Product References
Transcriptional reprogramming of skeletal muscle stem cells by the niche environment.
Nature communications
Lazure F,Farouni R,Sahinyan K,Blackburn DM,Hernández-Corchado A,Perron G,Lu T,Osakwe A,Ragoussis J,Crist C,Perkins TJ,Jahani-Asl A,Najafabadi HS,Soleimani VD
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to show that aging leads to a significant transcriptomic shift in their subpopulations accompanied by locus-specific gain and loss of chromatin accessibility and DNA methylation.
Wed Feb 01 00:00:00 EST 2023
A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressing Interneurons of the Striatum.
eNeuro
Kondabolu K,Doig NM,Ayeko O,Khan B,Torres A,Calvigioni D,Meletis K,Koós T,Magill PJ
A-11120 was used in Immunohistochemistry - Free Floating to show that glutamatergic striatum and subthalamic nucleus (STN) neurons are positioned to directly and powerfully influence striatal activity dynamics by virtue of their enriched innervation of GABAergic parvalbumin-expressing interneurons.
Sat Jul 01 00:00:00 EDT 2023
A Rab39-Klp98A-Rab35 endocytic recycling pathway is essential for rapid Golgi-dependent furrow ingression.
Development (Cambridge, England)
Miao H,Millage M,Rollins KR,Blankenship JT
A-11120 was used in Immunohistochemistry to suggest that an endocytic recycling pathway rapidly remobilizes membrane cargo from the cell surface and directs it to the trans-Golgi network to permit the initiation of new cycles of cleavage furrow formation.
Tue Aug 15 00:00:00 EDT 2023
ODF2 Negatively Regulates CP110 Levels at the Centrioles/Basal Bodies to Control the Biogenesis of Primary Cilia.
Cells
Otto M,Hoyer-Fender S
A-11120 was used in Immunocytochemistry-immunofluorescence to suggest that ODF2 most likely acts as a scaffold for the binding of proteins such as NEURL4 or HYLS1 to mediate CP110 degradation.
Fri Sep 01 00:00:00 EDT 2023
Neuron-glia interaction at the receptor level affects olfactory perception in adult Drosophila.
iScience
Calvin-Cejudo L,Martin F,Mendez LR,Coya R,Castañeda-Sampedro A,Gomez-Diaz C,Alcorta E
A-11120 was used in Immunohistochemistry (Frozen) to report a functional role for the glia that surround the soma of the olfactory receptor neurons (OSNs) in adult Drosophila.
Fri Jan 20 00:00:00 EST 2023
Phase separation of an actin nucleator by junctional microtubules regulates epithelial function.
Science advances
Tsukita K,Kitamata M,Kashihara H,Yano T,Fujiwara I,Day TF,Katsuno T,Kim J,Takenaga F,Tanaka H,Park S,Miyata M,Watanabe H,Kondoh G,Takahashi R,Tamura A,Tsukita S
A-11120 was used in Immunoprecipitation to establish that LLPS of the actin nucleator Cobl mediated dynamic microtubule-actin cross-talk in junctions, which fine-tuned the epithelial barrier.
Wed Feb 15 00:00:00 EST 2023
C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.
Autophagy
Yan BR,Li T,Coyaud E,Laurent EMN,St-Germain J,Zhou Y,Kim PK,Raught B,Brumell JH
A-11120 was used in Immunocytochemistry to indicate that C5orf51 is a positive regulator of RAB7A in its shuttling between late endosomes and mitochondria to enable mitophagy.
Fri Apr 01 00:00:00 EDT 2022
Insulin signaling couples growth and early maturation to cholesterol intake in Drosophila.
Current biology : CB
Texada MJ,Lassen M,Pedersen LH,Koyama T,Malita A,Rewitz K
A-11120 was used in Immunohistochemistry to show that a Npc1-TOR signaling system couples the sensing of the lipid cholesterol with cellular and systemic growth control and maturational timing, which may help explain both the link between cholesterol and cancer as well as the connection between body fat (obesity) and early puberty.
Mon Apr 11 00:00:00 EDT 2022
Nuclear morphogenesis: forming a heterogeneous nucleus during embryogenesis.
Development (Cambridge, England)
Tsai A,Crocker J
A-11120 was used in Immunohistochemistry to conclude that 'nuclear morphogenesis' may be a microscopic counterpart of the macroscopic process that shapes the animal body.
Tue Feb 15 00:00:00 EST 2022
Structure of Long-Range Direct and Indirect Spinocerebellar Pathways as Well as Local Spinal Circuits Mediating Proprioception.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pop IV,Espinosa F,Blevins CJ,Okafor PC,Ogujiofor OW,Goyal M,Mona B,Landy MA,Dean KM,Gurumurthy CB,Lai HC
A-11120 was used in Western Blotting to define the unique anatomic trajectories of long-range direct and indirect spinocerebellar pathways as well as local intersegmental spinal circuits using genetic tools in both male and female mice.
Wed Jan 26 00:00:00 EST 2022
Wing hearts in four-winged Ultrabithorax-mutant flies-the role of Hox genes in wing heart specification.
Genetics
Tögel M,Pass G,Paululat A
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to show that a second pair of functional wing hearts is formed in the transformed third thoracic segment and that all wing hearts originate from the wild-type population of wing heart progenitor cells.
Tue Jan 04 00:00:00 EST 2022
Reemployment of Kupffer's vesicle cells into axial and paraxial mesoderm via transdifferentiation.
Development, growth & differentiation
Ikeda T,Inamori K,Kawanishi T,Takeda H
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to indicate that differentiated KV-epithelial cells possess unique plasticity in that they are reemployed into mesodermal lineages through transdifferentiation after they complete their initial role in KV.
Fri Apr 01 00:00:00 EDT 2022
The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress.
Nature communications
Kubrak O,Koyama T,Ahrentløv N,Jensen L,Malita A,Naseem MT,Lassen M,Nagy S,Texada MJ,Halberg KV,Rewitz K
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to show that the endocrine cells of the Drosophila gut sense nutrient stress through a mechanism that involves the TOR pathway and in response secrete the peptide hormone allatostatin C, a Drosophila somatostatin homolog.
Fri Feb 04 00:00:00 EST 2022
Nanoscale segregation of channel and barrier claudins enables paracellular ion flux.
Nature communications
Gonschior H,Schmied C,Van der Veen RE,Eichhorst J,Himmerkus N,Piontek J,Günzel D,Bleich M,Furuse M,Haucke V,Lehmann M
A-11120 was used in Immunocytochemistry to suggest that nanoscale segregation of distinct channel-forming claudins enables barrier function combined with specific paracellular ion flux across tight junctions.
Thu Aug 25 00:00:00 EDT 2022
Disruption of the lipolysis pathway results in stem cell death through a sterile immunity-like pathway in adult Drosophila.
Cell reports
Aggarwal P,Liu Z,Cheng GQ,Singh SR,Shi C,Chen Y,Sun LV,Hou SX
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to identify an evolutionarily conserved pathway that sustains stem cells and CSCs, and its ablation results in an immunogenic cascade that promotes death of stem cells and CSCs as well as antitumor immunity.
Tue Jun 21 00:00:00 EDT 2022
Optogenetic stimulation of ventral tegmental area dopaminergic neurons in a female rodent model of depression: The effect of different stimulation patterns.
Journal of neuroscience research
Tong Y,Pfeiffer L,Serchov T,Coenen VA,Döbrössy MD
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to highlight that long-term accumulative stimulation on DA pathways is required for antidepressant and anxiolytic effect.
Tue Mar 01 00:00:00 EST 2022
Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity.
Neuron
Martins LF,Brambilla I,Motta A,de Pretis S,Bhat GP,Badaloni A,Malpighi C,Amin ND,Imai F,Almeida RD,Yoshida Y,Pfaff SL,Bonanomi D
A-11120 was used in Immunohistochemistry (Frozen) to show that Plexin-D1 receptor is required in endothelial cells for development of neuromuscular connectivity.
Wed Dec 21 00:00:00 EST 2022
A conditional GABAergic synaptic vesicle marker for Drosophila.
Journal of neuroscience methods
Certel SJ,McCabe BD,Stowers RS
A-11120 was used in Immunohistochemistry to develop and characterize a conditional marker of GABAergic synaptic vesicles for Drosophila, 9XV5-vGAT.
Fri Apr 15 00:00:00 EDT 2022
Macrophages and neutrophils are necessary for ER stress-induced β cell loss.
Cell reports
Yang B,Yang L,Wang Y,Maddison LA,Tang Z,Haigh S,Gong Y,Zhang Y,Covington BA,Bosma KJ,Tong X,Page-McCaw P,Gannon M,Deng Q,Chen W
A-11120 was used in Immunohistochemistry (Frozen) to reveal an important role of neutrophils in persistent ER stress-induced β cell loss.
Tue Aug 23 00:00:00 EDT 2022
A New Transgenic Tool to Study the Ret Signaling Pathway in the Enteric Nervous System.
International journal of molecular sciences
Bandla A,Melancon E,Taylor CR,Davidson AE,Eisen JS,Ganz J
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to find that EPCs and the majority of ENS neurons express ret:GFP during ENS development.
Sat Dec 10 00:00:00 EST 2022
Deficiency in coatomer complex I causes aberrant activation of STING signalling.
Nature communications
Steiner A,Hrovat-Schaale K,Prigione I,Yu CH,Laohamonthonkul P,Harapas CR,Low RRJ,De Nardo D,Dagley LF,Mlodzianoski MJ,Rogers KL,Zillinger T,Hartmann G,Gantier MP,Gattorno M,Geyer M,Volpi S,Davidson S,Masters SL
A-11120 was used in Immunoprecipitation to suggest targeted inhibition of the cGAS/STING pathway as a promising therapeutic approach.
Thu Apr 28 00:00:00 EDT 2022
Dorsomedial prefrontal cortex activation disrupts Pavlovian incentive motivation.
Frontiers in behavioral neuroscience
Halbout B,Hutson C,Wassum KM,Ostlund SB
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to show that the dmPFC does not mediate the expression of Pavlovian incentive motivation but instead has the capacity to exert pronounced inhibitory control over this process, suggesting that it is involved in adaptively regulating cue-motivated behavior.
Thu Dec 14 00:00:00 EST 2023
Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis.
eLife
Paulissen E,Palmisano NJ,Waxman JS,Martin BL
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to demonstrate a critical role for somite morphogenesis in organizing surrounding tissues to facilitate notochord positioning and angioblast migration, which is ultimately responsible for creating a functional cardiovascular system.
Wed Feb 09 00:00:00 EST 2022
Activation of a Locus Coeruleus to Dorsal Hippocampus Noradrenergic Circuit Facilitates Associative Learning.
Frontiers in cellular neuroscience
Tsetsenis T,Badyna JK,Li R,Dani JA
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to suggest that increasing of hippocampal noradrenergic activity can have important implications in the treatment of cognitive disorders that involve problems in contextual processing.
Sat Jul 16 00:00:00 EDT 2022
The endoplasmic reticulum adopts two distinct tubule forms.
Proceedings of the National Academy of Sciences of the United States of America
Wang B,Zhao Z,Xiong M,Yan R,Xu K
A-11120 was used in Immunocytochemistry to uncover a dynamic structural dichotomy for ER tubules with intriguing functional implications.
Tue May 03 00:00:00 EDT 2022
The insect somatostatin pathway gates vitellogenesis progression during reproductive maturation and the post-mating response.
Nature communications
Zhang C,Kim AJ,Rivera-Perez C,Noriega FG,Kim YJ
A-11120 was used in Immunohistochemistry to identify the neuropeptide allatostatin-C (AstC)-producing neurons that gate both the initiation of vitellogenesis (yolk accumulation) that occurs post-eclosion and its re-initiation post-mating.
Fri Feb 18 00:00:00 EST 2022
Fluorogenic DNA-PAINT for faster, low-background super-resolution imaging.
Nature methods
Chung KKH,Zhang Z,Kidd P,Zhang Y,Williams ND,Rollins B,Yang Y,Lin C,Baddeley D,Bewersdorf J
A-11120 was used in Immunocytochemistry-immunofluorescence to demonstrate a 26-fold increase in imaging speed over regular DNA-PAINT and show that our new implementation enables three-dimensional super-resolution DNA-PAINT imaging without optical sectioning.
Sun May 01 00:00:00 EDT 2022
Microscopic and biochemical monitoring of endosomal trafficking and extracellular vesicle secretion in an endogenous in vivo model.
Journal of extracellular vesicles
Linnemannstöns K,Karuna M P,Witte L,Choezom D,Honemann-Capito M,Lagurin AS,Schmidt CV,Shrikhande S,Steinmetz LK,Wiebke M,Lenz C,Gross JC
A-11120 was used in Western Blotting to present an in vivo model to study EV secretion using the fat body and the haemolymph of the fruit fly, Drosophila melanogaster.
Thu Sep 01 00:00:00 EDT 2022
Sox8 remodels the cranial ectoderm to generate the ear.
Proceedings of the National Academy of Sciences of the United States of America
Buzzi AL,Chen J,Thiery A,Delile J,Streit A
A-11120 was used in Immunohistochemistry to conclude that transcription factor Sox8 has the unique ability to remodel transcriptional networks in the cranial ectoderm toward ear identity.
Tue Jul 12 00:00:00 EDT 2022
Protein visualization and manipulation in Drosophila through the use of epitope tags recognized by nanobodies.
eLife
Xu J,Kim AR,Cheloha RW,Fischer FA,Li JSS,Feng Y,Stoneburner E,Binari R,Mohr SE,Zirin J,Ploegh HL,Perrimon N
A-11120 was used in Immunohistochemistry to characterize two short (15aa) NanoTag epitopes, 127D01 and VHH05, and their corresponding high-affinity nanobodies.
Tue Jan 25 00:00:00 EST 2022
A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila.
Nature metabolism
Malita A,Kubrak O,Koyama T,Ahrentløv N,Texada MJ,Nagy S,Halberg KV,Rewitz K
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to suggest that gut NPF-to-AKH signalling modulates specific appetites and regulates food choice to ensure homeostatic consumption of nutrients, providing insight into the hormonal mechanisms that underlie nutrient-specific hungers.
Tue Nov 01 00:00:00 EDT 2022
Transiently Nav1.8-expressing neurons are capable of sensing noxious stimuli in the brain.
Frontiers in cellular neuroscience
Tenza-Ferrer H,Collodetti M,Nicolau ES,Birbrair A,Magno LAV,Romano-Silva MA
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to identify a novel role for central Nav1.8 neurons in sensing nociception, which could be researched as a new approach to treating pain disorders.
Sat Sep 17 00:00:00 EDT 2022
The doublesex gene regulates dimorphic sexual and aggressive behaviors in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America
Han C,Peng Q,Sun M,Jiang X,Su X,Chen J,Ma M,Zhu H,Ji X,Pan Y
A-11120 was used in Immunohistochemistry to establish dimorphic sexual and aggressive behaviors.
Tue Sep 13 00:00:00 EDT 2022
Global Proximity Interactome of the Human Macroautophagy Pathway.
Autophagy
Tu YXI,Sydor AM,Coyaud E,Laurent EMN,Dyer D,Mellouk N,St-Germain J,Vernon RM,Forman-Kay JD,Li T,Hua R,Zhao K,Ridgway ND,Kim PK,Raught B,Brumell JH
A-11120 was used in Immunocytochemistry-immunofluorescence to perform proximity-dependent biotin identification (BioID) on 39 core human macroautophagy proteins, identifying over 700 unique high confidence proximity interactors with new putative connections between macroautophagic and essential cellular processes.
Sun May 01 00:00:00 EDT 2022
Magel2 knockdown in hypothalamic POMC neurons innervating the medial amygdala reduces susceptibility to diet-induced obesity.
Life science alliance
Choi Y,Min HY,Hwang J,Jo YH
A-11120 was used in Immunohistochemistry-immunofluorescence to provide evidence that knockdown of the Magel2 gene in ARCPOMC neurons innervating the MeA reduces susceptibility to diet-induced obesity with increased locomotor activity through activation of central GPER.
Tue Nov 01 00:00:00 EDT 2022
Synaptic components are required for glioblastoma progression in Drosophila.
PLoS genetics
Losada-Pérez M,Hernández García-Moreno M,García-Ricote I,Casas-Tintó S
A-11120 was used in Immunohistochemistry to indicate that both presynaptic and postsynaptic proteins play a role in GB progression and lethality.
Fri Jul 01 00:00:00 EDT 2022
Α γ-tubulin complex-dependent pathway suppresses ciliogenesis by promoting cilia disassembly.
Cell reports
Shankar S,Hsu ZT,Ezquerra A,Li CC,Huang TL,Coyaud E,Viais R,Grauffel C,Raught B,Lim C,Lüders J,Tsai SY,Hsia KC
A-11120 was used in Immunoprecipitation to demonstrate that Kif2A, a kinesin motor that bears microtubule-depolymerizing activity, is recruited to the cilium basal body in a γ-TuRC-dependent manner.
Tue Nov 15 00:00:00 EST 2022
New Insights into In Vivo Dopamine Physiology and Neurostimulation: A Fiber Photometry Study Highlighting the Impact of Medial Forebrain Bundle Deep Brain Stimulation on the Nucleus Accumbens.
Brain sciences
Miguel Telega L,Ashouri Vajari D,Stieglitz T,Coenen VA,Döbrössy MD
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to show that mfb-DBS can elicit an increased dopamine response during stimulation (5 s and 20 s DBS) compared to its baseline dopamine activity state, reaching its maximum peak amplitude in about 1 s and then recovering back after stimulation.
Fri Aug 19 00:00:00 EDT 2022
Madm/NRBP1 mediates synaptic maintenance and neurodegeneration-induced presynaptic homeostatic potentiation.
Cell reports
Mushtaq Z,Aavula K,Lasser DA,Kieweg ID,Lion LM,Kins S,Pielage J
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to provide insights into the molecular mechanisms underlying neurodegeneration-induced PHP with potential neurotherapeutic applications.
Tue Nov 29 00:00:00 EST 2022
Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration.
Development (Cambridge, England)
Cao Y,Xia Y,Balowski JJ,Ou J,Song L,Safi A,Curtis T,Crawford GE,Poss KD,Cao J
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to provide a new resource and principles for understanding the regulation of epicardial genetic programs during heart regeneration.
Tue Feb 15 00:00:00 EST 2022
The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repression.
eLife
Baccino-Calace M,Schmidt K,Müller M
A-11120 was used in Immunohistochemistry to show that the E3 ligase Thin links protein degradation-dependent proteostasis of Dysbindin to homeostatic regulation of neurotransmitter release.
Thu Jul 07 00:00:00 EDT 2022
Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication.
Molecular cell
Hossain M,Bhalla K,Stillman B
A-11120 was used in Immunoprecipitation to eport that multiple short linear protein motifs (SLiMs) within intrinsically disordered regions (IDRs) in ORC1 and CDC6 mediate cyclin-CDK-dependent and independent protein-protein interactions, conditional on the cell cycle phase.
Thu May 06 00:00:00 EDT 2021
Mechanism for food texture preference based on grittiness.
Current biology : CB
Li Q,Montell C
A-11120 was used in Immunohistochemistry to reveal the first role for this evolutionarily conserved, mechanically activated TMEM63 channel in an animal and provide an explanation of how flies can sense and behaviorally respond to the texture of food provided by particles.
Mon May 10 00:00:00 EDT 2021
Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function.
Glia
Böhme MA,McCarthy AW,Blaum N,Berezeckaja M,Ponimaskine K,Schwefel D,Walter AM
A-11120 was used in Immunohistochemistry to identify non-neuronal Synaptobrevin as the essential vesicular SNARE in Drosophila peripheral glia to insulate and metabolically supply neurons.
Sun Aug 01 00:00:00 EDT 2021
LanB1 Cooperates With Kon-Tiki During Embryonic Muscle Migration in Drosophila.
Frontiers in cell and developmental biology
Pérez-Moreno JJ,Santa-Cruz Mateos C,Martín-Bermudo MD,Estrada B
A-11120 was used in Immunohistochemistry to uncover a new role for the interaction between laminins and Kon-tiki/Perdido during Drosophila myogenesis.
Sat Jul 16 00:00:00 EDT 2022
CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression.
Journal of medical genetics
Cao X,Wolf A,Kim SE,Cabrera RM,Wlodarczyk BJ,Zhu H,Parker M,Lin Y,Steele JW,Han X,Ramaekers VT,Steinfeld R,Finnell RH,Lei Y
A-11120 was used in Western Blotting to identify causal mutations for cerebral folate deficiency by performing whole exome sequencing analysis on eight CFD trios and identified eight de novo mutations in seven trios.
Thu Jul 01 00:00:00 EDT 2021
In vitro discovery of novel prokaryotic ion channel candidates for antiarrhythmic gene therapy.
Methods in enzymology
Wu T,Nguyen HX,Bursac N
A-11120 was used in Immunocytochemistry-immunoflourescence to discover and characterize novel prokaryotic ion channels for use in gene and cell therapies for heart disease including cardiac arrhythmias.
Fri Jun 25 00:00:00 EDT 2021
Binge-Like Ethanol Drinking Increases Otx2, Wnt1, and Mdk Gene Expression in the Ventral Tegmental Area of Adult Mice.
Neuroscience insights
Coles C,Lasek AW
A-11120 was used in Immunohistochemistry to test a hypothesis that levels of OTX2 would be altered by binge-like ethanol consumption in adult animals.
Sun May 09 00:00:00 EDT 2021
Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity.
Nature communications
Zhang Y,Brown K,Yu Y,Ibrahim Z,Zandian M,Xuan H,Ingersoll S,Lee T,Ebmeier CC,Liu J,Panne D,Shi X,Ren X,Kutateladze TG
A-11120 was used in Immunocytochemistry to report that p300 forms phase separated condensates in the cell nucleus. The phase separation ability of p300 is regulated by autoacetylation and relies on its catalytic core components, including the histone acetyltransferase (HAT) domain, the autoinhibition loop, and bromodomain. p300 condensates sequester chromatin components, such as histone H3 tail and DNA, and are amplified through binding of p300 to the nucleosome.
Thu Jul 29 00:00:00 EDT 2021
Supramammillary neurons projecting to the septum regulate dopamine and motivation for environmental interaction in mice.
Nature communications
Kesner AJ,Shin R,Calva CB,Don RF,Junn S,Potter CT,Ramsey LA,Abou-Elnaga AF,Cover CG,Wang DV,Lu H,Yang Y,Ikemoto S
A-11120 was used in Immunohistochemistry (Frozen) to propose that the supramammillo-septo-VTA pathway regulates arousal that reinforces and energizes behavioral interaction with the environment.
Fri May 14 00:00:00 EDT 2021
Targeted molecular profiling of rare olfactory sensory neurons identifies fate, wiring, and functional determinants.
eLife
Arguello JR,Abuin L,Armida J,Mika K,Chai PC,Benton R
A-11120 was used in Immunohistochemistry to reveal the effectiveness of TaDa in profiling rare neural populations, identifies new roles for a transcription factor and a neuronal guidance molecule, and provides valuable datasets for future exploration.
Fri Mar 05 00:00:00 EST 2021
Gonadotropin Releasing Hormone (Gnrh) Triggers Neurogenesis in the Hypothalamus of Adult Zebrafish.
International journal of molecular sciences
Ceriani R,Whitlock KE
A-11120 was used in Immunocytochemistry to conclude that cells in the proliferative domains of the zebrafish POA do not express radial glia (tanycyte) markers vimentin and GFAP/Zrf1, and yet, are responsive to exogenously applied GnRH treatment.
Mon May 31 00:00:00 EDT 2021
WDR47 protects neuronal microtubule minus ends from katanin-mediated severing.
Cell reports
Buijs RR,Hummel JJA,Burute M,Pan X,Cao Y,Stucchi R,Altelaar M,Akhmanova A,Kapitein LC,Hoogenraad CC
A-11120 was used in Immunocytochemistry to propose a model where WDR47 protects CAMSAP2 at microtubule minus ends from katanin activity to ensure proper stabilization of the neuronal microtubule network.
Tue Jul 13 00:00:00 EDT 2021
Colocalization for super-resolution microscopy via optimal transport.
Nature computational science
Tameling C,Stoldt S,Stephan T,Naas J,Jakobs S,Munk A
A-11120 was used in Immunocytochemistry-immunoflourescence to demonstrate that well-established methods for the analysis of colocalization in diffraction-limited datasets and for coordinate-stochastic nanoscopy are not equally well suited for the analysis of high-resolution Stimulated emission depletion images.
Mon Mar 01 00:00:00 EST 2021
Spatial dynamics of the insulin receptor in living neurons.
Journal of neurochemistry
Gralle M,Labrecque S,Salesse C,De Koninck P
A-11120 was used in Immunocytochemistry-immunofluorescence to suggest an association of the neuronal insulin receptor with specific elements of the dendritic shaft, rather than excitatory synapses.
Fri Jan 01 00:00:00 EST 2021
Biophysical and biochemical properties of Deup1 self-assemblies: a potential driver for deuterosome formation during multiciliogenesis.
Biology open
Yamamoto S,Yabuki R,Kitagawa D
A-11120 was used in Immunocytochemistry-immunoflourescence to suggest that Deup1 forms the structural core of the deuterosome through self-assembly into stable macromolecular condensates.
Wed Mar 03 00:00:00 EST 2021
ER - lysosome contacts at a pre-axonal region regulate axonal lysosome availability.
Nature communications
Özkan N,Koppers M,van Soest I,van Harten A,Jurriens D,Liv N,Klumperman J,Kapitein LC,Hoogenraad CC,Farías GG
A-11120 was used in Immunocytochemistry to investigate if endoplasmic reticulum tubule - lysosome contacts at a pre-axonal region finely orchestrate axonal lysosome availability for proper neuronal function.
