10262 was used in Immunohistochemistry to test the effects of activating the dorsomedial hypothalamic projecting subset of vesicular glutamate transporter 2 lateral hypothalamus neurons on feeding and valence.
Thu Jul 01 00:00:00 EDT 2021
Functional diversity for body actions in the mesencephalic locomotor region.
Cell
Ferreira-Pinto MJ,Kanodia H,Falasconi A,Sigrist M,Esposito MS,Arber S
A10262 was used in Immunohistochemistry to identify and functionally dissect glutamatergic mesencephalic locomotor region subpopulations based on the premise that target connectivity might be linked to function.
Thu Aug 19 00:00:00 EDT 2021
An early cell shape transition drives evolutionary expansion of the human forebrain.
Cell
Benito-Kwiecinski S,Giandomenico SL,Sutcliffe M,Riis ES,Freire-Pritchett P,Kelava I,Wunderlich S,Martin U,Wray GA,McDole K,Lancaster MA
A10262 was used in Immunohistochemistry to study developmental mechanisms driving evolutionary brain expansion using cerebral organdies derived from human, gorilla and chimpanzee cells.
Thu Apr 15 00:00:00 EDT 2021
Ventral arkypallidal neurons inhibit accumbal firing to promote reward consumption.
Nature neuroscience
Vachez YM,Tooley JR,Abiraman K,Matikainen-Ankney B,Casey E,Earnest T,Ramos LM,Silberberg H,Godynyuk E,Uddin O,Marconi L,Le Pichon CE,Creed MC
A10262 was used in Immunohistochemistry to report that a subpopulation of VP neurons, the ventral arkypallidal (vArky) neurons, project back to the NAcSh, where they inhibit NAcSh neurons in vivo in mice.
Mon Mar 01 00:00:00 EST 2021
Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells.
Cell stem cell
Hawkins FJ,Suzuki S,Beermann ML,Barillà C,Wang R,Villacorta-Martin C,Berical A,Jean JC,Le Suer J,Matte T,Simone-Roach C,Tang Y,Schlaeger TM,Crane AM,Matthias N,Huang SXL,Randell SH,Wu J,Spence JR,Carraro G,Stripp BR,Rab A,Sorsher EJ,Horani A,Brody SL,Davis BR,Kotton DN
A10262 was used in Immunocytochemistry to report the directed differentiation of human iPSCs into airway basal cells ("iBCs"), a population resembling the stem cell of the airway epithelium.
Thu Jan 07 00:00:00 EST 2021
Tanycytic networks mediate energy balance by feeding lactate to glucose-insensitive POMC neurons.
The Journal of clinical investigation
Lhomme T,Clasadonte J,Imbernon M,Fernandois D,Sauve F,Caron E,da Silva Lima N,Heras V,Martinez-Corral I,Mueller-Fielitz H,Rasika S,Schwaninger M,Nogueiras R,Prevot V
A10262 was used in Immunocytochemistry to establish that tanycytes of the arcuate nucleus of the hypothalamus, specialized glia that line the wall of the third ventricle, convert brain glucose supplies into lactate that they transmit through monocarboxylate transporters to arcuate proopiomelanocortin neurons, which integrate this signal to drive their activity and to adapt the metabolic response to meet physiological demands.
Wed Sep 15 00:00:00 EDT 2021
Molecular classification of zebrafish retinal ganglion cells links genes to cell types to behavior.
Neuron
Kölsch Y,Hahn J,Sappington A,Stemmer M,Fernandes AM,Helmbrecht TO,Lele S,Butrus S,Laurell E,Arnold-Ammer I,Shekhar K,Sanes JR,Baier H
A10262 was used in Immunohistochemistry to establish a framework for systematically studying the functional architecture of the visual system.
Wed Feb 17 00:00:00 EST 2021
NDNF interneurons in layer 1 gain-modulate whole cortical columns according to an animal's behavioral state.
Neuron
Cohen-Kashi Malina K,Tsivourakis E,Kushinsky D,Apelblat D,Shtiglitz S,Zohar E,Sokoletsky M,Tasaka GI,Mizrahi A,Lampl I,Spiegel I
A10262 was used in Immunocytochemistry-immunoflourescence to analyze the role of GABAergic interneurons that are located in layer 1 and express Ndnf (L1 NDNF INs) in the state-dependent control over sensory processing.
Wed Jul 07 00:00:00 EDT 2021
Periphery signals generated by Piezo-mediated stomach stretch and Neuromedin-mediated glucose load regulate the Drosophila brain nutrient sensor.
Neuron
Oh Y,Lai JS,Min S,Huang HW,Liberles SD,Ryoo HD,Suh GSB
A10262 was used in Immunohistochemistry to investigate the mechanisms by which DH44 neurons or other nutrient sensors are regulated.
Wed Jun 16 00:00:00 EDT 2021
Highly selective brain-to-gut communication via genetically defined vagus neurons.
Neuron
Tao J,Campbell JN,Tsai LT,Wu C,Liberles SD,Lowell BB
A10262 was used in Immunohistochemistry to conclude that the vagus motor nerve communicates via genetically defined labeled lines to control functionally unique enteric neurons within discrete subregions of the gastrointestinal tract.
Wed Jul 07 00:00:00 EDT 2021
Requirement for an Otopetrin-like protein for acid taste in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America
Ganguly A,Chandel A,Turner H,Wang S,Liman ER,Montell C
A10262 was used in Immunohistochemistry to identify the acid taste receptor.
Tue Dec 21 00:00:00 EST 2021
Multiple Niche Compartments Orchestrate Stepwise Germline Stem Cell Progeny Differentiation.
Current biology : CB
Tu R,Duan B,Song X,Chen S,Scott A,Hall K,Blanck J,DeGraffenreid D,Li H,Perera A,Haug J,Xie T
A10262 was used in Immunocytochemistry to identify four inner germarial sheath subpopulations, which form linearly arranged niche compartments for controlling germline stem cell maintenance and multi-step progeny differentiation.
Mon Feb 22 00:00:00 EST 2021
Sleep deprivation results in diverse patterns of synaptic scaling across the Drosophila mushroom bodies.
Current biology : CB
Weiss JT,Donlea JM
A10262 was used in Immunohistochemistry-immunofluorescence to show that no single class showed uniform scaling across each constituent member, indicating that different rules may govern plasticity during sleep loss across cell types.
Mon Aug 09 00:00:00 EDT 2021
A transgenic system for targeted ablation of reproductive and maternal-effect genes.
Development (Cambridge, England)
Bertho S,Kaufman O,Lee K,Santos-Ledo A,Dellal D,Marlow FL
A10262 was used in Immunohistochemistry to report reverse genetic systems to identify genes with essential roles in zebrafish reproductive and maternal-effect processes.
Tue Jun 15 00:00:00 EDT 2021
A developmental lineage-based gene co-expression network for mouse pancreatic β-cells reveals a role for Zfp800 in pancreas development.
Development (Cambridge, England)
Osipovich AB,Dudek KD,Greenfest-Allen E,Cartailler JP,Manduchi E,Potter Case L,Choi E,Chapman AG,Clayton HW,Gu G,Stoeckert CJ,Magnuson MA
A10262 was used in Immunohistochemistry to demonstrate that developmentally oriented GCNs have utility for gaining new insights into gene regulation during organogenesis.
Sun Mar 21 00:00:00 EDT 2021
Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds.
Development (Cambridge, England)
Kowalczyk I,Lee C,Schuster E,Hoeren J,Trivigno V,Riedel L,Görne J,Wallingford JB,Hammes A,Feistel K
A10262 was used in Immunohistochemistry to suggest that, during neurulation, motifs within the intracellular domain of Lrp2 function as a hub that orchestrates endocytic membrane removal for efficient apical constriction, as well as PCP component trafficking in a temporospatial manner.
Tue Jan 26 00:00:00 EST 2021
Igf signaling couples retina growth with body growth by modulating progenitor cell division.
Development (Cambridge, England)
Becker C,Lust K,Wittbrodt J
A10262 was used in Immunohistochemistry to position Igf signaling as a key module for controlling retinal size and composition, with important evolutionary implications.
Thu Apr 01 00:00:00 EDT 2021
STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Matsuki T,Iio A,Ueda M,Tsuneura Y,Howell BW,Nakayama A
A10262 was used in Immunohistochemistry to demonstrate the importance of overlapping and unique roles of STK25 and MST3 to regulate Rho GTPase activities in cortical development.
Wed Oct 27 00:00:00 EDT 2021
Structural and Functional Synaptic Plasticity Induced by Convergent Synapse Loss in the Drosophila Neuromuscular Circuit.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wang Y,Lobb-Rabe M,Ashley J,Anand V,Carrillo RA
A10262 was used in Immunocytochemistry to study Drosophila neuronal plasticity in response to synapse loss.
Wed Feb 17 00:00:00 EST 2021
An Angiotensin-Responsive Connection from the Lamina Terminalis to the Paraventricular Nucleus of the Hypothalamus Evokes Vasopressin Secretion to Increase Blood Pressure in Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Frazier CJ,Harden SW,Alleyne AR,Mohammed M,Sheng W,Smith JA,Elsaafien K,Spector EA,Johnson DN,Scott KA,Krause EG,de Kloet AD
A10262 was used in Immunohistochemistry to reveal functional excitatory connections between angiotensin-sensitive neurons in the lamina terminals and vasopressin neurons in the paraventricular nucleus of the hypothalamus, and further indicate that activation of this circuit raises blood pressure.
Wed Feb 17 00:00:00 EST 2021
Bridging the Gap: The Importance of TUBA1A α-Tubulin in Forming Midline Commissures.
Frontiers in cell and developmental biology
Buscaglia G,Northington KR,Aiken J,Hoff KJ,Bates EA
A10262 was used in Western Blot to show that reduced Tuba1a, which constitutes the majority of α-tubulin in the developing brain, is sufficient to support neuronal migration and cortex development but not commissure formation, and provide mechanistic insight as to how TUBA1A tunes microtubule function to support neurodevelopment.
Tue Nov 15 00:00:00 EST 2022
Postsynaptic Targeting and Mobility of Membrane Surface-Localized hASIC1a.
Neuroscience bulletin
Song XL,Liu DS,Qiang M,Li Q,Liu MG,Li WG,Qi X,Xu NJ,Yang G,Zhu MX,Xu TL
A10262 was used in Western Blotting to demonstrate the synaptic location and high dynamics of functionally-relevant hASIC1a on the surface of excitatory synapses, supporting its involvement in synaptic functions.
Mon Feb 01 00:00:00 EST 2021
Optimization of adeno-associated viral vector-mediated transduction of the corticospinal tract: comparison of four promoters.
Gene therapy
Nieuwenhuis B,Haenzi B,Hilton S,Carnicer-Lombarte A,Hobo B,Verhaagen J,Fawcett JW
A10262 was used in Immunohistochemistry to report a side-by-side comparison between four commonly used promoters: the short CMV early enhancer/chicken β actin (sCAG), human cytomegalovirus (hCMV), mouse phosphoglycerate kinase (mPGK) and human synapsin (hSYN) promoter.
Mon Feb 01 00:00:00 EST 2021
Direct synaptic excitation between hilar mossy cells revealed with a targeted voltage sensor.
Hippocampus
Ma Y,Bayguinov PO,McMahon SM,Scharfman HE,Jackson MB
A10262 was used in Immunohistochemistry to investigate synaptic inputs to mossy cells (MCs) and the role MCs have in the network activity of the dentate gyrus.
Mon Nov 01 00:00:00 EDT 2021
Distracting stimuli evoke ventral tegmental area responses in rats during ongoing saccharin consumption.
The European journal of neuroscience
Peters KZ,Young AMJ,McCutcheon JE
A10262 was used in Immunohistochemistry to assess ventral tegmental area activity in rat brains during distraction stimuli.
Mon Mar 01 00:00:00 EST 2021
Multiple C2 domain-containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomains.
Molecular biology of the cell
Joshi AS,Ragusa JV,Prinz WA,Cohen S
A10262 was used in Western Blot to show that multiple C2 domain-containing transmembrane proteins, MCTP1 and MCTP2, are at sites of lipid droplet formation in specialized endoplasmic reticulum subdomains.
Tue Jun 01 00:00:00 EDT 2021
The Kunitz-type serine protease inhibitor Spint2 is required for cellular cohesion, coordinated cell migration and cell survival during zebrafish hatching gland development.
Developmental biology
Hatzold J,Wessendorf H,Pogoda HM,Bloch W,Hammerschmidt M
A10262 was used in Immunocytochemistry to study Kunitz-type serine protease inhibitor Spint2 in zebrafish hatching gland development.
Sun Aug 01 00:00:00 EDT 2021
Projections from the dorsomedial division of the bed nucleus of the stria terminalis to hypothalamic nuclei in the mouse.
The Journal of comparative neurology
Barbier M,González JA,Houdayer C,Burdakov D,Risold PY,Croizier S
A10262 was used in Immunohistochemistry-immunofluorescence to lay the foundation for a better understanding of the neuroanatomical basis of the stress-related feeding behaviors.
Thu Apr 01 00:00:00 EDT 2021
Novel inhibitory brainstem neurons with selective projections to spinal lamina I reduce both pain and itch.
The Journal of comparative neurology
Agostinelli LJ,Bassuk AG
A10262 was used in Immunohistochemistry to elucidate the role of the GABAergic LJA5 neurons involved in the regulation of pain and itch pathways to the brain.
Tue Jun 01 00:00:00 EDT 2021
Input-output connections of LJA5 prodynorphin neurons.
The Journal of comparative neurology
Agostinelli LJ,Mix MR,Hefti MM,Scammell TE,Bassuk AG
A10262 was used in Immunohistochemistry to characterize the efferent and afferent projections of a novel population of inhibitory neurons in the mouse brainstem (LJA5) in relation to known cell types in the mouse brainstem.
Mon Feb 01 00:00:00 EST 2021
Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord.
Nature communications
Alkaslasi MR,Piccus ZE,Hareendran S,Silberberg H,Chen L,Zhang Y,Petros TJ,Le Pichon CE
A10262 was used in Immunohistochemistry to study the transcriptomics of cholinergic neuron types in the adult mouse spinal cord.
Fri Apr 30 00:00:00 EDT 2021
Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding.
Nature communications
Han Y,Xia G,Srisai D,Meng F,He Y,Ran Y,He Y,Farias M,Hoang G,Tóth I,Dietrich MO,Chen MH,Xu Y,Wu Q
A10262 was used in Immunohistochemistry to suggest that this AgRP neural circuit plays a unique role in persistent control of energy expenditure and body weight, hinting next-generation therapeutic approaches for obesity and metabolic disorders.
Thu Jun 10 00:00:00 EDT 2021
Classification and genetic targeting of cell types in the primary taste and premotor center of the adult Drosophila brain.
eLife
Sterne GR,Otsuna H,Dickson BJ,Scott K
A10262 was used in Immunohistochemistry to provide insight into the anatomical organization of the SEZ (subesophageal zone) and generate resources that will facilitate further study of SEZ neurons and their contributions to sensory processing and behavior.
Thu Sep 02 00:00:00 EDT 2021
Dorsal clock neurons in Drosophila sculpt locomotor outputs but are dispensable for circadian activity rhythms.
iScience
Nettnin EA,Sallese TR,Nasseri A,Saurabh S,Cavanaugh DJ
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to clarify the role of the dorsal neuron 1 (DN1) population of clock neurons in the transmission of circadian information by the Drosophila core clock network.
Fri Sep 24 00:00:00 EDT 2021
An early Sox2-dependent gene expression programme required for hippocampal dentate gyrus development.
Open biology
Mercurio S,Alberti C,Serra L,Meneghini S,Berico P,Bertolini J,Becchetti A,Nicolis SK
A10262 was used in Immunohistochemistry to generate an allelic series of Sox2 conditional mutations in mouse, deleting Sox2 at different developmental stages.
Mon Feb 01 00:00:00 EST 2021
Crim1 and Kelch-like 14 exert complementary dual-directional developmental control over segmentally specific corticospinal axon projection targeting.
Cell reports
Sahni V,Itoh Y,Shnider SJ,Macklis JD
A10262 was used in Immunocytochemistry-immunoflourescence to investigate two of these candidate molecular controls, Crim1 and Kelch-like 14 (Klhl14), identifying their critical roles in directing CSN axons to appropriate spinal segmental levels in the white matter prior to axon collateralization.
Tue Oct 19 00:00:00 EDT 2021
Control of feeding by Piezo-mediated gut mechanosensation in Drosophila.
eLife
Min S,Oh Y,Verma P,Whitehead SC,Yapici N,Van Vactor D,Suh GS,Liberles S
A10262 was used in Immunohistochemistry to reveal that disrupting gut distension receptors changes feeding patterns and identify a key role for Drosophila Piezo in internal organ mechanosensation.
Thu Feb 18 00:00:00 EST 2021
Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development.
eLife
Zilova L,Weinhardt V,Tavhelidse T,Schlagheck C,Thumberger T,Wittbrodt J
A10262 was used in Immunohistochemistry to derive organoids from rapidly developing teleosts to overcome limitations and address species-specific cellular organisation.
Mon Jul 12 00:00:00 EDT 2021
Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1.
Scientific reports
Brown APY,Cossell L,Strom M,Tyson AL,Vélez-Fort M,Margrie TW
A10262 was used in Immunocytochemistry-immunoflourescence to examine and compare datasets from hierarchical segmentation ontologies, and applied it to long-range presynaptic connectivity onto excitatory and inhibitory neurons, mainly located in layer 2/3 (L2/3), of mouse primary visual cortex (V1).
Tue Mar 02 00:00:00 EST 2021
Group II Metabotropic Glutamate Receptors Modulate Sound Evoked and Spontaneous Activity in the Mouse Inferior Colliculus.
eNeuro
Kristaponyte I,Beebe NL,Young JW,Shanbhag SJ,Schofield BR,Galazyuk AV
A10262 was used in Immunohistochemistry to observe increased sound-evoked firing, as assessed by the rate-level functions (RLFs), in a subset of both GABAergic and non-GABAergic IC neurons following mGluR2/3 pharmacological activation.
Fri Jun 18 00:00:00 EDT 2021
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus.
JCI insight
Sano F,Shigetomi E,Shinozaki Y,Tsuzukiyama H,Saito K,Mikoshiba K,Horiuchi H,Cheung DL,Nabekura J,Sugita K,Aihara M,Koizumi S
A10262 was used in Immunohistochemistry to show that temporally distinct activation profiles of microglia and astrocytes collaboratively contributed to epileptogenesis in a drug-induced status epilepticus model.
Mon May 10 00:00:00 EDT 2021
Protocol for evaluating autophagy using LysoTracker staining in the epithelial follicle stem cells of the Drosophila ovary.
STAR protocols
Correa I,Wang M,Lee EH,Ruiz-Whalen DM,O'Reilly AM,Singh T
A10262 was used in Immunohistochemistry to visualise autophagy specifically in the epithelial follicle stem cells of the Drosophila ovary using the LysoTracker dye.
Fri Jun 18 00:00:00 EDT 2021
Epitope-preserving magnified analysis of proteome (eMAP).
Science advances
Park J,Khan S,Yun DH,Ku T,Villa KL,Lee JE,Zhang Q,Park J,Feng G,Nedivi E,Chung K
A10262 was used in Immunohistochemistry to investigate molecular heterogeneity in inhibitory synapses in the mouse brain neocortex and characterizing the spatial distributions of synaptic proteins within synapses in mouse and marmoset brains by epitope-preserving magnified analysis of proteome.
Fri Nov 12 00:00:00 EST 2021
TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K+ current.
Cell reports
Yoo S,Santos C,Reynders A,Marics I,Malapert P,Gaillard S,Charron A,Ugolini S,Rossignol R,El Khallouqi A,Springael JY,Parmentier M,Saurin AJ,Goaillard JM,Castets F,Clerc N,Moqrich A
A10262 was used in Immunohistochemistry to show that TAFA4 reverses inflammatory, postoperative, and spared nerve injury (SNI)-induced mechanical hypersensitivity in male and female mice.
Tue Oct 26 00:00:00 EDT 2021
Structural basis for noradrenergic regulation of neural circuits in the mouse olfactory bulb.
The Journal of comparative neurology
Horie S,Kiyokage E,Hayashi S,Inoue K,Sohn J,Hioki H,Furuta T,Toida K
A10262 was used in Immunocytochemistry to provide a morphological basis for olfactory modulation by centrifugal NA fibers derived from the LC.
Tue Jun 01 00:00:00 EDT 2021
A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus.
Developmental cell
Aronson BE,Scourzic L,Shah V,Swanzey E,Kloetgen A,Polyzos A,Sinha A,Azziz A,Caspi I,Li J,Pelham-Webb B,Glenn RA,Vierbuchen T,Wichterle H,Tsirigos A,Dawlaty MM,Stadtfeld M,Apostolou E
A10262 was used in Flow Cytometry, Immunocytochemistry, Western Blot to establish the IG-DMR as a bipartite control element that maintains imprinting by allele-specific restriction of the DNA (de)methylation machinery.
Mon Nov 22 00:00:00 EST 2021
Meiotic Cas9 expression mediates gene conversion in the male and female mouse germline.
PLoS biology
Weitzel AJ,Grunwald HA,Weber C,Levina R,Gantz VM,Hedrick SM,Bier E,Cooper KL
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to suggest that more robust Cas9 expression initiated during early meiosis I may improve the efficiency of gene conversion and further increase the rate of "super-mendelian" inheritance from both male and female mice.
Wed Dec 01 00:00:00 EST 2021
miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila.
eLife
Pandey M,Bansal S,Bar S,Yadav AK,Sokol NS,Tennessen JM,Kapahi P,Chawla G
A10262 was used in Western Blot to identify miR-125 as a conserved effector of the DR pathway and open the avenue for this small RNA molecule and its downstream effectors to be considered as potential drug candidates for the treatment of late-onset diseases and biomarkers for healthy aging in humans.
Tue Jun 08 00:00:00 EDT 2021
miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila.
eLife
Pandey M,Bansal S,Bar S,Yadav AK,Sokol NS,Tennessen JM,Kapahi P,Chawla G
A10262 was used in Western Blot to identify miR-125 as a conserved effector of the DR pathway and open the avenue for this small RNA molecule and its downstream effectors to be considered as potential drug candidates for the treatment of late-onset diseases and biomarkers for healthy aging in humans.
Tue Jun 08 00:00:00 EDT 2021
Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment.
Molecular therapy. Methods & clinical development
Maes ME,Wögenstein GM,Colombo G,Casado-Polanco R,Siegert S
A10262 was used in Immunocytochemistry-immunoflourescence to provide a foundation for future studies optimizing AAV-mediated microglia transduction and highlight that environmental conditions influence microglial transduction efficiency.
Fri Dec 10 00:00:00 EST 2021
R7 photoreceptor axon targeting depends on the relative levels of lost and found expression in R7 and its synaptic partners.
eLife
Douthit J,Hairston A,Lee G,Morrison CA,Holguera I,Treisman JE
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to show that the Drosophila CUB-LDL protein Lost and found (Loaf) is required in the UV-sensitive R7 photoreceptor for normal axon targeting only when Loaf is also present in its synaptic partners.
Tue May 18 00:00:00 EDT 2021
Phosphorylation-dependent control of Activity-regulated cytoskeleton-associated protein (Arc) protein by TNIK.
Journal of neurochemistry
Walczyk-Mooradally A,Holborn J,Singh K,Tyler M,Patnaik D,Wesseling H,Brandon NJ,Steen J,Graether SP,Haggarty SJ,Lalonde J
A10262 was used in Immunocytochemistry-immunofluorescence to reveal an unsuspected connection between Arc and TNIK.
Wed Sep 01 00:00:00 EDT 2021
Electrical synaptic transmission requires a postsynaptic scaffolding protein.
eLife
Lasseigne AM,Echeverry FA,Ijaz S,Michel JC,Martin EA,Marsh AJ,Trujillo E,Marsden KC,Pereda AE,Miller AC
A10262 was used in Immunohistochemistry to investigate the functional role of Zonula Occludens 1 in zebrafish by examining identifiable synaptic contacts of the Mauthner cell which forms stereotyped electrical synapses accessible to genetic, biochemical, cell biological, electrophysiological, and behavioral analyses.
Wed Apr 28 00:00:00 EDT 2021
BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish.
International journal of molecular sciences
Knickmeyer MD,Mateo JL,Heermann S
A10262 was used in Immunohistochemistry to indicate that BMP disrupts the formation of optic chiasm and retinal ganglion cell pathfinding in zebrafish.
Tue Apr 27 00:00:00 EDT 2021
Ventral pallidum DRD3 potentiates a pallido-habenular circuit driving accumbal dopamine release and cocaine seeking.
Neuron
Pribiag H,Shin S,Wang EH,Sun F,Datta P,Okamoto A,Guss H,Jain A,Wang XY,De Freitas B,Honma P,Pate S,Lilascharoen V,Li Y,Lim BK
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to investigate the specific contribution of DRD3 signaling to drug-mediated plasticity within neural circuits that drive motivated behaviors.
Wed Jul 07 00:00:00 EDT 2021
Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention.
Communications biology
Vignoli B,Sansevero G,Sasi M,Rimondini R,Blum R,Bonaldo V,Biasini E,Santi S,Berardi N,Lu B,Canossa M
A10262 was used in Immunohistochemistry - Free Floating to demonstrate that persistent synaptic strengthening invited astrocytic microdomains to convert initially internalized (pro)-brain-derived neurotrophic factor (proBDNF) into active prodomain (BDNFpro) and mature BDNF (mBDNF) for synaptic re-use.
Tue Oct 05 00:00:00 EDT 2021
Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age.
eLife
Sidisky JM,Weaver D,Hussain S,Okumus M,Caratenuto R,Babcock D
A10262 was used in Immunohistochemistry to demonstrate that a previously uncharacterized gene, CG31475, regulates synaptic maintenance in adult Drosophila NMJs.
Fri Mar 05 00:00:00 EST 2021
Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts.
eLife
Dalal JS,Winden KD,Salussolia CL,Sundberg M,Singh A,Pham TT,Zhou P,Pu WT,Miller MT,Sahin M
A10262 was used in Immunohistochemistry to implicate dysfunction of FMRP and its targets in TSC and suggest that treatments aimed at restoring the function of these pathways may be beneficial.
Wed Jul 14 00:00:00 EDT 2021
Insights on autophagosome-lysosome tethering from structural and biochemical characterization of human autophagy factor EPG5.
Communications biology
Nam SE,Cheung YWS,Nguyen TN,Gong M,Chan S,Lazarou M,Yip CK
A10262 was used in Immunocytochemistry to show that human EPG5 (hEPG5) adopts an extended shepherd's staff" architecture."
Fri Mar 05 00:00:00 EST 2021
PSA Depletion Induces the Differentiation of Immature Neurons in the Piriform Cortex of Adult Mice.
International journal of molecular sciences
Coviello S,Benedetti B,Jakubecova D,Belles M,Klimczak P,Gramuntell Y,Couillard-Despres S,Nacher J
A10262 was used in Immunohistochemistry to demonstrate that the polysialylated form of the neural cell adhesion molecule is involved in the development of immature neurons.
Thu May 27 00:00:00 EDT 2021
In situ architecture of neuronal α-Synuclein inclusions.
Nature communications
Trinkaus VA,Riera-Tur I,Martínez-Sánchez A,Bäuerlein FJB,Guo Q,Arzberger T,Baumeister W,Dudanova I,Hipp MS,Hartl FU,Fernández-Busnadiego R
A10262 was used in Immunocytochemistry to image a-synuclein inclusions and demonstrate the mechanisms of cellular interaction at molecular resolution using cryo-electron tomography.
Wed Apr 14 00:00:00 EDT 2021
NOTCH Signaling Controls Ciliary Body Morphogenesis and Secretion by Directly Regulating Nectin Protein Expression.
Cell reports
Pang J,Le L,Zhou Y,Tu R,Hou Q,Tsuchiya D,Thomas N,Wang Y,Yu Z,Alexander R,Thexton M,Lewis B,Corbin T,Durnin M,Li H,Ashery-Padan R,Yan D,Xie T
A10262 was used in Immunohistochemistry to show that NOTCH signaling in the ciliary body (CB) maintains the vitreous, intraocular pressure, and eye structures by regulating CB morphogenesis, aqueous humor secretion, and vitreous protein expression.
Tue Jan 12 00:00:00 EST 2021
Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling.
Nature communications
Chen D,McManus CE,Radmanesh B,Matzat LH,Lei EP
A10262 was used in Immunocytochemistry to provide evidence for temporal regulation of chromatin looping and enhancer accessibility during neuronal maturation.
Thu Nov 04 00:00:00 EDT 2021
Gene regulatory networks controlling temporal patterning, neurogenesis, and cell-fate specification in mammalian retina.
Cell reports
Lyu P,Hoang T,Santiago CP,Thomas ED,Timms AE,Appel H,Gimmen M,Le N,Jiang L,Kim DW,Chen S,Espinoza DF,Telger AE,Weir K,Clark BS,Cherry TJ,Qian J,Blackshaw S
A10262 was used in Flow cytometry/Cell sorting to provide a comprehensive picture of the cellular-level landscape of dynamic chromatin accessibility over the full course of retinal development and provides both a map of both candidate cis-regulatory elements and TF binding patterns.
Tue Nov 16 00:00:00 EST 2021
New reporter zebrafish line unveils heterogeneity among lymphatic endothelial cells during development.
Developmental dynamics : an official publication of the American Association of Anatomists
Frétaud M,Do Khoa N,Houel A,Lunazzi A,Boudinot P,Langevin C
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to develop a novel fish-adapted tissue clearing method, which allows deep imaging and 3D-visualization of vascular and lymphatic networks in the whole organism.
Sat May 01 00:00:00 EDT 2021
Identification of Novel Cross-Talk between the Neuroendocrine and Autonomic Stress Axes Controlling Blood Pressure.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Elsaafien K,Kirchner MK,Mohammed M,Eikenberry SA,West C,Scott KA,de Kloet AD,Stern JE,Krause EG
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to demonstrate that angiotensin II acts on PVNAgtr1a to conjoin hypothalamic-pituitary-adrenal axis activity with sympathetically mediated vasoconstriction in male mice.
Wed May 26 00:00:00 EDT 2021
Transmembrane topology and oligomeric nature of an astrocytic membrane protein, MLC1.
Open biology
Hwang J,Park K,Lee GY,Yoon BY,Kim H,Roh SH,Lee BC,Kim K,Lim HH
A10262 was used in Immunocytochemistry-immunofluorescence to provide a basis for both the high-resolution structural determination and functional characterization of the MLC1 protein.
Wed Dec 01 00:00:00 EST 2021
Neural circuitry linking mating and egg laying in Drosophila females.
Nature
Wang F,Wang K,Forknall N,Patrick C,Yang T,Parekh R,Bock D,Dickson BJ
A10262 was used in Immunocytochemistry to identify the neural circuitry that links egg laying to mating status in Drosophila melanogaster.
Sun Mar 01 00:00:00 EST 2020
A claustrum in reptiles and its role in slow-wave sleep.
Nature
Norimoto H,Fenk LA,Li HH,Tosches MA,Gallego-Flores T,Hain D,Reiter S,Kobayashi R,Macias A,Arends A,Klinkmann M,Laurent G
A10262 was used in Immunohistochemistry to report that a homologue of the claustrum, identified by single-cell transcriptomics and viral tracing of connectivity, also exists in a reptile-the Australian bearded dragon Pogona vitticeps.
Sat Feb 01 00:00:00 EST 2020
Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr+ Progenitors.
Cell
Wang D,Wang J,Bai L,Pan H,Feng H,Clevers H,Zeng YA
A10262 was used in Immunocytochemistry to demonstrate that the adult mouse pancreatic islet contains a population of Procr+ endocrine progenitors.
Thu Mar 19 00:00:00 EDT 2020
Elasticizing tissues for reversible shape transformation and accelerated molecular labeling.
Nature methods
Ku T,Guan W,Evans NB,Sohn CH,Albanese A,Kim JG,Frosch MP,Chung K
A10262 was used in Immunohistochemistry to develop the entangled link-augmented stretchable tissue-hydrogel technology capable of turning tissues into elastic hydrogels.
Mon Jun 01 00:00:00 EDT 2020
Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs.
Immunity
Oherle K,Acker E,Bonfield M,Wang T,Gray J,Lang I,Bridges J,Lewkowich I,Xu Y,Ahlfeld S,Zacharias W,Alenghat T,Deshmukh H
A10262 was used in Immunohistochemistry to demonstrate that pulmonary type 3 innate lymphoid cells descended from innate lymphoid cell precursors that populated a niche defined by fibroblasts in the developing lung.
Tue Feb 18 00:00:00 EST 2020
Associative and plastic thalamic signaling to the lateral amygdala controls fear behavior.
Nature neuroscience
Barsy B,Kocsis K,Magyar A,Babiczky Á,Szabó M,Veres JM,Hillier D,Ulbert I,Yizhar O,Mátyás F
A10262 was used in Immunohistochemistry to demonstrate that Calr+LT neurons provide integrated CS-US representations to the LA that support the formation of aversive memories.
Fri May 01 00:00:00 EDT 2020
Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein.
Nature cell biology
Zhang R,Lee DM,Jimah JR,Gerassimov N,Yang C,Kim S,Luvsanjav D,Winkelman J,Mettlen M,Abrams ME,Kalia R,Keene P,Pandey P,Ravaux B,Kim JH,Ditlev JA,Zhang G,Rosen MK,Frost A,Alto NM,Gardel M,Schmid SL,Svitkina TM,Hinshaw JE,Chen EH
A10262 was used in Western Blot, Immunocytochemistry to reveal a function of dynamin in propelling invasive membrane protrusions during myoblast fusion in vivo.
Mon Jun 01 00:00:00 EDT 2020
Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein.
Nature cell biology
Zhang R,Lee DM,Jimah JR,Gerassimov N,Yang C,Kim S,Luvsanjav D,Winkelman J,Mettlen M,Abrams ME,Kalia R,Keene P,Pandey P,Ravaux B,Kim JH,Ditlev JA,Zhang G,Rosen MK,Frost A,Alto NM,Gardel M,Schmid SL,Svitkina TM,Hinshaw JE,Chen EH
A10262 was used in Western Blot, Immunocytochemistry to reveal a function of dynamin in propelling invasive membrane protrusions during myoblast fusion in vivo.
Mon Jun 01 00:00:00 EDT 2020
CAMIO: a transgenic CRISPR pipeline to create diverse targeted genome deletions in Drosophila.
Nucleic acids research
Chen HM,Marques JG,Sugino K,Wei D,Miyares RL,Lee T
A10262 was used in Immunohistochemistry to develop a transgenic CRISPR pipeline in Drosphilia.
Thu May 07 00:00:00 EDT 2020
A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.
Neuron
Nguyen TA,Wu K,Pandey S,Lehr AW,Li Y,Bemben MA,Badger JD,Lauzon JL,Wang T,Zaghloul KA,Thurm A,Jain M,Lu W,Roche KW
A10262 was used in Immunocytochemistry to reveal a potential pathogenic mechanism for male bias in NLGN4X-associated ASD.
Wed Jun 03 00:00:00 EDT 2020
Estimation of Current and Future Physiological States in Insular Cortex.
Neuron
Livneh Y,Sugden AU,Madara JC,Essner RA,Flores VI,Sugden LA,Resch JM,Lowell BB,Andermann ML
A10262 was used in Immunohistochemistry to suggest that InsCtx integrates visceral-sensory signals of current physiological state with hypothalamus-gated amygdala inputs that signal upcoming ingestion of food or water to compute a prediction of future physiological state.
Wed Mar 18 00:00:00 EDT 2020
Amygdala Reward Neurons Form and Store Fear Extinction Memory.
Neuron
Zhang X,Kim J,Tonegawa S
A10262 was used in Immunohistochemistry to demonstrate that a fear extinction memory engram is formed and stored in a genetically distinct basolateral amygdala (BLA) neuronal population that drives reward behaviors and antagonizes the BLA's original fear neurons.
Wed Mar 18 00:00:00 EDT 2020
UPF2 leads to degradation of dendritically targeted mRNAs to regulate synaptic plasticity and cognitive function.
Molecular psychiatry
Notaras M,Allen M,Longo F,Volk N,Toth M,Li Jeon N,Klann E,Colak D
A10262 was used in Immunohistochemistry to establish that UPF2 regulates synaptic plasticity, cognition, and local protein synthesis in dendrites, providing fundamental insight into the neuron-specific function of NMD within the brain.