Fri Jul 23 00:00:00 EDT 2021
Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the epidermal growth factor receptor.
Stem cell reports
Resnik-Docampo M,Cunningham KM,Ruvalcaba SM,Choi C,Sauer V,Jones DL
A-11120 was used in Immunohistochemistry to show that the septate junction (SJ) protein Neuroglian (Nrg) is expressed in intestinal stem cells (ISCs) and enteroblasts (EBs) within the fly intestine.
Tue Jun 08 00:00:00 EDT 2021
A species-specific functional module controls formation of pollen apertures.
Nature plants
Lee BH,Wang R,Moberg IM,Reeder SH,Amom P,Tan MH,Amstutz K,Chandna P,Helton A,Andrianova EP,Zhulin IB,Dobritsa AA
A-11120 was used in Immunoprecipitation to present a new aperture factor, INP2, which satisfies the criteria for being a species-specific partner for INP1.
Thu Jul 01 00:00:00 EDT 2021
Wireless battery free fully implantable multimodal recording and neuromodulation tools for songbirds.
Nature communications
Ausra J,Munger SJ,Azami A,Burton A,Peralta R,Miller JE,Gutruf P
A-11120 was used in Immunohistochemistry to expand the use of wireless subdermally implantable neuromodulation and sensing tools to species previously excluded from in vivo real time experiments.
Tue Mar 30 00:00:00 EDT 2021
CDK1-Mediated Phosphorylation of BAG3 Promotes Mitotic Cell Shape Remodeling and the Molecular Assembly of Mitotic p62 Bodies.
Cells
Luthold C,Lambert H,Guilbert SM,Rodrigue MA,Fuchs M,Varlet AA,Fradet-Turcotte A,Lavoie JN
A-11120 was used in Immunoprecipitation to investigate protein phosphorylation in the regulation of mitotic cell shape remodeling.
Sat Oct 02 00:00:00 EDT 2021
polished rice mediates ecdysone-dependent control of Drosophila embryonic organogenesis.
Genes to cells : devoted to molecular & cellular mechanisms
Taira Y,Wada H,Hayashi S,Kageyama Y
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to demonstrate that ecdysone and its downstream target pri play essential roles in tracheal development by modulating cell fate decision.
Sat May 01 00:00:00 EDT 2021
SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan.
Nature communications
Johnson AE,Orr BO,Fetter RD,Moughamian AJ,Primeaux LA,Geier EG,Yokoyama JS,Miller BL,Davis GW
A-11120 was used in Western Blotting to characterise a VCP-binding co-factor (SVIP) that specifically recruits VCP to lysosomes.
Thu Jan 21 00:00:00 EST 2021
Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension.
Nature communications
McCray BA,Diehl E,Sullivan JM,Aisenberg WH,Zaccor NW,Lau AR,Rich DJ,Goretzki B,Hellmich UA,Lloyd TE,Sumner CJ
A-11120 was used in Western Blot to identify RhoA as a critical mediator of TRPV4-induced cell structure changes and suggest that disruption of TRPV4-RhoA binding may contribute to tissue-specific toxicity of TRPV4 neuropathy mutations.
Thu Mar 04 00:00:00 EST 2021
Substrate ubiquitination retains misfolded membrane proteins in the endoplasmic reticulum for degradation.
Cell reports
Sun Z,Guerriero CJ,Brodsky JL
A-11120 was used in Western Blot to indicate that polyubiquitination is sufficient to retain misfolded membrane proteins in the ER prior to ERAD.
Tue Sep 21 00:00:00 EDT 2021
An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system.
Science advances
Kim YJ,Kong Q,Yamamoto S,Kuramoto K,Huang M,Wang N,Hong JH,Xiao T,Levine B,Qiu X,Zhao Y,Miller RJ,Dong H,Meltzer HY,Xu M,He C
A-11120 was used in Immunohistochemistry to demonstrate that an autophagy-related protein Becn2 is a previously unidentified regulator of cocaine reward behaviors.
Mon Feb 01 00:00:00 EST 2021
Starvation-induced regulation of carbohydrate transport at the blood-brain barrier is TGF-β-signaling dependent.
eLife
Hertenstein H,McMullen E,Weiler A,Volkenhoff A,Becker HM,Schirmeier S
A-11120 was used in Immunohistochemistry to elucidate the molecular mechanisms of adaptive carbohydrate transport during brain-sparing functions in hunger or malnutrition.
Tue May 25 00:00:00 EDT 2021
Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications.
Nature communications
Tamada K,Fukumoto K,Toya T,Nakai N,Awasthi JR,Tanaka S,Okabe S,Spitz F,Saitow F,Suzuki H,Takumi T
A-11120 was used in Immunohistochemistry to provide an insight into the role of Ndn in paternal 15q duplication and a mouse model of paternal Dup15q syndrome.
Thu Jul 01 00:00:00 EDT 2021
BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage.
Nature communications
Kang Z,Fu P,Alcivar AL,Fu H,Redon C,Foo TK,Zuo Y,Ye C,Baxley R,Madireddy A,Buisson R,Bielinsky AK,Zou L,Shen Z,Aladjem MI,Xia B
A-11120 was used in Immunoprecipitation to investigate the mechanism of radio-resistant DNA synthesis (RDS) in BRCA2 deficient cells.
Wed Oct 13 00:00:00 EDT 2021
Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.
Nature
Guo X,Aviles G,Liu Y,Tian R,Unger BA,Lin YT,Wiita AP,Xu K,Correia MA,Kampmann M
A-11120 was used in Immunocytochemistry-immunoflourescence to identify the molecular players that signal mitochondrial stress to the cytosol.
Sun Mar 01 00:00:00 EST 2020
Nanoscale subcellular architecture revealed by multicolor three-dimensional salvaged fluorescence imaging.
Nature methods
Zhang Y,Schroeder LK,Lessard MD,Kidd P,Chung J,Song Y,Benedetti L,Li Y,Ries J,Grimm JB,Lavis LD,De Camilli P,Rothman JE,Baddeley D,Bewersdorf J
A-11120 was used in In vitro Assay to resolve the highly convoluted Golgi apparatus and the close contacts between the endoplasmic reticulum and the plasma membrane with three-dimensional fluorescence images.
Sat Feb 01 00:00:00 EST 2020
Structure-Mediated RNA Decay by UPF1 and G3BP1.
Molecular cell
Fischer JW,Busa VF,Shao Y,Leung AKL
A-11120 was used in Western Blotting to characterize a genome-wide RNA decay pathway that reduces the half-lives of mRNAs based on overall 3' UTR structure formed by base pairing.
Thu Apr 02 00:00:00 EDT 2020
CaMKII Measures the Passage of Time to Coordinate Behavior and Motivational State.
Neuron
Thornquist SC,Langer K,Zhang SX,Rogulja D,Crickmore MA
A-11120 was used in Immunohistochemistry-immunofluorescence to discover whether the activation and gradual relaxation of calcium-independent CaMKII measure a 6-min time window to coordinate two male-specific events during Drosophila mating: sperm transfer and a simultaneous decrease in motivation.
Wed Jan 22 00:00:00 EST 2020
Epigenetic Signaling in Glia Controls Presynaptic Homeostatic Plasticity.
Neuron
Wang T,Morency DT,Harris N,Davis GW
A-11120 was used in Immunohistochemistry-immunofluorescence to present evidence that the SAGA complex is necessary for homeostatic plasticity, demonstrating involvement of four new genes in homeostatic plasticity.
Wed Feb 05 00:00:00 EST 2020
Disruption of mosGILT in Anopheles gambiae impairs ovarian development and Plasmodium infection.
The Journal of experimental medicine
Yang J,Schleicher TR,Dong Y,Park HB,Lan J,Cresswell P,Crawford J,Dimopoulos G,Fikrig E
A-11120 was used in Immunohistochemistry-immunofluorescence to show female mosquitoes with mutations in mosquito gamma-interferon-inducible lysosomal thiol reductase (mosGILT) exhibit defected ovarian development and refractoriness to Plasmodium.
Mon Jan 06 00:00:00 EST 2020
Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors.
The Journal of experimental medicine
Tao T,Shi H,Wang M,Perez-Atayde AR,London WB,Gutierrez A,Lemos B,Durbin AD,Look AT
A-11120 was used in Immunocytochemistry to propose a clinical trial of mTOR inhibitors as a means to shrink large ganglioneuromas before resection in order to reduce surgical morbidity.
Mon Oct 05 00:00:00 EDT 2020
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
The EMBO journal
Weinert S,Gimber N,Deuschel D,Stuhlmann T,Puchkov D,Farsi Z,Ludwig CF,Novarino G,López-Cayuqueo KI,Planells-Cases R,Jentsch TJ
A-11120 was used in Immunohistochemistry to generate Clcn3unc/unc mice in which ClC-3 is converted into a Cl- channel.
Mon May 04 00:00:00 EDT 2020
Dysregulation of TFEB contributes to manganese-induced autophagic failure and mitochondrial dysfunction in astrocytes.
Autophagy
Zhang Z,Yan J,Bowman AB,Bryan MR,Singh R,Aschner M
A-11120 was used in Immunohistochemistry to indicate that the dysregulation of TFEB (transcription factor EB) is involved in manganese-induced autotrophic failure.
Sat Aug 01 00:00:00 EDT 2020
RNAi-Based Gene Therapy Rescues Developmental and Epileptic Encephalopathy in a Genetic Mouse Model.
Molecular therapy : the journal of the American Society of Gene Therapy
Aimiuwu OV,Fowler AM,Sah M,Teoh JJ,Kanber A,Pyne NK,Petri S,Rosenthal-Weiss C,Yang M,Harper SQ,Frankel WN
A-11120 was used in Immunohistochemistry to results underscore the potential for RNAi gene therapy to treat DNM1 disease and other genetic DEEs where treatment would require inhibition of the pathogenic gene product.
Wed Jul 08 00:00:00 EDT 2020
Centrioles are amplified in cycling progenitors of olfactory sensory neurons.
PLoS biology
Ching K,Stearns T
A-11120 was used in Immunocytochemistry-immunoflourescence to describe a role for rosettes in centriole amplification by highlighting their formation in cycling progenitor cells and identifying developmental timing of centriole amplification.
Tue Sep 01 00:00:00 EDT 2020
Acute inhibition of centriolar satellite function and positioning reveals their functions at the primary cilium.
PLoS biology
Aydin ÖZ,Taflan SO,Gurkaslar C,Firat-Karalar EN
A-11120 was used in Immunocytochemistry-immunoflourescence to explore the mechanisms regulating centriolar satellite function and positioning.
Mon Jun 01 00:00:00 EDT 2020
Adenoviral protein E4orf4 interacts with the polarity protein Par3 to induce nuclear rupture and tumor cell death.
The Journal of cell biology
Dziengelewski C,Rodrigue MA,Caillier A,Jacquet K,Boulanger MC,Bergeman J,Fuchs M,Lambert H,Laprise P,Richard DE,Bordeleau F,Huot MÉ,Lavoie JN
A-11120 was used in Immunoprecipitation to show that the tumoricidal effect of E4orf4 is typified by changes in nuclear dynamics that depend on its interaction with the polarity protein Par3 and actomyosin contractility.
Mon Apr 06 00:00:00 EDT 2020
The kinesin motor Klp98A mediates apical to basal Wg transport.
Development (Cambridge, England)
Witte L,Linnemannstöns K,Schmidt K,Honemann-Capito M,Grawe F,Wodarz A,Gross JC
A-11120 was used in Immunocytochemistry to conclude that transcytosis-independent routes for Wg trafficking exist and demonstrate that Wg can be recycled apically via Rab4-recycling endosomes in the absence of Klp98A.
Fri Aug 14 00:00:00 EDT 2020
Ykt6-dependent endosomal recycling is required for Wnt secretion in the Drosophila wing epithelium.
Development (Cambridge, England)
Linnemannstöns K,Witte L,Karuna M P,Kittel JC,Danieli A,Müller D,Nitsch L,Honemann-Capito M,Grawe F,Wodarz A,Gross JC
A-11120 was used in Immunocytochemistry to investigate how Wnts are sorted at the level of endosomes by the versatile v-SNARE Ykt6.
Fri Aug 14 00:00:00 EDT 2020
Estrogen Receptor α Regulates Ethanol Excitation of Ventral Tegmental Area Neurons and Binge Drinking in Female Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Vandegrift BJ,Hilderbrand ER,Satta R,Tai R,He D,You C,Chen H,Xu P,Coles C,Brodie MS,Lasek AW
A-11120 was used in Immunohistochemistry to examine the role of ER subtypes (ERα and ERβ) in regulating the ethanol sensitivity of VTA neurons in female mice and found that ERα promotes the enhanced ethanol response of VTA neurons.
Wed Jul 01 00:00:00 EDT 2020
Hypersensitivity of Vps33B mutant flies to non-pathogenic infections is dictated by aberrant activation of p38b MAP kinase.
Traffic (Copenhagen, Denmark)
Zhang J,Tracy C,Pasare C,Zeng J,Krämer H
A-11120 was used in Immunohistochemistry to demonstrate that p38b MAP kinase contributes to the Vps33B protein deficient-associated enhanced inflammatory response.
Tue Sep 01 00:00:00 EDT 2020
CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions.
Structure (London, England : 1993)
Ochi T,Quarantotti V,Lin H,Jullien J,Rosa E Silva I,Boselli F,Barnabas DD,Johnson CM,McLaughlin SH,Freund SMV,Blackford AN,Kimata Y,Goldstein RE,Jackson SP,Blundell TL,Dutcher SK,Gergely F,van Breugel M
A-11120 was used in Immunocytochemistry to demonstrate that CCDC61 binds microtubules and that residues involved in CCDC61 microtubule binding are important for ciliary function in Chlamydomonas.
Tue Jun 02 00:00:00 EDT 2020
A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function.
Journal of cell science
Dehnen L,Janz M,Verma JK,Psathaki OE,Langemeyer L,Fröhlich F,Heinisch JJ,Meyer H,Ungermann C,Paululat A
A-11120 was used in Immunohistochemistry to suggest a key role for Bulli in the Rab5 to Rab7 transition during endosomal maturation rather than a direct influence on the GEF activity of Mon1-Ccz1.
Thu Jul 09 00:00:00 EDT 2020
TWIST1 Homodimers and Heterodimers Orchestrate Lineage-Specific Differentiation.
Molecular and cellular biology
Fan X,Waardenberg AJ,Demuth M,Osteil P,Sun JQJ,Loebel DAF,Graham M,Tam PPL,Fossat N
A-11120 was used in Western Blotting to reveal that TWIST1 homodimers and heterodimers with TCF3, TCF4, and TCF12 E-proteins are the predominant dimer combinations by proteomic profiling of human TWIST1-expressing cell lines and transcriptome analysis of mouse cranial mesenchyme.
Thu May 14 00:00:00 EDT 2020
Loss of Dmrt5 Affects the Formation of the Subplate and Early Corticogenesis.
Cerebral cortex (New York, N.Y. : 1991)
Ratié L,Desmaris E,García-Moreno F,Hoerder-Suabedissen A,Kelman A,Theil T,Bellefroid EJ,Molnár Z
A-11120 was used in Immunohistochemistry-immunofluorescence to demonstrate a novel function of Dmrt5 in regulating marginal zone and subplate formation and migration of cortical neurons to cortical plate.
Thu May 14 00:00:00 EDT 2020
In-frame fusion of SUMO1 enhances βarrestin2's association with activated GPCRs as well as with nuclear pore complexes.
Cellular signalling
Nagi K,Kaur S,Bai Y,Shenoy SK
A-11120 was used in Immunoprecipitation to investigate the role of SUMOylation in the trafficking of βarrestin and GPCR complexes.
Sun Nov 01 00:00:00 EDT 2020
Pax4 Gene Delivery Improves Islet Transplantation Efficacy by Promoting β Cell Survival and α-to-β Cell Transdifferentiation.
Cell transplantation
Parajuli KR,Zhang Y,Cao AM,Wang H,Fonseca VA,Wu H
A-11120 was used in Immunocytochemistry to suggest that Pax4 gene delivery into donor islets may be considered as an adjunct therapy for islet transplantation, which can either improve the therapeutic outcome of islet transplantation using the same amount of donor islets or allow the use of fewer donor islets to achieve normoglycemia.
Thu Aug 12 00:00:00 EDT 2021
Diesel Exhaust Extract Exposure Induces Neuronal Toxicity by Disrupting Autophagy.
Toxicological sciences : an official journal of the Society of Toxicology
Barnhill LM,Khuansuwan S,Juarez D,Murata H,Araujo JA,Bronstein JM
A-11120 was used in Flow Cytometry to link environmental exposure to altered proteostasis in an in vivo model system.
Wed Jul 01 00:00:00 EDT 2020
14-3-3 targets keratin intermediate filaments to mechanically sensitive cell-cell contacts.
Molecular biology of the cell
Mariani RA,Paranjpe S,Dobrowolski R,Weber GF
A-11120 was used in Immunocytochemistry to indicate that 14-3-3 acts on keratin IFs and is involved in their reorganization to sites of cell adhesion.
Wed Apr 15 00:00:00 EDT 2020
Enhancer activation by FGF signalling during otic induction.
Developmental biology
Tambalo M,Anwar M,Ahmed M,Streit A
A-11120 was used in Immunohistochemistry to show that during ear induction FGF signalling modifies the chromatin landscape to promote enhancer activation and chromatin accessibility.
Wed Jan 01 00:00:00 EST 2020
PROX1 is a specific and dynamic marker of sacral neural crest cells in the chicken intestine.
The Journal of comparative neurology
Margarido AS,Le Guen L,Falco A,Faure S,Chauvet N,de Santa Barbara P
A-11120 was used in Immunocytochemistry to indicate that PROX1 is the first marker that specifically identifies sNCCs.
Wed Apr 01 00:00:00 EDT 2020
Glioblastoma hijacks microglial gene expression to support tumor growth.
Journal of neuroinflammation
Maas SLN,Abels ER,Van De Haar LL,Zhang X,Morsett L,Sil S,Guedes J,Sen P,Prabhakar S,Hickman SE,Lai CP,Ting DT,Breakefield XO,Broekman MLD,El Khoury J
A-11120 was used in Immunohistochemistry-immunofluorescence to study how glioblastoma brain tumours can avoid tumour sensing, suppress immune responses and enhance tumour growth by altering microglial gene expression.
Thu Apr 16 00:00:00 EDT 2020
Glioblastoma hijacks microglial gene expression to support tumor growth.
Journal of neuroinflammation
Maas SLN,Abels ER,Van De Haar LL,Zhang X,Morsett L,Sil S,Guedes J,Sen P,Prabhakar S,Hickman SE,Lai CP,Ting DT,Breakefield XO,Broekman MLD,El Khoury J
A-11120 was used in Immunohistochemistry-immunofluorescence to study how glioblastoma brain tumours can avoid tumour sensing, suppress immune responses and enhance tumour growth by altering microglial gene expression.
Thu Apr 16 00:00:00 EDT 2020
Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow.
Nature communications
Mishra V,Re DB,Le Verche V,Alvarez MJ,Vasciaveo A,Jacquier A,Doulias PT,Greco TM,Nizzardo M,Papadimitriou D,Nagata T,Rinchetti P,Perez-Torres EJ,Politi KA,Ikiz B,Clare K,Than ME,Corti S,Ischiropoulos H,Lotti F,Califano A,Przedborski S
A-11120 was used in Immunocytochemistry-immunoflourescence to support the usefulness of integrative, systems biology approach to gain insights into complex neurobiological disease processes as in ALS and posit that the proposed methodology is not restricted to this biological context and could be used in a variety of other non-cell-autonomous communication mechanisms.
Wed Nov 04 00:00:00 EST 2020
A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol.
Nature communications
Gerdes C,Waal N,Offner T,Fornasiero EF,Wender N,Verbarg H,Manzini I,Trenkwalder C,Mollenhauer B,Strohäker T,Zweckstetter M,Becker S,Rizzoli SO,Basmanav FB,Opazo F
A-11120 was used in Western Blotting to characterize this biosensor in cells and tissues to finally reveal the presence of transmittable αSyn in human cerebrospinal fluid, demonstrating the potential of FluoReSyn for clinical research and diagnostics.
Mon Jun 01 00:00:00 EDT 2020
Cell-to-cell communication mediates glioblastoma progression in Drosophila.
Biology open
Portela M,Mitchell T,Casas-Tintó S
A-11120 was used in Immunohistochemistry-immunofluorescence to demonstrate the temporal organisation of the main cellular events that occur in Glioblastoma, including cell-to-cell interactions, neurodegeneration and tumour microtubes expansion.
Tue Sep 29 00:00:00 EDT 2020
Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration.
eLife
Ye Z,Su Z,Xie S,Liu Y,Wang Y,Xu X,Zheng Y,Zhao M,Jiang L
A-11120 was used in Immunocytochemistry-immunoflourescence to demonstrate regeneration of exhausted sox2+ progenitors requires lin28a.
Thu Apr 30 00:00:00 EDT 2020
Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex.
Nature communications
Wie J,Bharthur A,Wolfgang M,Narayanan V,Ramsey K,Aranda K,Zhang Q,Zhou Y,Ren D
A-11120 was used in Western Blotting to investigate the auxiliary subunits and functional significance of the NALCN complex.
Fri Jul 03 00:00:00 EDT 2020
Protocol for In Vivo Evaluation and Use of Destabilizing Domains in the Eye, Liver, and Beyond.
STAR protocols
Ramadurgum P,Daniel S,Hulleman JD
A-11120 was used in Immunohistochemistry-immunofluorescence to implement and evaluate a DD-POI in mouse ocular and hepatic tissue.
Fri Sep 18 00:00:00 EDT 2020
A Screen for PKN3 Substrates Reveals an Activating Phosphorylation of ARHGAP18.
International journal of molecular sciences
Dibus M,Brábek J,Rösel D
A-11120 was used in Immunoprecipitation to show that.
Tue Oct 20 00:00:00 EDT 2020
Feeding-dependent tentacle development in the sea anemone Nematostella vectensis.
Nature communications
Ikmi A,Steenbergen PJ,Anzo M,McMullen MR,Stokkermans A,Ellington LR,Gibson MC
A-11120 was used in Immunohistochemistry to demonstrate that the crosstalk between Target of Rapamycin (TOR) and Fibroblast growth factor receptor b (Fgfrb) signaling in ring muscles defines tentacle primordia in fed polyps.
Wed Sep 02 00:00:00 EDT 2020
Feeding-dependent tentacle development in the sea anemone Nematostella vectensis.
Nature communications
Ikmi A,Steenbergen PJ,Anzo M,McMullen MR,Stokkermans A,Ellington LR,Gibson MC
A-11120 was used in Immunohistochemistry to demonstrate that the crosstalk between Target of Rapamycin (TOR) and Fibroblast growth factor receptor b (Fgfrb) signaling in ring muscles defines tentacle primordia in fed polyps.
Wed Sep 02 00:00:00 EDT 2020
Drosophila Synaptotagmin 7 negatively regulates synaptic vesicle release and replenishment in a dosage-dependent manner.
eLife
Guan Z,Quiñones-Frías MC,Akbergenova Y,Littleton JT
A-11120 was used in Immunocytochemistry-immunoflourescence to determine if Drosophila Syt7 plays a conserved role as the Ca2+ sensor for asynchronous fusion and short-term facilitation.
Tue Apr 28 00:00:00 EDT 2020
FoxO suppresses endoplasmic reticulum stress to inhibit growth of Tsc1-deficient tissues under nutrient restriction.
eLife
Gupta A,Stocker H
A-11120 was used in Western Blotting to highlight the role of FoxO in limiting ER stress to regulate Tsc1 mutant overgrowth.
Thu Jun 11 00:00:00 EDT 2020
Emx2 regulates hair cell rearrangement but not positional identity within neuromasts.
eLife
Ohta S,Ji YR,Martin D,Wu DK
A-11120 was used in Immunohistochemistry-immunofluorescence to investigate whether Emx2 mediates this effect by changing location of hair bundle establishment or positions of HCs since daughter HCs are known to switch positions with each other.
Wed Dec 30 00:00:00 EST 2020
The Protein Arginine Methyltransferase PRMT8 and Substrate G3BP1 Control Rac1-PAK1 Signaling and Actin Cytoskeleton for Dendritic Spine Maturation.
Cell reports
Lo LH,Dong R,Lyu Q,Lai KO
A-11120 was used in Immunocytochemistry to unravel arginine methylation as a crucial regulatory mechanism for actin cytoskeleton during synapse development.
Tue Jun 09 00:00:00 EDT 2020
Activation of the ARCPOMC→MeA Projection Reduces Food Intake.
Frontiers in neural circuits
Kwon E,Jo YH
A-11120 was used in Immunohistochemistry to examine the role of a novel ARCPOMC→MeA neural circuit in the regulation of short-term food intake.
Mon Oct 04 00:00:00 EDT 2021
Serotonergic modulation of visual neurons in Drosophila melanogaster.
PLoS genetics
Sampson MM,Myers Gschweng KM,Hardcastle BJ,Bonanno SL,Sizemore TR,Arnold RC,Gao F,Dacks AM,Frye MA,Krantz DE
A-11120 was used in Immunohistochemistry to demonstrate that serotonin modulates the physiology of interneurons involved in early visual processing in Drosophila.
Sat Aug 01 00:00:00 EDT 2020
TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2.
Nature communications
Woolums BM,McCray BA,Sung H,Tabuchi M,Sullivan JM,Ruppell KT,Yang Y,Mamah C,Aisenberg WH,Saavedra-Rivera PC,Larin BS,Lau AR,Robinson DN,Xiang Y,Wu MN,Sumner CJ,Lloyd TE
A-11120 was used in Immunohistochemistry-immunofluorescence to highlight an integral role for CaMKII in neuronal TRPV4-associated Ca2+ responses, the importance of tightly regulated Ca2+ dynamics for mitochondrial axonal transport, and the therapeutic promise of TRPV4 antagonists for patients with TRPV4-related neurodegenerative diseases.
Fri May 29 00:00:00 EDT 2020
RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
eLife
Fuller GG,Han T,Freeberg MA,Moresco JJ,Ghanbari Niaki A,Roach NP,Yates JR,Myong S,Kim JK
A-11120 was used in Immunocytochemistry-immunoflourescence to demonstrate that RNA nucleates phase separation of the glycolysis machinery in response to hypoxic stress.
Thu Apr 16 00:00:00 EDT 2020
Inappropriate cathepsin K secretion promotes its enzymatic activation driving heart and valve malformation.
JCI insight
Lu PN,Moreland T,Christian CJ,Lund TC,Steet RA,Flanagan-Steet H
A-11120 was used in Immunohistochemistry to investigate the contribution of cathepsins during cardiovascular development and congenital disease.
Thu Oct 15 00:00:00 EDT 2020
Differentiating Drosophila female germ cells initiate Polycomb silencing by regulating PRC2-interacting proteins.
eLife
DeLuca SZ,Ghildiyal M,Pang LY,Spradling AC
A-11120 was used in Immunocytochemistry to show that Drosophila female germline stem cells (GSCs) provide a powerful system for studying Polycomb silencing.
Mon Aug 10 00:00:00 EDT 2020
Tetraspanin 33 (TSPAN33) regulates endocytosis and migration of human B lymphocytes by affecting the tension of the plasma membrane.
The FEBS journal
Navarro-Hernandez IC,López-Ortega O,Acevedo-Ochoa E,Cervantes-Díaz R,Romero-Ramírez S,Sosa-Hernández VA,Meza-Sánchez DE,Juárez-Vega G,Pérez-Martínez CA,Chávez-Munguía B,Galván-Hernández A,Antillón A,Ortega-Blake I,Santos-Argumedo L,Hernández-Hernández JM,Maravillas-Montero JL
A-11120 was used in Western Blotting to illustrate that TSPAN33 regulates adhesion and migration of B lymphocytes by cotrolling the mechanical properties of their plasma membrane.
Sat Aug 01 00:00:00 EDT 2020
Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production.
Nature communications
Kwon E,Joung HY,Liu SM,Chua SC,Schwartz GJ,Jo YH
A-11120 was used in Immunocytochemistry to report that a subset of ARC POMC neurons innervate the liver via preganglionic parasympathetic acetylcholine (ACh) neurons in the dorsal motor nucleus of the vagus (DMV).
Tue Dec 08 00:00:00 EST 2020
TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells.
Cell reports
Balka KR,Louis C,Saunders TL,Smith AM,Calleja DJ,D'Silva DB,Moghaddas F,Tailler M,Lawlor KE,Zhan Y,Burns CJ,Wicks IP,Miner JJ,Kile BT,Masters SL,De Nardo D
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot to investigate molecular responses to STING in myeloid cells.
Tue Apr 07 00:00:00 EDT 2020
Analysis of the "centrosome-ome" identifies MCPH1 deletion as a cause of centrosome amplification in human cancer.
Scientific reports
Denu RA,Burkard ME
A-11120 was used in Western Blotting to study the causes of centrosome amplification (CA) in human cancer.
Fri Jul 17 00:00:00 EDT 2020
Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy.
Nature communications
Zaninello M,Palikaras K,Naon D,Iwata K,Herkenne S,Quintana-Cabrera R,Semenzato M,Grespi F,Ross-Cisneros FN,Carelli V,Sadun AA,Tavernarakis N,Scorrano L
A-11120 was used in Immunocytochemistry to identify AMPK and autophagy as targetable components of autosomal dominant optic atrophy (ADOA) pathogenesis.
Wed Aug 12 00:00:00 EDT 2020
Oligodendrocyte-specific Argonaute profiling identifies microRNAs associated with experimental autoimmune encephalomyelitis.
Journal of neuroinflammation
Ma Q,Matsunaga A,Ho B,Oksenberg JR,Didonna A
A-11120 was used in Immunohistochemistry-immunofluorescence to show a dual role for miRNAs in autoimmune demyelination.
Mon Oct 12 00:00:00 EDT 2020
Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17.
Cell reports
Niu J,Sanders SS,Jeong HK,Holland SM,Sun Y,Collura KM,Hernandez LM,Huang H,Hayden MR,Smith GM,Hu Y,Jin Y,Thomas GM
A-11120 was used in Immunohistochemistry to demonstrate that two palmitoylation-dependent pathways mediate the control of somal and distal axon integrity.
Tue Nov 17 00:00:00 EST 2020
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway.
Science (New York, N.Y.)
Lee YR,Chen M,Lee JD,Zhang J,Lin SY,Fu TM,Chen H,Ishikawa T,Chiang SY,Katon J,Zhang Y,Shulga YV,Bester AC,Fung J,Monteleone E,Wan L,Shen C,Hsu CH,Papa A,Clohessy JG,Teruya-Feldstein J,Jain S,Wu H,Matesic L,Chen RH,Wei W,Pandolfi PP
A-11120 was used in Western Blotting to unravel a potential therapeutic strategy for cancer prevention and treatment through PTEN reactivation.
Fri May 17 00:00:00 EDT 2019
PRR5, 7 and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis.
Nucleic acids research
Li B,Wang Y,Zhang Y,Tian W,Chong K,Jang JC,Wang L
A-11120 was used in Immunoprecipitation to study the role of the circadian clock in the regulation of cell proliferation.
Tue Jun 04 00:00:00 EDT 2019
Stromalin Constrains Memory Acquisition by Developmentally Limiting Synaptic Vesicle Pool Size.
Neuron
Phan A,Thomas CI,Chakraborty M,Berry JA,Kamasawa N,Davis RL
A-11120 was used in Immunohistochemistry to identify a new mechanism for memory suppression and to show that the size of the synaptic vesicle (SV) pool is controlled genetically and independently from other aspects of neuron structure and function through Stromalin in Drosophila.
Wed Jan 02 00:00:00 EST 2019
Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity.
Neuron
Farías GG,Fréal A,Tortosa E,Stucchi R,Pan X,Portegies S,Will L,Altelaar M,Hoogenraad CC
A-11120 was used in Immunocytochemistry-immunoflourescence to demonstrate that the interplay between microtubules and the endoplasmic reticulum is essential for neuronal polarity.
Wed Apr 03 00:00:00 EDT 2019
Brd4 and P300 Confer Transcriptional Competency during Zygotic Genome Activation.
Developmental cell
Chan SH,Tang Y,Miao L,Darwich-Codore H,Vejnar CE,Beaudoin JD,Musaev D,Fernandez JP,Benitez MDJ,Bazzini AA,Moreno-Mateos MA,Giraldez AJ
A-11120 was used in Immunohistochemistry-immunofluorescence to conclude that P300 and Brd4 are sufficient to trigger genome-wide transcriptional competency by regulating histone acetylation on the first zygotic genes in zebrafish.
Mon Jun 17 00:00:00 EDT 2019
CEH-60/PBX and UNC-62/MEIS Coordinate a Metabolic Switch that Supports Reproduction in C. elegans.
Developmental cell
Dowen RH
A-11120 was used in Chromatin immunoprecipitation to conclude that CEH-60 governs an elaborate transcriptional network that balances stress responses and longevity against reproduction during developmental transitions.
Mon Apr 22 00:00:00 EDT 2019
Nucleus Accumbens Fast-Spiking Interneurons Constrain Impulsive Action.
Biological psychiatry
Pisansky MT,Lefevre EM,Retzlaff CL,Trieu BH,Leipold DW,Rothwell PE
A-11120 was used in Immunohistochemistry to study the regulation of impulsive behavior by fast-spiking interneurons (FSIs).
Sun Dec 01 00:00:00 EST 2019
A small number of cholinergic neurons mediate hyperaggression in female Drosophila.
Proceedings of the National Academy of Sciences of the United States of America
Palavicino-Maggio CB,Chan YB,McKellar C,Kravitz EA
A-11120 was used in Immunohistochemistry to find that the same 2 to 4 pairs of neurons likely were identified with both.
Tue Aug 20 00:00:00 EDT 2019
Resolving titin's lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes.
Proceedings of the National Academy of Sciences of the United States of America
Rudolph F,Hüttemeister J,da Silva Lopes K,Jüttner R,Yu L,Bergmann N,Friedrich D,Preibisch S,Wagner E,Lehnart SE,Gregorio CC,Gotthardt M
A-11120 was used in Western Blotting to find titin mRNA, protein synthesis and degradation compartmentalized toward the Z-disk in adult, but not embryonic cardiomyocytes.
Tue Dec 10 00:00:00 EST 2019
Serotonergic Modulation of Aggression in Drosophila Involves GABAergic and Cholinergic Opposing Pathways.
Current biology : CB
Alekseyenko OV,Chan YB,Okaty BW,Chang Y,Dymecki SM,Kravitz EA
A-11120 was used in Immunohistochemistry-immunofluorescence to show further that neurons utilizing serotonin, GABA, ACh, and short neuropeptide F interact in the LC12 optic glomerulus.
Mon Jul 08 00:00:00 EDT 2019
Chemokine signaling links cell-cycle progression and cilia formation for left-right symmetry breaking.
PLoS biology
Liu J,Zhu C,Ning G,Yang L,Cao Y,Huang S,Wang Q
A-11120 was used in Immunohistochemistry to uncover a role for Cxcr4 signaling in L-R patterning and provide fundamental insights into the molecular linkage between cell-cycle progression and ciliogenesis.
Thu Aug 01 00:00:00 EDT 2019
Glioblastoma cells vampirize WNT from neurons and trigger a JNK/MMP signaling loop that enhances glioblastoma progression and neurodegeneration.
PLoS biology
Portela M,Venkataramani V,Fahey-Lozano N,Seco E,Losada-Perez M,Winkler F,Casas-Tintó S
A-11120 was used in Immunohistochemistry to reveal a molecular mechanism for TM production, infiltration, and maintenance that can explain both neuron-dependent tumor progression and also the neural decay associated with GB.
Sun Dec 01 00:00:00 EST 2019
S-nitrosoglutathione inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses: A possible role of S-nitrosation.
British journal of pharmacology
Bouressam ML,Lecat S,Raoul A,Gaucher C,Perrin-Sarrado C,Lartaud I,Dupuis F
A-11120 was used in Flow cytometry/Cell sorting to evaluate the effects of S-nitrosation on both AngII dependent and AngII-independent cerebrovascular responses.
Sat Jun 01 00:00:00 EDT 2019
GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner.
Diabetes
Zhang Y,Parajuli KR,Fava GE,Gupta R,Xu W,Nguyen LU,Zakaria AF,Fonseca VA,Wang H,Mauvais-Jarvis F,Sloop KW,Wu H
A-11120 was used in Immunofluorescence to propose a bidirectional role for glucagon-like peptide 1 in glucagon secretion depending on glucose levels via it's receptor in pancreatic α-cells.
Tue Jan 01 00:00:00 EST 2019
A theory of centriole duplication based on self-organized spatial pattern formation.
The Journal of cell biology
Takao D,Yamamoto S,Kitagawa D
A-11120 was used in Immunocytochemistry-immunoflourescence to propose that the self-patterning of Plk4 is crucial for the regulation of centriole duplication.
Mon Nov 04 00:00:00 EST 2019
Cell ratcheting through the Sbf RabGEF directs force balancing and stepped apical constriction.
The Journal of cell biology
Miao H,Vanderleest TE,Jewett CE,Loerke D,Blankenship JT
A-11120 was used in Immunohistochemistry to address the mechanisms to achieve the irreversibility of pulsed events while allowing the emergence of uniform epithelial behaviours in drosophila gastrulation.
Mon Nov 04 00:00:00 EST 2019
The PI(4)P phosphatase Sac2 controls insulin granule docking and release.
The Journal of cell biology
Nguyen PM,Gandasi NR,Xie B,Sugahara S,Xu Y,Idevall-Hagren O
A-11120 was used in Western Blotting to identify a phosphoinositide switch on the surface on insulin granules that is required for stable granule docking at the plasma membrane and impaired in human type 2 diabetes.
Mon Nov 04 00:00:00 EST 2019
Rat Mesenchymal Stromal Cell Sheets Suppress Renal Fibrosis via Microvascular Protection.
Stem cells translational medicine
Imafuku A,Oka M,Miyabe Y,Sekiya S,Nitta K,Shimizu T
A-11120 was used in Immunohistochemistry to demonstrate that bone marrow-derived mesenchymal stromal cell (BMSC)-sheet transplantation for a rat renal ischemia-reperfusion-injury (IRI) model suppressed renal fibrosis via microvascular (MV) protection.
Sun Dec 01 00:00:00 EST 2019
Ethanol acts on KCNK13 potassium channels in the ventral tegmental area to increase firing rate and modulate binge-like drinking.
Neuropharmacology
You C,Savarese A,Vandegrift BJ,He D,Pandey SC,Lasek AW,Brodie MS
A-11120 was used in Immunohistochemistry-immunofluorescence to show the KCNK13 potassium channel can modulate binge drinking by increasing ventral tegmental area firing rate upon ethanol exposure.
Tue Jan 01 00:00:00 EST 2019
High Sensitivity Mapping of Cortical Dopamine D2 Receptor Expressing Neurons.
Cerebral cortex (New York, N.Y. : 1991)
Khlghatyan J,Quintana C,Parent M,Beaulieu JM
A-11120 was used in Immunohistochemistry-fresh tissue to identify and map cortical dopamine D2 receptor expressing neurons.
Wed Aug 14 00:00:00 EDT 2019
Hippocampal Subgranular Zone FosB Expression Is Critical for Neurogenesis and Learning.
Neuroscience
Manning CE,Eagle AL,Kwiatkowski CC,Achargui R,Woodworth H,Potter E,Ohnishi Y,Leinninger GM,Robison AJ
A-11120 was used in Immunocytochemistry-immunoflourescence to demonstrate that FosB gene expression in SGZ is necessary for both hippocampal neurogenesis and memory formation.
Wed May 15 00:00:00 EDT 2019
Force balances between interphase centrosomes as revealed by laser ablation.
Molecular biology of the cell
Odell J,Sikirzhytski V,Tikhonenko I,Cobani S,Khodjakov A,Koonce M
A-11120 was used in Immunocytochemistry to study the mechanisms responsible for the positioning of multiple centrosomes.
Mon Jul 01 00:00:00 EDT 2019
Horizontal Boundary Cells, a Special Group of Somitic Cells, Play Crucial Roles in the Formation of Dorsoventral Compartments in Teleost Somite.
Cell reports
Abe K,Shimada A,Tayama S,Nishikawa H,Kaneko T,Tsuda S,Karaiwa A,Matsui T,Ishitani T,Takeda H
A-11120 was used in Immunohistochemistry to reveal the mechanisms underlying the dorsoventral boundary in the teleost trunk by specialized boundary cells.
Tue Apr 16 00:00:00 EDT 2019
Self-organization of Plk4 regulates symmetry breaking in centriole duplication.
Nature communications
Yamamoto S,Kitagawa D
A-11120 was used in Immunocytochemistry-immunoflourescence to examine the role of intrinsic self-organisation of Plk4 in symmetry breaking in the process of centriole duplication.
Thu Apr 18 00:00:00 EDT 2019
Mechanism of Acetic Acid Gustatory Repulsion in Drosophila.
Cell reports
Rimal S,Sang J,Poudel S,Thakur D,Montell C,Lee Y
A-11120 was used in Immunohistochemistry to indicate that flies taste acids through a repertoire of receptors, enabling them to discriminate foods on the basis of acid composition rather than just pH.
Tue Feb 05 00:00:00 EST 2019
The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish.
Scientific reports
Stanic K,Reig G,Figueroa RJ,Retamal PA,Wichmann IA,Opazo JC,Owen GI,Corvalán AH,Concha ML,Amigo JD
A-11120 was used in Immunohistochemistry to determine the physiology and pathology of the Repremo-like gene.
Thu May 09 00:00:00 EDT 2019
A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites.
eLife
Jiang N,Rasmussen JP,Clanton JA,Rosenberg MF,Luedke KP,Cronan MR,Parker ED,Kim HJ,Vaughan JC,Sagasti A,Parrish JZ
A-11120 was used in Western Blotting to study the developmental and functional roles of the ensheathment of peripheral arbors of somatosensory neurons in vertebrate and invertebrate epidermal cells.
Mon Mar 11 00:00:00 EDT 2019
Chaperonin TRiC/CCT supports mitotic exit and entry into endocycle in Drosophila.
PLoS genetics
Ohhara Y,Nakamura A,Kato Y,Yamakawa-Kobayashi K
A-11120 was used in Immunohistochemistry-immunofluorescence to study the underlying mechanisms of the mitotic to endocycle switch in Drosophila.
Mon Apr 01 00:00:00 EDT 2019
Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala.
eLife
Ostroff LE,Santini E,Sears R,Deane Z,Kanadia RN,LeDoux JE,Lhakhang T,Tsirigos A,Heguy A,Klann E
A-11120 was used in Immunohistochemistry to demonstrate that axonal translation occurs in the adult forebrain and is altered after learning.
Wed Dec 11 00:00:00 EST 2019
Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration.
eLife
Čapek D,Smutny M,Tichy AM,Morri M,Janovjak H,Heisenberg CP
A-11120 was used in Immunohistochemistry to analyse how restricted activation of non-canonical Wnt signalling affects directed anterior axial mesendoderm cell migration within the zebrafish gastrula.
Wed Jan 16 00:00:00 EST 2019
Essential long-range action of Wingless/Wnt in adult intestinal compartmentalization.
PLoS genetics
Tian A,Duwadi D,Benchabane H,Ahmed Y
A-11120 was used in Immunohistochemistry to provide new evidence that supports the requirement for the direct, long-range action of Wingless in tissue patterning, with relevance for animal development, tissue homeostasis and Wnt-driven disease.
Sat Jun 01 00:00:00 EDT 2019
WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis.
Nature communications
Tsarouhas V,Liu D,Tsikala G,Fedoseienko A,Zinn K,Matsuda R,Billadeau DD,Samakovlis C
A-11120 was used in Immunocytochemistry-immunoflourescence to study the coordination of F-actin networks and their role in cellular activities.
Thu May 16 00:00:00 EDT 2019
Multiple Patterns of Axonal Collateralization of Single Layer III Neurons of the Rat Presubiculum.
Frontiers in neural circuits
Honda Y,Furuta T
A-11120 was used in Immunohistochemistry to demonstrate that layer III of the rat presubiculum consists of multiple types of cortical projection neurons and interneurons, and also suggest that inputs from a single presubicular layer III neuron can directly affect a band-like zone of the MEC.
Tue Mar 03 00:00:00 EST 2020
The MADS-box transcription factor PHERES1 controls imprinting in the endosperm by binding to domesticated transposons.
eLife
Batista RA,Moreno-Romero J,Qiu Y,van Boven J,Santos-González J,Figueiredo DD,Köhler C
A-11120 was used in Chromatin immunoprecipitation to provide an example of the molecular domestication of these elements which, by distributing PHE1 binding sites throughout the genome, have facilitated the recruitment of crucial endosperm regulators into a single transcriptional network.
Mon Dec 02 00:00:00 EST 2019
Reward signaling in a recurrent circuit of dopaminergic neurons and peptidergic Kenyon cells.
Nature communications
Lyutova R,Selcho M,Pfeuffer M,Segebarth D,Habenstein J,Rohwedder A,Frantzmann F,Wegener C,Thum AS,Pauls D
A-11120 was used in Immunohistochemistry-immunofluorescence to suggest that recurrent signaling routes within the larval mushroom body circuitry may represent a mechanism subserving memory stabilization.
Mon Jul 15 00:00:00 EDT 2019
Polo-like kinase 4 maintains centriolar satellite integrity by phosphorylation of centrosomal protein 131 (CEP131).
The Journal of biological chemistry
Denu RA,Sass MM,Johnson JM,Potts GK,Choudhary A,Coon JJ,Burkard ME
A-11120 was used in Immunocytochemistry-immunoflourescence to conclude that PLK4 phosphorylates CEP131 at Ser-78 to maintains centriolar satellite integrity.
Fri Apr 19 00:00:00 EDT 2019
Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties.
Cell reports
Foggetti A,Baccini G,Arnold P,Schiffelholz T,Wulff P
A-11120 was used in Immunohistochemistry to show that a subset of hippocampal parvalbumin-positive interneurons forms numerous dendritic spines with highly variable densities and input-selective organization.
Tue Jun 25 00:00:00 EDT 2019
Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila.
eLife
Wu SF,Ja YL,Zhang YJ,Yang CH
A-11120 was used in Immunohistochemistry-immunofluorescence to uncover one mechanism by which Drosophila integrate taste and tactile information when deciding where to deposit their eggs and reveal that TMC-expressing neurons play opposing roles in hardness discrimination in two different decisions.
Tue Jun 11 00:00:00 EDT 2019
Dynamics of a hippocampal neuronal ensemble encoding trace fear memory revealed by in vivo Ca2+ imaging.
PloS one
Zhang L,Chen X,Sindreu C,Lu S,Storm DR,Zweifel LS,Xia Z
A-11120 was used in Immunohistochemistry to identify, using in vivo calcium imaging, a group of CA1 cells in the mouse hippocampus responsible for encoding the trace fear memory.
Mon Mar 02 00:00:00 EST 2020
The Expression of Key Guidance Genes at a Forebrain Axon Turning Point Is Maintained by Distinct Fgfr Isoforms but a Common Downstream Signal Transduction Mechanism.
eNeuro
Yang JJ,Bertolesi GE,Dueck S,Hehr CL,McFarlane S
A-11120 was used in Immunohistochemistry to investigate whether there are common features of the regulatory pathways that control the expression of sema3a and slit1 at a forebrain single axon guidance decision point.
Mon Feb 10 00:00:00 EST 2020
BMP signaling is required for nkx2.3-positive pharyngeal pouch progenitor specification in zebrafish.
PLoS genetics
Li L,Ning G,Yang S,Yan Y,Cao Y,Wang Q
A-11120 was used in Immunohistochemistry to identify a population of nkx2.3+ pouch progenitors in zebrafish embryos and demonstrate an essential requirement of ectodermal BMP2b for their specification.
Fri Feb 01 00:00:00 EST 2019
Prior observation of fear learning enhances subsequent self-experienced fear learning with an overlapping neuronal ensemble in the dorsal hippocampus.
Molecular brain
Nomura H,Teshirogi C,Nakayama D,Minami M,Ikegaya Y
A-11120 was used in Immunohistochemistry to investigate whether prior observation of a conspecific receiving contextual fear conditioning affects subsequent self-experienced fear conditioning and how neuronal ensembles represent the integration of the observation and self-experience.
Thu Mar 14 00:00:00 EDT 2019
Rapid active zone remodeling consolidates presynaptic potentiation.
Nature communications
Böhme MA,McCarthy AW,Grasskamp AT,Beuschel CB,Goel P,Jusyte M,Laber D,Huang S,Rey U,Petzoldt AG,Lehmann M,Göttfert F,Haghighi P,Hell SW,Owald D,Dickman D,Sigrist SJ,Walter AM
A-11120 was used in Immunohistochemistry-immunofluorescence to show that presynaptic active zones consist of nano-modular release sites, and identify a molecular sequence that adds modules within minutes of inducing homeostatic plasticity.
Wed Mar 06 00:00:00 EST 2019
In vivo assembly and trafficking of olfactory Ionotropic Receptors.
BMC biology
Abuin L,Prieto-Godino LL,Pan H,Gutierrez C,Huang L,Jin R,Benton R
A-11120 was used in Immunohistochemistry-immunofluorescence to study the role of the extracellular ligand-binding domain in tuning ionotropic receptors.
Wed Apr 17 00:00:00 EDT 2019
Nanoscale coupling of endocytic pit growth and stability.
Science advances
Lehmann M,Lukonin I,Noé F,Schmoranzer J,Clementi C,Loerke D,Haucke V
A-11120 was used in Immunocytochemistry-immunoflourescence to combine computational modeling, automated tracking of clathrin-coated endocytic pits (CCP) dynamics, electron microscopy, and functional rescue experiments to demonstrate that CCP growth and lifetime are closely correlated and mechanistically linked by the early-acting endocytic F-BAR protein FCHo2.
Fri Nov 01 00:00:00 EDT 2019
Protein kinase D up-regulates transcription of VEGF receptor-2 in endothelial cells by suppressing nuclear localization of the transcription factor AP2β.
The Journal of biological chemistry
Wang Y,Hoeppner LH,Angom RS,Wang E,Dutta S,Doeppler HR,Wang F,Shen T,Scarisbrick IA,Guha S,Storz P,Bhattacharya R,Mukhopadhyay D
A-11120 was used in Chromatin immunoprecipitation to investigate how protein kinase D regulates ascular endothelial growth factor signaling.
Fri Oct 25 00:00:00 EDT 2019
A Basal Ganglia Circuit Sufficient to Guide Birdsong Learning.
Neuron
Xiao L,Chattree G,Oscos FG,Cao M,Wanat MJ,Roberts TF
A-11120 was used in Immunohistochemistry-immunofluorescence to define a central role for reinforcement mechanisms in learning vocalisations and demonstrate minimal circuit elements for learning vocal behaviours in singing birds.
Wed Apr 04 00:00:00 EDT 2018
Motivation, Perception, and Chance Converge to Make a Binary Decision.