Tue Dec 01 00:00:00 EST 2020
Tuba8 Drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini.
Developmental cell
Ramos SI,Makeyev EV,Salierno M,Kodama T,Kawakami Y,Sahara S
A10262 was used in Immunocytochemistry to how that the non-canonical tubulin Tuba8, transiently expressed in cortical progenitors, drives differentiation of RGs into apical intermediate progenitors, a more restricted progenitor type lacking attachment to the basal lamina.
Mon Feb 24 00:00:00 EST 2020
Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function.
Developmental cell
DeSisto J,O'Rourke R,Jones HE,Pawlikowski B,Malek AD,Bonney S,Guimiot F,Jones KL,Siegenthaler JA
A10262 was used in Immunohistochemistry to investigate the heterogeneity and development of meningeal fibroblasts.
Mon Jul 06 00:00:00 EDT 2020
Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass.
Proceedings of the National Academy of Sciences of the United States of America
Kim SM,Taneja C,Perez-Pena H,Ryu V,Gumerova A,Li W,Ahmad N,Zhu LL,Liu P,Mathew M,Korkmaz F,Gera S,Sant D,Hadelia E,Ievleva K,Kuo TC,Miyashita H,Liu L,Tourkova I,Stanley S,Lizneva D,Iqbal J,Sun L,Tamler R,Blair HC,New MI,Haider S,Yuen T,Zaidi M
A10262 was used in Immunohistochemistry to report that two widely-used drugs for erectile dysfunction, tadalafil and vardenafil, trigger bone gain in mice through a combination of anabolic and antiresorptive actions on the skeleton.
Tue Jun 23 00:00:00 EDT 2020
Evolutionarily ancient BAH-PHD protein mediates Polycomb silencing.
Proceedings of the National Academy of Sciences of the United States of America
Wiles ET,McNaught KJ,Kaur G,Selker JML,Ormsby T,Aravind L,Selker EU
A10262 was used in Western Blotting to devised and implemented a forward genetic scheme to identify factors required for H3K27 methylation-mediated silencing in the filamentous fungus Neurospora crassa.
Tue May 26 00:00:00 EDT 2020
De Novo Frameshift Variants in the Neuronal Splicing Factor NOVA2 Result in a Common C-Terminal Extension and Cause a Severe Form of Neurodevelopmental Disorder.
American journal of human genetics
Mattioli F,Hayot G,Drouot N,Isidor B,Courraud J,Hinckelmann MV,Mau-Them FT,Sellier C,Goldman A,Telegrafi A,Boughton A,Gamble C,Moutton S,Quartier A,Jean N,Van Ness P,Grotto S,Nambot S,Douglas G,Si YC,Chelly J,Shad Z,Kaplan E,Dineen R,Golzio C,Charlet-Berguerand N,Mandel JL,Piton A
A10262 was used in Immunocytochemistry to report six individuals with de novo frameshift variants in NOVA2 affected with a severe neurodevelopmental disorder characterized by intellectual disability (ID), motor and speech delay, autistic features, hypotonia, feeding difficulties, spasticity or ataxic gait, and abnormal brain MRI.
Thu Apr 02 00:00:00 EDT 2020
Disruption of EGF Feedback by Intestinal Tumors and Neighboring Cells in Drosophila.
Current biology : CB
Ngo S,Liang J,Su YH,O'Brien LE
A10262 was used in Immunohistochemistry to demonstrate that Drosophila APC-/- tumors trigger widespread Rho expression in non-apoptotic cells, resulting in chronic EGF signaling.
Mon Apr 20 00:00:00 EDT 2020
Dynamic interactions of the 5-HT6 receptor with protein partners control dendritic tree morphogenesis.
Science signaling
Pujol CN,Dupuy V,Séveno M,Runtz L,Bockaert J,Marin P,Chaumont-Dubel S
A10262 was used in Immunocytochemistry to highlight the complex allosteric modulation of GPCRs by protein partners and demonstrate how dynamic interactions between GPCRs and their protein partners can control the different steps of highly coordinated cellular processes, such as dendritic tree morphogenesis.
Tue Feb 11 00:00:00 EST 2020
CHC22 clathrin mediates traffic from early secretory compartments for human GLUT4 pathway biogenesis.
The Journal of cell biology
Camus SM,Camus MD,Figueras-Novoa C,Boncompain G,Sadacca LA,Esk C,Bigot A,Gould GW,Kioumourtzoglou D,Perez F,Bryant NJ,Mukherjee S,Brodsky FM
A10262 was used in Immunocytochemistry-immunoflourescence to show that GLUT4 transits through the early secretory pathway more slowly than the constitutively secreted GLUT1 transporter and localize CHC22 to the ER-to-Golgi intermediate compartment (ERGIC).
Mon Jan 06 00:00:00 EST 2020
Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase.
The Journal of cell biology
Armistead J,Hatzold J,van Roye A,Fahle E,Hammerschmidt M
A10262 was used in Immunocytochemistry-immunoflourescence to elucidate the mechanisms underlying the double face of Matriptase function in vivo and reveal the potential use of combinatorial carcinoma treatments when such double-face mechanisms are involved.
Mon Feb 03 00:00:00 EST 2020
Increased transcription of transglutaminase 1 mediates neuronal death in in vitro models of neuronal stress and Aβ1-42-mediated toxicity.
Neurobiology of disease
Tripathy D,Migazzi A,Costa F,Roncador A,Gatto P,Fusco F,Boeri L,Albani D,Juárez-Hernández JL,Musio C,Colombo L,Salmona M,Wilhelmus MMM,Drukarch B,Pennuto M,Basso M
A10262 was used in Western Blot to investigate if a precision medicine pipeline that integrates high-throughput chemical screens with matched patient-derived cell lines and patient-derived xenografts (PDX) helps to identify new treatments for colorectal cancer.
Wed Jul 01 00:00:00 EDT 2020
Temporal control of Wnt signaling is required for habenular neuron diversity and brain asymmetry.
Development (Cambridge, England)
Guglielmi L,Bühler A,Moro E,Argenton F,Poggi L,Carl M
A10262 was used in Immunohistochemistry to suggest a feedback mechanism whereby the tumor suppressor Wnt inhibitory factor Wif1 controls the Wnt dynamics in the environment of habenular precursor cells.
Mon Mar 16 00:00:00 EDT 2020
Enhanced Golic+: highly effective CRISPR gene targeting and transgene HACKing in Drosophila.
Development (Cambridge, England)
Chen HM,Yao X,Ren Q,Chang CC,Liu LY,Miyares RL,Lee T
A10262 was used in Immunocytochemistry to demonstrate its utility by transforming GAL4 enhancer-trap lines into tissue-specific Cas9-expressing lines.
Thu Jun 11 00:00:00 EDT 2020
Genetic developmental timing revealed by inter-species transplantations in fish.
Development (Cambridge, England)
Fuhrmann JF,Buono L,Adelmann L,Martinez-Morales JR,Centanin L
A10262 was used in Immunohistochemistry to report that inter-species blastula transplantations result in the ectopic formation of a retina formed by donor cells - a module.
Mon Nov 23 00:00:00 EST 2020
Evidence of two types of balance between stem cell mitosis and enterocyte nucleus growth in the Drosophila midgut.
Development (Cambridge, England)
Tamamouna V,Panagi M,Theophanous A,Demosthenous M,Michail M,Papadopoulou M,Teloni S,Pitsouli C,Apidianakis Y
A10262 was used in Immunohistochemistry to study the role of tissue-intrinsic regenerative signaling in stem cell mitosis of adult Drosophila midgut of different genetic backgrounds.
Mon Jun 08 00:00:00 EDT 2020
Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract.
Development (Cambridge, England)
Sidhwani P,Leerberg DM,Boezio GLM,Capasso TL,Yang H,Chi NC,Roman BL,Stainier DYR,Yelon D
A10262 was used in Immunohistochemistry to indicate that cardiac function modulates OFT morphogenesis by triggering endocardial cell accumulation that induces OFT lumen expansion and shapes OFT dimensions.
Wed Jun 17 00:00:00 EDT 2020
The stem-like Stat3-responsive cells of zebrafish intestine are Wnt/β-catenin dependent.
Development (Cambridge, England)
Peron M,Dinarello A,Meneghetti G,Martorano L,Facchinello N,Vettori A,Licciardello G,Tiso N,Argenton F
A10262 was used in Immunocytochemistry to indicate that Jak/Stat3 signalling is needed for intestinal stem cell maintenance and possibly crucial in controlling Wnt/β-catenin-dependent colorectal cancer cell proliferation.
Fri Jun 19 00:00:00 EDT 2020
A combinatorial code of transcription factors specifies subtypes of visual motion-sensing neurons in Drosophila.
Development (Cambridge, England)
Hörmann N,Schilling T,Ali AH,Serbe E,Mayer C,Borst A,Pujol-Martí J
A10262 was used in Immunohistochemistry to investigate the genetic programmes underlying the acquisition of the different morphologies defining the four T4/T5 subtypes, which are essential for detecting visual motion along the four cardinal directions.
Wed May 13 00:00:00 EDT 2020
Slow Waves Promote Sleep-Dependent Plasticity and Functional Recovery after Stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Facchin L,Schöne C,Mensen A,Bandarabadi M,Pilotto F,Saxena S,Libourel PA,Bassetti CLA,Adamantidis AR
A10262 was used in Immunohistochemistry to investigate the role of optogenetically induced sleep slow waves in an animal model of ischemic stroke and identify sleep as a window for poststroke intervention that promotes neuroplasticity and facilitates sensorimotor recovery.
Wed Nov 04 00:00:00 EST 2020
Rapid Release of Ca2+ from Endoplasmic Reticulum Mediated by Na+/Ca2+ Exchange.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Liu CH,Chen Z,Oliva MK,Luo J,Collier S,Montell C,Hardie RC
A10262 was used in Immunocytochemistry-immunoflourescence to demonstrate a rapid light-induced depletion of ER Ca2+ stores mediated by Na+/Ca2+ exchange across the ER membrane.
Wed Apr 15 00:00:00 EDT 2020
A New Gorilla Adenoviral Vector with Natural Lung Tropism Avoids Liver Toxicity and Is Amenable to Capsid Engineering and Vector Retargeting.
Journal of virology
Lu ZH,Dmitriev IP,Brough DE,Kashentseva EA,Li J,Curiel DT
A10262 was used in Immunohistochemistry-immunofluorescence to evaluate the utility and safety of a new low-seroprevalence gorilla adenovirus (GAd; GC46) as a gene transfer vector in mice.
Mon May 04 00:00:00 EDT 2020
Myeloma Cells Down-Regulate Adiponectin in Bone Marrow Adipocytes Via TNF-Alpha.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Morris EV,Suchacki KJ,Hocking J,Cartwright R,Sowman A,Gamez B,Lea R,Drake MT,Cawthorn WP,Edwards CM
A10262 was used in Immunocytochemistry to support disease progression.
Fri May 01 00:00:00 EDT 2020
Radial Migration Dynamics Is Modulated in a Laminar and Area-Specific Manner During Primate Corticogenesis.
Frontiers in cell and developmental biology
Cortay V,Delaunay D,Patti D,Gautier E,Doerflinger N,Giroud P,Knoblauch K,Huissoud C,Kennedy H,Dehay C
A10262 was used in Immunohistochemistry to investigate specific features of radial migration within non-human primates.
Fri Nov 13 00:00:00 EST 2020
Cep57 and Cep57l1 function redundantly to recruit the Cep63-Cep152 complex for centriole biogenesis.
Journal of cell science
Zhao H,Yang S,Chen Q,Duan X,Li G,Huang Q,Zhu X,Yan X
A10262 was used in Immunocytochemistry-immunoflourescence to find that Cep57 and its paralog Cep57l1 function redundantly to recruit the Cep63-Cep152 complex for centriole duplication.
Fri Jul 03 00:00:00 EDT 2020
Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny.
Human molecular genetics
Gilet JG,Ivanova EL,Trofimova D,Rudolf G,Meziane H,Broix L,Drouot N,Courraud J,Skory V,Voulleminot P,Osipenko M,Bahi-Buisson N,Yalcin B,Birling MC,Hinckelmann MV,Kwok BH,Allingham JS,Chelly J
A10262 was used in Immunohistochemistry to investigate RosaCre-, NestinCre- and NexCre-driven expression of the mutation to dissect the pathophysiological mechanisms underlying neurodevelopmental cortical abnormalities.
Fri Mar 27 00:00:00 EDT 2020
Synj1 haploinsufficiency causes dopamine neuron vulnerability and alpha-synuclein accumulation in mice.
Human molecular genetics
Pan PY,Sheehan P,Wang Q,Zhu X,Zhang Y,Choi I,Li X,Saenz J,Zhu J,Wang J,El Gaamouch F,Zhu L,Cai D,Yue Z
A10262 was used in Immunocytochemistry to demonstrate down-regulation of SYNJ1 transcript in a subset of sporadic PD brains, implicating a potential role of Synj1 deficiency in the decline of dopaminergic function during aging.
Tue Aug 11 00:00:00 EDT 2020
Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition.
Cerebral cortex (New York, N.Y. : 1991)
Mehr A,Hick M,Ludewig S,Müller M,Herrmann U,von Engelhardt J,Wolfer DP,Korte M,Müller UC
A10262 was used in Immunocytochemistry to reveal a crucial role of APP family proteins in inhibitory interneurons to maintain functional network activity.
Mon Jun 01 00:00:00 EDT 2020
Impaired LH surge amplitude in gonadotrope-specific progesterone receptor knockout mice.
The Journal of endocrinology
Toufaily C,Schang G,Zhou X,Wartenberg P,Boehm U,Lydon JP,Roelfsema F,Bernard DJ
A10262 was used in Immunohistochemistry-immunofluorescence to indicate that PR function in gonadotropes may be limited to regulation of LH surge amplitude in female mice via a currently unknown mechanism.
Wed Jan 01 00:00:00 EST 2020
A Family of Auxiliary Subunits of the TRP Cation Channel Encoded by the Complex inaF Locus.
Genetics
Chen Z,Montell C
A10262 was used in Immunohistochemistry to reveal a previously unknown TRP interacting protein, INAF-C, which is expressed exclusively in the ultraviolet-sensing R7 photoreceptor cells, using Drosophila melanogaster.
Wed Jul 01 00:00:00 EDT 2020
Social behavior in mice following chronic optogenetic stimulation of hippocampal engrams.
Neurobiology of learning and memory
Doucette E,Merfeld E,Leblanc H,Monasterio A,Cincotta C,Grella SL,Logan J,Ramirez S
A10262 was used in Immunohistochemistry to examine whether chronic optogenetic reactivation of discrete sets of cells in the dorsal dentate gyrus (dDG) is sufficient to modulate social behaviours in mice.
Tue Dec 01 00:00:00 EST 2020
A cell type-specific expression map of NCoR1 and SMRT transcriptional co-repressors in the mouse brain.
The Journal of comparative neurology
Iemolo A,Montilla-Perez P,Lai IC,Meng Y,Nolan S,Wen J,Rusu I,Dulcis D,Telese F
A10262 was used in Immunohistochemistry-immunofluorescence to use fluorescent immunohistochemistry to map gene expression patterns throughout the adult mouse brain.
Tue Sep 01 00:00:00 EDT 2020
Hippocampal growth hormone modulates relational memory and the dendritic spine density in CA1.
Learning & memory (Cold Spring Harbor, N.Y.)
Haugland KG,Olberg A,Lande A,Kjelstrup KB,Brun VH
A10262 was used in Immunohistochemistry to imply that GH is a neuromodulator with strong influence over hippocampal plasticity and relational memory by mechanisms involving modulation of dendritic spines.
Sat Feb 01 00:00:00 EST 2020
Expression of a Barhl1a reporter in subsets of retinal ganglion cells and commissural neurons of the developing zebrafish brain.
Scientific reports
Albadri S,Armant O,Aljand-Geschwill T,Del Bene F,Carl M,Strähle U,Poggi L
A10262 was used in Immunohistochemistry to explore the spatio-temporal expression of a Barh1a reporter in retinal cells.
Mon Jun 01 00:00:00 EDT 2020
Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement.
Science advances
Kim S,Kim N,Lee J,Kim S,Hong J,Son S,Heo W
A10262 was used in Immunocytochemistry-immunoflourescence to identify a novel mechanism linking Fas activation in immature neurons to ERK activation in neural stem cells using optogenetically activatable Fas receptor.
Wed Apr 01 00:00:00 EDT 2020
P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b.
Cells
Naffa R,Vogel L,Hegedűs L,Pászty K,Tóth S,Kelemen K,Singh N,Reményi A,Kállay E,Cserepes M,Tóvári J,Grusch M,Enyedi Á
A10262 was used in Immunocytochemistry-immunoflourescence to suggest that the p38 MAPK pathway plays a key role in PMCA4b degradation and inhibition of this pathway-by increasing the stability of PMCA4b-may provide a potential therapeutic target for inhibition of melanoma progression and metastasis.
Wed May 13 00:00:00 EDT 2020
Muscle and epidermal contributions of the structural protein β-spectrin promote hypergravity-induced motor neuron axon defects in C. elegans.
Scientific reports
Kalichamy SS,Alcantara AV,Kim BS,Park J,Yoon KH,Lee JI
A10262 was used in Immunohistochemistry to show that a mutation in the unc-70 gene that encodes the cytoskeletal β-spectrin protein suppresses hypergravity-induced axon defects.
Thu Dec 03 00:00:00 EST 2020
Wdr47 Controls Neuronal Polarization through the Camsap Family Microtubule Minus-End-Binding Proteins.
Cell reports
Chen Y,Zheng J,Li X,Zhu L,Shao Z,Yan X,Zhu X
A10262 was used in Immunoprecipitation to indicate that Wdr47 facilitates proper neurite remodeling through Camsaps to fine-tune regional microtubule dynamics and organization during early stages of neuronal polarization.
Tue Apr 21 00:00:00 EDT 2020
Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets.
Cell reports
Maheshwari U,Kraus D,Vilain N,Holwerda SJB,Cankovic V,Maiorano NA,Kohler H,Satoh D,Sigrist M,Arber S,Kratochwil CF,Di Meglio T,Ducret S,Rijli FM
A10262 was used in Immunohistochemistry to conclude that Hoxa5 coordinates postmitotic specification, migration, settling position, and sub-circuit assembly of PN neuron subsets in the cortico-cerebellar pathway.
Tue Jun 16 00:00:00 EDT 2020
A comparison of AAV-vector production methods for gene therapy and preclinical assessment.
Scientific reports
Davidsson M,Negrini M,Hauser S,Svanbergsson A,Lockowandt M,Tomasello G,Manfredsson FP,Heuer A
A10262 was used in Immunohistochemistry to show the novel protocol enables most standardly equipped labortories to produce small batches of high quality and high titer AAV vectors for their experiment needs.
Wed Dec 09 00:00:00 EST 2020
Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon.
Cell reports
Di Marco B,Crouch EE,Shah B,Duman C,Paredes MF,Ruiz de Almodovar C,Huang EJ,Alfonso J
A10262 was used in Immunohistochemistry to demonstrate the relationship between vascular filopodia and neural stem cell behaviour during neurogenesis.
Tue Oct 13 00:00:00 EDT 2020
Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex.
eLife
D'Souza RS,Lim JY,Turgut A,Servage K,Zhang J,Orth K,Sosale NG,Lazzara MJ,Allegood J,Casanova JE
A10262 was used in Western Blotting to identify a new pathway that links calcium influx to focal adhesion (FA) turnover during cell migration.
Wed Apr 01 00:00:00 EDT 2020
Cholinergic Projections From the Pedunculopontine Tegmental Nucleus Contact Excitatory and Inhibitory Neurons in the Inferior Colliculus.
Frontiers in neural circuits
Noftz WA,Beebe NL,Mellott JG,Schofield BR
A10262 was used in Immunohistochemistry (PFA fixed) to suggest cholinergic projections from the PPT have a widespread influence over the IC, likely affecting many aspects of midbrain auditory processing.
Mon Oct 04 00:00:00 EDT 2021
The neural basis for a persistent internal state in Drosophila females.
eLife
Deutsch D,Pacheco D,Encarnacion-Rivera L,Pereira T,Fathy R,Clemens J,Girardin C,Calhoun A,Ireland E,Burke A,Dorkenwald S,McKellar C,Macrina T,Lu R,Lee K,Kemnitz N,Ih D,Castro M,Halageri A,Jordan C,Silversmith W,Wu J,Seung HS,Murthy M
A10262 was used in Immunohistochemistry-immunofluorescence to show a subset of Doublesex+ pC1 neurons in the Drosophila female brain can drive minutes-long changes in female behavior in the presence of male.
Mon Nov 23 00:00:00 EST 2020
Controlling motor neurons of every muscle for fly proboscis reaching.
eLife
McKellar CE,Siwanowicz I,Dickson BJ,Simpson JH
A10262 was used in Immunocytochemistry to investigate the anatomy of all the primary motor neurons in the fly proboscis and characterise their contributions to its diverse reaching movements.
Thu Jun 25 00:00:00 EDT 2020
Knockdown of Son, a mouse homologue of the ZTTK syndrome gene, causes neuronal migration defects and dendritic spine abnormalities.
Molecular brain
Ueda M,Matsuki T,Fukada M,Eda S,Toya A,Iio A,Tabata H,Nakayama A
A10262 was used in Immunohistochemistry to support that the neural abnormalities in ZTTK syndrome are caused by SON haploinsufficiency independent of the types of mutation that results in functional or dysfunctional proteins.
Sun May 24 00:00:00 EDT 2020
Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice.
PloS one
Sos KE,Mayer MI,Takács VT,Major A,Bardóczi Z,Beres BM,Szeles T,Saito T,Saido TC,Mody I,Freund TF,Nyiri G
A10262 was used in Immunohistochemistry-immunofluorescence to suggest that PV interneurons are highly resistant to amyloidosis in APPNL-F mice and amyloid-induced increase in hippocampal pyramidal cell excitability may be compensated by PV-positive AIS-targeting cells.
Tue Aug 11 00:00:00 EDT 2020
Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances the learning of cue-reward contingency.
eLife
Crouse RB,Kim K,Batchelor HM,Girardi EM,Kamaletdinova R,Chan J,Rajebhosale P,Pittenger ST,Role LW,Talmage DA,Jing M,Li Y,Gao XB,Mineur YS,Picciotto MR
A10262 was used in Immunohistochemistry to indicate BLA ACh signaling carries important information about salient events in cue-reward learning.
Fri Sep 18 00:00:00 EDT 2020
Acute brain injuries trigger microglia as an additional source of the proteoglycan NG2.
Acta neuropathologica communications
Huang W,Bai X,Meyer E,Scheller A
A10262 was used in Immunohistochemistry to study NG2 expression indicated by transgenic fluorescent proteins in microglia after tMCAO (transient middle cerebral artery occlusion) or cortical stab wound injury (SWI), using three knock-in mouse lines (NG2-CreERT2, CX3CR1-EGFP and NG2-EYFP).
Wed Aug 26 00:00:00 EDT 2020
Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia.
Cell reports
Di Nardo A,Lenoël I,Winden KD,Rühmkorf A,Modi ME,Barrett L,Ercan-Herbst E,Venugopal P,Behne R,Lopes CAM,Kleiman RJ,Bettencourt-Dias M,Sahin M
A10262 was used in Immunocytochemistry-immunoflourescence to examine whether neuronal cilia are affected in TSC.
Tue Jun 23 00:00:00 EDT 2020
Myelination of parvalbumin interneurons shapes the function of cortical sensory inhibitory circuits.
Nature communications
Benamer N,Vidal M,Balia M,Angulo MC
A10262 was used in Immunohistochemistry to study the requirement of fast-spiking interneurons myelination in FSI-mediated feedforward inhibition of cortical sensory circuits.
Tue Oct 13 00:00:00 EDT 2020
Non-invasive optical control of endogenous Ca2+ channels in awake mice.
Nature communications
Kim S,Kyung T,Chung JH,Kim N,Keum S,Lee J,Park H,Kim HM,Lee S,Shin HS,Heo WD
A10262 was used in Immunohistochemistry to present an ultra-light-sensitive optogenetic Ca2+ modulator, named monSTIM1 encompassing engineered cryptochrome2 for manipulating Ca2+ signaling in the brain of awake mice through non-invasive light delivery.
Fri Jan 10 00:00:00 EST 2020
Calbindin-D9k is a Novel Risk Gene for Neurodegenerative Disease.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Jung EM,Yoo YM,Park SY,Ahn C,Jeon BH,Hong EJ,Kim WY,Jeung EB
A10262 was used in Immunohistochemistry to investigate the importance of calbindin-D9k and downstream calcium regulation in neurodegenerative diseases.
Sat May 02 00:00:00 EDT 2020
Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release.
Nature communications
Ye L,Orynbayev M,Zhu X,Lim EY,Dereddi RR,Agarwal A,Bergles DE,Bhat MA,Paukert M
A10262 was used in Immunohistochemistry to show that locomotion-induced Ca2+ elevations in mouse astroglia are inhibited by ethanol and can be reversed by enhancing norepinephrine release.
Wed Dec 02 00:00:00 EST 2020
NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma.
Cell reports
Cheng Y,Liao S,Xu G,Hu J,Guo D,Du F,Contreras A,Cai KQ,Peri S,Wang Y,Corney DC,Noronha AM,Chau LQ,Zhou G,Wiest DL,Bellacosa A,Wechsler-Reya RJ,Zhao Y,Yang ZJ
A10262 was used in Immunohistochemistry to demonstrate that tumor cells in medulloblastoma (MB) retain their capacity to differentiate in a similar way as their normal originating cells, cerebellar granule neuron precursors.
Tue Jun 23 00:00:00 EDT 2020
Efficient training of mice on the 5-choice serial reaction time task in an automated rodent training system.
Scientific reports
Birtalan E,Bánhidi A,Sanders JI,Balázsfi D,Hangya B
A10262 was used in Immunohistochemistry to develop an automated training system for the rodent 5-choice serial reaction time task used to test sensory-motor systems.
Mon Dec 21 00:00:00 EST 2020
Synaptic Vesicle Precursors and Lysosomes Are Transported by Different Mechanisms in the Axon of Mammalian Neurons.
Cell reports
De Pace R,Britt DJ,Mercurio J,Foster AM,Djavaherian L,Hoffmann V,Abebe D,Bonifacino JS
A10262 was used in Immunocytochemistry-immunoflourescence to demonstrate that SVPs and lysosomes are distinct organelles that rely on different machineries for axonal transport in mammalian neurons.
Tue Jun 16 00:00:00 EDT 2020
2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.
International journal of molecular sciences
Lee YJ,Kim HR,Lee CY,Hyun SA,Ko MY,Lee BS,Hwang DY,Ka M
A10262 was used in Immunocytochemistry-immunoflourescence to investigate the molecular mechanism of the antidepressant effect of 2-Phenethylamine(PEA) in a mouse model of corticosterone-induced depression.
Mon Nov 30 00:00:00 EST 2020
A positive feedback loop between Flower and PI(4,5)P2 at periactive zones controls bulk endocytosis in Drosophila.
eLife
Li TN,Chen YJ,Lu TY,Wang YT,Lin HC,Yao CK
A10262 was used in Western Blotting to study the regulation of activity-dependent bulk endocytosis in drosophila.
Thu Dec 10 00:00:00 EST 2020
Differential Pain-Related Behaviors and Bone Disease in Immunocompetent Mouse Models of Myeloma.
JBMR plus
Diaz-delCastillo M,Kamstrup D,Olsen RB,Hansen RB,Pembridge T,Simanskaite B,Jimenez-Andrade JM,Lawson MA,Heegaard AM
A10262 was used in Immunohistochemistry to provide the first in-depth behavioral characterization of an immunocompetent mouse model of MM presenting the clinical disease features: osteolytic bone disease and bone pain.
Sat Feb 01 00:00:00 EST 2020
Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations.
eLife
Chen C,Soto G,Dumrongprechachan V,Bannon N,Kang S,Kozorovitskiy Y,Parisiadou L
A10262 was used in Immunocytochemistry to show that R1441C and G2019S knock-in mice enabled thorough evaluation of dendritic spines and synapses on pathway-identified SPNs.
Fri Oct 02 00:00:00 EDT 2020
The non-receptor tyrosine kinase Pyk2 modulates acute locomotor effects of cocaine in D1 receptor-expressing neurons of the nucleus accumbens.
Scientific reports
de Pins B,Montalban E,Vanhoutte P,Giralt A,Girault JA
A10262 was used in Immunohistochemistry-immunofluorescence to study the role of Pyk2 in the molecular pathway of D1 receptor-expressing neurons.
Mon Apr 20 00:00:00 EDT 2020
TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema.
JCI insight
Weber J,Rajan S,Schremmer C,Chao YK,Krasteva-Christ G,Kannler M,Yildirim AÖ,Brosien M,Schredelseker J,Weissmann N,Grimm C,Gudermann T,Dietrich A
A10262 was used in Immunohistochemistry to illustrate essential functions of TRPV4 channels in alveolar epithelial cells and in protection from edema formation.
Thu Oct 15 00:00:00 EDT 2020
Characterization of transgenic mouse lines for selectively targeting satellite glial cells and macrophages in dorsal root ganglia.
PloS one
Rabah Y,Rubino B,Moukarzel E,Agulhon C
A10262 was used in Immunocytochemistry to characterize in dorsal root ganglia (DRGs), different genetically-modified mouse lines previously used for studying astrocytes and microglia, with the goal to implement them for investigating DRG SGC and macrophage functions.
Tue Oct 27 00:00:00 EDT 2020
The Zebrafish Amygdaloid Complex - Functional Ground Plan, Molecular Delineation, and Everted Topology.
Frontiers in neuroscience
Porter BA,Mueller T
A10262 was used in Immunohistochemistry to investigate and compare the mechanism by which the zebrafish amygdala and the telencephalon topologically relate to behaviour and compare this to the corresponding structures in mammals.
Fri Sep 03 00:00:00 EDT 2021
Loss of the Antimicrobial Peptide Metchnikowin Protects Against Traumatic Brain Injury Outcomes in Drosophila melanogaster.
G3 (Bethesda, Md.)
Swanson LC,Rimkus SA,Ganetzky B,Wassarman DA
A10262 was used in Immunocytochemistry to demonstrate that TBI-induced expression of Metchnikowin in the brain activates acute and chronic secondary injury pathways in Drosophila.
Wed Sep 02 00:00:00 EDT 2020
Sex differences in dendritic spine density and morphology in auditory and visual cortices in adolescence and adulthood.
Scientific reports
Parker EM,Kindja NL,Cheetham CEJ,Sweet RA
A10262 was used in Immunohistochemistry to support the possibility of developmental sex differences in DSD in visual and auditory regions and provide evidence of layer-specific refinement of DSD over adolescent brain development.
Wed Jun 10 00:00:00 EDT 2020
A novel mouse model of glucagon-like peptide-1 receptor expression: A look at the brain.
The Journal of comparative neurology
Graham DL,Durai HH,Trammell TS,Noble BL,Mortlock DP,Galli A,Stanwood GD
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to provide detailed images of GLP-1R-mApple expression and distribution within the brain and characterization of these neurons.
Thu Oct 01 00:00:00 EDT 2020
Unc-4 acts to promote neuronal identity and development of the take-off circuit in the Drosophila CNS.
eLife
Lacin H,Williamson WR,Card GM,Skeath JB,Truman JW
A10262 was used in Immunohistochemistry-immunofluorescence to nvestigated the developmental and molecular basis of behavior by focusing on lineage-specific functions of the homeodomain transcription factor, Unc-4 in Drosophila.
Fri Mar 27 00:00:00 EDT 2020
Dlp-mediated Hh and Wnt signaling interdependence is critical in the niche for germline stem cell progeny differentiation.
Science advances
Tu R,Duan B,Song X,Xie T
A10262 was used in Immunohistochemistry-immunofluorescence to reveal a novel mechanism for Hh/Wnt signaling-mediated direct dlp repression and a novel regulatory mechanism for Dlp-mediated Hh/Wnt signaling interdependence in the germline stem cell (GSC) differentiation niche.
Fri May 01 00:00:00 EDT 2020
Vitamin D Supplementation Rescues Aberrant NF-κB Pathway Activation and Partially Ameliorates Rett Syndrome Phenotypes in Mecp2 Mutant Mice.
eNeuro
Ribeiro MC,Moore SM,Kishi N,Macklis JD,MacDonald JL
A10262 was used in Immunocytochemistry to elucidate fundamental neurobiology of Rett syndrome (RTT) and provide foundation that NF-κB pathway inhibition might be a therapeutic target for RTT.
Fri Jun 18 00:00:00 EDT 2021
Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet.
Molecular metabolism
Kellard JA,Rorsman NJG,Hill TG,Armour SL,van de Bunt M,Rorsman P,Knudsen JG,Briant LJB
A10262 was used in Immunocytochemistry to suggest that reduced delta-cell function, combined with intrinsic changes in alpha-cells including sensitivity to somatostatin, accounts for the hyperglucagonaemia in mice fed a HFD.
Thu Oct 01 00:00:00 EDT 2020
Early-Life Stress Regulates Cardiac Development through an IL-4-Glucocorticoid Signaling Balance.
Cell reports
Apaydin DC,Jaramillo PAM,Corradi L,Cosco F,Rathjen FG,Kammertoens T,Filosa A,Sawamiphak S
A10262 was used in Immunohistochemistry-immunofluorescence to show that exposure to brain-processed stress disrupts myocardial growth by reducing cardiomyocyte mitotic activity.
Tue Nov 17 00:00:00 EST 2020
Maturational Changes in Mouse Cutaneous Touch and Piezo2-Mediated Mechanotransduction.
Cell reports
Michel N,Narayanan P,Shomroni O,Schmidt M
A10262 was used in Immunohistochemistry to emphasize the need for accurate age matching and uncovers hitherto unknown maturational plasticity in cutaneous touch at the level of behavior, mechanotransduction, and transcripts.
Tue Jul 21 00:00:00 EDT 2020
A role for spindles in the onset of rapid eye movement sleep.
Nature communications
Bandarabadi M,Herrera CG,Gent TC,Bassetti C,Schindler K,Adamantidis AR
A10262 was used in Immunohistochemistry to extend the classical TRN-TC-CT spindle pathway to include non-sensory thalamic nuclei and implicate spindles in the onset of REM sleep.
Fri Oct 16 00:00:00 EDT 2020
A Cell-Based Assay Optimized for High-Content Cilia Imaging with Primary Rat Hippocampal Neurons.
STAR protocols
Di Nardo A,Vasquez S,Sahin M
A10262 was used in Immunohistochemistry-immunofluorescence to develop a cell-based assay to monitor cilia in rat hippocampal neurons using lentiviral-mediated shRNA-based gene silencing.
Fri Dec 18 00:00:00 EST 2020
A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila.
Nature
Oh Y,Lai JS,Mills HJ,Erdjument-Bromage H,Giammarinaro B,Saadipour K,Wang JG,Abu F,Neubert TA,Suh GSB
A10262 was used in Immunohistochemistry to identify a pair of glucose-sensing neurons with bifurcated axons in the brain of Drosophila.
Tue Oct 01 00:00:00 EDT 2019
Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex.
Nature
Poulopoulos A,Murphy AJ,Ozkan A,Davis P,Hatch J,Kirchner R,Macklis JD
A10262 was used in Immunocytochemistry-immunoflourescence to illuminate the relationships between subcellular distributions of RNA and protein in developing projection neurons, and provide a systems-level approach for the discovery of subtype- and stage-specific molecular substrates of circuit wiring, miswiring, and the potential for regeneration.
Tue Jan 01 00:00:00 EST 2019
Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements.
Nature genetics
Ly P,Brunner SF,Shoshani O,Kim DH,Lan W,Pyntikova T,Flanagan AM,Behjati S,Page DC,Campbell PJ,Cleveland DW
A10262 was used in Immunocytochemistry-immunoflourescence to integrate a centromere-specific inactivation approach with selection for a conditionally essential gene, a strategy termed CEN-SELECT, to systematically interrogate the structural landscape of mis-segregated chromosomes.
Mon Apr 01 00:00:00 EDT 2019
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.