Neuron
Zhang SX,Miner LE,Boutros CL,Rogulja D,Crickmore MA
A-11120 was used in Immunohistochemistry (PFA fixed) to reveal a central role for chance neuronal events in the decision of a male fly to court.
Wed Jul 25 00:00:00 EDT 2018
Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation.
The Journal of experimental medicine
Carpier JM,Zucchetti AE,Bataille L,Dogniaux S,Shafaq-Zadah M,Bardin S,Lucchino M,Maurin M,Joannas LD,Magalhaes JG,Johannes L,Galli T,Goud B,Hivroz C
A-11120 was used in Immunohistochemistry to study the retrograde traffic of linker for activation of T cells from the plasma membrane to the Golgi-trans-Golgi network.
Mon Apr 02 00:00:00 EDT 2018
Engineered cardiac tissue patch maintains structural and electrical properties after epicardial implantation.
Biomaterials
Jackman CP,Ganapathi AM,Asfour H,Qian Y,Allen BW,Li Y,Bursac N
A-11120 was used in Immunohistochemistry to demonstrate generation of highly functional cardiac tissue patches that can robustly engraft on the epicardial surface, vascularize, and maintain electrical function, but do not couple with host tissue.
Thu Mar 01 00:00:00 EST 2018
Nek9 Phosphorylation Defines a New Role for TPX2 in Eg5-Dependent Centrosome Separation before Nuclear Envelope Breakdown.
Current biology : CB
Eibes S,Gallisà-Suñé N,Rosas-Salvans M,Martínez-Delgado P,Vernos I,Roig J
A-11120 was used in Western blotting following immunoprecipitation to uncover an unsuspected role for the nuclear microtubule-associated protein TPX2 before nuclear envelope breakdown and define a novel regulatory mechanism for centrosome separation in prophase.
Mon Jan 08 00:00:00 EST 2018
Nek9 Phosphorylation Defines a New Role for TPX2 in Eg5-Dependent Centrosome Separation before Nuclear Envelope Breakdown.
Current biology : CB
Eibes S,Gallisà-Suñé N,Rosas-Salvans M,Martínez-Delgado P,Vernos I,Roig J
A-11120 was used in Western blotting following immunoprecipitation to uncover an unsuspected role for the nuclear microtubule-associated protein TPX2 before nuclear envelope breakdown and define a novel regulatory mechanism for centrosome separation in prophase.
Mon Jan 08 00:00:00 EST 2018
Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex.
Science signaling
Portela M,Yang L,Paul S,Li X,Veraksa A,Parsons LM,Richardson HE
A-11120 was used in Immunohistochemistry-immunofluorescence to study the mechanism by which Lgl controls vesicular acidification and Notch activity in tumorigenesis.
Tue Jun 05 00:00:00 EDT 2018
Structural insights into Rhino-Deadlock complex for germline piRNA cluster specification.
EMBO reports
Yu B,Lin YA,Parhad SS,Jin Z,Ma J,Theurkauf WE,Zhang ZZ,Huang Y
A-11120 was used in Western Blotting to explain the cross-species incompatibility of two sibling species at the molecular level.
Sun Jul 01 00:00:00 EDT 2018
The adherens junction-associated LIM domain protein Smallish regulates epithelial morphogenesis.
The Journal of cell biology
Beati H,Peek I,Hordowska P,Honemann-Capito M,Glashauser J,Renschler FA,Kakanj P,Ramrath A,Leptin M,Luschnig S,Wiesner S,Wodarz A
A-11120 was used in Immunohistochemistry-immunofluorescence to propose that Smash is a key regulator of morphogenesis coordinating planar cell polarity and actomyosin contractility at the zonula adherens.
Mon Mar 05 00:00:00 EST 2018
The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing Drosophila eye.
Development (Cambridge, England)
Del Bel LM,Griffiths N,Wilk R,Wei HC,Blagoveshchenskaya A,Burgess J,Polevoy G,Price JV,Mayinger P,Brill JA
A-11120 was used in Immunohistochemistry-immunofluorescence to study the role of phosphoinositide phosphatase Sac1 in the patterning of interommatidial cells in the developing Drosophila eye.
Thu May 31 00:00:00 EDT 2018
Bsx controls pineal complex development.
Development (Cambridge, England)
Schredelseker T,Driever W
A-11120 was used in Immunohistochemistry to identify the differentiation of multiple cell types in the zebrafish pineal complex is due to the brain-specific homeobox gene.
Mon Jul 09 00:00:00 EDT 2018
Reciprocal Negative Regulation Between Lmx1a and Lmo4 Is Required for Inner Ear Formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Huang Y,Hill J,Yatteau A,Wong L,Jiang T,Petrovic J,Gan L,Dong L,Wu DK
A-11120 was used in Immunohistochemistry to examine the interaction between Lmx1a and Lmo4 in the formation of the mammalian inner ear.
Wed Jun 06 00:00:00 EDT 2018
HSPB8 and BAG3 cooperate to promote spatial sequestration of ubiquitinated proteins and coordinate the cellular adaptive response to proteasome insufficiency.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Guilbert SM,Lambert H,Rodrigue MA,Fuchs M,Landry J,Lavoie JN
A-11120 was used in Immunocytochemistry-immunoflourescence to show that HSPB8 cooperates with BAG3 to coordinate the sequestration of harmful proteins and the cellular adaptive response upon proteasome inhibition.
Sun Jul 01 00:00:00 EDT 2018
The Joubert syndrome protein ARL13B binds tubulin to maintain uniform distribution of proteins along the ciliary membrane.
Journal of cell science
Revenkova E,Liu Q,Gusella GL,Iomini C
A-11120 was used in Immunocytochemistry-immunoflourescence to propose a so far unknown function of ARL13B in anchoring ciliary membrane proteins to the axoneme through the direct interaction of its G-domain with tubulin.
Fri May 04 00:00:00 EDT 2018
APC/CFzr regulates cardiac and myoblast cell numbers, and plays a crucial role during myoblast fusion.
Journal of cell science
Drechsler M,Meyer H,Wilmes AC,Paululat A
A-11120 was used in Immunohistochemistry-immunofluorescence to indicate that protein destruction and turnover constitute major events during myoblast fusion.
Tue Jul 17 00:00:00 EDT 2018
Tension-dependent regulation of mammalian Hippo signaling through LIMD1.
Journal of cell science
Ibar C,Kirichenko E,Keepers B,Enners E,Fleisch K,Irvine KD
A-11120 was used in Proximity Ligation Assay to study the tension-dependent regulation of mammalian Hippo signalling through LIMD1.
Fri Mar 02 00:00:00 EST 2018
Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3.
Psychoneuroendocrinology
Savarese A,Lasek AW
A-11120 was used in Immunohistochemistry to study anxiety like behaviour in Lmo3Z mice.
Fri Jun 01 00:00:00 EDT 2018
Tagging of Weakly Expressed Toxoplasma gondii Calcium-Related Genes with High-Affinity Tags.
The Journal of eukaryotic microbiology
Hortua Triana MA,Márquez-Nogueras KM,Chang L,Stasic AJ,Li C,Spiegel KA,Sharma A,Li ZH,Moreno SNJ
A-11120 was used in Immunohistochemistry to design a Carboxy-terminus tagging plasmid containing the previously characterized "spaghetti monster-HA" (smHA) or "spaghetti monster-MYC" (smMYC) tags.
Sun Jul 01 00:00:00 EDT 2018
Characterization of TCDD-inducible poly-ADP-ribose polymerase (TIPARP/ARTD14) catalytic activity.
The Biochemical journal
Gomez A,Bindesbøll C,Satheesh SV,Grimaldi G,Hutin D,MacPherson L,Ahmed S,Tamblyn L,Cho T,Nebb HI,Moen A,Anonsen JH,Grant DM,Matthews J
A-11120 was used in Immunoprecipitation to report the biochemical characterization of the mono-ADP-ribosyltransferase 2,3,7,8-tetrachlorodibenzo-p-dioxin poly-ADP-ribose polymerase, which is known to repress aryl hydrocarbon receptor-dependent transcription.
Tue Dec 11 00:00:00 EST 2018
Endodermal pouch-expressed dmrt2b is important for pharyngeal cartilage formation.
Biology open
Li L,Mao A,Wang P,Ning G,Cao Y,Wang Q
A-11120 was used in Immunohistochemistry-immunofluorescence to study how transcription factors expressed in endodermal pouches regulate pharyngeal skeleton development through tissue-tissue interactions.
Mon Dec 17 00:00:00 EST 2018
Drosophila Ror is a nervous system-specific co-receptor for Wnt ligands.
Biology open
Ripp C,Loth J,Petrova I,Linnemannstöns K,Ulepic M,Fradkin L,Noordermeer J,Wodarz A
A-11120 was used in Immunoprecipitation to identify Drosophila Ror as a Wnt co-receptor expressed in the nervous system.
Fri Nov 02 00:00:00 EDT 2018
Diverse populations of local interneurons integrate into the Drosophila adult olfactory circuit.
Nature communications
Liou NF,Lin SH,Chen YJ,Tsai KT,Yang CJ,Lin TY,Wu TH,Lin HJ,Chen YT,Gohl DM,Silies M,Chou YH
A-11120 was used in Immunohistochemistry to elucidate how Drosophila olfactory local interneurons develop and contribute to constructing the olfactory circuit.
Fri Jun 08 00:00:00 EDT 2018
IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes.
Cell reports
Atakpa P,Thillaiappan NB,Mataragka S,Prole DL,Taylor CW
A-11120 was used in Proximity Ligation Assay to demonstrate that lysosomes sequester Ca2+ released by all IP3R subtypes, but not Ca2+ entering cells through store-operated Ca2+ entry.
Tue Dec 11 00:00:00 EST 2018
Orexin Depolarizes Central Amygdala Neurons via Orexin Receptor 1, Phospholipase C and Sodium-Calcium Exchanger and Modulates Conditioned Fear.
Frontiers in neuroscience
Dustrude ET,Caliman IF,Bernabe CS,Fitz SD,Grafe LA,Bhatnagar S,Bonaventure P,Johnson PL,Molosh AI,Shekhar A
A-11120 was used in Immunohistochemistry to explore the specific mechanisms underlying orexin neurotransmission within the central nucleus.
Sat Sep 17 00:00:00 EDT 2022
A dopaminergic switch for fear to safety transitions.
Nature communications
Luo R,Uematsu A,Weitemier A,Aquili L,Koivumaa J,McHugh TJ,Johansen JP
A-11120 was used in Immunohistochemistry-immunofluorescence to demonstrate a novel function for the canonical midbrain ventral tegmental area-dopamine reward system.
Wed Jun 27 00:00:00 EDT 2018
Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development.
Nature communications
Yuan X,Song M,Devine P,Bruneau BG,Scott IC,Wilson MD
A-11120 was used in Immunohistochemistry-immunofluorescence to identify enhancers involved in the initial events of cardiogenesis, which occurs during the phylotypic period.
Mon Nov 26 00:00:00 EST 2018
Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration.
Molecular neurodegeneration
Jeong GR,Jang EH,Bae JR,Jun S,Kang HC,Park CH,Shin JH,Yamamoto Y,Tanaka-Yamamoto K,Dawson VL,Dawson TM,Hur EM,Lee BD
A-11120 was used in Immunohistochemistry to suggest that Rab GTPases may mediate leucine-rich repeat kinase 2 toxicity in the progression of Parkinson's disease.
Tue Feb 13 00:00:00 EST 2018
The role of calretinin-expressing granule cells in olfactory bulb functions and odor behavior.
Scientific reports
Hardy D,Malvaut S,Breton-Provencher V,Saghatelyan A
A-11120 was used in Immunohistochemistry to study the role of calretinin-expressing granule cells in olfactory bulb functions and odour behaviour.
Wed Jun 20 00:00:00 EDT 2018
The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II.
Autophagy
Onnis A,Cianfanelli V,Cassioli C,Samardzic D,Pelicci PG,Cecconi F,Baldari CT
A-11120 was used in Immunocytochemistry-immunofluorescence to identify mitochondrial p66SHC as a novel regulator of autophagy and mitophagy in B cells and implicate p66SHC-mediated coordination of autophagy and apoptosis in B cell survival and differentiation.
Tue Oct 22 00:00:00 EDT 2019
The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II.
Autophagy
Onnis A,Cianfanelli V,Cassioli C,Samardzic D,Pelicci PG,Cecconi F,Baldari CT
A-11120 was used in Immunocytochemistry-immunofluorescence to identify mitochondrial p66SHC as a novel regulator of autophagy and mitophagy in B cells and implicate p66SHC-mediated coordination of autophagy and apoptosis in B cell survival and differentiation.
Tue Oct 22 00:00:00 EDT 2019
The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II.
Autophagy
Onnis A,Cianfanelli V,Cassioli C,Samardzic D,Pelicci PG,Cecconi F,Baldari CT
A-11120 was used in Immunocytochemistry-immunofluorescence to identify mitochondrial p66SHC as a novel regulator of autophagy and mitophagy in B cells and implicate p66SHC-mediated coordination of autophagy and apoptosis in B cell survival and differentiation.
Tue Oct 22 00:00:00 EDT 2019
miR-34b/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation.
Stem cell reports
De Gregorio R,Pulcrano S,De Sanctis C,Volpicelli F,Guatteo E,von Oerthel L,Latagliata EC,Esposito R,Piscitelli RM,Perrone-Capano C,Costa V,Greco D,Puglisi-Allegra S,Smidt MP,di Porzio U,Caiazzo M,Mercuri NB,Li M,Bellenchi GC
A-11120 was used in Immunocytochemistry to study the role of miR-34b/c in neuronal commitment and enhancing in vitro generation of dopaminergic neurons.
Tue Apr 10 00:00:00 EDT 2018
Blimp-1/PRDM1 is a critical regulator of Type III Interferon responses in mammary epithelial cells.
Scientific reports
Elias S,Robertson EJ,Bikoff EK,Mould AW
A-11120 was used in Chromatin immunoprecipitation to demonstrate that type III IFN-λ profoundly influences the behavior of MECs and identify Blimp-1 as a critical regulator of IFN signaling cascades.
Wed Jan 10 00:00:00 EST 2018
Origin of Gamma Frequency Power during Hippocampal Sharp-Wave Ripples.
Cell reports
Oliva A,Fernández-Ruiz A,Fermino de Oliveira E,Buzsáki G
A-11120 was used in Immunohistochemistry to study the origin of gamma frequency power during hippocampal sharp-wave ripples.
Tue Nov 13 00:00:00 EST 2018
Adult-specific insulin-producing neurons in Drosophila melanogaster.
The Journal of comparative neurology
Ohhara Y,Kobayashi S,Yamakawa-Kobayashi K,Yamanaka N
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to provide a neuroanatomical basis for understanding remodeling of the neuropeptidergic system during insect development and evolution.
Fri Jun 01 00:00:00 EDT 2018
Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes.
Nature communications
Mariotti L,Losi G,Lia A,Melone M,Chiavegato A,Gómez-Gonzalo M,Sessolo M,Bovetti S,Forli A,Zonta M,Requie LM,Marcon I,Pugliese A,Viollet C,Bettler B,Fellin T,Conti F,Carmignoto G
A-11120 was used in Immunohistochemistry to identify a signalling specificity between interneuron subtypes and astrocytes, suggesting astrocytes also function as non-neuronal components of inhibitory circuits.
Mon Jan 08 00:00:00 EST 2018
Diversification of heart progenitor cells by EGF signaling and differential modulation of ETS protein activity.
eLife
Schwarz B,Hollfelder D,Scharf K,Hartmann L,Reim I
A-11120 was used in Immunohistochemistry (PFA fixed) to demonstrate that the Tbx20 ortholog Midline acts as a direct target of the EGFR effector Pointed to repress ostial fates.
Tue Jun 05 00:00:00 EDT 2018
The Drosophila melanogaster Na+/Ca2+ Exchanger CALX Controls the Ca2+ Level in Olfactory Sensory Neurons at Rest and After Odorant Receptor Activation.
Frontiers in cellular neuroscience
Halty-deLeon L,Hansson BS,Wicher D
A-11120 was used in Immunohistochemistry-immunofluorescence to study the importance of the Drosophila melanogaster Na+/Ca2+ Exchanger, CALX, in regulating the calcium level of olfactory sensory neurons.
Thu Oct 01 00:00:00 EDT 2020
Intrinsic Projections of Layer Vb Neurons to Layers Va, III, and II in the Lateral and Medial Entorhinal Cortex of the Rat.
Cell reports
Ohara S,Onodera M,Simonsen ØW,Yoshino R,Hioki H,Iijima T,Tsutsui KI,Witter MP
A-11120 was used in Immunohistochemistry-immunofluorescence to characterise the neuronal innervation by layer Vb neurons in the entorhinal cortex of the rat.
Tue Jul 03 00:00:00 EDT 2018
Differential Requirement for Translation Initiation Factor Pathways during Ecdysone-Dependent Neuronal Remodeling in Drosophila.
Cell reports
Rode S,Ohm H,Anhäuser L,Wagner M,Rosing M,Deng X,Sin O,Leidel SA,Storkebaum E,Rentmeister A,Zhu S,Rumpf S
A-11120 was used in Immunohistochemistry to propose that an eIF3-eIF4A-dependent alternative initiation pathway bypasses 4E-BP to ensure adequate translation of ecdysone-induced genes.
Tue Aug 28 00:00:00 EDT 2018
Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement.
Nature communications
Jia G,Preussner J,Chen X,Guenther S,Yuan X,Yekelchyk M,Kuenne C,Looso M,Zhou Y,Teichmann S,Braun T
A-11120 was used in Immunohistochemistry-immunofluorescence to characterise mouse cardiac progenitor cells marked by Nkx2-5 and Isl1 expression from E7.5 to E9.5.
Mon Nov 19 00:00:00 EST 2018
Intestinal Snakeskin Limits Microbial Dysbiosis during Aging and Promotes Longevity.
iScience
Salazar AM,Resnik-Docampo M,Ulgherait M,Clark RI,Shirasu-Hiza M,Jones DL,Walker DW
A-11120 was used in Immunohistochemistry-immunofluorescence to examine the results of altered expression of Snakeskin, a septate junction-specific protein, in Drosophila.
Fri Nov 30 00:00:00 EST 2018
Identification of preoptic sleep neurons using retrograde labelling and gene profiling.
Nature
Chung S,Weber F,Zhong P,Tan CL,Nguyen TN,Beier KT,Hörmann N,Chang WC,Zhang Z,Do JP,Yao S,Krashes MJ,Tasic B,Cetin A,Zeng H,Knight ZA,Luo L,Dan Y
A-11120 was used in Immunohistochemistry to elucidate the circuit mechanism underlying the role of the preoptic area of the hypothalamus in sleep generation.
Thu May 25 00:00:00 EDT 2017
Retrograde semaphorin-plexin signalling drives homeostatic synaptic plasticity.
Nature
Orr BO,Fetter RD,Davis GW
A-11120 was used in Immunohistochemistry-immunofluorescence to study the molecular mechanisms of neuronal homeostatic signalling in order to establish clear connections to the causes and progression of neurological disease.
Thu Oct 05 00:00:00 EDT 2017
The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation.
Cell research
Wei S,Dai M,Liu Z,Ma Y,Shang H,Cao Y,Wang Q
A-11120 was used in Western Blotting to reveal that Net1-regulated Β-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.
Wed Feb 01 00:00:00 EST 2017
Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.
Nature genetics
Tchasovnikarova IA,Timms RT,Douse CH,Roberts RC,Dougan G,Kingston RE,Modis Y,Lehner PJ
A-11120 was used in Immunocytochemistry to identify MORC2 as an essential gene required for epigenetic silencing by the HUSH complex.
Sat Jul 01 00:00:00 EDT 2017
LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis.
Cancer cell
Zhu S,Zhang X,Weichert-Leahey N,Dong Z,Zhang C,Lopez G,Tao T,He S,Wood AC,Oldridge D,Ung CY,van Ree JH,Khan A,Salazar BM,Lummertz da Rocha E,Zimmerman MW,Guo F,Cao H,Hou X,Weroha SJ,Perez-Atayde AR,Neuberg DS,Meves A,McNiven MA,van Deursen JM,Li H,Maris JM,Look AT
A-11120 was used in Immunohistochemistry to provide in vivo validation of LMO1 as an important oncogene that promotes neuroblastoma initiation, progression, and widespread metastatic dissemination.
Mon Sep 11 00:00:00 EDT 2017
Medullary Reticular Neurons Mediate Neuropeptide Y-Induced Metabolic Inhibition and Mastication.
Cell metabolism
Nakamura Y,Yanagawa Y,Morrison SF,Nakamura K
A-11120 was used in Immunohistochemistry to show that GABAergic intermediate and parvicellular reticular nuclei neurons mediate hypothalamus-derived hunger signalling by coordinating autonomic and feeding motor systems to reduce energy expenditure and promote feeding.
Tue Feb 07 00:00:00 EST 2017
Astrocytic Process Plasticity and IKKβ/NF-κB in Central Control of Blood Glucose, Blood Pressure, and Body Weight.
Cell metabolism
Zhang Y,Reichel JM,Han C,Zuniga-Hertz JP,Cai D
A-11120 was used in Immunohistochemistry to study how astrocytic process plasticity and IKKΒ/NF-κB play significant roles in central control of blood glucose, blood pressure, and body weight.
Tue May 02 00:00:00 EDT 2017
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Nature neuroscience
Rathjen T,Yan X,Kononenko NL,Ku MC,Song K,Ferrarese L,Tarallo V,Puchkov D,Kochlamazashvili G,Brachs S,Varela L,Szigeti-Buck K,Yi CX,Schriever SC,Tattikota SG,Carlo AS,Moroni M,Siemens J,Heuser A,van der Weyden L,Birkenfeld AL,Niendorf T,Poulet JFA,Horvath TL,Tschöp MH,Heinig M,Trajkovski M,Haucke V,Poy MN
A-11120 was used in Immunohistochemistry to identify essential roles for cell adhesion molecule 1-mediated neuronal input in weight regulation and provide insight into the central pathways contributing to human obesity.
Tue Aug 01 00:00:00 EDT 2017
Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT.
Neuron
Aguilar JI,Dunn M,Mingote S,Karam CS,Farino ZJ,Sonders MS,Choi SJ,Grygoruk A,Zhang Y,Cela C,Choi BJ,Flores J,Freyberg RJ,McCabe BD,Mosharov EV,Krantz DE,Javitch JA,Sulzer D,Sames D,Rayport S,Freyberg Z
A-11120 was used in Immunohistochemistry to show that cell depolarisation increases synaptic vesicle dopamine content prior to release via vesicular hyperacidification.
Wed Aug 30 00:00:00 EDT 2017
Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly.
Neuron
Soykan T,Kaempf N,Sakaba T,Vollweiter D,Goerdeler F,Puchkov D,Kononenko NL,Haucke V
A-11120 was used in Immunocytochemistry-immunoflourescence to suggest that synaptic vesicle membranes are predominantly retrieved via clathrin-independent endocytosis mediated by formin-dependent actin assembly.
Wed Feb 22 00:00:00 EST 2017
A Circuit Node that Integrates Convergent Input from Neuromodulatory and Social Behavior-Promoting Neurons to Control Aggression in Drosophila.
Neuron
Watanabe K,Chiu H,Pfeiffer BD,Wong AM,Hoopfer ED,Rubin GM,Anderson DJ
A-11120 was used in Immunohistochemistry to identify octopamine receptor-expressing neurons responsible for controlling aggression in Drosophila.
Wed Aug 30 00:00:00 EDT 2017
Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells.
Nature structural & molecular biology
Liaunardy-Jopeace A,Murton BL,Mahesh M,Chin JW,James JR
A-11120 was used in Western Blotting to quantitatively measure the kinetics of LCK catalytic activity in situ.
Fri Dec 01 00:00:00 EST 2017
Generation of multipotent induced cardiac progenitor cells from mouse fibroblasts and potency testing in ex vivo mouse embryos.
Nature protocols
Lalit PA,Rodriguez AM,Downs KM,Kamp TJ
A11120 was used in immunocytochemistry to develop a protocol to generate expandable and multipotent induced cardiac progenitor cells from mouse adult fibroblasts
Mon May 01 00:00:00 EDT 2017
LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation.
Protein & cell
Yan R,Liu Z
A11120 was used in western blot to find that LRRK2 regulates Rip2 and promotes inflammatory cytokine induction through the Nod1/2-Rip2 pathway
Sun Jan 01 00:00:00 EST 2017
Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development.
Proceedings of the National Academy of Sciences of the United States of America
Huang H,Lin X,Liang Z,Zhao T,Du S,Loy MMT,Lai KO,Fu AKY,Ip NY
A-11120 was used in Immunoprecipitation to demonstrate that the Cdk5-dependent phosphorylation of liprinα1 is important for the postsynaptic organization during activity-dependent synapse development.
Tue Aug 15 00:00:00 EDT 2017
BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon.
Proceedings of the National Academy of Sciences of the United States of America
Farías GG,Guardia CM,De Pace R,Britt DJ,Bonifacino JS
A-11120 was used in Immunocytochemistry-immunofluorescence to illustrate how a general mechanism for lysosome dispersal in nonneuronal cells is adapted to drive polarized transport in neurons, and emphasize the importance of this mechanism for critical axonal processes.
Tue Apr 04 00:00:00 EDT 2017
The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma.
Oncogene
Tao T,Sondalle SB,Shi H,Zhu S,Perez-Atayde AR,Peng J,Baserga SJ,Look AT
A-11120 was used in Immunocytochemistry-immunoflourescence to indicate that digestive organ expansion factor and other components of the small ribosomal subunit processome provide a novel site of vulnerability in neuroblastoma cells.
Thu Jul 06 00:00:00 EDT 2017
ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.