Nature neuroscience
Klim JR,Williams LA,Limone F,Guerra San Juan I,Davis-Dusenbery BN,Mordes DA,Burberry A,Steinbaugh MJ,Gamage KK,Kirchner R,Moccia R,Cassel SH,Chen K,Wainger BJ,Woolf CJ,Eggan K
A10262 was used in Immunocytochemistry to report transcripts whose abundance in human motor neurons are sensitive to TDP-43 depletion.
Fri Feb 01 00:00:00 EST 2019
Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output.
Nature neuroscience
Giandomenico SL,Mierau SB,Gibbons GM,Wenger LMD,Masullo L,Sit T,Sutcliffe M,Boulanger J,Tripodi M,Derivery E,Paulsen O,Lakatos A,Lancaster MA
A10262 was used in Immunohistochemistry to reveal a remarkable self-organization of corticofugal and callosal tracts with a functional output, providing new opportunities to examine relevant aspects of human CNS development and disease.
Mon Apr 01 00:00:00 EDT 2019
Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice.
Nature neuroscience
Shen M,Wang F,Li M,Sah N,Stockton ME,Tidei JJ,Gao Y,Korabelnikov T,Kannan S,Vevea JD,Chapman ER,Bhattacharyya A,van Praag H,Zhao X
A10262 was used in Immunohistochemistry to show that FMRP-deficient immature neurons exhibit impaired dendritic maturation, altered expression of mitochondrial genes, fragmented mitochondria, impaired mitochondrial function, and increased oxidative stress.
Fri Mar 01 00:00:00 EST 2019
State-specific gating of salient cues by midbrain dopaminergic input to basal amygdala.
Nature neuroscience
Lutas A,Kucukdereli H,Alturkistani O,Carty C,Sugden AU,Fernando K,Diaz V,Flores-Maldonado V,Andermann ML
A10262 was used in Immunohistochemistry to investigate if ventral tegmental area dopamine axons that innervate basal amygdala axons may provide a reinforcement signal of motivational salience that invigorates adaptive behaviors by promoting learned responses to appetitive or aversive cues in distinct, intermingled sets of basal amygdala excitatory neurons.
Fri Nov 01 00:00:00 EDT 2019
Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation.
Molecular cell
Zhang W,Chuang YA,Na Y,Ye Z,Yang L,Lin R,Zhou J,Wu J,Qiu J,Savonenko A,Leahy DJ,Huganir R,Linden DJ,Worley PF
A10262 was used in Western Blotting to provide an atomic model for dynamic and local control of Arc function underlying synaptic plasticity and memory.
Thu Jul 11 00:00:00 EDT 2019
The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits.
Neuron
Li MM,Madara JC,Steger JS,Krashes MJ,Balthasar N,Campbell JN,Resch JM,Conley NJ,Garfield AS,Lowell BB
A10262 was used in Immunohistochemistry-immunofluorescence to report that PVH prodynorphin-expressing (PVHPDYN) neurons function independently and additively with PVHMC4R neurons to account for the totality of PVHSIM1 neuron-mediated satiety.
Wed May 08 00:00:00 EDT 2019
A Neural Circuit Encoding the Experience of Copulation in Female Drosophila.
Neuron
Shao L,Chung P,Wong A,Siwanowicz I,Kent CF,Long X,Heberlein U
A10262 was used in Immunohistochemistry to investigate the effect of coital sensory inputs from those of male Drosophila ejaculate.
Wed Jun 05 00:00:00 EDT 2019
Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements.
Neuron
Paixão S,Loschek L,Gaitanos L,Alcalà Morales P,Goulding M,Klein R
A10262 was used in Immunohistochemistry to suggest that Zic2 neurons integrate sensory input from cutaneous afferents with descending signals from the brain to promote corrective movements and transmit processed touch information back to the brain.
Wed Nov 20 00:00:00 EST 2019
Nuclear receptor corepressor 1 represses cardiac hypertrophy.
EMBO molecular medicine
Li C,Sun XN,Chen BY,Zeng MR,Du LJ,Liu T,Gu HH,Liu Y,Li YL,Zhou LJ,Zheng XJ,Zhang YY,Zhang WC,Liu Y,Shi C,Shao S,Shi XR,Yi Y,Liu X,Wang J,Auwerx J,Wang ZV,Jia F,Li RG,Duan SZ
A10262 was used in Western Blotting to reveal that cardiomyocyte-specific nuclear receptor corepressor 1 knockout mice manifested cardiac hypertrophy at baseline and had more severe cardiac hypertrophy and dysfunction after pressure overload.
Thu Nov 07 00:00:00 EST 2019
Sidekick Is a Key Component of Tricellular Adherens Junctions that Acts to Resolve Cell Rearrangements.
Developmental cell
Letizia A,He D,Astigarraga S,Colombelli J,Hatini V,Llimargas M,Treisman JE
A10262 was used in Immunohistochemistry-immunofluorescence to suggest that Polychaetoid and Canoe link Sidekick to the actin cytoskeleton to enable tricellular adherens junctions to maintain or transmit cell bond tension during epithelial cell rearrangements.
Mon Aug 05 00:00:00 EDT 2019
An SH3PX1-Dependent Endocytosis-Autophagy Network Restrains Intestinal Stem Cell Proliferation by Counteracting EGFR-ERK Signaling.
Developmental cell
Zhang P,Holowatyj AN,Roy T,Pronovost SM,Marchetti M,Liu H,Ulrich CM,Edgar BA
A10262 was used in Immunohistochemistry to demonstrate that SH3PX1, a Drosophila sorting nexin used in intracellular vesicle trafficking, can affect gut homeostasis and lifespan by restraining intestinal stem cell (ISC) division through disruptions in endocytosis/autophagy networks, ultimately resulting in EGFR-dependent cancers.
Mon May 20 00:00:00 EDT 2019
Developmentally Arrested Precursors of Pontine Neurons Establish an Embryonic Blueprint of the Drosophila Central Complex.
Current biology : CB
Andrade IV,Riebli N,Nguyen BM,Omoto JJ,Cardona A,Hartenstein V
A10262 was used in Immunohistochemistry to provide a framework of landmarks for the ongoing analyses of the L1 brain circuitry.
Mon Feb 04 00:00:00 EST 2019
An Inhibitory Lateral Hypothalamic-Preoptic Circuit Mediates Rapid Arousals from Sleep.
Current biology : CB
Venner A,De Luca R,Sohn LT,Bandaru SS,Verstegen AMJ,Arrigoni E,Fuller PM
A10262 was used in Immunohistochemistry to investigate the synaptic drives that regulate the ventrolateral preoptic to control arousal levels in vivo.
Mon Dec 16 00:00:00 EST 2019
Changes in chromatin accessibility ensure robust cell cycle exit in terminally differentiated cells.
PLoS biology
Ma Y,McKay DJ,Buttitta L
A10262 was used in Immunohistochemistry-immunofluorescence to provide evidence that developmentally programmed, temporal changes in chromatin accessibility at a small subset of critical cell cycle genes act to enforce cell cycle exit during terminal differentiation in the Drosophila melanogaster wing.
Sun Sep 01 00:00:00 EDT 2019
Transcriptional control of morphological properties of direction-selective T4/T5 neurons in Drosophila.
Development (Cambridge, England)
Schilling T,Ali AH,Leonhardt A,Borst A,Pujol-Martí J
A10262 was used in Immunohistochemistry-immunofluorescence to help to link structure, function and development in a neuronal type performing a computation that is conserved across vertebrate and invertebrate visual systems.
Tue Jan 29 00:00:00 EST 2019
Paraventricular Thalamus Controls Behavior during Motivational Conflict.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Choi EA,Jean-Richard-Dit-Bressel P,Clifford CWG,McNally GP
A10262 was used in Immunohistochemistry to show a role for the paraventricular thalamus (PVT) in behavioral control during motivational conflict.
Wed Jun 19 00:00:00 EDT 2019
Monensin Sensitive 1 Regulates Dendritic Arborization in Drosophila by Modulating Endocytic Flux.
Frontiers in cell and developmental biology
Harish RK,Tendulkar S,Deivasigamani S,Ratnaparkhi A,Ratnaparkhi GS
A10262 was used in Immunohistochemistry to conduct genetic epistasis experiments, by modulating the activity of Rab5, Rab7, and Rab11 in da neurons, in Mon1 mutants, and demonstrate that the ability of Mon1 to regulate arborization is possibly due to its effect on the recycling pathway.
Thu Oct 01 00:00:00 EDT 2020
Widespread Cell-Specific Prolactin Receptor Expression in Multiple Murine Organs.
Endocrinology
Aoki M,Wartenberg P,Grünewald R,Phillipps HR,Wyatt A,Grattan DR,Boehm U
A10262 was used in Immunohistochemistry to investigate Prlr expression with a single cell resolution, through development of a knock-in mouse strain in which Cre recombinase is expressed together with the long isoform of the Prlr using an internal ribosome entry site. When crossed to a Cre-dependent reporter mouse strain, Cre-mediated recombination will genetically label cells that acutely express the Prlr as well as cells that have transiently expressed the Prlr during development.
Fri Nov 01 00:00:00 EDT 2019
Modulation of burst firing of neurons in nucleus reticularis of the thalamus by GluN2C-containing NMDA receptors.
Molecular pharmacology
Liu J,Shelkar GP,Zhao F,Clausen RP,Dravid SM
A10262 was used in Immunohistochemistry to study the role of GluN2C-containing receptors in the regulation of nRT neurons and suggest GluN2C-selective in vivo targeting of NMDA receptors by AICP.
Mon Jun 03 00:00:00 EDT 2019
Multiplexed calcium imaging of single-synapse activity and astroglial responses in the intact brain.
Neuroscience letters
Reynolds JP,Zheng K,Rusakov DA
A10262 was used in Immunohistochemistry-immunofluorescence to find that, unexpectedly, Ca2+ elevations in the perisynaptic astrocytic regions consistently precede local presynaptic Ca2+ signals during spontaneous brain activity associated with anaesthesia.
Thu Jan 10 00:00:00 EST 2019
Developmental changes in interkinetic nuclear migration dynamics with respect to cell-cycle progression in the mouse cerebral cortex ventricular zone.
The Journal of comparative neurology
Fousse J,Gautier E,Patti D,Dehay C
A10262 was used in Immunohistochemistry to examine the relationship between interkinetic nuclear migration and cell-cycle progression of apical progenitors in the ventricular zone at different stages of mouse cerebral corticogenesis.
Mon Jul 01 00:00:00 EDT 2019
Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogaster.
Life science alliance
Weigelt CM,Hahn O,Arlt K,Gruhn M,Jahn AJ,Eßer J,Werner JA,Klein C,Büschges A,Grönke S,Partridge L
A10262 was used in Immunohistochemistry-immunofluorescence to show that miR-210 is specifically expressed in sensory organs, including photoreceptors.
Fri Feb 01 00:00:00 EST 2019
Genomic Decoding of Neuronal Depolarization by Stimulus-Specific NPAS4 Heterodimers.
Cell
Brigidi GS,Hayes MGB,Delos Santos NP,Hartzell AL,Texari L,Lin PA,Bartlett A,Ecker JR,Benner C,Heinz S,Bloodgood BL
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to show that APs and EPSPs in mouse hippocampal neurons trigger two spatially segregated and molecularly distinct induction mechanisms that lead to the expression of the ITF NPAS4.
Thu Oct 03 00:00:00 EDT 2019
Stress-induced phospho-ubiquitin formation causes parkin degradation.
Scientific reports
Kovalchuke L,Mosharov EV,Levy OA,Greene LA
A10262 was used in Immunocytochemistry-immunoflourescence to determine the mechanisms by which stress decreases parkin protein levels using cultured neuronal cells and the PD-relevant stressor, L-DOPA.
Mon Aug 12 00:00:00 EDT 2019
The landscape of multiscale transcriptomic networks and key regulators in Parkinson's disease.
Nature communications
Wang Q,Zhang Y,Wang M,Song WM,Shen Q,McKenzie A,Choi I,Zhou X,Pan PY,Yue Z,Zhang B
A10262 was used in Immunohistochemistry to develop multiscale gene network models of Parkinson's disease and identify potential key regulators of the disease which require further investigation.
Wed Nov 20 00:00:00 EST 2019
Arx Expression Suppresses Ventralization of the Developing Dorsal Forebrain.
Scientific reports
Lim Y,Cho IT,Shi X,Grinspan JB,Cho G,Golden JA
A10262 was used in Immunohistochemistry to suggest a link between the control of dorsoventral identity of progenitor cells and the control of their proliferation.
Fri Jan 18 00:00:00 EST 2019
TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.
Nature communications
Ivanova EL,Gilet JG,Sulimenko V,Duchon A,Rudolf G,Runge K,Collins SC,Asselin L,Broix L,Drouot N,Tilly P,Nusbaum P,Vincent A,Magnant W,Skory V,Birling MC,Pavlovic G,Godin JD,Yalcin B,Hérault Y,Dráber P,Chelly J,Hinckelmann MV
A10262 was used in Immunohistochemistry to study the effect of missense TUBG1 variants on cortical development.
Mon May 13 00:00:00 EDT 2019
Differential regulation of the Drosophila sleep homeostat by circadian and arousal inputs.
eLife
Ni JD,Gurav AS,Liu W,Ogunmowo TH,Hackbart H,Elsheikh A,Verdegaal AA,Montell C
A10262 was used in Immunocytochemistry to propose that dFB neurons integrate synaptic inputs from distinct sets of upstream sleep-promoting circadian clock neurons, and arousal neurons.
Tue Feb 05 00:00:00 EST 2019
Loss of Neurofascin-186 Disrupts Alignment of AnkyrinG Relative to Its Binding Partners in the Axon Initial Segment.
Frontiers in cellular neuroscience
Alpizar SA,Baker AL,Gulledge AT,Hoppa MB
A10262 was used in Immunocytochemistry-immunoflourescence to establish that the regulation of AnkG and sodium channel accumulation within the axon initial segment can happen independently to each other so may be mediated by other binding partners.
Thu Oct 01 00:00:00 EDT 2020
GIPC proteins negatively modulate Plexind1 signaling during vascular development.
eLife
Carretero-Ortega J,Chhangawala Z,Hunt S,Narvaez C,Menéndez-González J,Gay CM,Zygmunt T,Li X,Torres-Vázquez J
A10262 was used in Immunohistochemistry-immunofluorescence to identify the role of GIPC as a negative modulator of antiangiogenic PLXND1 signaling and its trafficking shapes vascular development.
Fri May 03 00:00:00 EDT 2019
Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury.
Cell reports
Takeoka A,Arber S
A10262 was used in Immunohistochemistry to show that proprioceptive afferents interacting with local spinal circuits serve as a continued driving force to initiate and maintain locomotor output after injury.
Tue Apr 02 00:00:00 EDT 2019
Stoichiometric optimization of Gata4, Hand2, Mef2c, and Tbx5 expression for contractile cardiomyocyte reprogramming.
Scientific reports
Zhang Z,Zhang W,Nam YJ
A10262 was used in Immunocytochemistry to demonstrate the stoichiometric requirement of GHMT expression for structural and functional progresses of cardiomyocyte reprogramming.
Fri Oct 18 00:00:00 EDT 2019
Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo.
The Journal of biological chemistry
Lomash RM,Petralia RS,Holtzclaw LA,Tsuda MC,Wang YX,Badger JD,Cameron HA,Youle RJ,Roche KW
A10262 was used in Immunocytochemistry-immunoflourescence to conclude that the brain-specific dynamin GTPase neurolastin exhibits stress-responsive localization to mitochondria and is required for proper mitochondrial morphology.
Fri Jul 26 00:00:00 EDT 2019
Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis.
Cell stem cell
Wang J,Cui Y,Yu Z,Wang W,Cheng X,Ji W,Guo S,Zhou Q,Wu N,Chen Y,Chen Y,Song X,Jiang H,Wang Y,Lan Y,Zhou B,Mao L,Li J,Yang H,Guo W,Yang X
A10262 was used in Immunohistochemistry to delineate how the brain endothelium maintains lactate homeostasis and contributes to adult hippocampal neurogenesis and cognitive functions.
Thu Dec 05 00:00:00 EST 2019
Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses.
Cell reports
Iannielli A,Ugolini GS,Cordiglieri C,Bido S,Rubio A,Colasante G,Valtorta M,Cabassi T,Rasponi M,Broccoli V
A10262 was used in Immunocytochemistry-immunofluorescence to dissect the mitochondrial dysfunctions associated with a genetic form of Parkinson's disease (PD) with OPA1 mutations.
Tue Dec 24 00:00:00 EST 2019
A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours.
Nature communications
Fu R,Han CF,Ni T,Di L,Liu LJ,Lv WC,Bi YR,Jiang N,He Y,Li HM,Wang S,Xie H,Chen BA,Wang XS,Weiss SJ,Lu T,Guo QL,Wu ZQ
A10262 was used in Immunohistochemistry to identify the ZEB1/p53 axis as a stroma-specific signaling pathway that promotes mammary epithelial tumours.
Fri Jul 19 00:00:00 EDT 2019
Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron.
eLife
Zhang X,Coates K,Dacks A,Günay C,Lauritzen JS,Li F,Calle-Schuler SA,Bock D,Gaudry Q
A10262 was used in Immunohistochemistry to demonstrate that antennal lobe derived inhibition arises from local GABAergic inputs and acts as a means of gain control on branch-specific inputs that the CSDns receive within the lateral horn.
Tue Jul 02 00:00:00 EDT 2019
Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury.
Cellular and molecular gastroenterology and hepatology
Jones JC,Brindley CD,Elder NH,Myers MG,Rajala MW,Dekaney CM,McNamee EN,Frey MR,Shroyer NF,Dempsey PJ
A10262 was used in Immunohistochemistry-immunofluorescence to show that Defa4Cre-expressing Paneth cells possess cellular plasticity, can dedifferentiate into multipotent stem cells upon Notch activation, and can contribute to intestinal regeneration in an acute injury model.
Tue Jun 04 00:00:00 EDT 2019
Reduced SERCA Function Preferentially Affects Wnt Signaling by Retaining E-Cadherin in the Endoplasmic Reticulum.
Cell reports
Suisse A,Treisman JE
A10262 was used in Immunohistochemistry-immunofluorescence to show that Wnt signaling is more sensitive to changes in calcium levels than the Notch and Hippo pathways, potentially complicating the use of calcium pump inhibitors as cancer therapeutics.