The Journal of cell biology
Kawabe H,Mitkovski M,Kaeser PS,Hirrlinger J,Opazo F,Nestvogel D,Kalla S,Fejtova A,Verrier SE,Bungers SR,Cooper BH,Varoqueaux F,Wang Y,Nehring RB,Gundelfinger ED,Rosenmund C,Rizzoli SO,Südhof TC,Rhee JS,Brose N
A-11120 was used in Immunocytochemistry to demonstrate that bMunc13-2 is recruited to synapses by ELKS1, but not ELKS2, and that this recruitment determines basal synaptic vesicle priming and short-term plasticity.
Mon Apr 03 00:00:00 EDT 2017
A derivative of platelet-derived growth factor receptor alpha binds to the trimer of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cells.
PLoS pathogens
Stegmann C,Hochdorfer D,Lieber D,Subramanian N,Stöhr D,Laib Sampaio K,Sinzger C
A-11120 was used in Immunocytochemistry-immunoflourescence to study the use of soluble derivatives of the platelet-derived growth factor receptor alpha to inhibit human cytomegalovirus infection of various cell types.
Sat Apr 01 00:00:00 EDT 2017
The Repression of Atoh1 by Neurogenin1 during Inner Ear Development.
Frontiers in molecular neuroscience
Gálvez H,Tena JJ,Giraldez F,Abelló G
A-11120 was used in Immunohistochemistry to understand the molecular basis of Atonal homologue 1 expression being counteracted by Neurogenin 1.
Wed Sep 30 00:00:00 EDT 2020
Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes.
Journal of neurochemistry
Frank RAW,Zhu F,Komiyama NH,Grant SGN
A-11120 was used in Flow Cytometry, Immunoprecipitation, and Western Blot to gain insight into the mechanisms that govern the constituents of postsynaptic supercomplexes and the diversity of synapse types.
Tue Aug 01 00:00:00 EDT 2017
The Rap1-cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B cell immune synapse.
Journal of cell science
Wang JC,Lee JY,Christian S,Dang-Lawson M,Pritchard C,Freeman SA,Gold MR
A-11120 was used in Immunohistochemistry to elucidate the importance of the Rap1-cofilin-1 pathway in B-cell receptor-induced polarisation of the microtubule organising centre.
Wed Mar 15 00:00:00 EDT 2017
Cell-cycle-dependent TGFβ-BMP antagonism regulates neural tube closure by modulating tight junctions.
Journal of cell science
Amarnath S,Agarwala S
A-11120 was used in Immunohistochemistry to demonstrate that cell-cycle-dependent BMP and TGFΒ antagonism elicits median hinge point formation by dynamically regulating interactions between apical and basolateral polarity proteins.
Sun Jan 01 00:00:00 EST 2017
Cell-cycle-dependent TGFβ-BMP antagonism regulates neural tube closure by modulating tight junctions.
Journal of cell science
Amarnath S,Agarwala S
A-11120 was used in Immunohistochemistry to demonstrate that cell-cycle-dependent BMP and TGFΒ antagonism elicits median hinge point formation by dynamically regulating interactions between apical and basolateral polarity proteins.
Sun Jan 01 00:00:00 EST 2017
Kon-tiki enhances PS2 integrin adhesion and localizes its ligand, Thrombospondin, in the myotendinous junction.
Journal of cell science
Pérez-Moreno JJ,Espina-Zambrano AG,García-Calderón CB,Estrada B
A-11120 was used in Immunohistochemistry to show how integrins and transmembrane proteoglycans are regulated and coordinated.
Wed Mar 01 00:00:00 EST 2017
The centriolar satellite protein CCDC66 interacts with CEP290 and functions in cilium formation and trafficking.
Journal of cell science
Conkar D,Culfa E,Odabasi E,Rauniyar N,Yates JR,Firat-Karalar EN
A-11120 was used in Immunocytochemistry-immunoflourescence to identify CCDC66 as a targeting factor for centrosome and cilium proteins.
Sat Apr 15 00:00:00 EDT 2017
Morphological study of a connexin 43-GFP reporter mouse highlights glial heterogeneity, amacrine cells, and olfactory ensheathing cells.
Journal of neuroscience research
Theofilas P,Steinhäuser C,Theis M,Derouiche A
A11120 was used in immunohistochemistry to develop a mouse line to examine connexin 43-expressing central nervous system cells and astroglial cell morphology
Wed Nov 01 00:00:00 EDT 2017
Neutral Competition for Drosophila Follicle and Cyst Stem Cell Niches Requires Vesicle Trafficking Genes.
Genetics
Cook MS,Cazin C,Amoyel M,Yamamoto S,Bach E,Nystul T
A-11120 was used in Immunohistochemistry to demonstrate a critical role for vesicle trafficking in stem cell niche competition and differentiation.
Sat Jul 01 00:00:00 EDT 2017
A Genetic Analysis of the Caenorhabditis elegans Detoxification Response.
Genetics
Fukushige T,Smith HE,Miwa J,Krause MW,Hanover JA
A-11120 was used in Western Blotting to study the genetic pathways involved in the detoxification response in Caenorhabditis elegans.
Thu Jun 01 00:00:00 EDT 2017
Optogenetic activation of amygdala projections to nucleus accumbens can arrest conditioned and unconditioned alcohol consummatory behavior.
Neuroscience
Millan EZ,Kim HA,Janak PH
A-11120 was used in Immunohistochemistry-immunofluorescence to activate basolateral amygdala axonal terminals targeting the shell of nucleus accumbens, and investigate a possible influence over cue-conditioned alcohol seeking and alcohol drinking.
Sat Sep 30 00:00:00 EDT 2017
Operant responding for optogenetic excitation of LDTg inputs to the VTA requires D1 and D2 dopamine receptor activation in the NAcc.
Behavioural brain research
Steidl S,O'Sullivan S,Pilat D,Bubula N,Brown J,Vezina P
A-11120 was used in Immunohistochemistry-immunofluorescence to assess whether laterodorsal tegmental nucleus inputs contribute to reward function by regulating mesolimbic dopamine signalling.
Wed Aug 30 00:00:00 EDT 2017
miR-27 regulates chondrogenesis by suppressing focal adhesion kinase during pharyngeal arch development.
Developmental biology
Kara N,Wei C,Commanday AC,Patton JG
A-11120 was used in Immunohistochemistry-immunofluorescence to study the novel role of miR-27 as a positive regulator of chondrogenesis.
Fri Sep 01 00:00:00 EDT 2017
A novel proteolytic event controls Hedgehog intracellular sorting and distribution to receptive fields.
Biology open
Daniele JR,Chu T,Kunes S
A-11120 was used in Immunohistochemistry to examine the mechanisms governing the transmission and secretion of Hedgehog.
Mon May 15 00:00:00 EDT 2017
Kinetics of the LOV domain of ZEITLUPE determine its circadian function in Arabidopsis.
eLife
Pudasaini A,Shim JS,Song YH,Shi H,Kiba T,Somers DE,Imaizumi T,Zoltowski BD
A-11120 was used in Immunoprecipitation to provide new mechanisms indicating how PAS/LOV proteins integrate environmental variables in complex networks.
Tue Feb 28 00:00:00 EST 2017
Overexpression of human NR2B receptor subunit in LMAN causes stuttering and song sequence changes in adult zebra finches.
Scientific reports
Chakraborty M,Chen LF,Fridel EE,Klein ME,Senft RA,Sarkar A,Jarvis ED
A11120 was used in immunocytochemistry to propose that N-methyl-D-aspartate subtype 2B glutamate receptor subunit expression in the adult lateral magnocellular nucleus of the anterior nidopallium is important adult courtship song
Fri Apr 21 00:00:00 EDT 2017
apterous Brain Neurons Control Receptivity to Male Courtship in Drosophila Melanogaster Females.
Scientific reports
Aranha MM,Herrmann D,Cachitas H,Neto-Silva RM,Dias S,Vasconcelos ML
A-11120 was used in Immunocytochemistry to identify a novel set of neurons in the Drosophila melanogaster brain controlling sexual receptivity in the female without triggering the postmating response.
Wed Apr 12 00:00:00 EDT 2017
Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress.
Cell reports
Jin M,Fuller GG,Han T,Yao Y,Alessi AF,Freeberg MA,Roach NP,Moresco JJ,Karnovsky A,Baba M,Yates JR,Gitler AD,Inoki K,Klionsky DJ,Kim JK
A-11120 was used in Immunoprecipitation to elucidate the mechanism by which glycolysis is upregulated under conditions such as hypoxia and high energy demand to promote cell proliferation.
Tue Jul 25 00:00:00 EDT 2017
Optogenetic excitation in the ventral tegmental area of glutamatergic or cholinergic inputs from the laterodorsal tegmental area drives reward.
The European journal of neuroscience
Steidl S,Wang H,Ordonez M,Zhang S,Morales M
A-11120 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to study how LDTg-cholinergic and LDTg-glutamatergic inputs to the VTA each contribute to the net rewarding effects of exciting LDTg axons in the VTA.
Wed Feb 01 00:00:00 EST 2017
Higher Arc Nucleus-to-Cytoplasm Ratio during Sleep in the Superficial Layers of the Mouse Cortex.
Frontiers in neural circuits
Honjoh S,de Vivo L,Okuno H,Bito H,Tononi G,Cirelli C
A-11120 was used in Immunohistochemistry to investigate whether a change in Arc dynamics temporally correlates with sleep-dependent GluA1 down-regulation in the murine cerebral cortex.
Wed May 23 00:00:00 EDT 2018
PCH1 and PCHL promote photomorphogenesis in plants by controlling phytochrome B dark reversion.
Nature communications
Enderle B,Sheerin DJ,Paik I,Kathare PK,Schwenk P,Klose C,Ulbrich MH,Huq E,Hiltbrunner A
A-11120 was used in Western Blotting to elucidate the role of the homologous phytochrome B-binding proteins, PCH1 and PCHL, in enhancing light sensitivity in plants.
Wed Dec 20 00:00:00 EST 2017
Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling.
Nature communications
Lu TY,MacDonald JM,Neukomm LJ,Sheehan AE,Bradshaw R,Logan MA,Freeman MR
A11120 was used in immunohistochemistry to determine whether Draper is cell autonomously required for glial activation of transcriptional reporters after axonal injury
Mon Feb 06 00:00:00 EST 2017
Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1.
Nature communications
Liang X,Budnar S,Gupta S,Verma S,Han SP,Hill MM,Daly RJ,Parton RG,Hamilton NA,Gomez GA,Yap AS
A-11120 was used in Immunocytochemistry-immunoflourescence to identify a novel function of cortactin as a regulator of RhoA signaling.
Thu Oct 05 00:00:00 EDT 2017
Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell.
Journal of experimental & clinical cancer research : CR
Ashraf W,Bronner C,Zaayter L,Ahmad T,Richert L,Alhosin M,Ibrahim A,Hamiche A,Mely Y,Mousli M
A-11120 was used in IP/Western Blotting to investigate the interaction between UHRF1 and TIP60, to elucidate the dialogue between the two proteins.
Thu Dec 21 00:00:00 EST 2017
Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell.
Journal of experimental & clinical cancer research : CR
Ashraf W,Bronner C,Zaayter L,Ahmad T,Richert L,Alhosin M,Ibrahim A,Hamiche A,Mely Y,Mousli M
A-11120 was used in IP/Western Blotting to investigate the interaction between UHRF1 and TIP60, to elucidate the dialogue between the two proteins.
Thu Dec 21 00:00:00 EST 2017
Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons.
eLife
Athilingam JC,Ben-Shalom R,Keeshen CM,Sohal VS,Bender KJ
A-11120 was used in Immunohistochemistry to show how changes in passive membrane properties can affect neuronal excitability and the temporal filtering of synaptic inputs.
Tue Dec 05 00:00:00 EST 2017
Kinesin-1 promotes chondrocyte maintenance during skeletal morphogenesis.
PLoS genetics
Santos-Ledo A,Garcia-Macia M,Campbell PD,Gronska M,Marlow FL
A-11120 was used in Immunohistochemistry to show essential Kif5B functions in promoting cartilage remodelling and chondrocyte maintenance during zebrafish craniofacial morphogenesis.
Sat Jul 01 00:00:00 EDT 2017
Sorting at embryonic boundaries requires high heterotypic interfacial tension.
Nature communications
Canty L,Zarour E,Kashkooli L,François P,Fagotto F
A-11120 was used in Immunocytochemistry-immunoflourescence to elucidate the mechanisms of cellular sorting at embryonic boundaries.
Mon Jul 31 00:00:00 EDT 2017
DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1.
Nature communications
Wong JT,Akhbar F,Ng AYE,Tay ML,Loi GJE,Pek JW
A-11120 was used in Immunohistochemistry to identifiy DIP1 as a sisRNA regulatory protein that controls germline stem cell self-renewal in Drosophila.
Mon Oct 02 00:00:00 EDT 2017
An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer.
Cell
Wu L,Zhou B,Oshiro-Rapley N,Li M,Paulo JA,Webster CM,Mou F,Kacergis MC,Talkowski ME,Carr CE,Gygi SP,Zheng B,Soukas AA
A-11120 was used in Chromatin immunoprecipitation to identify a unified mechanism by which metformin kills cancer cells and extends lifespan, and illuminates potential cancer targets.
Thu Dec 15 00:00:00 EST 2016
Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells.
Nature neuroscience
Xue Y,Qian H,Hu J,Zhou B,Zhou Y,Hu X,Karakhanyan A,Pang Z,Fu XD
A-11120 was used in Immunocytochemistry to demonstrate the presence of two separate regulatory gatekeepers controlling neuronal conversion and maturation in human adult fibroblast cells.
Wed Jun 01 00:00:00 EDT 2016
Regrowth of Serotonin Axons in the Adult Mouse Brain Following Injury.
Neuron
Jin Y,Dougherty SE,Wood K,Sun L,Cudmore RH,Abdalla A,Kannan G,Pletnikov M,Hashemi P,Linden DJ
A-11120 was used in Immunohistochemistry to investigate the regrowth of serotonin axons in the adult mouse neocortex following injury.
Wed Aug 17 00:00:00 EDT 2016
Dopaminergic Circuitry Underlying Mating Drive.
Neuron
Zhang SX,Rogulja D,Crickmore MA
A-11120 was used in Immunohistochemistry-immunofluorescence to demonstrate the existence of male mating drive in Drosophila, which is transiently and cumulatively reduced as reproductive capacity is depleted by copulations.
Wed Jul 06 00:00:00 EDT 2016
Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber Stretch and Integrin-Mediated Adhesion.
Developmental cell
Kraft-Sheleg O,Zaffryar-Eilot S,Genin O,Yaseen W,Soueid-Baumgarten S,Kessler O,Smolkin T,Akiri G,Neufeld G,Cinnamon Y,Hasson P
A-11120 was used in Immunohistochemistry to show that lysyl oxidase-like 3 (LoxL3) is a key regulator of integrin signalling that ensures localised control of the cascade.
Mon Mar 07 00:00:00 EST 2016
Regulation of Drosophila Brain Wiring by Neuropil Interactions via a Slit-Robo-RPTP Signaling Complex.
Developmental cell
Oliva C,Soldano A,Mora N,De Geest N,Claeys A,Erfurth ML,Sierralta J,Ramaekers A,Dascenco D,Ejsmont RK,Schmucker D,Sanchez-Soriano N,Hassan BA
A-11120 was used in Immunohistochemistry to explore the signaling and regulation of axonal wiring molecule Slit and its Round-About (Robo) receptors during Drosophila neuronal circuit wiring.
Mon Oct 24 00:00:00 EDT 2016
A Negative Feedback Loop between PHYTOCHROME INTERACTING FACTORs and HECATE Proteins Fine-Tunes Photomorphogenesis in Arabidopsis.
The Plant cell
Zhu L,Xin R,Bu Q,Shen H,Dang J,Huq E
A-11120 was used in Immunoprecipitation to show that PIFs and HECs constitute a negative feedback loop to fine-tune photomorphogenesis in Arabidopsis thaliana.
Fri Apr 01 00:00:00 EDT 2016
Motor Behavior Mediated by Continuously Generated Dopaminergic Neurons in the Zebrafish Hypothalamus Recovers after Cell Ablation.
Current biology : CB
McPherson AD,Barrios JP,Luks-Morgan SJ,Manfredi JP,Bonkowsky JL,Douglass AD,Dorsky RI
A-11120 was used in Immunohistochemistry to identify a progenitor population in the zebrafish hypothalamus that continuously generates neurons that express tyrosine hydroxylase.
Mon Jan 25 00:00:00 EST 2016
Familial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry.
Science signaling
Tong BC,Lee CS,Cheng WH,Lai KO,Foskett JK,Cheung KH
A-11120 was used in Immunocytochemistry to indicate that γ-secretase activity may physiologically regulate capacitative Ca(2+) entry by targeting STIM1.
Tue Sep 06 00:00:00 EDT 2016
Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation.
The Journal of cell biology
Schiffmacher AT,Xie V,Taneyhill LA
A-11120 was used in Immunohistochemistry to examine how Cadherin-6B proteolysis orchestrates multiple pro-epithelial-to-mesenchymal transition regulatory inputs to ensure proper cranial neural crest epithelial-to-mesenchymal transition.
Mon Dec 05 00:00:00 EST 2016
Vegfa signals through ERK to promote angiogenesis, but not artery differentiation.
Development (Cambridge, England)
Shin M,Beane TJ,Quillien A,Male I,Zhu LJ,Lawson ND
A-11120 was used in Immunohistochemistry to implicate ERK as a specific effector of vascular endothelial growth factor a signalling in the induction of angiogenic genes during sprouting.
Sat Oct 15 00:00:00 EDT 2016
Rab8 directs furrow ingression and membrane addition during epithelial formation in Drosophila melanogaster.
Development (Cambridge, England)
Mavor LM,Miao H,Zuo Z,Holly RM,Xie Y,Loerke D,Blankenship JT
A-11120 was used in Immunocytochemistry to show that Rab8 has striking dynamic behaviours in vivo.
Tue Mar 01 00:00:00 EST 2016
Cholesterol Biosynthesis Supports Myelin Gene Expression and Axon Ensheathment through Modulation of P13K/Akt/mTor Signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mathews ES,Appel B
A-11120 was used in Immunohistochemistry to suggest cholesterol formation and PI3K/Akt/mTOR signalling functions as a feed forward mechanism to produce large amounts of myelin membrane necessary for axon ensheathment.
Wed Jul 20 00:00:00 EDT 2016
Ire1 supports normal ER differentiation in developing Drosophila photoreceptors.
Journal of cell science
Xu Z,Chikka MR,Xia H,Ready DF
A-11120 was used in immunohistochemistry to investigate the role of Ire1 in endoplasmic reticulum differentiation in the developing Drosophila compound eye photoreceptors
Tue Mar 01 00:00:00 EST 2016
Coronin 1B supports RhoA signaling at cell-cell junctions through Myosin II.
Cell cycle (Georgetown, Tex.)
Priya R,Wee K,Budnar S,Gomez GA,Yap AS,Michael M
A11120 was used in immunocytochemistry to investigate the role of Coronin 1B in regulating the non-muscle myosin II pool
Wed Nov 16 00:00:00 EST 2016
PLEKHA7 defines an apical junctional complex with cytoskeletal associations and miRNA-mediated growth implications.
Cell cycle (Georgetown, Tex.)
Kourtidis A,Anastasiadis PZ
A-11120 was used in Western Blotting to further investigate the function and interacting partners of PLEKHA7 at the zonula adherens.
Tue Dec 13 00:00:00 EST 2016
SMN deficiency does not induce oxidative stress in SMA iPSC-derived astrocytes or motor neurons.
Human molecular genetics
Patitucci TN,Ebert AD
A-11120 was used in Immunocytochemistry to study if oxidative stress contributes to spinal muscular atrophy (SMA) astrocyte pathology.
Mon Feb 01 00:00:00 EST 2016
An optogenetic mouse model of rett syndrome targeting on catecholaminergic neurons.
Journal of neuroscience research
Zhang S,Johnson CM,Cui N,Xing H,Zhong W,Wu Y,Jiang C
A-11120 was used in Immunohistochemistry to demonstrate the feasibility of generating double-transgenic mice for studies of Rett syndrome with commercially available mice.
Sat Oct 01 00:00:00 EDT 2016
CRASP: CFP reconstitution across synaptic partners.
Biochemical and biophysical research communications
Li Y,Guo A,Li H
A-11120 was used in immunocytochemistry and immunohistochemistry to characterize CRASP (CFP reconstitution across synaptic partners)
Fri Jan 15 00:00:00 EST 2016
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin.
Nature communications
Fusté NP,Fernández-Hernández R,Cemeli T,Mirantes C,Pedraza N,Rafel M,Torres-Rosell J,Colomina N,Ferrezuelo F,Dolcet X,Garí E
A-11120 was used in immunocytochemistry to determine regulation of metastasis and cell invasion through the phosphorylation of paxillin due to cytoplasmic cyclin D1
Mon May 16 00:00:00 EDT 2016
The hydrolethalus syndrome protein HYLS-1 regulates formation of the ciliary gate.
Nature communications
Wei Q,Zhang Y,Schouteden C,Zhang Y,Zhang Q,Dong J,Wonesch V,Ling K,Dammermann A,Hu J
A-11120 was used in immunoprecipitation and western blot investigate the role of HYLS-1 in transition fibre formation
Thu Aug 18 00:00:00 EDT 2016
Presynaptic DLG regulates synaptic function through the localization of voltage-activated Ca(2+) Channels.
Scientific reports
Astorga C,Jorquera RA,Ramírez M,Kohler A,López E,Delgado R,Córdova A,Olguín P,Sierralta J
A-11120 was used in Immunohistochemistry to study the contribution of DLG to the basal synaptic-function at the Drosophila larval neuromuscular junction.
Tue Aug 30 00:00:00 EDT 2016
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.
eLife
Plate L,Cooley CB,Chen JJ,Paxman RJ,Gallagher CM,Madoux F,Genereux JC,Dobbs W,Garza D,Spicer TP,Scampavia L,Brown SJ,Rosen H,Powers ET,Walter P,Hodder P,Wiseman RL,Kelly JW
A-11120 was used in Immunohistochemistry to evaluate the ability of small molecule-dependent endoplasmic reticulum reprogramming to ameliorate imbalances in endoplasmic reticulum function associated with degenerative protein aggregation diseases.
Wed Jul 20 00:00:00 EDT 2016
Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch.
eLife
Gallagher CM,Garri C,Cain EL,Ang KK,Wilson CG,Chen S,Hearn BR,Jaishankar P,Aranda-Diaz A,Arkin MR,Renslo AR,Walter P
A-11120 was used in Immunocytochemistry-immunoflourescence to discover and develop Ceapins, a class of pyrazole amides that block ATF6α signaling in response to ER stress.
Wed Jul 20 00:00:00 EDT 2016
Imaging Approaches to Investigate Myonuclear Positioning in Drosophila.
Methods in molecular biology (Clifton, N.J.)
Azevedo M,Schulman VK,Folker E,Balakrishnan M,Baylies M
A-11120 was used in Immunohistochemistry-immunofluorescence to describe time-lapse and fixed imaging methodologies using both the Drosophila embryo and the larva to investigate mechanisms of myonuclear positioning.
Thu Dec 07 00:00:00 EST 2017
Dissociation of Golgi-associated DHHC-type Zinc Finger Protein (GODZ)- and Sertoli Cell Gene with a Zinc Finger Domain-β (SERZ-β)-mediated Palmitoylation by Loss of Function Analyses in Knock-out Mice.
The Journal of biological chemistry
Kilpatrick CL,Murakami S,Feng M,Wu X,Lal R,Chen G,Du K,Luscher B
A-11120 was used in Immunocytochemistry-immunoflourescence to investigate the substrate specificity of Golgi-associated DHHC-type zinc finger protein and its paralog Sertoli cell gene with a zinc finger domain-Β.
Fri Dec 30 00:00:00 EST 2016
Allatostatin A Signalling in Drosophila Regulates Feeding and Sleep and Is Modulated by PDF.
PLoS genetics
Chen J,Reiher W,Hermann-Luibl C,Sellami A,Cognigni P,Kondo S,Helfrich-Förster C,Veenstra JA,Wegener C
A11120 was used in immunohistochemistry to show that thermogenetic activation of allatostatin A-expressing PLP neurons and enteroendocrine cells reduces feeding and promotes sleep in fruit flies
Thu Sep 01 00:00:00 EDT 2016
Characterization of the interaction between the HIV-1 Gag structural polyprotein and the cellular ribosomal protein L7 and its implication in viral nucleic acid remodeling.
Retrovirology
Mekdad HE,Boutant E,Karnib H,Biedma ME,Sharma KK,Malytska I,Laumond G,Roy M,Réal E,Paillart JC,Moog C,Darlix JL,Mély Y,de Rocquigny H
A-11120 was used in Immunoprecipitation to show that GagNC interacts with the ribosomal protein RPL7 endowed with nucleic acid chaperone activity, favoring the notion that RPL7 could be a Gag helper chaperoning factor possibly contributing to the start of Gag assembly.
Thu Aug 11 00:00:00 EDT 2016
Four of the six Drosophila rhodopsin-expressing photoreceptors can mediate circadian entrainment in low light.
The Journal of comparative neurology
Saint-Charles A,Michard-Vanhée C,Alejevski F,Chélot E,Boivin A,Rouyer F
A-11120 was used in Immunohistochemistry, ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot to reveal different contributions of rhodopsin-expressing photoreceptors and suggest the existence of several circuits for rhodopsin-dependent circadian entrainment.
Sat Oct 01 00:00:00 EDT 2016
Insect odorant receptor trafficking requires calmodulin.
BMC biology
Bahk S,Jones WD
A-11120 was used in Immunohistochemistry to show CaM regulates odorant receptor trafficking and olfactory responses in Drosophila olfactory neurons via the olfactory co-receptor Orco.