Tue Jan 08 00:00:00 EST 2019
Critical role for Piccolo in synaptic vesicle retrieval.
eLife
Ackermann F,Schink KO,Bruns C,Izsvák Z,Hamra FK,Rosenmund C,Garner CC
A10262 was used in Immunocytochemistry to study the synaptic function of Piccolo in rats.
Fri May 10 00:00:00 EDT 2019
Vps8 overexpression inhibits HOPS-dependent trafficking routes by outcompeting Vps41/Lt.
eLife
Lőrincz P,Kenéz LA,Tóth S,Kiss V,Varga Á,Csizmadia T,Simon-Vecsei Z,Juhász G
A10262 was used in Immunohistochemistry-immunofluorescence to show that Vps8 overexpression inhibits HOPS-dependent trafficking routes including late endosome maturation.
Thu Jun 13 00:00:00 EDT 2019
Neurotransmitter identity is acquired in a lineage-restricted manner in the Drosophila CNS.
eLife
Lacin H,Chen HM,Long X,Singer RH,Lee T,Truman JW
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to find that the acetylcholine specific gene ChAT is transcribed in many glutamatergic and GABAergic neurons, but these transcripts typically do not leave the nucleus and are not translated.
Tue Mar 26 00:00:00 EDT 2019
Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis.
Cell
Hilgendorf KI,Johnson CT,Mezger A,Rice SL,Norris AM,Demeter J,Greenleaf WJ,Reiter JF,Kopinke D,Jackson PK
A10262 was used in Immunocytochemistry to investigate whether preadipocytes use their cilia to sense and respond to external cues to remodel white adipose tissue.
Wed Nov 27 00:00:00 EST 2019
Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD.
Nature communications
Yuva-Aydemir Y,Almeida S,Krishnan G,Gendron TF,Gao FB
A10262 was used in Immunocytochemistry to describe a Drosophila model in which poly(GR) expression in adult neurons causes axonal and locomotor defects and premature death without apparent TDP-43 pathology.
Fri Nov 29 00:00:00 EST 2019
Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut.
Nature communications
Patel PH,Pénalva C,Kardorff M,Roca M,Pavlović B,Thiel A,Teleman AA,Edgar BA
A10262 was used in Immunohistochemistry to show that p38 signalling is activated in adult Drosophila midgut enterocytes in response to diverse stresses including pathogenic bacterial infection and chemical and mechanical insult.
Wed Sep 25 00:00:00 EDT 2019
Synapse-specific opioid modulation of thalamo-cortico-striatal circuits.
eLife
Birdsong WT,Jongbloets BC,Engeln KA,Wang D,Scherrer G,Mao T
A10262 was used in Immunohistochemistry to suggest that opioid effects on pain and reward may be shaped by the relative selectivity of opioid drugs to the specific circuit components.
Fri May 17 00:00:00 EDT 2019
The WT1-like transcription factor Klumpfuss maintains lineage commitment of enterocyte progenitors in the Drosophila intestine.
Nature communications
Korzelius J,Azami S,Ronnen-Oron T,Koch P,Baldauf M,Meier E,Rodriguez-Fernandez IA,Groth M,Sousa-Victor P,Jasper H
A10262 was used in Immunohistochemistry to show transcription factor Klumpfuss can suppress the action of proneural gene Scute to influence enteroendocrine fate.
Wed Sep 11 00:00:00 EDT 2019
A synaptic threshold mechanism for computing escape decisions.
Nature
Evans DA,Stempel AV,Vale R,Ruehle S,Lefler Y,Branco T
A10262 was used in Immunohistochemistry to show that dPAG glutamatergic neurons compute escape decisions and escape vigour using a synaptic mechanism to threshold threat information received from the mSC.
Fri Jun 01 00:00:00 EDT 2018
Thalamic dual control of sleep and wakefulness.
Nature neuroscience
Gent TC,Bandarabadi M,Herrera CG,Adamantidis AR
A10262 was used in Immunohistochemistry to show that spontaneous firing of centromedial thalamus neurons in mice is phase-advanced to global cortical active states and NREM-wake transitions.
Sun Jul 01 00:00:00 EDT 2018
Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons.
The Journal of clinical investigation
Steinkellner T,Zell V,Farino ZJ,Sonders MS,Villeneuve M,Freyberg RJ,Przedborski S,Lu W,Freyberg Z,Hnasko TS
A10262 was used in Immunohistochemistry to suggest that the balance of VGLUT2 expression is a crucial determinant of DA neuron survival.
Thu Feb 01 00:00:00 EST 2018
Vascular Compartmentalization of Functional Hyperemia from the Synapse to the Pia.
Neuron
Rungta RL,Chaigneau E,Osmanski BF,Charpak S
A10262 was used in Immunohistochemistry to study the spatial-temporal dynamics of functional hyperemia.
Wed Jul 25 00:00:00 EDT 2018
Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition.
The EMBO journal
Richter MC,Ludewig S,Winschel A,Abel T,Bold C,Salzburger LR,Klein S,Han K,Weyer SW,Fritz AK,Laube B,Wolfer DP,Buchholz CJ,Korte M,Müller UC
A10262 was used in Western Blotting to study the roles of amyloid precursor protein α and Β fragments.
Fri Jun 01 00:00:00 EDT 2018
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch.
Proceedings of the National Academy of Sciences of the United States of America
Emrick JJ,Mathur A,Wei J,Gracheva EO,Gronert K,Rosenblum MD,Julius D
A10262 was used in Immunohistochemistry to study the pathophysiology of itch in in atopic dermatitis.
Tue Dec 18 00:00:00 EST 2018
Gene Therapy via Trans-Splicing for LMNA-Related Congenital Muscular Dystrophy.
Molecular therapy. Nucleic acids
Azibani F,Brull A,Arandel L,Beuvin M,Nelson I,Jollet A,Ziat E,Prudhon B,Benkhelifa-Ziyyat S,Bitoun M,Lorain S,Bonne G,Bertrand AT
A10262 was used in Immunohistochemistry to assess the potential of Lmna-mRNA repair by spliceosome-mediated RNA trans-splicing as a therapeutic approach for LMNA-related congenital muscular dystrophy.
Fri Mar 02 00:00:00 EST 2018
ANKRD11 associated with intellectual disability and autism regulates dendrite differentiation via the BDNF/TrkB signaling pathway.
Neurobiology of disease
Ka M,Kim WY
A10262 was used in Immunohistochemistry to study the neurological role of ANKRD11 during brain development.
Thu Mar 01 00:00:00 EST 2018
Diet regulates membrane extension and survival of niche escort cells for germline homeostasis via insulin signaling.
Development (Cambridge, England)
Su YH,Rastegri E,Kao SH,Lai CM,Lin KY,Liao HY,Wang MH,Hsu HJ
A10262 was used in Immunohistochemistry-immunofluorescence to conclude that dietary cues stimulate insulin signaling in the niche to regulate escort cell cellular structure, probably via Fax-dependent cytoskeleton remodeling.
Thu Apr 05 00:00:00 EDT 2018
Bsx controls pineal complex development.
Development (Cambridge, England)
Schredelseker T,Driever W
A10262 was used in Immunohistochemistry to identify the differentiation of multiple cell types in the zebrafish pineal complex is due to the brain-specific homeobox gene.
Mon Jul 09 00:00:00 EDT 2018
Basolateral Amygdala Neurons Maintain Aversive Emotional Salience.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sengupta A,Yau JOY,Jean-Richard-Dit-Bressel P,Liu Y,Millan EZ,Power JM,McNally GP
A10262 was used in Immunohistochemistry to show that brief optogenetic inhibition of BLA neurons around moments of aversive reinforcement or nonreinforcement causes reductions in the salience of conditioned stimuli, rendering these stimuli less able to be learned about and less able to control fear or safety behaviors.
Wed Mar 21 00:00:00 EDT 2018
Task Division within the Prefrontal Cortex: Distinct Neuron Populations Selectively Control Different Aspects of Aggressive Behavior via the Hypothalamus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Biro L,Sipos E,Bruzsik B,Farkas I,Zelena D,Balazsfi D,Toth M,Haller J
A10262 was used in Immunohistochemistry-immunofluorescence to suggest a direct prefrontal control over the hypothalamus, which is involved in the modulation of quantitative and qualitative aspects of aggressive behavior through distinct prefrontohypothalamic projections.
Wed Apr 25 00:00:00 EDT 2018
A Novel Short Isoform of Cytosolic PSD-95 Interactor (Cypin) Regulates Neuronal Development.
Molecular neurobiology
Patel MV,Swiatkowski P,Kwon M,Rodriguez AR,Campagno K,Firestein BL
A10262 was used in Western Blotting to conclude that cypin and cypinS play distinct roles in neuronal development.
Wed Aug 01 00:00:00 EDT 2018
The Drosophila Epidermal Growth Factor Receptor does not act in the nucleus.
Journal of cell science
Courgeon M,He DQ,Liu HH,Legent K,Treisman JE
A10262 was used in Immunohistochemistry-immunofluorescence to show that, when expressed at physiological levels, the cytoplasmic domain of the Drosophila EGFR does not have access to the nucleus.
Thu Sep 20 00:00:00 EDT 2018
Region-specific Expression of NMDA Receptor GluN2C Subunit in Parvalbumin-Positive Neurons and Astrocytes: Analysis of GluN2C Expression using a Novel Reporter Model.
Neuroscience
Ravikrishnan A,Gandhi PJ,Shelkar GP,Liu J,Pavuluri R,Dravid SM
A10262 was used in Immunohistochemistry to find that a previous GluN2C Β-gal reporter model excluded expression from PV-neurons and certain thalamic nuclei but exhibited expression in the retrosplenial cortex.
Fri Jun 01 00:00:00 EDT 2018
A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices.
Cell reports
Minamisawa G,Kwon SE,Chevée M,Brown SP,O'Connor DH
A10262 was used in Immunohistochemistry to show that a non-canonical feedback circuit, originating in layer 4 of S2, rapidly modulates early tactile processing.
Tue May 29 00:00:00 EDT 2018
Stonewall and Brickwall: Two Partially Redundant Determinants Required for the Maintenance of Female Germline in Drosophila.
G3 (Bethesda, Md.)
Shukla V,Dhiman N,Nayak P,Dahanukar N,Deshpande G,Ratnaparkhi GS
A10262 was used in Immunohistochemistry-immunofluorescence to show that brwl and stwl likely share a common MADF-BESS ancestor and they are expressed in overlapping spatiotemporal domains to ensure robust development of the female germline.
Thu May 31 00:00:00 EDT 2018
MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells.
Cell reports
Kawabata Galbraith K,Fujishima K,Mizuno H,Lee SJ,Uemura T,Sakimura K,Mishina M,Watanabe N,Kengaku M
A10262 was used in Immunocytochemistry to show that MTSS1 plays a dual role as a formin inhibitor and ARP2/3 activator in dendritic filopodia therefore determining final neuronal morphology.
Tue Jul 03 00:00:00 EDT 2018
MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells.
Cell reports
Kawabata Galbraith K,Fujishima K,Mizuno H,Lee SJ,Uemura T,Sakimura K,Mishina M,Watanabe N,Kengaku M
A10262 was used in Immunocytochemistry to show that MTSS1 plays a dual role as a formin inhibitor and ARP2/3 activator in dendritic filopodia therefore determining final neuronal morphology.
Tue Jul 03 00:00:00 EDT 2018
A Statistically Representative Atlas for Mapping Neuronal Circuits in the Drosophila Adult Brain.
Frontiers in neuroinformatics
Arganda-Carreras I,Manoliu T,Mazuras N,Schulze F,Iglesias JE,Bühler K,Jenett A,Rouyer F,Andrey P
A10262 was used in Immunohistochemistry-immunofluorescence to evaluate the performance of different strategies for building adult Drosophila brain templates and atlases.
Tue Sep 29 00:00:00 EDT 2020
Post-crossing segment of dI1 commissural axons forms collateral branches to motor neurons in the developing spinal cord.
The Journal of comparative neurology
Kaneyama T,Shirasaki R
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to extend ing adjacent to the floor plate without entering nearby motor columns.
Wed Aug 15 00:00:00 EDT 2018
The Central Amygdala Corticotropin-releasing hormone (CRH) Neurons Modulation of Anxiety-like Behavior and Hippocampus-dependent Memory in Mice.
Neuroscience
Paretkar T,Dimitrov E
A10262 was used in Immunohistochemistry to investigate the role of corticotropin-releasing hormone neurons in the central amygdala.
Mon Oct 15 00:00:00 EDT 2018
Dietary polyphenols enhance optogenetic recall of fear memory in hippocampal dentate gyrus granule neuron subpopulations.
Communications biology
Smith C,Frolinger T,Brathwaite J,Sims S,Pasinetti GM
A10262 was used in Immunohistochemistry to report the effect of polyphenols in promoting memory funtion.
Sat Jan 11 00:00:00 EST 2020
Sugar Promotes Feeding in Flies via the Serine Protease Homolog scarface.
Cell reports
Prasad N,Hens K
A10262 was used in Immunohistochemistry to determine that the Scarface serine protease homolog mediates the hedonic control of feeding in Drosophila.
Tue Sep 18 00:00:00 EDT 2018
Blocking TNFα-driven astrocyte purinergic signaling restores normal synaptic activity during epileptogenesis.
Glia
Nikolic L,Shen W,Nobili P,Virenque A,Ulmann L,Audinat E
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to indicate that targeting the coupling of TNFα with astrocyte purinergic signaling may be a therapeutic strategy for reducing glial glutamate release and normalizing synaptic activity in epilepsy.
Sat Dec 01 00:00:00 EST 2018
Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum.
Nature communications
Faget L,Zell V,Souter E,McPherson A,Ressler R,Gutierrez-Reed N,Yoo JH,Dulcis D,Hnasko TS
A10262 was used in Immunohistochemistry to findings highlight cell-type and projection-target specific roles for VP neurons in behavioral reinforcement, dysregulation of which could contribute to the emergence of negative symptoms associated with drug addiction and other neuropsychiatric disease.
Tue Feb 27 00:00:00 EST 2018
Homeostatic circuits selectively gate food cue responses in insular cortex.
Nature
Livneh Y,Ramesh RN,Burgess CR,Levandowski KM,Madara JC,Fenselau H,Goldey GJ,Diaz VE,Jikomes N,Resch JM,Lowell BB,Andermann ML
A10262 was used in Immunohistochemistry to use circuit mapping and pathway-specific manipulations to uncover a pathway from AgRP neurons to the insular cortex.
Thu Jun 29 00:00:00 EDT 2017
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea.
Nature
Nonomura K,Woo SH,Chang RB,Gillich A,Qiu Z,Francisco AG,Ranade SS,Liberles SD,Patapoutian A
A10262 was used in immunohistochemistry - frozen section to report that global and sensory neuron-specific ablation of the mechanically activated ion channel Piezo2 causes respiratory distress and death in newborn mice
Thu Jan 12 00:00:00 EST 2017
Life-Long Genetic and Functional Access to Neural Circuits Using Self-Inactivating Rabies Virus.
Cell
Ciabatti E,González-Rueda A,Mariotti L,Morgese F,Tripodi M
A10262 was used in Immunohistochemistry to develop a self-inactivating ΔG-rabies virus that transcriptionally disappears from the infected neurons while leaving permanent genetic access to the traced network.
Thu Jul 13 00:00:00 EDT 2017
Prefrontal cortical control of a brainstem social behavior circuit.
Nature neuroscience
Franklin TB,Silva BA,Perova Z,Marrone L,Masferrer ME,Zhan Y,Kaplan A,Greetham L,Verrechia V,Halman A,Pagella S,Vyssotski AL,Illarionova A,Grinevich V,Branco T,Gross CT
A10262 was used in immunohistochemistry to analyze behavioral adaptation to social defeat in mice and reveal a critical contribution of neural projections from the medial prefrontal cortex to the dorsal periaqueductal gray
Wed Feb 01 00:00:00 EST 2017
Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior.
Nature neuroscience
Jung EM,Moffat JJ,Liu J,Dravid SM,Gurumurthy CB,Kim WY
A10262 was used in Immunohistochemistry to demonstrate a critical role for Arid1b in interneuron development and behaviour and provide insight into the pathogenesis of autism spectrum disorder and intellectual disability.
Fri Dec 01 00:00:00 EST 2017
Gsα deficiency in the dorsomedial hypothalamus underlies obesity associated with Gsα mutations.
The Journal of clinical investigation
Chen M,Shrestha YB,Podyma B,Cui Z,Naglieri B,Sun H,Ho T,Wilson EA,Li YQ,Gavrilova O,Weinstein LS
A10262 was used in Immunohistochemistry-immunofluorescence to show that Gsα imprinting in the dorsomedial hypothalamus underlies the parent-of-origin metabolic phenotype that results from Gsα mutations.
Wed Feb 01 00:00:00 EST 2017
Serotonergic Projections Govern Postnatal Neuroblast Migration.
Neuron
García-González D,Khodosevich K,Watanabe Y,Rollenhagen A,Lübke JHR,Monyer H
A10262 was used in Immunohistochemistry-immunofluorescence to identify a serotonergic mechanism that governs migration of postnatally generated neurons in the mouse brain.
Wed May 03 00:00:00 EDT 2017
Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material.
Neuron
Ryglewski S,Vonhoff F,Scheckel K,Duch C
A10262 was used in Immunohistochemistry to show that synaptic input locally directs dendrite growth but intra-neuronal dendrite redistributions limit morphological variability.
Wed Feb 08 00:00:00 EST 2017
Axonal Endoplasmic Reticulum Ca2+ Content Controls Release Probability in CNS Nerve Terminals.
Neuron
de Juan-Sanz J,Holt GT,Schreiter ER,de Juan F,Kim DS,Ryan TA
A10262 was used in Immunocytochemistry to determine the role of the endoplasmic reticulum Ca2+ in neuronal disease.
Wed Feb 22 00:00:00 EST 2017
Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors.
Neuron
Kim J,Zhang X,Muralidhar S,LeBlanc SA,Tonegawa S
A10262 was used in Immunohistochemistry-immunofluorescence to reveal genetically defined neural circuits in the amygdala that promote and suppress appetitive behaviors analogous to the direct and indirect pathways of the basal ganglia.
Wed Mar 22 00:00:00 EDT 2017
Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms.