Thu Sep 29 00:00:00 EDT 2016
Meiotic chromosome mobility in fission yeast is resistant to environmental stress.
Scientific reports
Illner D,Lorenz A,Scherthan H
A-11120 was used in Immunocytochemistry-immunoflourescence to study the response of yeast meiotic chromosome mobility to environmental stress.
Thu Apr 14 00:00:00 EDT 2016
Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages.
Nature communications
Canton J,Schlam D,Breuer C,Gütschow M,Glogauer M,Grinstein S
A-11120 was used in immunocytochemistry to learn about facilitation of the uptake of NOD2 ligands in macrophages and signal constitutive macropinocytosis by calcium-sennsing receptors
Wed Apr 06 00:00:00 EDT 2016
Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis.
Nature communications
Xu Q,Zhang Y,Wei Q,Huang Y,Hu J,Ling K
A-11120 was used in immunoprecipitation and western blot to identify factors that initiata ciliogenesis
Fri Feb 26 00:00:00 EST 2016
Cytoskeletal Filamin A Differentially Modulates RNA Polymerase III Gene Transcription in Transformed Cell Lines.
The Journal of biological chemistry
Wang J,Zhao S,Wei Y,Zhou Y,Shore P,Deng W
A11120 was used in western blot to elucidate how cytoskeletal filamin A suppresses cell proliferation
Fri Nov 25 00:00:00 EST 2016
A subcortical inhibitory signal for behavioral arrest in the thalamus.
Nature neuroscience
Giber K,Diana MA,Plattner V,Dugué GP,Bokor H,Rousseau CV,Maglóczky Z,Havas L,Hangya B,Wildner H,Zeilhofer HU,Dieudonné S,Acsády L
A-11120 was used in immunohistochemistry to investigate synaptic inhibition of the intralaminar thalamic nuclei
Wed Apr 01 00:00:00 EDT 2015
Role of Tet1 and 5-hydroxymethylcytosine in cocaine action.
Nature neuroscience
Feng J,Shao N,Szulwach KE,Vialou V,Huynh J,Zhong C,Le T,Ferguson D,Cahill ME,Li Y,Koo JW,Ribeiro E,Labonte B,Laitman BM,Estey D,Stockman V,Kennedy P,Couroussé T,Mensah I,Turecki G,Faull KF,Ming GL,Song H,Fan G,Casaccia P,Shen L,Jin P,Nestler EJ
A-11120 was used in immunohistochemistry to study the role of ten-eleven translocation enzymes and 5-hydroxymethylcytosine on gene transcription in brain
Wed Apr 01 00:00:00 EDT 2015
Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions.
Nature cell biology
Priya R,Gomez GA,Budnar S,Verma S,Cox HL,Hamilton NA,Yap AS
A-11120 was used in immunocytochemistry to identify factors that regulate the stability of the RhoA zone
Thu Oct 01 00:00:00 EDT 2015
Astrocyte uncoupling as a cause of human temporal lobe epilepsy.
Brain : a journal of neurology
Bedner P,Dupper A,Hüttmann K,Müller J,Herde MK,Dublin P,Deshpande T,Schramm J,Häussler U,Haas CA,Henneberger C,Theis M,Steinhäuser C
A-11120 was used in immunohistochemistry - paraffin section to assess astrocyte function in hippocampal specimens from patients with mesial temporal lobe epilepsy without and with sclerosis
Fri May 01 00:00:00 EDT 2015
piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway.
Developmental cell
Phillips CM,Brown KC,Montgomery BE,Ruvkun G,Montgomery TA
A-11120 was used in Immunoprecipitation to uncover a role for piRNAs in protecting essential genes from RNA silencing.
Mon Aug 24 00:00:00 EDT 2015
Mitotic Membrane Turnover Coordinates Differential Induction of the Heart Progenitor Lineage.
Developmental cell
Cota CD,Davidson B
A-11120 was used in Immunohistochemistry-Immunofluorescence on wholemounted tissues to redefine the relationship between cell division and adhesive signalling, revealing how mitotic membrane turnover orchestrates adhesion-dependent signal polarisation.
Mon Sep 14 00:00:00 EDT 2015
Subunit composition of a DEG/ENaC mechanosensory channel of Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America
Chen Y,Bharill S,Isacoff EY,Chalfie M
A-11120 was used in immunohistochemistry to characterize the subunit composition of a DEG/ENaC Caenorhabditis elegans mechanosensory channel
Tue Sep 15 00:00:00 EDT 2015
Memory formation and retrieval of neuronal silencing in the auditory cortex.
Proceedings of the National Academy of Sciences of the United States of America
Nomura H,Hara K,Abe R,Hitora-Imamura N,Nakayama R,Sasaki T,Matsuki N,Ikegaya Y
A-11120 was used in immunohistochemistry to test if neuronal silencing promotes memory formation and behavioral expression
Tue Aug 04 00:00:00 EDT 2015
Role of the subesophageal zone in sensorimotor control of orientation in Drosophila larva.
Current biology : CB
Tastekin I,Riedl J,Schilling-Kurz V,Gomez-Marin A,Truman JW,Louis M
A-11120 was used in Immunohistochemistry to investigate the role of the suboesophageal zone in sensorimotor control of orientation in Drosophila larva.
Mon Jun 01 00:00:00 EDT 2015
Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function.
Science signaling
Travers T,Shao H,Joughin BA,Lauffenburger DA,Wells A,Camacho CJ
A-11120 was used in western blot to determine the impact of phosphorylation on the interaction between alpha-actinin-4 and actin.
Tue May 26 00:00:00 EDT 2015
The neuropeptide tachykinin is essential for pheromone detection in a gustatory neural circuit.
eLife
Shankar S,Chua JY,Tan KJ,Calvert ME,Weng R,Ng WC,Mori K,Yew JY
A-11120 was used in immunohistochemistry to study processing of the anti-aphrodisiac pheromone (3R,11Z,19Z)-3-acetoxy-11,19-octacosadien-1-ol (CH503) in male fruit flies
Wed Jun 17 00:00:00 EDT 2015
Spatiotemporal dynamics of traction forces show three contraction centers in migratory neurons.
The Journal of cell biology
Jiang J,Zhang ZH,Yuan XB,Poo MM
A-11120 was used in Immunofluorescence to characterise the differences between multiple dynamics of the traction force underlying neuronal migration.
Mon Jun 08 00:00:00 EDT 2015
Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction.
The Journal of cell biology
Daneshjou N,Sieracki N,van Nieuw Amerongen GP,Conway DE,Schwartz MA,Komarova YA,Malik AB
A-11120 was used in immunocytochemistry to investigate the role of Rac1 in stabilizing mature endothelial adherens junctions
Mon Jan 05 00:00:00 EST 2015
Phosphorylated ubiquitin chain is the genuine Parkin receptor.
The Journal of cell biology
Okatsu K,Koyano F,Kimura M,Kosako H,Saeki Y,Tanaka K,Matsuda N
A-11120 was used in immunocytochemistry to investigate how PINK1 recruits Parkin
Mon Apr 13 00:00:00 EDT 2015
Coordinate control of terminal dendrite patterning and dynamics by the membrane protein Raw.
Development (Cambridge, England)
Lee J,Peng Y,Lin WY,Parrish JZ
A-11120 was used in immunoprecipitation to assess the developmental origin of subcompartments in axons and dendrites
Thu Jan 01 00:00:00 EST 2015
A somatic permeability barrier around the germline is essential for Drosophila spermatogenesis.
Development (Cambridge, England)
Fairchild MJ,Smendziuk CM,Tanentzapf G
A-11120 was used in Immunohistochemistry-immunofluorescence to suggest that the permeability barrier around the germline serves an important regulatory function during Drosophila spermatogenesis.
Thu Jan 15 00:00:00 EST 2015
Axonal wrapping in the Drosophila PNS is controlled by glia-derived neuregulin homolog Vein.
Development (Cambridge, England)
Matzat T,Sieglitz F,Kottmeier R,Babatz F,Engelen D,Klämbt C
A-11120 was used in Immunohistochemistry to show that the wrapping glia orchestrates the development of the different glial cell layers in a peripheral nerve in Drosophila.
Wed Apr 01 00:00:00 EDT 2015
The transmembrane protein Crumbs displays complex dynamics during follicular morphogenesis and is regulated competitively by Moesin and aPKC.
Development (Cambridge, England)
Sherrard KM,Fehon RG
A-11120 was used in immunohistochemistry to elucidate the role of Crumbs in epithelial morphogenesis.
Fri May 15 00:00:00 EDT 2015
The retinal determination gene Dachshund restricts cell proliferation by limiting the activity of the Homothorax-Yorkie complex.
Development (Cambridge, England)
Brás-Pereira C,Casares F,Janody F
A-11120 was used in Immunohistochemistry to demonstrate the role of human dachshund homolog DACH1 in tumorigenesis and suggest that DACH1 might prevent cellular transformation by limiting the oncogenic activity of YAP and/or TAZ.
Wed Apr 15 00:00:00 EDT 2015
Fbxw7 Limits Myelination by Inhibiting mTOR Signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kearns CA,Ravanelli AM,Cooper K,Appel B
A-11120 was used in immunohistochemistry - frozen section to determine factors that regulate mTOR activity during myelination
Wed Nov 04 00:00:00 EST 2015
Long-delayed expression of the immediate early gene Arc/Arg3.1 refines neuronal circuits to perpetuate fear memory.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nakayama D,Iwata H,Teshirogi C,Ikegaya Y,Matsuki N,Nomura H
A-11120 was used in Immunohistochemistry to characterise late Arc expression in the mouse hippocampus following associative fear learning.
Wed Jan 14 00:00:00 EST 2015
Identified Serotonin-Releasing Neurons Induce Behavioral Quiescence and Suppress Mating in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pooryasin A,Fiala A
A-11120 was used in immunohistochemistry - free floating to study factors that regulate arousal negatively and induce states of quiescence using Drosophila
Wed Sep 16 00:00:00 EDT 2015
Neovascularization in the pulmonary endothelium is regulated by the endosome: Rab4-mediated trafficking and p18-dependent signaling.
American journal of physiology. Lung cellular and molecular physiology
Chichger H,Braza J,Duong H,Stark M,Harrington EO
A-11120 was used in western blot to investigate the role of p18, Rab4, Rab7, and Rab9 in vessel formation within the pulmonary vasculature.
Thu Oct 01 00:00:00 EDT 2015
Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae.
Journal of cell science
Mohan J,Morén B,Larsson E,Holst MR,Lundmark R
A-11120 was used in Immunocytochemistry-immunoflourescence to demonstrate that cavin3 is targeted to caveolae by cavin1, where it interacts with the scaffolding domain of caveolin1 and promotes caveolae dynamics.
Sun Mar 01 00:00:00 EST 2015
Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae.
Journal of cell science
Mohan J,Morén B,Larsson E,Holst MR,Lundmark R
A-11120 was used in Immunocytochemistry-immunoflourescence to demonstrate that cavin3 is targeted to caveolae by cavin1, where it interacts with the scaffolding domain of caveolin1 and promotes caveolae dynamics.
Sun Mar 01 00:00:00 EST 2015
A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size.
Cell cycle (Georgetown, Tex.)
Xia X,Gholkar A,Senese S,Torres JZ
A-11120 was used in immunocytochemistry to report a role for an LCMT1-PME-1 methylation in regulating mitotic spindle size
Tue Apr 19 00:00:00 EDT 2016
Stable maintenance of de novo assembled human artificial chromosomes in embryonic stem cells and their differentiated progeny in mice.
Cell cycle (Georgetown, Tex.)
Liskovykh M,Ponomartsev S,Popova E,Bader M,Kouprina N,Larionov V,Alenina N,Tomilin A
A-11120 was used in Immunohistochemistry to provide the first example of fully synthetic DNA behaving like a normal chromosome in cells of living animal.
Tue Jan 26 00:00:00 EST 2016
A Drosophila Gustatory Receptor Required for Strychnine Sensation.
Chemical senses
Lee Y,Moon SJ,Wang Y,Montell C
A-11120 was used in Immunohistochemistry to support an emerging model that Drosophila gustatory receptors fall broadly into two specificity classes.
Tue Sep 01 00:00:00 EDT 2015
Characterization of Panglial Gap Junction Networks in the Thalamus, Neocortex, and Hippocampus Reveals a Unique Population of Glial Cells.
Cerebral cortex (New York, N.Y. : 1991)
Griemsmann S,Höft SP,Bedner P,Zhang J,von Staden E,Beinhauer A,Degen J,Dublin P,Cope DW,Richter N,Crunelli V,Jabs R,Willecke K,Theis M,Seifert G,Kettenmann H,Steinhäuser C
A-11120 was used in immunohistochemistry to describe the formation of coupled networks between astrocytes and oligodendrocytes in the murine ventrobasal thalamus and compare these associations with those found in the hippocampus and cortex.
Thu Oct 01 00:00:00 EDT 2015
The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations.
Frontiers in behavioral neuroscience
Scardochio T,Trujillo-Pisanty I,Conover K,Shizgal P,Clarke PB
A-11120 was used in Immunohistochemistry to investigate the potential role of phasic dopamine release in rat 50-kHz call emissions.
Wed Dec 23 00:00:00 EST 2015
Nurr1 blocks the mitogenic effect of FGF-2 and EGF, inducing olfactory bulb neural stem cells to adopt dopaminergic and dopaminergic-GABAergic neuronal phenotypes.
Developmental neurobiology
Vergaño-Vera E,Díaz-Guerra E,Rodríguez-Traver E,Méndez-Gómez HR,Solís Ó,Pignatelli J,Pickel J,Lee SH,Moratalla R,Vicario-Abejón C
A-11120 was used in immunocytochemistry to investigate their role Nurr1 in the generation of dopaminergic neurons
Sat Aug 01 00:00:00 EDT 2015
Projections from the subparaventricular zone define four channels of output from the circadian timing system.
The Journal of comparative neurology
Vujovic N,Gooley JJ,Jhou TC,Saper CB
A-11120 was used in immunohistochemistry to test if there are differences in efferent outputs from the four quadrants of the subparaventricular zone of the hypothalamus.
Tue Dec 15 00:00:00 EST 2015
Neuropeptide F neurons modulate sugar reward during associative olfactory learning of Drosophila larvae.
The Journal of comparative neurology
Rohwedder A,Selcho M,Chassot B,Thum AS
A-11120 was used in immunohistochemistry to test if Drosophila neuropeptide F neurons are involved in classical olfactory conditioning
Tue Dec 15 00:00:00 EST 2015
Bazooka/PAR3 is dispensable for polarity in Drosophila follicular epithelial cells.
Biology open
Shahab J,Tiwari MD,Honemann-Capito M,Krahn MP,Wodarz A
A-11120 was used in western blot to determine the genetic hierarchy to establish and maintain apico-basal polarity in Drosophila
Fri Mar 13 00:00:00 EDT 2015
Mesodermal origin of median fin mesenchyme and tail muscle in amphibian larvae.
Scientific reports
Taniguchi Y,Kurth T,Medeiros DM,Tazaki A,Ramm R,Epperlein HH
A-11120 was used in immunohistochemistry to determine the origins of fin mesenchyme and tail muscle in amphibians
Thu Jun 18 00:00:00 EDT 2015
Human Embryonic Stem Cell-Derived Progenitors Assist Functional Sensory Axon Regeneration after Dorsal Root Avulsion Injury.
Scientific reports
Hoeber J,Trolle C,Konig N,Du Z,Gallo A,Hermans E,Aldskogius H,Shortland P,Zhang SC,Deumens R,Kozlova EN
A-11120 was used in immunohistochemistry to assess dorsal root avulsion injury and how human embryonic stem cell-derived progenitors assist functional sensory axo regeneration
Mon Jun 08 00:00:00 EDT 2015
The presence of cortical neurons in striatal-cortical co-cultures alters the effects of dopamine and BDNF on medium spiny neuron dendritic development.
Frontiers in cellular neuroscience
Penrod RD,Campagna J,Panneck T,Preese L,Lanier LM
A-11120 was used in immunocytochemistry to investigate medium spiny neuron development.
Mon Aug 10 00:00:00 EDT 2015
Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function.
Nature communications
Muhammad K,Reddy-Alla S,Driller JH,Schreiner D,Rey U,Böhme MA,Hollmann C,Ramesh N,Depner H,Lützkendorf J,Matkovic T,Götz T,Bergeron DD,Schmoranzer J,Goettfert F,Holt M,Wahl MC,Hell SW,Scheiffele P,Walter AM,Loll B,Sigrist SJ
A-11120 was used in Immunohistochemistry-immunofluorescence to study the role of presynaptic spinophilin in fine-tuning neurexin/neuroligin signalling to control active zone number and functionality, thereby optimising them for action potential-induced exocytosis.
Fri Oct 16 00:00:00 EDT 2015
Specific Localization of the Drosophila Telomere Transposon Proteins and RNAs, Give Insight in Their Behavior, Control and Telomere Biology in This Organism.
PloS one
López-Panadès E,Gavis ER,Casacuberta E
A-11120 was used in immunoprecipitation to characterize drosophila telomere transposon proteins and RNA for specific localization to give insight into control, behavior, and telomere biology
Wed Apr 13 00:00:00 EDT 2016
Transducin duplicates in the zebrafish retina and pineal complex: differential specialisation after the teleost tetraploidisation.
PloS one
Lagman D,Callado-Pérez A,Franzén IE,Larhammar D,Abalo XM
A-11120 was used in immunohistochemistry to characterize the results of 350 million years of evolution on the alpha, beta and gamma subunits of transducins
Tue Feb 23 00:00:00 EST 2016
A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis.
PLoS genetics
Fuchs M,Luthold C,Guilbert SM,Varlet AA,Lambert H,Jetté A,Elowe S,Landry J,Lavoie JN
A-11120 was used in immunoprecipitation to characterize the role of BAG3-HSPB8 in mitosis
Thu Oct 01 00:00:00 EDT 2015
Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo.
PloS one
Kokkinopoulos I,Ishida H,Saba R,Ruchaya P,Cabrera C,Struebig M,Barnes M,Terry A,Kaneko M,Shintani Y,Coppen S,Shiratori H,Ameen T,Mein C,Hamada H,Suzuki K,Yashiro K
A-11120 was used in immunohistochemistry to characterize cardiac progenitor/precursor cells.
Wed Jul 06 00:00:00 EDT 2016
The Formin Diaphanous Regulates Myoblast Fusion through Actin Polymerization and Arp2/3 Regulation.
PLoS genetics
Deng S,Bothe I,Baylies MK
A-11120 was used in immunohistochemistry to study regulation of myoblast fusion through Arp2/3 regulation and actin polymerization due to the formin diaphanous
Sat Aug 01 00:00:00 EDT 2015
A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells.
mBio
Selleck EM,Orchard RC,Lassen KG,Beatty WL,Xavier RJ,Levine B,Virgin HW,Sibley LD
A-11120 was used in immunocytochemistry to characterize restriction of Toxoplasma gondii growth in a strain-specific manner in IFN-gamma-activated human cells due to a noncanonical autophagy pathway
Tue Sep 08 00:00:00 EDT 2015
Axis Patterning by BMPs: Cnidarian Network Reveals Evolutionary Constraints.
Cell reports
Genikhovich G,Fried P,Prünster MM,Schinko JB,Gilles AF,Fredman D,Meier K,Iber D,Technau U
A-11120 was used in immunocytochemistry to report that BMP signaling is required for asymmetric Hox gene expression and mesentery formation
Tue Mar 17 00:00:00 EDT 2015
Isolation of Undifferentiated Female Germline Cells from Adult Drosophila Ovaries.
Current protocols in stem cell biology
Lim RSM,Osato M,Kai T
A-11120 was used in Flow Cytometry, ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot to isolate undifferentiated, stem cell-like germline cells from adult Drosophila ovaries and demonstrate effective purification in considerably large quantities.
Mon Aug 03 00:00:00 EDT 2015
Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread.
Nature
Czuczman MA,Fattouh R,van Rijn JM,Canadien V,Osborne S,Muise AM,Kuchroo VK,Higgins DE,Brumell JH
A-11120 was used in Immunohistochemistry-immunofluorescence to study the exploitation of efferocytosis by Listeria monocytogenes to promote cell-to-cell spread during infection.
Thu May 08 00:00:00 EDT 2014
Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor.
Cell
Rodriguez-Bravo V,Maciejowski J,Corona J,Buch HK,Collin P,Kanemaki MT,Shah JV,Jallepalli PV
A-11120 was used in immunocytochemistry to report that nuclear pore complexes in interphase cells function as scaffolds for anaphase-inhibitory signaling.
Thu Feb 27 00:00:00 EST 2014
Female contact modulates male aggression via a sexually dimorphic GABAergic circuit in Drosophila.
Nature neuroscience
Yuan Q,Song Y,Yang CH,Jan LY,Jan YN
A-11120 was used in immunohistochemistry to determine the basic neural pathway underlying intraspecific male-male aggression.
Wed Jan 01 00:00:00 EST 2014
Mimicking the extracellular matrix with functionalized, metal-assembled collagen peptide scaffolds.
Biomaterials
Hernandez-Gordillo V,Chmielewski J
A-11120 was used in western blot to describe the use of collagen mimetic peptides to create a 3-D matrix in response to metal ion stimuli
Fri Aug 01 00:00:00 EDT 2014
Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase.
Proceedings of the National Academy of Sciences of the United States of America
Ribeiro P,Holder M,Frith D,Snijders AP,Tapon N
A-11120 was used in Western Blotting to study the role of Crumbs in the homeostatic mechanism allowing precise tuning of Yki function.
Tue May 13 00:00:00 EDT 2014
C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.
Proceedings of the National Academy of Sciences of the United States of America
Ye X,Zeng H,Ning G,Reiter JF,Liu A
A-11120 was used in immunocytochemistry to determine the function of C2 calcium-dependent domain containing 3
Tue Feb 11 00:00:00 EST 2014
Candidate neural substrates for off-edge motion detection in Drosophila.
Current biology : CB
Shinomiya K,Karuppudurai T,Lin TY,Lu Z,Lee CH,Meinertzhagen IA
A-11120 was used in Immunohistochemistry to demonstrate that multiple types of transmedulla neurons provide complex inputs to T5 at their terminals in the third neuropil.
Mon May 19 00:00:00 EDT 2014
Integration of signals along orthogonal axes of the vertebrate neural tube controls progenitor competence and increases cell diversity.
PLoS biology
Sasai N,Kutejova E,Briscoe J
A-11120 was used in Immunohistochemistry to study how the interplay between cellular competence and inductive signals controls pattern formation and increases cell type diversity in the neural tube.
Tue Jul 01 00:00:00 EDT 2014
EGFR signaling promotes self-renewal through the establishment of cell polarity in Drosophila follicle stem cells.
eLife
Castanieto A,Johnston MJ,Nystul TG
A-11120 was used in Immunohistochemistry-immunofluorescence to demonstrate that the EGFR-mediated regulation of apical-basal polarity is essential for the segregation of stem cell and daughter cell fates.
Mon Dec 01 00:00:00 EST 2014
A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region.
eLife
Schroeder CM,Ostrem JM,Hertz NT,Vale RD
A-11120 was used in Western Blotting to determine the crystal structure of the conserved light intermediate chain domain, which binds the motor heavy chain, from a thermophilic fungus.
Wed Oct 01 00:00:00 EDT 2014
Septins promote stress fiber-mediated maturation of focal adhesions and renal epithelial motility.
The Journal of cell biology
Dolat L,Hunyara JL,Bowen JR,Karasmanis EP,Elgawly M,Galkin VE,Spiliotis ET
A-11120 was used in Immunoprecipitation to study the organisation of the transverse arc and radial stress fibres at leading lamella of migrating renal epithelia.
Mon Oct 27 00:00:00 EDT 2014
Lhx3 and Lhx4 suppress Kolmer-Agduhr interneuron characteristics within zebrafish axial motoneurons.
Development (Cambridge, England)
Seredick S,Hutchinson SA,Van Ryswyk L,Talbot JC,Eisen JS
A-11120 was used in immunohistochemistry to investigate the roles of Lhx3 and its paralog Lhx4 in the development of motoneurons and ventral interneurons.
Wed Oct 01 00:00:00 EDT 2014
Kremen1 restricts Dkk activity during posterior lateral line development in zebrafish.
Development (Cambridge, England)
McGraw HF,Culbertson MD,Nechiporuk AV
A-11120 was used in immunohistochemistry to study the effect of Wnt signaling modulation in the posterior lateral line primordium
Fri Aug 01 00:00:00 EDT 2014
The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline.
Development (Cambridge, England)
Williams LS,Ganguly S,Loiseau P,Ng BF,Palacios IM
A-11120 was used in western blot to elucidate how Kinesin heavy chain regulates its specificity while assisting in intracellular transport
Wed Jan 01 00:00:00 EST 2014
Deprivation-induced strengthening of presynaptic and postsynaptic inhibitory transmission in layer 4 of visual cortex during the critical period.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nahmani M,Turrigiano GG
A-11120 was used in immunohistochemistry - free floating to study the mechanisms underlying fast-spiking inhibitory plasticity
Wed Feb 12 00:00:00 EST 2014
A competitive advantage by neonatally engrafted human glial progenitors yields mice whose brains are chimeric for human glia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Windrem MS,Schanz SJ,Morrow C,Munir J,Chandler-Militello D,Wang S,Goldman SA
A-11120 was used in Immunocytochemistry to examine the competitive advantage of human glial progenitors that have been xenografted into the hypomyelinated shiverer mouse forebrain.