Developmental cell
Ma X,Zhu X,Han Y,Story B,Do T,Song X,Wang S,Zhang Y,Blanchette M,Gogol M,Hall K,Peak A,Anoja P,Xie T
A10262 was used in Immunohistochemistry to report that Aub promotes GSC self-renewal and GSC progeny differentiation.
Mon Apr 24 00:00:00 EDT 2017
A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size.
Developmental cell
Zhang P,Pei C,Wang X,Xiang J,Sun BF,Cheng Y,Qi X,Marchetti M,Xu JW,Sun YP,Edgar BA,Yuan Z
A10262 was used in Immunohistochemistry to demonstrate that interaction between Drosophila E2F1 and Sd disrupts Yki/Sd complex formation and thereby suppresses Yki target gene expression.
Mon Dec 04 00:00:00 EST 2017
Homozygous Truncating Variants in TBC1D23 Cause Pontocerebellar Hypoplasia and Alter Cortical Development.
American journal of human genetics
Ivanova EL,Mau-Them FT,Riazuddin S,Kahrizi K,Laugel V,Schaefer E,de Saint Martin A,Runge K,Iqbal Z,Spitz MA,Laura M,Drouot N,Gérard B,Deleuze JF,de Brouwer APM,Razzaq A,Dollfus H,Assir MZ,Nitchké P,Hinckelmann MV,Ropers H,Riazuddin S,Najmabadi H,van Bokhoven H,Chelly J
A10262 was used in Immunocytochemistry-immunoflourescence to propose that mutations in TBC1D23 are responsible for a form of PCH with small, normally proportioned cerebellum and should be screened in individuals with syndromic pontocereballar hypoplasia.
Thu Sep 07 00:00:00 EDT 2017
Stem Cell-Intrinsic, Seven-up-Triggered Temporal Factor Gradients Diversify Intermediate Neural Progenitors.
Current biology : CB
Ren Q,Yang CP,Liu Z,Sugino K,Mok K,He Y,Ito M,Nern A,Otsuna H,Lee T
Mon May 08 00:00:00 EDT 2017
Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development.
Glia
O'Sullivan ML,Puñal VM,Kerstein PC,Brzezinski JA,Glaser T,Wright KM,Kay JN
A10262 was used in Immunohistochemistry to study the factors controlling vascularisation of the retina.
Sun Oct 01 00:00:00 EDT 2017
Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types.
Development (Cambridge, England)
Villani R,Hodgson S,Legrand J,Greaney J,Wong HY,Pichol-Thievend C,Adolphe C,Wainwight B,Francois M,Khosrotehrani K
A10262 was used in Immunofluorescence in immunohistochemistry on frozen tissues to conclude that SOX18 acts as a mesenchymal molecular switch necessary for the formation and function of the dermal papilla in all hair types.
Mon May 15 00:00:00 EDT 2017
After Nerve Injury, Lineage Tracing Shows That Myelin and Remak Schwann Cells Elongate Extensively and Branch to Form Repair Schwann Cells, Which Shorten Radically on Remyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gomez-Sanchez JA,Pilch KS,van der Lans M,Fazal SV,Benito C,Wagstaff LJ,Mirsky R,Jessen KR
A10262 was used in Immunocytochemistry-immunoflourescence to show that the generation of these repair-supportive Schwann cells involves an extensive cellular elongation and branching, often to form long, parallel processes.
Wed Sep 13 00:00:00 EDT 2017
Paraventricular Thalamus Balances Danger and Reward.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Choi EA,McNally GP
A10262 was used in Immunohistochemistry to show a key role for the rat paraventricular nucleus of the thalamus (PVT), a nucleus of the dorsal midline thalamus, in this interaction.
Wed Mar 15 00:00:00 EDT 2017
A Unique "Angiotensin-Sensitive" Neuronal Population Coordinates Neuroendocrine, Cardiovascular, and Behavioral Responses to Stress.
The Journal of neuroscience : the official journal of the Society for Neuroscience
de Kloet AD,Wang L,Pitra S,Hiller H,Smith JA,Tan Y,Nguyen D,Cahill KM,Sumners C,Stern JE,Krause EG
A10262 was used in Immunohistochemistry-immunofluorescence to establish that a distinct population of angiotensin-sensitive neurons is integral to coordinate stress responses so can be implicated as a target for relief of these diseases.
Wed Mar 29 00:00:00 EDT 2017
Imaging Voltage in Genetically Defined Neuronal Subpopulations with a Cre Recombinase-Targeted Hybrid Voltage Sensor.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Bayguinov PO,Ma Y,Gao Y,Zhao X,Jackson MB
A10262 was used in Immunohistochemistry to present a line that expresses a hybrid optical voltage sensor which will allow for the study of the emergent properties of neural circuits and permit experimental tests of the roles of specific types of neurons in complex circuit activity.
Wed Sep 20 00:00:00 EDT 2017
Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pan PY,Li X,Wang J,Powell J,Wang Q,Zhang Y,Chen Z,Wicinski B,Hof P,Ryan TA,Yue Z
A10262 was used in Immunocytochemistry-immunoflourescence to study the mechanism of nigral vulnerability by LRRK2 in Parkinson's disease.
Wed Nov 22 00:00:00 EST 2017
Regulation of Hippocampal 5-HT Release by P2X7 Receptors in Response to Optogenetic Stimulation of Median Raphe Terminals of Mice.
Frontiers in molecular neuroscience
Gölöncsér F,Baranyi M,Balázsfi D,Demeter K,Haller J,Freund TFF,Zelena D,Sperlágh B
A10262 was used in Immunohistochemistry to study the mechanism of median raphe region (MRR) modulation by P2rx7.
Sat Jan 29 00:00:00 EST 2022
Contribution of amygdala CRF neurons to chronic pain.
Experimental neurology
Andreoli M,Marketkar T,Dimitrov E
A10262 was used in Immunohistochemistry to demonstrate that the continuous activity of CRF neurons brought about by persistent pain leads to impaired SIA, which is a symptom of dysregulation of descending pain inhibition.
Fri Dec 01 00:00:00 EST 2017
Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT3 receptor expression via acetate production.
American journal of physiology. Gastrointestinal and liver physiology
Bhattarai Y,Schmidt BA,Linden DR,Larson ED,Grover M,Beyder A,Farrugia G,Kashyap PC
A10262 was used in Immunohistochemistry to find that gut microbiota alters serotonin (5-HT)-evoked intestinal secretion in a 5-HT3 receptor-dependent mechanism and gut microbiota metabolite acetate alters 5-HT3 receptor expression in colonoids.
Sat Jul 01 00:00:00 EDT 2017
VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.
Experimental cell research
Jessen TN,Jessen JR
A10262 was used in Western Blotting to dissect the molecular underpinnings of how VANGL2 regulates MMP activity and cell adhesion to the ECM.
Fri Dec 15 00:00:00 EST 2017
Anatomical and molecular characterization of dopamine D1 receptor-expressing neurons of the mouse CA1 dorsal hippocampus.
Brain structure & function
Puighermanal E,Cutando L,Boubaker-Vitre J,Honoré E,Longueville S,Hervé D,Valjent E
A10262 was used in immunohistochemistry - frozen section to examine D1 receptor-containing neurons within the CA1 subfield of the dorsal hippocampus
Mon May 01 00:00:00 EDT 2017
Pnrc2 regulates 3'UTR-mediated decay of segmentation clock-associated transcripts during zebrafish segmentation.
Developmental biology
Gallagher TL,Tietz KT,Morrow ZT,McCammon JM,Goldrich ML,Derr NL,Amacher SL
A10262 was used in Immunohistochemistry to show that Pnrc2 promotes 3'UTR-mediated decay of developmentally-regulated segmentation clock transcripts and we uncover an additional post-transcriptional regulatory layer that ensures oscillatory protein expression in the absence of cyclic mRNA decay.
Fri Sep 01 00:00:00 EDT 2017
Synaptic distribution of individually labeled mitral cells in the external plexiform layer of the mouse olfactory bulb.
The Journal of comparative neurology
Matsuno T,Kiyokage E,Toida K
A10262 was used in immunohistochemistry - frozen section to investigate the output regulation of mitral cells
Mon May 01 00:00:00 EDT 2017
Descending projections from the basal forebrain to the orexin neurons in mice.
The Journal of comparative neurology
Agostinelli LJ,Ferrari LL,Mahoney CE,Mochizuki T,Lowell BB,Arrigoni E,Scammell TE
A10262 was used in immunohistochemistry - frozen section to record the pattern of basal forebrain projections to the orexin neurons across multiple basal forebrain regions and neuronal types
Mon May 01 00:00:00 EDT 2017
Structural basis for cholinergic regulation of neural circuits in the mouse olfactory bulb.
The Journal of comparative neurology
Hamamoto M,Kiyokage E,Sohn J,Hioki H,Harada T,Toida K
A10262 was used in immunohistochemistry to investigate cholinergic regulation of the olfactory bulb and examine neural morphology
Wed Feb 15 00:00:00 EST 2017
Hox2 Genes Are Required for Tonotopic Map Precision and Sound Discrimination in the Mouse Auditory Brainstem.
Cell reports
Karmakar K,Narita Y,Fadok J,Ducret S,Loche A,Kitazawa T,Genoud C,Di Meglio T,Thierry R,Bacelo J,Lüthi A,Rijli FM
A10262 was used in Immunohistochemistry to determine the role of Hox factors in tonotopic refinement of connectivity in the mammalian auditory circuit.
Tue Jan 03 00:00:00 EST 2017
Labeling Aversive Memory Trace in Mouse Using a Doxycycline-inducible Expression System.
Bio-protocol
Du J,Koffman EE
A10262 was used in Immunohistochemistry (PFA fixed) to investigate memory tracing in mice.
Fri Oct 20 00:00:00 EDT 2017
Labeling Aversive Memory Trace in Mouse Using a Doxycycline-inducible Expression System.
Bio-protocol
Du J,Koffman EE
A10262 was used in Immunohistochemistry (PFA fixed) to investigate memory tracing in mice.
Fri Oct 20 00:00:00 EDT 2017
Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior.
eLife
Wircer E,Blechman J,Borodovsky N,Tsoory M,Nunes AR,Oliveira RF,Levkowitz G
A10262 was used in immunocytochemistry to investigate the effects of the developmental transcription factor orthopedia on hypothalamic development and function
Tue Jan 17 00:00:00 EST 2017
Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy.
Cell reports
Cho GS,Lee DI,Tampakakis E,Murphy S,Andersen P,Uosaki H,Chelko S,Chakir K,Hong I,Seo K,Chen HV,Chen X,Basso C,Houser SR,Tomaselli GF,O'Rourke B,Judge DP,Kass DA,Kwon C
A10262 was used in Immunohistochemistry to demonstrate that PSC-CMs mature into adult CMs when transplanted into neonatal hearts.
Tue Jan 10 00:00:00 EST 2017
Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth.
Nature communications
Ragni CV,Diguet N,Le Garrec JF,Novotova M,Resende TP,Pop S,Charon N,Guillemot L,Kitasato L,Badouel C,Dufour A,Olivo-Marin JC,Trouvé A,McNeill H,Meilhac SM
A10262 was used in immunohistochemistry to find that that Fat4 modulates Hippo signaling and restricts hearth growth in mice
Mon Feb 27 00:00:00 EST 2017
An optogenetic toolbox for unbiased discovery of functionally connected cells in neural circuits.
Nature communications
Förster D,Dal Maschio M,Laurell E,Baier H
A10262 was used in Immunohistochemistry to report a new genetic toolbox, 'Optobow', which enables simultaneous optogenetic activation of single neurons in zebrafish and measuring the activity of downstream neurons in the network.
Mon Jul 24 00:00:00 EDT 2017
Chromatin organization changes during the establishment and maintenance of the postmitotic state.
Epigenetics & chromatin
Ma Y,Buttitta L
A10262 was used in Immunohistochemistry to study the relationship between chromatin organisation, terminal differentiation and cell cycle exit.
Fri Nov 10 00:00:00 EST 2017
Expression of the novel maternal centrosome assembly factor Wdr8 is required for vertebrate embryonic mitoses.
Nature communications
Inoue D,Stemmer M,Thumberger T,Ruppert T,Bärenz F,Wittbrodt J,Gruss OJ
A10262 was used in immunocytochemistry and western blot to discover Wdr8 as a novel maternally essential protein that is required for centrosome assembly during embryonic mitoses of medaka (Oryzias latipes)
Wed Jan 18 00:00:00 EST 2017
The Protein Encoded by the CCDC170 Breast Cancer Gene Functions to Organize the Golgi-Microtubule Network.
EBioMedicine
Jiang P,Li Y,Poleshko A,Medvedeva V,Baulina N,Zhang Y,Zhou Y,Slater CM,Pellegrin T,Wasserman J,Lindy M,Efimov A,Daly M,Katz RA,Chen X
A10262 was used in Immunocytochemistry to demonstrate that CCDC170 plays an essential role in Golgi-associated MT organization and stabilization, and implicate a mechanism for how perturbations in the CCDC170 gene may contribute to the hallmark changes in cell polarity and motility seen in breast cancer.
Tue Aug 01 00:00:00 EDT 2017
Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration.
Development (Cambridge, England)
Kaslin J,Kroehne V,Ganz J,Hans S,Brand M
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to find that neuroepithelial cells are the predominant stem cell type supporting cerebellar regeneration after injury.
Sat Apr 15 00:00:00 EDT 2017
Transient acidosis while retrieving a fear-related memory enhances its lability.
eLife
Du J,Price MP,Taugher RJ,Grigsby D,Ash JJ,Stark AC,Hossain Saad MZ,Singh K,Mandal J,Wemmie JA,Welsh MJ
A10262 was used in Immunohistochemistry to study transient acidosis as a means to modify aversive memories.
Mon Jun 26 00:00:00 EDT 2017
A specific GABAergic synapse onto oligodendrocyte precursors does not regulate cortical oligodendrogenesis.
Glia
Balia M,Benamer N,Angulo MC
A10262 was used in Immunocytochemistry, Western Blot, Immunohistochemistry to show that, during cortical development, the γ2-mediated interneuron-to-OPC synapses do not play a role in oligodendrogenesis and suggest that these synapses finely tune OPC self-maintenance capacity.
Wed Nov 01 00:00:00 EDT 2017
Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera.
Stem cell reports
Lee SG,Mikhalchenko AE,Yim SH,Lobanov AV,Park JK,Choi KH,Bronson RT,Lee CK,Park TJ,Gladyshev VN
A10262 was used in Immunocytochemistry to report the generation of induced pluripotent stem cells (iPSCs) from naked mole rat (NMR) fibroblasts and their contribution to mouse-NMR chimeric embryos.
Tue Nov 14 00:00:00 EST 2017
Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth.
Stem cell reports
Lim NR,Shohayeb B,Zaytseva O,Mitchell N,Millard SS,Ng DCH,Quinn LM
A10262 was used in Immunohistochemistry to study the role of wd40-repeat protein 62 (WDR62) in the growth of major brain lineages.
Tue Jul 11 00:00:00 EDT 2017
Expansion microscopy with conventional antibodies and fluorescent proteins.
Nature methods
Chozinski TJ,Halpern AR,Okawa H,Kim HJ,Tremel GJ,Wong RO,Vaughan JC
A10262 was used in Immunocytochemistry to develop and characterized new methods for linking fluorophores to the polymer that now enable expansion microscopy with conventional fluorescently labeled antibodies and fluorescent proteins.
Wed Jun 01 00:00:00 EDT 2016
Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency.
Immunity
Terashima A,Okamoto K,Nakashima T,Akira S,Ikuta K,Takayanagi H
A10262 was used in Western Blotting to study how lymphoma persists after the accelerated sepsis induced-lymphocyte apoptosis subsides.
Tue Jun 21 00:00:00 EDT 2016
Antagonistic negative and positive neurons of the basolateral amygdala.
Nature neuroscience
Kim J,Pignatelli M,Xu S,Itohara S,Tonegawa S
A10262 was used in immunohistochemistry - free floating to identify two genetically distinct, spatially segregated populations of excitatory neurons in the basolateral amygdala that participate in valence-specific behaviors
Thu Dec 01 00:00:00 EST 2016
Sex-specific regulation of Lgr3 in Drosophila neurons.
Proceedings of the National Academy of Sciences of the United States of America
Meissner GW,Luo SD,Dias BG,Texada MJ,Baker BS
A10262 was used in immunohistochemistry to analyze sex-specific regulation of Lgr3 in Drosophila neurons
Tue Mar 01 00:00:00 EST 2016
Glial Cell Calcium Signaling Mediates Capillary Regulation of Blood Flow in the Retina.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Biesecker KR,Srienc AI,Shimoda AM,Agarwal A,Bergles DE,Kofuji P,Newman EA
A10262 was used in immunohistochemistry to report that glial calcium signaling modulates capillary but not arteriole blood flow
Wed Sep 07 00:00:00 EDT 2016
Native Piezo2 Interactomics Identifies Pericentrin as a Novel Regulator of Piezo2 in Somatosensory Neurons.
Journal of proteome research
Narayanan P,Sondermann J,Rouwette T,Karaca S,Urlaub H,Mitkovski M,Gomez-Varela D,Schmidt M
A10262 was used in immunohistochemistry - frozen section to identify pericentrin as a novel regulator of piezo2 in somatosensory neurons by native piezo2 interactomics
Fri Aug 05 00:00:00 EDT 2016
Angiotensin Type-2 Receptors Influence the Activity of Vasopressin Neurons in the Paraventricular Nucleus of the Hypothalamus in Male Mice.
Endocrinology
de Kloet AD,Pitra S,Wang L,Hiller H,Pioquinto DJ,Smith JA,Sumners C,Stern JE,Krause EG
A10262 was used in immunohistochemistry - frozen section to determine how influence is made regarding activity of vasopressin neurons in the paraventricular nucleus of the hypothalamus in male mice by angiotensin type-2 receptors
Mon Aug 01 00:00:00 EDT 2016
Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system.
Brain structure & function
de Kloet AD,Wang L,Ludin JA,Smith JA,Pioquinto DJ,Hiller H,Steckelings UM,Scheuer DA,Sumners C,Krause EG
A10262 was used in Immunohistochemistry to examine angiotensin type-2 receptor distribution in the central nervous system.