Wed Nov 26 00:00:00 EST 2014
Similar roles of substantia nigra and ventral tegmental dopamine neurons in reward and aversion.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ilango A,Kesner AJ,Keller KL,Stuber GD,Bonci A,Ikemoto S
A-11120 was used in immunohistochemistry to study dopamine neurons in the substantia nigra pars compacta.
Wed Jan 15 00:00:00 EST 2014
BBS mutations modify phenotypic expression of CEP290-related ciliopathies.
Human molecular genetics
Zhang Y,Seo S,Bhattarai S,Bugge K,Searby CC,Zhang Q,Drack AV,Stone EM,Sheffield VC
A-11120 was used in immunocytochemistry to explore the underlying mechanisms of the variable expressivity of CEP290 in ciliopathies.
Wed Jan 01 00:00:00 EST 2014
Cadherin-6B is proteolytically processed during epithelial-to-mesenchymal transitions of the cranial neural crest.
Molecular biology of the cell
Schiffmacher AT,Padmanabhan R,Jhingory S,Taneyhill LA
A-11120 was used in immunohistochemistry - frozen section to study Cad6B proteolysis in the neural crest of chickens
Wed Jan 01 00:00:00 EST 2014
Mutations in Fis1 disrupt orderly disposal of defective mitochondria.
Molecular biology of the cell
Shen Q,Yamano K,Head BP,Kawajiri S,Cheung JT,Wang C,Cho JH,Hattori N,Youle RJ,van der Bliek AM
A-11120 was used in immunocytochemistry to evaluate if Fis1 acts in sequence with Mff at the ER-mitochondrial interface
Wed Jan 01 00:00:00 EST 2014
Dynamic miRNA expression patterns during retinal regeneration in zebrafish: reduced dicer or miRNA expression suppresses proliferation of Müller glia-derived neuronal progenitor cells.
Developmental dynamics : an official publication of the American Association of Anatomists
Rajaram K,Harding RL,Bailey T,Patton JG,Hyde DR
A-11120 was used in Immunohistochemistry to examine the potential roles of microRNAs in regulating retinal regeneration in zebrafish.
Mon Dec 01 00:00:00 EST 2014
The role of inab in axon morphology of an identified zebrafish motoneuron.
PloS one
Van Ryswyk L,Simonson L,Eisen JS
A-11120 was used in immunohistochemistry to identify zebrafish genes needed for motor neuron development.
Fri Jan 09 00:00:00 EST 2015
Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9.
mBio
Shen B,Brown KM,Lee TD,Sibley LD
A-11120 was used in immunocytochemistry to characterize CRISPR/CAS9 and gene disruption in various strains of Toxoplasma gondii
Tue May 13 00:00:00 EDT 2014
Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex.
Nature communications
Ye T,Ip JP,Fu AK,Ip NY
A-11120 was used in immunohistochemistry - frozen section to study the initiation and regulation of radial migration.
Fri Sep 05 00:00:00 EDT 2014
Distinct functions of the laminin β LN domain and collagen IV during cardiac extracellular matrix formation and stabilization of alary muscle attachments revealed by EMS mutagenesis in Drosophila.
BMC developmental biology
Hollfelder D,Frasch M,Reim I
A-11120 was used in Immunohistochemistry-immunofluorescence to examine the roles of the laminin Β LN domain and collagen IV during cardiac extracellular matrix formation and stabilisation of alary muscle attachments in Drosophila.
Tue Jun 17 00:00:00 EDT 2014
Kank Is an EB1 interacting protein that localises to muscle-tendon attachment sites in Drosophila.
PloS one
Clohisey SM,Dzhindzhev NS,Ohkura H
A-11120 was used in Immunocytochemistry to identify Kank, the sole Drosophila orthologue of human Kank proteins, as an EB1 interactor that predominantly localises to embryonic attachment sites between muscle and tendon cells.
Mon May 18 00:00:00 EDT 2015
Proper connectivity of Drosophila motion detector neurons requires Atonal function in progenitor cells.
Neural development
Oliva C,Choi CM,Nicolai LJ,Mora N,De Geest N,Hassan BA
A-11120 was used in immunohistochemistry to discuss the composition of the optic lobe in Drosophila.
Wed Feb 26 00:00:00 EST 2014
Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy.
eLife
Yamano K,Fogel AI,Wang C,van der Bliek AM,Youle RJ
A-11120 was used in immunocytochemistry to analyze the governing of autophagosome biogenesis during mitophagy via mitochondrial Rab GAPs
Tue Feb 25 00:00:00 EST 2014
Endopolyploidization and flowering time are antagonistically regulated by checkpoint component MAD1 and immunity modulator MOS1.
Nature communications
Bao Z,Zhang N,Hua J
A-11120 was used in Immunoprecipitation to reveal MOS1, MAD1 and SUF4 as regulators of endopolyploidisation and flowering time.
Fri Nov 28 00:00:00 EST 2014
Non-canonical roles for Yorkie and Drosophila Inhibitor of Apoptosis 1 in epithelial tube size control.
PloS one
Robbins RM,Gbur SC,Beitel GJ
A-11120 was used in immunohistochemistry to find new non-apoptotic roles for Yki, DIAP1 and Ice in epithelial tube size regulation
Mon Mar 30 00:00:00 EDT 2015
A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases.
The Journal of biological chemistry
Landry MC,Champagne C,Boulanger MC,Jetté A,Fuchs M,Dziengelewski C,Lavoie JN
A-11120 was used in Immunoprecipitation to uncover a functional connection between mitochondria-shaping proteins and the small GTPase Rab11a, a key regulator of polarised transport via recycling endosomes.
Fri Jan 24 00:00:00 EST 2014
Hypoxia-inducible factor 2 alpha is essential for hepatic outgrowth and functions via the regulation of leg1 transcription in the zebrafish embryo.
PloS one
Lin TY,Chou CF,Chung HY,Chiang CY,Li CH,Wu JL,Lin HJ,Pai TW,Hu CH,Tzou WS
A-11120 was used in western blot to study the role of Hifs in hepatogenesis using zebrafish.
Tue Feb 24 00:00:00 EST 2015
The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome.
PLoS genetics
Chamling X,Seo S,Searby CC,Kim G,Slusarski DC,Sheffield VC
A-11120 was used in immunoprecipitation to demonstrate that AZI1 regulates BBSome ciliary trafficking activity.
Sat Feb 01 00:00:00 EST 2014
MicroRNA-92a upholds Bmp signaling by targeting noggin3 during pharyngeal cartilage formation.
Developmental cell
Ning G,Liu X,Dai M,Meng A,Wang Q
A-11120 was used in Immunohistochemistry to examine the mechanism by which miR-92a maintains Bmp signalling during pharyngeal cartilage formation.
Mon Feb 11 00:00:00 EST 2013
Host and bacterial factors that regulate LC3 recruitment to Listeria monocytogenes during the early stages of macrophage infection.
Autophagy
Lam GY,Cemma M,Muise AM,Higgins DE,Brumell JH
A-11120 was used in Immunocytochemistry to examine the host and bacterial factors which mediate LC3 recruitment to Listeria monocytogenes at 1 hour postinfection.
Mon Jul 01 00:00:00 EDT 2013
Ionizing irradiation-induced radical stress stalls live meiotic chromosome movements by altering the actin cytoskeleton.
Proceedings of the National Academy of Sciences of the United States of America
Illner D,Scherthan H
A-11120 was used in immunocytochemistry to determine the impact of ionizing radiation on chromosome recombination in live pachytene cells
Tue Oct 01 00:00:00 EDT 2013
Cyclin A degradation by primate cytomegalovirus protein pUL21a counters its innate restriction of virus replication.
PLoS pathogens
Caffarelli N,Fehr AR,Yu D
A-11120 was used in western blot to study the ability of primate CMV pUL21a to degrade cyclin A and the implications for virus replication.
Wed Sep 03 00:00:00 EDT 2014
Mapping the subcellular distribution of α-synuclein in neurons using genetically encoded probes for correlated light and electron microscopy: implications for Parkinson's disease pathogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Boassa D,Berlanga ML,Yang MA,Terada M,Hu J,Bushong EA,Hwang M,Masliah E,George JM,Ellisman MH
A-11120 was used in Western Blotting to determine the distribution of α-synuclein when overexpressed in primary neurons at supramolecular and cellular scales in three dimensions.
Wed Feb 06 00:00:00 EST 2013
Neurokinin-1 receptor-expressing neurons that contain serotonin and gamma-aminobutyric acid in the rat rostroventromedial medulla are involved in pain processing.
The journal of pain
Chen T,Wang XL,Qu J,Wang W,Zhang T,Yanagawa Y,Wu SX,Li YQ
A-11120 was used in immunohistochemistry to study the role of a specific group of neurons in pain processing in the rat rostroventromedial medulla.
Thu Aug 01 00:00:00 EDT 2013
Determination of the membrane topology of lemur tyrosine kinase 2 (LMTK2) by fluorescence protease protection.
American journal of physiology. Cell physiology
Nixon A,Jia Y,White C,Bradbury NA
A-11120 was used in western blot to examine the topology and orientation of LMTK2 within cellular membranes.
Tue Jan 15 00:00:00 EST 2013
Transient JMJD2B-mediated reduction of H3K9me3 levels improves reprogramming of embryonic stem cells into cloned embryos.
Molecular and cellular biology
Antony J,Oback F,Chamley LW,Oback B,Laible G
A-11120 was used in immunocytochemistry to generate and characterize mouse embryonic stem cells with inducible expression of JMJD2B.
Fri Mar 01 00:00:00 EST 2013
Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particles.
Human gene therapy
Löw K,Aebischer P,Schneider BL
A-11120 was used in immunohistochemistry to evaluate the transduction efficacy of nigral neurons with adeno-associated viral vectors
Sat Jun 01 00:00:00 EDT 2013
Multimodal exercises simultaneously stimulating cortical and brainstem pathways after unilateral corticospinal lesion.
Brain research
Harel NY,Yigitkanli K,Fu Y,Cafferty WB,Strittmatter SM
A-11120 was used in Immunohistochemistry to study whether a combination of physical exercises simultaneously stimulating cortical and brainstem pathways above the injury strengthens corticobulbar connections through Hebbian-like mechanisms.
Wed Nov 13 00:00:00 EST 2013
Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/β-catenin pathway in a Drosophila model for intellectual disability.
PloS one
Vandewalle J,Langen M,Zschätzsch M,Nijhof B,Kramer JM,Brems H,Bauters M,Lauwers E,Srahna M,Marynen P,Verstreken P,Schenck A,Hassan BA,Froyen G
A-11120 was used in immunohistochemistry to study the role of HUWE expression on the developing nervous system.
Wed Oct 01 00:00:00 EDT 2014
Optogenetic delay of status epilepticus onset in an in vivo rodent epilepsy model.
PloS one
Sukhotinsky I,Chan AM,Ahmed OJ,Rao VR,Gradinaru V,Ramakrishnan C,Deisseroth K,Majewska AK,Cash SS
A-11120 was used in Immunohistochemistry to identify an essential role of hippocampal excitatory neurons in an in vivo rodent epilepsy model and illustrate the power of optogenetic approaches for elucidation of seizure mechanisms.
Mon Dec 09 00:00:00 EST 2013
Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia.
Cell reports
Loktev AV,Jackson PK
A-11120 was used in Immunocytochemistry-immunoflourescence to demonstrate that trafficking of specific G-protein-coupled receptor subsets to neuronal cilia is essential for effective neuronal signalling by their ligands.
Thu Dec 12 00:00:00 EST 2013
Developmental regulation of nucleolus size during Drosophila eye differentiation.
PloS one
Baker NE
A-11120 was used in immunohistochemistry to assess nucleolar size in the Drosophila eye imaginal disc.
Tue Dec 03 00:00:00 EST 2013
Protein phosphatase 1ß limits ring canal constriction during Drosophila germline cyst formation.
PloS one
Yamamoto S,Bayat V,Bellen HJ,Tan C
A-11120 was used in immunohistochemistry to investigate how ring canal formation, maintenance, and growth are regulated
Wed Mar 05 00:00:00 EST 2014
Regulation of circadian behavioral output via a MicroRNA-JAK/STAT circuit.
Cell
Luo W,Sehgal A
A-11120 was used in immunohistochemistry to report that miR-279 modulates the JAK/STAT pathway to drive rest:activity rhythms in Drosophila.
Fri Feb 17 00:00:00 EST 2012
CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons.
Nature cell biology
Ricciardi S,Ungaro F,Hambrock M,Rademacher N,Stefanelli G,Brambilla D,Sessa A,Magagnotti C,Bachi A,Giarda E,Verpelli C,Kilstrup-Nielsen C,Sala C,Kalscheuer VM,Broccoli V
A-11120 was used in immunocytochemistry and immunohistochemistry to elucidate the function of CDKL5 in neurons.
Sat Sep 01 00:00:00 EDT 2012
Drosophila Src regulates anisotropic apical surface growth to control epithelial tube size.
Nature cell biology
Nelson KS,Khan Z,Molnár I,Mihály J,Kaschube M,Beitel GJ
A-11120 was used in immunohistochemistry to study how intestinal tube dimensions are regulated.
Sun Mar 25 00:00:00 EDT 2012
A quantitative TR-FRET plate reader immunoassay for measuring autophagy.
Autophagy
Hancock MK,Hermanson SB,Dolman NJ
A-11120 was used in western blot to develop a TR-FRET immuno-assay for the quantitative measurement of autophagy using GFP-tagged LC3B.
Wed Aug 01 00:00:00 EDT 2012
MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline.
Genes & development
Phillips CM,Montgomery TA,Breen PC,Ruvkun G
A-11120 was used in Immunohistochemistry to study the specific roles of mutator class genes involved in RNA silencing, and their relationship with other small interfering RNA factors.
Sun Jul 01 00:00:00 EDT 2012
Motor neurons controlling fluid ingestion in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America
Manzo A,Silies M,Gohl DM,Scott K
A-11120 was used in immunohistochemistry to assess how pumping is regulated and characterize motor neurons innervating the pump.
Tue Apr 17 00:00:00 EDT 2012
Timing of intra-arterial neural stem cell transplantation after hypoxia-ischemia influences cell engraftment, survival, and differentiation.
Stroke
Rosenblum S,Wang N,Smith TN,Pendharkar AV,Chua JY,Birk H,Guzman R
A-11120 was used in immunocytochemistry and immunohistochemistry to examine the effect of timing of neuronal stem cell transplantation on cell engraftment, survival, and differentiation.
Fri Jun 01 00:00:00 EDT 2012
Drosophila PATJ supports adherens junction stability by modulating Myosin light chain activity.
The Journal of cell biology
Sen A,Nagy-Zsvér-Vadas Z,Krahn MP
A-11120 was used in immunohistochemistry to characterize PATJ mutant epithelium
Mon Nov 12 00:00:00 EST 2012
Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a.
PLoS pathogens
Fehr AR,Gualberto NC,Savaryn JP,Terhune SS,Yu D
A-11120 was used in western blot to study the role of the proteasome in the disruption of the anaphase-promoting complex by the pUL21a protein of human CMV.
Tue Jan 29 00:00:00 EST 2013
Glucocorticoid suppresses dendritic spine development mediated by down-regulation of caldesmon expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tanokashira D,Morita T,Hayashi K,Mayanagi T,Fukumoto K,Kubota Y,Yamashita T,Sobue K
A-11120 was used in immunocytochemistry to study the role of reduced caldesmon expression in the mechanism by which glucocorticoids inhibit dendritic spine development.
Wed Oct 17 00:00:00 EDT 2012
Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gokhale A,Larimore J,Werner E,So L,Moreno-De-Luca A,Lese-Martin C,Lupashin VV,Smith Y,Faundez V
A-11120 was used in Immunoprecipitation to elucidate the mechanisms engaged by dysbindin which define schizophrenia susceptibility pathways.
Wed Mar 14 00:00:00 EDT 2012
A GABAergic inhibitory neural circuit regulates visual reversal learning in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ren Q,Li H,Wu Y,Ren J,Guo A
A-11120 was used in immunohistochemistry - frozen section to investigate the neural circuitry mechanism supporting flexible behavior.
Wed Aug 22 00:00:00 EDT 2012
GBF1 (Gartenzwerg)-dependent secretion is required for Drosophila tubulogenesis.
Journal of cell science
Wang S,Meyer H,Ochoa-Espinosa A,Buchwald U,Onel S,Altenhein B,Heinisch JJ,Affolter M,Paululat A
A-11120 was used in immunohistochemistry to characterize a series of loss-of-function mutants for the Drosophila ArfGEF, Gartenzwerg.
Sun Jan 15 00:00:00 EST 2012
Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions.
Molecular and cellular biology
Morgan MA,Mould AW,Li L,Robertson EJ,Bikoff EK
A-11120 was used in Immunoprecipitation to propose that developmentally regulated alternative splicing is influenced by chromatin structure at the locus and fine-tunes Blimp-1's functional capabilities.
Sat Sep 01 00:00:00 EDT 2012
The Lewis GFP transgenic rat strain is a useful cell donor for neural transplantation.
Cell transplantation
Krause M,Ganser C,Kobayashi E,Papazoglou A,Nikkhah G
A-11120 was used in Immunocytochemistry-immunoflourescence to investigate the potential of green fluorescent protein-transgenic Lewis rats to serve as donor tissue for neural stem cell transplantation.
Fri Dec 06 00:00:00 EST 2013
The phosphoinositide-associated protein Rush hour regulates endosomal trafficking in Drosophila.
Molecular biology of the cell
Gailite I,Egger-Adam D,Wodarz A
A-11120 was used in immunohistochemistry to study the role of Rush in endocytosis.
Wed Feb 01 00:00:00 EST 2012
Stat3 defines three populations of Müller glia and is required for initiating maximal müller glia proliferation in the regenerating zebrafish retina.
The Journal of comparative neurology
Nelson CM,Gorsuch RA,Bailey TJ,Ackerman KM,Kassen SC,Hyde DR
A-11120 was used in immunohistochemistry to elucidate the role of Stat3, Ascla, and Lin28a in Müller glia reentry into the cell cycle following damage to the zebrafish retina.
Sat Dec 15 00:00:00 EST 2012
Coordinate development of skin cells and cutaneous sensory axons in zebrafish.
The Journal of comparative neurology
O'Brien GS,Rieger S,Wang F,Smolen GA,Gonzalez RE,Buchanan J,Sagasti A
A-11120 was used in immunohistochemistry to analyze cutaneous innervation in the head, trunk, and tail of zebrafish embryos and larvae.
Thu Mar 01 00:00:00 EST 2012
mRNA cycles through hypoxia-induced stress granules in live Drosophila embryonic muscles.
The International journal of developmental biology
van der Laan AM,van Gemert AM,Dirks RW,Noordermeer JN,Fradkin LG,Tanke HJ,Jost CR
A-11120 was used in Immunohistochemistry to study Drosophila stress granule formation and dynamics in vivo.
Wed Jun 26 00:00:00 EDT 2013
Atmospheric scanning electron microscope for correlative microscopy.
Methods in cell biology
Morrison IE,Dennison CL,Nishiyama H,Suga M,Sato C,Yarwood A,O'Toole PJ
A-11120 was used in immunocytochemistry to describe a new correlative scanning electron and optical microscope.
Wed Dec 05 00:00:00 EST 2012
Insulin-Producing Cells in the Drosophila Brain also Express Satiety-Inducing Cholecystokinin-Like Peptide, Drosulfakinin.
Frontiers in endocrinology
Söderberg JA,Carlsson MA,Nässel DR
A-11120 was used in immunohistochemistry to investigate satiety signals in Drosophila.
Thu Sep 13 00:00:00 EDT 2012
Dynamics of major histocompatibility complex class I association with the human peptide-loading complex.
The Journal of biological chemistry
Panter MS,Jain A,Leonhardt RM,Ha T,Cresswell P
A-11120 was used in immunoprecipitation to characterize the stoichiometry of human peptide-loading complex
Fri Sep 07 00:00:00 EDT 2012
Mechanism of evenness interrupted (Evi)-exosome release at synaptic boutons.
The Journal of biological chemistry
Koles K,Nunnari J,Korkut C,Barria R,Brewer C,Li Y,Leszyk J,Zhang B,Budnik V
A-11120 was used in Immunocytochemistry to unravel the in vivo mechanisms required for Evenness Interrupted vesicle release.
Fri May 11 00:00:00 EDT 2012
Zebrafish Mnx proteins specify one motoneuron subtype and suppress acquisition of interneuron characteristics.
Neural development
Seredick SD,Van Ryswyk L,Hutchinson SA,Eisen JS
A-11120 was used in immunohistochemistry to examine the roles of Mnx family transcription factors in specifying the subtypes of individually identified zebrafish primary motoneurons
Mon Nov 05 00:00:00 EST 2012
Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells.
PloS one
Patrushev N,Seidel-Rogol B,Salazar G
A-11120 was used in immunocytochemistry to explore the role of zinc in vascular dysfunction.
Mon Aug 20 00:00:00 EDT 2012
The role of the bHLH protein hairy in morphogenetic furrow progression in the developing Drosophila eye.
PloS one
Bhattacharya A,Baker NE
A-11120 was used in immunohistochemistry to examine the relationships among hairy, daughterless, and other HLH genes.
Thu May 09 00:00:00 EDT 2013
Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse.
PloS one
Vessey KA,Fletcher EL
A-11120 was used in immunohistochemistry to characterize P2X7-R knock out mice
Tue May 29 00:00:00 EDT 2012
Lmo4 in the basolateral complex of the amygdala modulates fear learning.
PloS one
Maiya R,Kharazia V,Lasek AW,Heberlein U
A-11120 was used in Immunohistochemistry to demonstrate a novel role for the transcriptional regulator Lmo4 in fear learning.
Mon Aug 20 00:00:00 EDT 2012
Dynamin 1 regulates amyloid generation through modulation of BACE-1.
PloS one
Zhu L,Su M,Lucast L,Liu L,Netzer WJ,Gandy SE,Cai D
A-11120 was used in Western Blotting to study the regulation of beta-site amyloid precursor protein-Cleaving Enzyme 1 distribution among endosomes, TGN and plasma membrane.
Fri Feb 15 00:00:00 EST 2013
Drosophila Brainbow: a recombinase-based fluorescence labeling technique to subdivide neural expression patterns.
Nature methods
Hampel S,Chung P,McKellar CE,Hall D,Looger LL,Simpson JH
A-11120 was used in immunohistochemistry to use Drosophila Brainbow to study the innervation patterns of multiple antennal lobe projection neuron lineages and to observe the trajectories of individual aminergic neurons.
Tue Mar 01 00:00:00 EST 2011
Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase.
Autophagy
Huang J,Birmingham CL,Shahnazari S,Shiu J,Zheng YT,Smith AC,Campellone KG,Heo WD,Gruenheid S,Meyer T,Welch MD,Ktistakis NT,Kim PK,Klionsky DJ,Brumell JH
A-11120 was used in Western Blotting to study the mechanism of autophagosome formation, to better understand the autophagy of eukaryotic cells in immunity.
Sat Jan 01 00:00:00 EST 2011
The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway.
Autophagy
Cemma M,Kim PK,Brumell JH
A-11120 was used in immunoprecipitation to report that p62 and NDP52 act cooperatively to drive efficient antibacterial autophagy
Tue Mar 01 00:00:00 EST 2011
Engrailed homeoprotein acts as a signaling molecule in the developing fly.
Development (Cambridge, England)
Layalle S,Volovitch M,Mugat B,Bonneaud N,Parmentier ML,Prochiantz A,Joliot A,Maschat F
A-11120 was used in western blot to report homeoprotein signaling in Drosophila.
Wed Jun 01 00:00:00 EDT 2011
A requirement for nuclear factor-kappaB in developmental and plasticity-associated synaptogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Boersma MC,Dresselhaus EC,De Biase LM,Mihalas AB,Bergles DE,Meffert MK
A-11120 was used in immunocytochemistry to study the role of p65 in dendritic spine formation and morphology in murine hippocampal neurons.
Wed Apr 06 00:00:00 EDT 2011
A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dusonchet J,Kochubey O,Stafa K,Young SM,Zufferey R,Moore DJ,Schneider BL,Aebischer P
A-11120 was used in immunohistochemistry to generate a rat model using the mutant G2019S of LRRK2 to study Parkinson's disease.
Wed Jan 19 00:00:00 EST 2011
Peptidomics and peptide hormone processing in the Drosophila midgut.
Journal of proteome research
Reiher W,Shirras C,Kahnt J,Baumeister S,Isaac RE,Wegener C
A-11120 was used in immunohistochemistry to identify enteroendocrine peptides in the fruit fly.
Fri Apr 01 00:00:00 EDT 2011
Co-expression of serotonin 5-HT(1B) and 5-HT(4) receptors in p11 containing cells in cerebral cortex, hippocampus, caudate-putamen and cerebellum.
Neuropharmacology
Egeland M,Warner-Schmidt J,Greengard P,Svenningsson P
A-11120 was used in immunohistochemistry to determine the expression of 5-HT(1B)R and/or 5-HT(4)R in cerebral cortex, hippocampus, cerebellum and caudate-putamen in p11 containing neurons.
Thu Sep 01 00:00:00 EDT 2011
Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells.
Molecular biology of the cell
Zlatic SA,Tornieri K,L'Hernault SW,Faundez V
A-11120 was used in immunoprecipitation to suggest that Vps class C/HOPS subunits incorporate into clathrin-coated endosomal domains and carriers in mammalian cells
Sun May 15 00:00:00 EDT 2011
Regulation of insulin-producing cells in the adult Drosophila brain via the tachykinin peptide receptor DTKR.
The Journal of experimental biology
Birse RT,Söderberg JA,Luo J,Winther AM,Nässel DR
A-11120 was used in immunocytochemistry to study the regulation of Drosophila insulin-like peptides production and release in adult fruit flies.