Tue Mar 01 00:00:00 EST 2016
Differential Nanos 2 protein stability results in selective germ cell accumulation in the sea urchin.
Developmental biology
Oulhen N,Wessel GM
A10262 was used in immunocytochemistry to study Nanos localization and stability in the sea urchin
Sat Oct 01 00:00:00 EDT 2016
Differentiation potential of individual olfactory c-Kit+ progenitors determined via multicolor lineage tracing.
Developmental neurobiology
Goss GM,Chaudhari N,Hare JM,Nwojo R,Seidler B,Saur D,Goldstein BJ
A10262 was used in immunohistochemistry - frozen section to assess the differentiation potential of individual globose cells
Tue Mar 01 00:00:00 EST 2016
Unsupervised lineage-based characterization of primate precursors reveals high proliferative and morphological diversity in the OSVZ.
The Journal of comparative neurology
Pfeiffer M,Betizeau M,Waltispurger J,Pfister SS,Douglas RJ,Kennedy H,Dehay C
A10262 was used in immunohistochemistry - frozen section to develop a method of unbiased lineage analysis that automatically identifies cell types
Mon Feb 15 00:00:00 EST 2016
Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks.
Nature communications
González JA,Iordanidou P,Strom M,Adamantidis A,Burdakov D
A10262 was used in immunohistochemistry to study orexin networks and hypothalamici MCH for awakek dynamics and brain-wide direct inputs
Fri Apr 22 00:00:00 EDT 2016
Lineage mapping identifies molecular and architectural similarities between the larval and adult Drosophila central nervous system.
eLife
Lacin H,Truman JW
A10262 was used in immunohistochemistry to study molecular and architectural differences by lineage m apping between larval and adult drosophila central nervous system
Tue Mar 15 00:00:00 EDT 2016
Apoptotic Activity of MeCP2 Is Enhanced by C-Terminal Truncating Mutations.
PloS one
Williams AA,Mehler VJ,Mueller C,Vonhoff F,White R,Duch C
A10262 was used in immunocytochemistry study the function of the MeCP2 C-terminus
Mon Jul 31 00:00:00 EDT 2017
Functional integration of a serotonergic neuron in the Drosophila antennal lobe.
eLife
Zhang X,Gaudry Q
A10262 was used in immunohistochemistry clarify how serotonergic neurons respond to odor stimulation and integrate synaptically into local circuits
Tue Aug 30 00:00:00 EDT 2016
Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit.
eLife
Hatzold J,Beleggia F,Herzig H,Altmüller J,Nürnberg P,Bloch W,Wollnik B,Hammerschmidt M
A10262 was used in Immunohistochemistry-immunofluorescence on wholemounted tissues to identify hypotonic stress as a previously unrecognized contributor to tumor development and establish a novel paradigm of tumor suppression.
Mon May 30 00:00:00 EDT 2016
Growth hormone biases amygdala network activation after fear learning.
Translational psychiatry
Gisabella B,Farah S,Peng X,Burgos-Robles A,Lim SH,Goosens KA
A10262 was used in immunohistochemistry - frozen section to study how growth hormone affects fear memory formation
Tue Nov 29 00:00:00 EST 2016
A neural basis for melanocortin-4 receptor-regulated appetite.
Nature neuroscience
Garfield AS,Li C,Madara JC,Shah BP,Webber E,Steger JS,Campbell JN,Gavrilova O,Lee CE,Olson DP,Elmquist JK,Tannous BA,Krashes MJ,Lowell BB
A10262 was used in immunohistochemistry to show the bidirectional control of feeding following real-time activation and inhibition of PVH(MC4R) neurons
Mon Jun 01 00:00:00 EDT 2015
Niche appropriation by Drosophila intestinal stem cell tumours.
Nature cell biology
Patel PH,Dutta D,Edgar BA
A10262 was used in immunohistochemistry - paraffin section to use Drosophilia to investigate how loss of differentiation initiates tumorigenesis
Tue Sep 01 00:00:00 EDT 2015
Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder.
Molecular psychiatry
Bavamian S,Mellios N,Lalonde J,Fass DM,Wang J,Sheridan SD,Madison JM,Zhou F,Rueckert EH,Barker D,Perlis RH,Sur M,Haggarty SJ
A10262 was used in Immunocytochemistry to study the role of microRNAs in bipolar disorder.
Fri May 01 00:00:00 EDT 2015
Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Liu Y,Miao Q,Yuan J,Han S,Zhang P,Li S,Rao Z,Zhao W,Ye Q,Geng J,Zhang X,Cheng L
A10262 was used in Immunocytochemistry to show that expression of achaete-scute complex homolog-like 1 alone is sufficient to convert dorsal midbrain astrocytes of mice into functional induced neuronal cells in vitro and vivo.
Wed Jun 24 00:00:00 EDT 2015
In Utero Development of Kisspeptin/GnRH Neural Circuitry in Male Mice.
Endocrinology
Kumar D,Periasamy V,Freese M,Voigt A,Boehm U
A10262 was used in immunohistochemistry - frozen section to examine the role of kisspeptin/GPR54 in the developing brain
Tue Sep 01 00:00:00 EDT 2015
mTORC1 and mTORC2 have largely distinct functions in Purkinje cells.
The European journal of neuroscience
Angliker N,Burri M,Zaichuk M,Fritschy JM,Rüegg MA
A10262 was used in immunohistochemistry to understand the functions of mTORC1 and mTORC2 in Purkinje cells
Thu Oct 01 00:00:00 EDT 2015
Structural basis for serotonergic regulation of neural circuits in the mouse olfactory bulb.
The Journal of comparative neurology
Suzuki Y,Kiyokage E,Sohn J,Hioki H,Toida K
A10262 was used in immunohistochemistry to identify the mechanism for serotonergic regulation of neural circuits in the mouse olfactory bulb
Sun Feb 01 00:00:00 EST 2015
GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function.
eLife
Burguete AS,Almeida S,Gao FB,Kalb R,Akins MR,Bonini NM
A10262 was used in immunohistochemistry to characterize GGGGCC microsatelline RNA and induction of branching defects, neuritical localization, and perturbing of transport granule function
Wed Dec 09 00:00:00 EST 2015
Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32.
eNeuro
Polito M,Guiot E,Gangarossa G,Longueville S,Doulazmi M,Valjent E,Hervé D,Girault JA,Paupardin-Tritsch D,Castro LR,Vincent P
A10262 was used in immunohistochemistry to examine the mechanism of type 10A phosphodiesterase inhibitors.
Wed Oct 14 00:00:00 EDT 2015
drd2-cre:ribotag mouse line unravels the possible diversity of dopamine d2 receptor-expressing cells of the dorsal mouse hippocampus.
Hippocampus
Puighermanal E,Biever A,Espallergues J,Gangarossa G,De Bundel D,Valjent E
A10262 was used in Immunocytochemistry-immunofluorescence to suggest that in addition to the glutamatergic hilar mossy cells, D2R-expressing cells constitute a subpopulation of GABAergic hippocampal interneurons.
Wed Jul 01 00:00:00 EDT 2015
Bidirectional switch of the valence associated with a hippocampal contextual memory engram.
Nature
Redondo RL,Kim J,Arons AL,Ramirez S,Liu X,Tonegawa S
A10262 was used in immunohistochemistry to assess the bidirectional switch of the valence associated with a contextual memory engram of the hippocampal region
Thu Sep 18 00:00:00 EDT 2014
Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 in Drosophila.
Autophagy
Nagy P,Kárpáti M,Varga A,Pircs K,Venkei Z,Takáts S,Varga K,Erdi B,Hegedűs K,Juhász G
A10262 was used in immunohistochemistry to study the Atg17/FIP200 complex that localizes to perilysosomal Ref(2)P aggregates and activates Atg1 in Drosophila that promotes autophagy
Sat Mar 01 00:00:00 EST 2014
Olfactory ensheathing cells, but not Schwann cells, proliferate and migrate extensively within moderately X-irradiated juvenile rat brain.
Glia
Lankford KL,Brown RJ,Sasaki M,Kocsis JD
A10262 was used in immunohistochemistry - frozen section to study migration of transplanted olfactory ensheathing cells and Schwann cells in rat spinal cord
Wed Jan 01 00:00:00 EST 2014
The myeloid-binding peptide adenoviral vector enables multi-organ vascular endothelial gene targeting.
Laboratory investigation; a journal of technical methods and pathology
Lu ZH,Kaliberov S,Zhang J,Muz B,Azab AK,Sohn RE,Kaliberova L,Du Y,Curiel DT,Arbeit JM
A10262 was used in immunohistochemistry to test the body-wide tropism of the Ad5-myeloid cell-binding peptide-expressing vector, its myeloid cell necessity, and vector-endothelial cell expression dose response
Fri Aug 01 00:00:00 EDT 2014
Differential responsiveness of distinct retinal domains to Atoh7.
Mechanisms of development
Sinn R,Peravali R,Heermann S,Wittbrodt J
A10262 was used in immunohistochemistry to explore the differential susceptibilities of early retinal progenitor cells to Atoh7 in vivo
Fri Aug 01 00:00:00 EDT 2014
Calretinin-positive L5a pyramidal neurons in the development of the paralemniscal pathway in the barrel cortex.
Molecular brain
Liu J,Liu B,Zhang X,Yu B,Guan W,Wang K,Yang Y,Gong Y,Wu X,Yanagawa Y,Wu S,Zhao C
A10262 was used in Immunohistochemistry to explore the cellular features of L5a neurons and to provide a morphological basis for studying their roles in the development of the paralemniscal pathway and in information integration.
Tue Nov 18 00:00:00 EST 2014
Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients with PKD1 mutations.
Journal of the American Society of Nephrology : JASN
Freedman BS,Lam AQ,Sundsbak JL,Iatrino R,Su X,Koon SJ,Wu M,Daheron L,Harris PC,Zhou J,Bonventre JV
A10262 was used in immunocytochemistry to investigate the relationship between pathopolycystin- and polycystin-2 in the pathogenesis of PKD.
Tue Oct 01 00:00:00 EDT 2013
Pou5f1-dependent EGF expression controls E-cadherin endocytosis, cell adhesion, and zebrafish epiboly movements.
Developmental cell
Song S,Eckerle S,Onichtchouk D,Marrs JA,Nitschke R,Driever W
A10262 was used in immunohistochemistry - paraffin section to study the role of E-cadherin endosomal trafficking to development of zebrafish
Mon Mar 11 00:00:00 EDT 2013
Adult zebrafish as a model system for cutaneous wound-healing research.
The Journal of investigative dermatology
Richardson R,Slanchev K,Kraus C,Knyphausen P,Eming S,Hammerschmidt M
A10262 was used in immunohistochemistry - paraffin section to develop and characterize a zebrafish model of skin repair
Sat Jun 01 00:00:00 EDT 2013
TrkB signaling directs the incorporation of newly generated periglomerular cells in the adult olfactory bulb.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Bergami M,Vignoli B,Motori E,Pifferi S,Zuccaro E,Menini A,Canossa M
A10262 was used in immunohistochemistry to understand the role of TrkB in the integration of new periglomerular cells in the adult olfactory bulb
Wed Jul 10 00:00:00 EDT 2013
notch3 is essential for oligodendrocyte development and vascular integrity in zebrafish.
Disease models & mechanisms
Zaucker A,Mercurio S,Sternheim N,Talbot WS,Marlow FL
A10262 was used in immunohistochemistry - paraffin section to study how Notch3 regulates oligodendrocyte precursor cell development
Sun Sep 01 00:00:00 EDT 2013
CD2AP links cortactin and capping protein at the cell periphery to facilitate formation of lamellipodia.
Molecular and cellular biology
Zhao J,Bruck S,Cemerski S,Zhang L,Butler B,Dani A,Cooper JA,Shaw AS
A10262 was used in immunocytochemistry to analyze the facilitation of lamellipodia formation by CD2AP linking capping protein and cortactin at the cell periphery
Tue Jan 01 00:00:00 EST 2013
Localization of neurones expressing the gap junction protein Connexin45 within the adult spinal dorsal horn: a study using Cx45-eGFP reporter mice.
Brain structure & function
Chapman RJ,Lall VK,Maxeiner S,Willecke K,Deuchars J,King AE
A10262 was used in immunohistochemistry to identify Cx45-positive neurones in the adult spinal dorsal horn
Wed May 01 00:00:00 EDT 2013
A unique mouse model for investigating the properties of amyotrophic lateral sclerosis-associated protein TDP-43, by in utero electroporation.
Neuroscience research
Akamatsu M,Takuma H,Yamashita T,Okada T,Keino-Masu K,Ishii K,Kwak S,Masu M,Tamaoka A
A10262 was used in immunohistochemistry to develop a method using in utero electroporation to introduce pathogenic genes into the brain of mice to study amyotrophic lateral sclerosis.
Sun Dec 01 00:00:00 EST 2013
Thymosin β4-sulfoxide attenuates inflammatory cell infiltration and promotes cardiac wound healing.
Nature communications
Evans MA,Smart N,Dubé KN,Bollini S,Clark JE,Evans HG,Taams LS,Richardson R,Lévesque M,Martin P,Mills K,Riegler J,Price AN,Lythgoe MF,Riley PR
A10262 was used in immunohistochemistry to assess cardiac wound healing and inflammatory cell infiltration is attenuated by thymosin beta-4-sulfoxide
Mon Dec 30 00:00:00 EST 2013
Development and specification of cerebellar stem and progenitor cells in zebrafish: from embryo to adult.
Neural development
Kaslin J,Kroehne V,Benato F,Argenton F,Brand M
A10262 was used in immunohistochemistry to examine the diverse neural stem and progenitor cell types in the teleost fish brain.
Sat May 04 00:00:00 EDT 2013
Accelerated high-yield generation of limb-innervating motor neurons from human stem cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Amoroso MW,Croft GF,Williams DJ,O'Keeffe S,Carrasco MA,Davis AR,Roybon L,Oakley DH,Maniatis T,Henderson CE,Wichterle H
A10262 was used in Immunocytochemistry-immunofluorescence to facilitate in-depth study of motor neuron subtype-specific properties, disease modeling, and development of large-scale cell-based screening assays.
Wed Jan 09 00:00:00 EST 2013
An epigenetic feedback regulatory loop involving microRNA-195 and MBD1 governs neural stem cell differentiation.
PloS one
Liu C,Teng ZQ,McQuate AL,Jobe EM,Christ CC,von Hoyningen-Huene SJ,Reyes MD,Polich ED,Xing Y,Li Y,Guo W,Zhao X
A10262 was used in immunohistochemistry to report that MBD1 deficiency in adult neural stem/progenitor cells results in altered expression of several noncoding microRNAs
Tue Jul 09 00:00:00 EDT 2013
CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons.
Nature cell biology
Ricciardi S,Ungaro F,Hambrock M,Rademacher N,Stefanelli G,Brambilla D,Sessa A,Magagnotti C,Bachi A,Giarda E,Verpelli C,Kilstrup-Nielsen C,Sala C,Kalscheuer VM,Broccoli V
A10262 was used in immunocytochemistry to elucidate the function of CDKL5 in neurons.
Sat Sep 01 00:00:00 EDT 2012
Dopaminergic modulation of mitral cells and odor responses in the zebrafish olfactory bulb.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Bundschuh ST,Zhu P,Schärer YP,Friedrich RW
A10262 was used in immunohistochemistry (frozen) to examine the role of dopamine in odor processing.
Wed May 16 00:00:00 EDT 2012
Mechanism and function of Vav1 localisation in TCR signalling.
Journal of cell science
Ksionda O,Saveliev A,Köchl R,Rapley J,Faroudi M,Smith-Garvin JE,Wülfing C,Rittinger K,Carter T,Tybulewicz VL
A10262 was used in western blot to suggest that Vav1 is recruited to the immunological synapse by binding to SLP76 and that this interaction results in calcium flux
Thu Nov 15 00:00:00 EST 2012
Maturation of spinal motor neurons derived from human embryonic stem cells.
PloS one
Takazawa T,Croft GF,Amoroso MW,Studer L,Wichterle H,Macdermott AB
A10262 was used in immunocytochemistry to examine the morphological and electrophysiological changes during the maturation of neurons differentiated from human embryonic stem.
Mon Dec 03 00:00:00 EST 2012
Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease.
Human molecular genetics
Gaughwin PM,Ciesla M,Lahiri N,Tabrizi SJ,Brundin P,Björkqvist M
A10262 was used in immunocytochemistry to identify miR-34b as a biomarker of Huntington's disease
Wed Jun 01 00:00:00 EDT 2011
Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes.
Cell
Taelman VF,Dobrowolski R,Plouhinec JL,Fuentealba LC,Vorwald PP,Gumper I,Sabatini DD,De Robertis EM
A10262 was used in immunocytochemistry to determine the molecular mechanisms by which canonical Wnt signaling suppresses glycogen synthase kinase 3 activity.
Thu Dec 23 00:00:00 EST 2010
The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate.
Developmental cell
Doupé DP,Klein AM,Simons BD,Jones PH
A10262 was used in immunohistochemistry to use lineage tracing to study the origins of the murine epidermis
Tue Feb 16 00:00:00 EST 2010
Nitric oxide induces pathological synapse loss by a protein kinase G-, Rho kinase-dependent mechanism preceded by myosin light chain phosphorylation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sunico CR,González-Forero D,Domínguez G,García-Verdugo JM,Moreno-López B
A10262 was used in immunohistochemistry to study induction of pathological synapse loss by a protein kinase G-, Rho kinase-dependent mechanism preceded by myosin light chain phosphorylation due to nitric oxide
Wed Jan 20 00:00:00 EST 2010
MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1.
Stem cells (Dayton, Ohio)
Smrt RD,Szulwach KE,Pfeiffer RL,Li X,Guo W,Pathania M,Teng ZQ,Luo Y,Peng J,Bordey A,Jin P,Zhao X
A10262 was used in immunohistochemistry - free floating to investigate the role of miR-137 in neuronal maturation
Tue Jun 01 00:00:00 EDT 2010
Directed differentiation of hippocampal stem/progenitor cells in the adult brain.
Nature neuroscience
Jessberger S,Toni N,Clemenson GD,Ray J,Gage FH
A10262 was used in immunocytochemistry and immunohistochemistry - frozen section to analyze hippocampal stem/progenitor cells in the adult brain and directed differentiation
Fri Aug 01 00:00:00 EDT 2008