Thu Dec 15 00:00:00 EST 2011
Involvement of the Drosophila taurine/aspartate transporter dEAAT2 in selective olfactory and gustatory perceptions.
The Journal of comparative neurology
Besson MT,Sinakevitch I,Melon C,Iché-Torres M,Birman S
A-11120 was used in immunocytochemistry to investigate the expression and function of excitatory amino acid transporters.
Sat Oct 01 00:00:00 EDT 2011
Transgenic zebrafish expressing green fluorescent protein in dopaminergic neurons of the ventral diencephalon.
Developmental dynamics : an official publication of the American Association of Anatomists
Xi Y,Yu M,Godoy R,Hatch G,Poitras L,Ekker M
A-11120 was used in immunohistochemistry to characterize transgenic zebrafish in which the green fluorescent protein is expressed under the control the dopamine transporter gene.
Tue Nov 01 00:00:00 EDT 2011
Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants.
Learning & memory (Cold Spring Harbor, N.Y.)
Guan Z,Buhl LK,Quinn WG,Littleton JT
A-11120 was used in Western Blotting to characterize the Radish-dependent anesthesia-resistant memory pathway and its link to cAMP signaling via comparison of synaptic connectivity in Drosophila memory mutants.
Thu Jul 07 00:00:00 EDT 2011
Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants.
Learning & memory (Cold Spring Harbor, N.Y.)
Guan Z,Buhl LK,Quinn WG,Littleton JT
A-11120 was used in Western Blotting to characterize the Radish-dependent anesthesia-resistant memory pathway and its link to cAMP signaling via comparison of synaptic connectivity in Drosophila memory mutants.
Thu Jul 07 00:00:00 EDT 2011
Post-embryonic nerve-associated precursors to adult pigment cells: genetic requirements and dynamics of morphogenesis and differentiation.
PLoS genetics
Budi EH,Patterson LB,Parichy DM
A-11120 was used in immunohistochemistry to study the morphogenesis and differentiation of pigment cells in various post-embryonic stages
Sun May 01 00:00:00 EDT 2011
Meningococcus Hijacks a β2-adrenoceptor/β-Arrestin pathway to cross brain microvasculature endothelium.
Cell
Coureuil M,Lécuyer H,Scott MG,Boularan C,Enslen H,Soyer M,Mikaty G,Bourdoulous S,Nassif X,Marullo S
A-11120 was used in immunocytochemistry to investigate how N. meningitidis stimulates the beta2-adrenoceptor/beta-arrestin signaling pathway in endothelial cells.
Thu Dec 23 00:00:00 EST 2010
TRPC1 is essential for in vivo angiogenesis in zebrafish.
Circulation research
Yu PC,Gu SY,Bu JW,Du JL
A-11120 was used in Immunohistochemistry to provide the first in vivo evidence that TRPC1 is essential for angiogenesis.
Fri Apr 16 00:00:00 EDT 2010
TRPC1 is essential for in vivo angiogenesis in zebrafish.
Circulation research
Yu PC,Gu SY,Bu JW,Du JL
A-11120 was used in Immunohistochemistry to provide the first in vivo evidence that TRPC1 is essential for angiogenesis.
Fri Apr 16 00:00:00 EDT 2010
Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brain.
Molecular therapy : the journal of the American Society of Gene Therapy
Markakis EA,Vives KP,Bober J,Leichtle S,Leranth C,Beecham J,Elsworth JD,Roth RH,Samulski RJ,Redmond DE
A-11120 was used in immunohistochemistry - free floating to determine the transduction efficiency of adeno-associated virus vectors of serotypes 1-6 in vivo
Mon Mar 01 00:00:00 EST 2010
Genetically encoded dendritic marker sheds light on neuronal connectivity in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America
Nicolaï LJ,Ramaekers A,Raemaekers T,Drozdzecki A,Mauss AS,Yan J,Landgraf M,Annaert W,Hassan BA
A-11120 was used in immunohistochemistry to establish a genetically encoded, specific, universal, and phenotypically neutral marker of the somatodendritic compartment of Drosophilia
Tue Nov 23 00:00:00 EST 2010
The tumor-associated EpCAM regulates morphogenetic movements through intracellular signaling.
The Journal of cell biology
Maghzal N,Vogt E,Reintsch W,Fraser JS,Fagotto F
A-11120 was used in Immunohistochemistry to identify tumour-associated epithelial cell adhesion molecule as a regulator of morphogenetic movements.
Mon Nov 01 00:00:00 EDT 2010
Formation of a Bazooka-Stardust complex is essential for plasma membrane polarity in epithelia.
The Journal of cell biology
Krahn MP,Bückers J,Kastrup L,Wodarz A
A-11120 was used in immunohistochemistry to report a phosphorylation-dependent interaction between the Baz-PAR-3 and Crb complexes during the establishment of epithelial polarity
Mon Sep 06 00:00:00 EDT 2010
Biogenesis of GPI-anchored proteins is essential for surface expression of sodium channels in zebrafish Rohon-Beard neurons to respond to mechanosensory stimulation.
Development (Cambridge, England)
Nakano Y,Fujita M,Ogino K,Saint-Amant L,Kinoshita T,Oda Y,Hirata H
A-11120 was used in immunocytochemistry to study the contribution of sodium channels to mechanosensory responses in zebrafish
Sat May 01 00:00:00 EDT 2010
Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 induction.
Journal of neurochemistry
Sulg M,Kirjavainen A,Pajusola K,Bueler H,Ylikoski J,Laiho M,Pirvola U
A-11120 was used in immunocytochemistry to study the response of auditory and balance hair cells to forced cell cycle reactivation and p53 up-regulation.
Mon Mar 01 00:00:00 EST 2010
Efficient generation of mature cerebellar Purkinje cells from mouse embryonic stem cells.
Journal of neuroscience research
Tao O,Shimazaki T,Okada Y,Naka H,Kohda K,Yuzaki M,Mizusawa H,Okano H
A-11120 was used in immunocytochemistry to investigate the differentiation into cerebellar Purkinje cells from mouse embryonic stem cells
Mon Feb 01 00:00:00 EST 2010
Neuropeptides in the Drosophila central complex in modulation of locomotor behavior.
The Journal of experimental biology
Kahsai L,Martin JR,Winther AM
A-11120 was used in Immunocytochemistry to investigate the roles of two different neuropeptides, Drosophila tachykinin (DTK) and short neuropeptide F (sNPF), in aspects of locomotor behaviour.
Thu Jul 01 00:00:00 EDT 2010
Multiple neuropeptides in the Drosophila antennal lobe suggest complex modulatory circuits.
The Journal of comparative neurology
Carlsson MA,Diesner M,Schachtner J,Nässel DR
A-11120 was used in immunocytochemistry to analyze the expression of neuropeptides in the Drosophila antennal lobes.
Sun Aug 15 00:00:00 EDT 2010
Synaptic maturation of the Xenopus retinotectal system: effects of brain-derived neurotrophic factor on synapse ultrastructure.
The Journal of comparative neurology
Nikolakopoulou AM,Meynard MM,Marshak S,Cohen-Cory S
A-11120 was used in immunohistochemistry - free floating to analyze the contribution of brain-derived neurotrophic factor to the ultrastructural organization of the Xenopus retinotectal system.
Thu Apr 01 00:00:00 EDT 2010
Physiological and morphological characterization of local interneurons in the Drosophila antennal lobe.
Journal of neurophysiology
Seki Y,Rybak J,Wicher D,Sachse S,Hansson BS
A-11120 was used in immunohistochemistry to characterize local interneurons
Sun Aug 01 00:00:00 EDT 2010
Characterization of pseudo-response regulators in plants.
Methods in enzymology
Kim WY,Salomé PA,Fujiwara S,Somers DE,McClung CR
A-11120 was used in western blot to discuss methods to study clock-regulated pseudo-response regulator genes and their proteins
Wed Jan 26 00:00:00 EST 2011
Insulin signaling, lifespan and stress resistance are modulated by metabotropic GABA receptors on insulin producing cells in the brain of Drosophila.
PloS one
Enell LE,Kapan N,Söderberg JA,Kahsai L,Nässel DR
A-11120 was used in immunocytochemistry to investigate factors that regulate Drosophila insulin-like protein production and release
Thu Dec 30 00:00:00 EST 2010
Cell cycle arrest by a gradient of Dpp signaling during Drosophila eye development.
BMC developmental biology
Firth LC,Bhattacharya A,Baker NE
A-11120 was used in immunohistochemistry to review the role of Dpp in eye development
Tue Mar 09 00:00:00 EST 2010
A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation.
Cell
Padmanabhan S,Mukhopadhyay A,Narasimhan SD,Tesz G,Czech MP,Tissenbaum HA
A-11120 was used in Western Blotting to demonstrate that PPTR-1 functions by regulating worm AKT-1 phosphorylation at Threonine 350.
Fri Mar 06 00:00:00 EST 2009
Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame.
Cell research
Shao L,Feng W,Sun Y,Bai H,Liu J,Currie C,Kim J,Gama R,Wang Z,Qian Z,Liaw L,Wu WS
A-11120 was used in Immunocytochemistry to present a lentivirus reprogramming system in which defined factors are fused in-frame into a single open reading frame via self-cleaving 2A sequences.
Sun Mar 01 00:00:00 EST 2009
Heterogeneity of Kir4.1 channel expression in glia revealed by mouse transgenesis.
Glia
Tang X,Taniguchi K,Kofuji P
A-11120 was used in immunocytochemistry to visualize and study Kir4.1 expression in vivo
Tue Dec 01 00:00:00 EST 2009
Neuroprotective effects of mesenchymal stem cells derived from human embryonic stem cells in transient focal cerebral ischemia in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Liu YP,Seçkin H,Izci Y,Du ZW,Yan YP,Başkaya MK
A-11120 was used in Immunohistochemistry to show intravenously administered embryonic mesenchymal stem cells differentiated into neuronal and endothelial cells, and were neuroprotective in transient focal cerebral ischemia.
Wed Apr 01 00:00:00 EDT 2009
Temporal regulation of Ig gene diversification revealed by single-cell imaging.
Journal of immunology (Baltimore, Md. : 1950)
Ordinario EC,Yabuki M,Larson RP,Maizels N
A-11120 was used in immunocytochemistry to examine when in the cell cycle Ig gene conversion occurs
Thu Oct 01 00:00:00 EDT 2009
Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa.
American journal of physiology. Cell physiology
Bajmoczi M,Gadjeva M,Alper SL,Pier GB,Golan DE
A-11120 was used in Immunocytochemistry-immunoflourescence to investigate the molecular bases for the hypersusceptibility of cystic fibrosis patients to Pseudomonas aeruginosa.
Sat Aug 01 00:00:00 EDT 2009
METT-10, a putative methyltransferase, inhibits germ cell proliferative fate in Caenorhabditis elegans.
Genetics
Dorsett M,Westlund B,Schedl T
A-11120 was used in immunohistochemistry to determine whether Caenorhabditis elgans METT-10 methyltranmsferase functions to inhibit germ-cell proliferation
Tue Sep 01 00:00:00 EDT 2009
Subpopulations of human embryonic stem cells with distinct tissue-specific fates can be selected from pluripotent cultures.
Stem cells and development
King FW,Ritner C,Liszewski W,Kwan HC,Pedersen A,Leavitt AD,Bernstein HS
Tue Dec 01 00:00:00 EST 2009
Yersinia pestis can reside in autophagosomes and avoid xenophagy in murine macrophages by preventing vacuole acidification.
Infection and immunity
Pujol C,Klein KA,Romanov GA,Palmer LE,Cirota C,Zhao Z,Bliska JB
A-11120 was used in immunohistochemistry and western blot to elucidate how Yersinia pestis survives inside macrophages
Mon Jun 01 00:00:00 EDT 2009
The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors.
Developmental biology
Courbard JR,Djiane A,Wu J,Mlodzik M
A-11120 was used in Immunohistochemistry-immunofluorescence to show that Scribble is part of the Strabismus (Stbm)/Van Gogh (Vang) Planar Cell Polarisation (PCP) complex and may act as an effector of Stbm/Vang during PCP establishment.
Tue Sep 01 00:00:00 EDT 2009
Transgenic mice expressing a cameleon fluorescent Ca2+ indicator in astrocytes and Schwann cells allow study of glial cell Ca2+ signals in situ and in vivo.
Journal of neuroscience methods
Atkin SD,Patel S,Kocharyan A,Holtzclaw LA,Weerth SH,Schram V,Pickel J,Russell JT
A-11120 was used in immunohistochemistry to determine if Ca2+-signaling stimuli in astrocytes cause substantial and rapid Ca2+ signals in YC 3.60-expressing astrocytes
Thu Jul 30 00:00:00 EDT 2009
Advanced laboratory techniques for sample processing and immunolabeling using microwave radiation.
Journal of neuroscience methods
Ferris AM,Giberson RT,Sanders MA,Day JR
A-11120 was used in immunocytochemistry to assess the use of microwave-assisted formaldehyde fixation for immunohistological studies
Tue Sep 15 00:00:00 EDT 2009
Identification of Wnt-responsive cells in the zebrafish hypothalamus.
Zebrafish
Wang X,Lee JE,Dorsky RI
A-11120 was used in immunohistochemistry to elucidate the exact roles of canonical Wnt signaling in neurogenesis
Sun Mar 01 00:00:00 EST 2009
Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components.
PloS one
Haren L,Stearns T,Lüders J
A-11120 was used in Western Blotting to support a model in which Plk1-dependent recruitment of gamma-tubulin to mitotic centrosomes is regulated upstream of GCP-WD, involves multiple PCM proteins and therefore potentially multiple Plk1 substrates.
Fri Jun 19 00:00:00 EDT 2009
Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome.
The Journal of experimental medicine
Ip WK,Takahashi K,Moore KJ,Stuart LM,Ezekowitz RA
A-11120 was used in Immunoprecipitation to determine how combinatorial use of innate immune defence mechanisms defines the response.
Mon Jan 21 00:00:00 EST 2008
Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome.
The Journal of experimental medicine
Ip WK,Takahashi K,Moore KJ,Stuart LM,Ezekowitz RA
A-11120 was used in Immunoprecipitation to determine how combinatorial use of innate immune defence mechanisms defines the response.
Mon Jan 21 00:00:00 EST 2008
Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer.
Oncogene
Frederick LA,Matthews JA,Jamieson L,Justilien V,Thompson EA,Radisky DC,Fields AP
A-11120 was used in Immunoprecipitation to elucidate the mechanism by which protein kinase Ciota activates Rac1 in non-small cell lung cancer.
Thu Aug 14 00:00:00 EDT 2008
Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer.
Oncogene
Frederick LA,Matthews JA,Jamieson L,Justilien V,Thompson EA,Radisky DC,Fields AP
A-11120 was used in Immunoprecipitation to elucidate the mechanism by which protein kinase Ciota activates Rac1 in non-small cell lung cancer.
Thu Aug 14 00:00:00 EDT 2008
The Clp1/Cdc14 phosphatase contributes to the robustness of cytokinesis by association with anillin-related Mid1.
The Journal of cell biology
Clifford DM,Wolfe BA,Roberts-Galbraith RH,McDonald WH,Yates JR,Gould KL
A-11120 was used in Immunoprecipitation to investigate the role of the fission yeast Cdc14 homolog, Clp1/Flp1, in cytokinesis.
Mon Apr 07 00:00:00 EDT 2008
The C. elegans F-spondin family protein SPON-1 maintains cell adhesion in neural and non-neural tissues.
Development (Cambridge, England)
Woo WM,Berry E,Hudson ML,Swale RE,Goncharov A,Chisholm AD
A-11120 was used in immunohistochemistry to report that spondin maintains cell-matrix adhesion in multiple C. elegans tissues
Fri Aug 01 00:00:00 EDT 2008
Coexpression of wild-type and mutant prion proteins alters their cellular localization and partitioning into detergent-resistant membranes.
Traffic (Copenhagen, Denmark)
Schiff E,Campana V,Tivodar S,Lebreton S,Gousset K,Zurzolo C
A-11120 was used in western blot to generate and characterize cells that co-express wild type and mutant PrP
Tue Jul 01 00:00:00 EDT 2008
A regulatory role of the Rnq1 nonprion domain for prion propagation and polyglutamine aggregates.
Molecular and cellular biology
Kurahashi H,Ishiwata M,Shibata S,Nakamura Y
A-11120 was used in immunoprecipitation to characterize the role of the non-prion domain of Rnq1
Thu May 01 00:00:00 EDT 2008
Neural stem cells reduce brain injury after unilateral carotid ligation.
Pediatric neurology
Comi AM,Cho E,Mulholland JD,Hooper A,Li Q,Qu Y,Gary DS,McDonald JW,Johnston MV
A-11120 was used in immunohistochemistry - frozen section to assess the use of stem cells to treat neonatal stroke
Fri Feb 01 00:00:00 EST 2008
Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain.
Molecular biology of the cell
Wong J,Lerrigo R,Jang CY,Fang G
A-11120 was used in Immunocytochemistry to conclude that phosphorylation of HURP by Aurora A provides a regulatory mechanism for the control of spindle assembly and function.
Thu May 01 00:00:00 EDT 2008
Phosphatidylinositol-4-kinase type II alpha contains an AP-3-sorting motif and a kinase domain that are both required for endosome traffic.
Molecular biology of the cell
Craige B,Salazar G,Faundez V
A-11120 was used in western blot to test if PI4KIIalpha behaves both as a membrane protein cargo as well as an enzymatic regulator of adaptor function
Tue Apr 01 00:00:00 EDT 2008
Transplantation of mouse embryonic stem cells into the cochlea of an auditory-neuropathy animal model: effects of timing after injury.
Journal of the Association for Research in Otolaryngology : JARO
Lang H,Schulte BA,Goddard JC,Hedrick M,Schulte JB,Wei L,Schmiedt RA
A-11120 was used in immunohistochemistry - paraffin section to study the survival and differentiation of embryonic stem cells introduced into the inner ear of gerbils
Sun Jun 01 00:00:00 EDT 2008
Pineal gland expression of the transcription factor Egr-1 is restricted to a population of glia that are distinct from nestin-immunoreactive cells.
Journal of molecular histology
Man PS,Carter DA
A-11120 was used in immunohistochemistry to observe the cellular expression pattern of Egr-1 in the adult rat pineal
Fri Feb 01 00:00:00 EST 2008
Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia.
Developmental biology
Boyle S,Misfeldt A,Chandler KJ,Deal KK,Southard-Smith EM,Mortlock DP,Baldwin HS,de Caestecker M
A-11120 was used in immunohistochemistry to characterize metanephric mesenchyme cells and determine their fate
Tue Jan 01 00:00:00 EST 2008
Type 1 corticotropin-releasing factor receptor expression reported in BAC transgenic mice: implications for reconciling ligand-receptor mismatch in the central corticotropin-releasing factor system.
The Journal of comparative neurology
Justice NJ,Yuan ZF,Sawchenko PE,Vale W
A-11120 was used in immunohistochemistry - free floating to use a transgenic mouse to study expression of the corticotrophin-releasing factor receptor.
Mon Dec 01 00:00:00 EST 2008
Atypical expression of Drosophila gustatory receptor genes in sensory and central neurons.
The Journal of comparative neurology
Thorne N,Amrein H
A-11120 was used in immunocytochemistry to characterize the expression of six highly conserved gustatory receptor genes.
Fri Feb 01 00:00:00 EST 2008
Novel strategy to selectively label excitatory and inhibitory neurons in the cerebral cortex of mice.
Journal of neuroscience methods
Basu K,Gravel C,Tomioka R,Kaneko T,Tamamaki N,Sík A
A-11120 was used in immunocytochemistry to characterize a novel process for selectively labeling inhibitory and excitatory neurons in the cerebral cortex of mice
Fri May 30 00:00:00 EDT 2008
Cellular and molecular determinants targeting the Caenorhabditis elegans PHR protein RPM-1 to perisynaptic regions.
Developmental dynamics : an official publication of the American Association of Anatomists
Abrams B,Grill B,Huang X,Jin Y
A-11120 was used in immunocytochemistry to study RPM-1 localization in wild-type and in several mutants that affect synaptic development
Sat Mar 01 00:00:00 EST 2008
The IRG mouse: a two-color fluorescent reporter for assessing Cre-mediated recombination and imaging complex cellular relationships in situ.
Genesis (New York, N.Y. : 2000)
De Gasperi R,Rocher AB,Sosa MA,Wearne SL,Perez GM,Friedrich VL,Hof PR,Elder GA
A-11120 was used in Immunohistochemistry-floating tissue to develop a transgenic reporter line in which a red fluorescent protein is expressed ubiquitously prior to Cre-mediated recombination and an enhanced green fluorescent protein following recombination.
Sun Jun 01 00:00:00 EDT 2008
Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton.
The Journal of biological chemistry
Mayanagi T,Morita T,Hayashi K,Fukumoto K,Sobue K
A-11120 was used in Immunocytochemistry-immunoflourescence to identify the glucocorticoid receptor-dependent upregulation of caldesmon in the regulation of cell migration.
Fri Nov 07 00:00:00 EST 2008
Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin I.
The Journal of biological chemistry
Sumandea MP,Rybin VO,Hinken AC,Wang C,Kobayashi T,Harleton E,Sievert G,Balke CW,Feinmark SJ,Solaro RJ,Steinberg SF
A-11120 was used in Immunoprecipitation to study the role of PKCdelta-Tyr311/Thr505 phosphorylation as dynamically regulated modifications that alter PKCdelta enzymology and allow for stimulus-specific control of cardiac mechanics during growth factor stimulation and oxidative stress.
Fri Aug 15 00:00:00 EDT 2008
Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts).
BMC cell biology
Ehehalt R,Sparla R,Kulaksiz H,Herrmann T,Füllekrug J,Stremmel W
A-11120 was used in Immunocytochemistry-immunoflourescence to analyse the regulation of long chain fatty acid uptake by the dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains.
Wed Aug 13 00:00:00 EDT 2008
Glutamate, GABA and acetylcholine signaling components in the lamina of the Drosophila visual system.
PloS one
Kolodziejczyk A,Sun X,Meinertzhagen IA,Nässel DR
A-11120 was used in immunocytochemistry to explore neurotransmitter circuits in the lamina of Drosophila
Wed May 07 00:00:00 EDT 2008
A large population of diverse neurons in the Drosophila central nervous system expresses short neuropeptide F, suggesting multiple distributed peptide functions.
BMC neuroscience
Nässel DR,Enell LE,Santos JG,Wegener C,Johard HA
A-11120 was used in immunocytochemistry to determine the distribution of the snpf transcript and its peptide products in the central nervous system of Drosophila relative to other neuronal markers
Fri Sep 19 00:00:00 EDT 2008
Dlx transcription factors promote migration through repression of axon and dendrite growth.
Neuron
Cobos I,Borello U,Rubenstein JL
A-11120 was used in immunohistochemistry - frozen section to assess promotion of migration through repression of dendrite and axon growth by Dlx transcription factors
Thu Jun 21 00:00:00 EDT 2007
Survival of adult neurons lacking cholesterol synthesis in vivo.
BMC neuroscience
Fünfschilling U,Saher G,Xiao L,Möbius W,Nave KA
A-11120 was used in immunohistochemistry - free floating to discuss the contribution of neurons and glial cells to total brain cholesterol metabolism
Tue Jan 02 00:00:00 EST 2007
Efficient generation of retinal progenitor cells from human embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Lamba DA,Karl MO,Ware CB,Reh TA
A-11120 was used in immunocytochemistry and immunohistochemistry to determine how human embryonic stem cells are efficiently generated from retinal progenitor cells
Tue Aug 22 00:00:00 EDT 2006
Gsalpha is involved in sugar perception in Drosophila melanogaster.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ueno K,Kohatsu S,Clay C,Forte M,Isono K,Kidokoro Y
A-11120 was used in immunohistochemistry to suggest that Gs is the G-protein alpha subunit responsible for Gr5a-mediated sugar-taste transduction
Wed Jun 07 00:00:00 EDT 2006
Expression of Drosophila BarH1-H2 homeoproteins in developing dopaminergic cells and segmental nerve a (SNa) motoneurons.
The European journal of neuroscience
Garces A,Bogdanik L,Thor S,Carroll P
A-11120 was used in immunohistochemistry to determine B-H1/-H2 homeoprotein expression patterns within the embryonic ventral nerve cord of Drosophila
Sat Jul 01 00:00:00 EDT 2006
The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eye.
Cell
Djiane A,Yogev S,Mlodzik M
A-11120 was used in Immunohistochemistry to describe a direct molecular link between apical/basal determinants and Frizzled-mediated planar cell polarity establishment in the Drosophila eye.
Fri May 20 00:00:00 EDT 2005
Determination of absolute protein numbers in single synapses by a GFP-based calibration technique.
Nature methods
Sugiyama Y,Kawabata I,Sobue K,Okabe S
A-11120 was used in immunocytochemistry to develop a technique to estimate the amounts of proteins in macromolecular complexes
Thu Sep 01 00:00:00 EDT 2005
Roles of Pdk1p, a fission yeast protein related to phosphoinositide-dependent protein kinase, in the regulation of mitosis and cytokinesis.
Molecular biology of the cell
Bimbó A,Liu J,Balasubramanian MK
A-11120 was used in immunocytochemistry to elucidate the effects of Pdk1p on cytokinesis
Fri Jul 01 00:00:00 EDT 2005
Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes.
The Journal of biological chemistry
Frescas D,Valenti L,Accili D
A-11120 was used in Immunoprecipitation to show that Sirtuin activation or hydrogen peroxide treatment overrides the phosphorylation-dependent nuclear exclusion of FoxO1 caused by growth factors and causes nuclear translocation of FoxO1 in hepatocytes.
Fri May 27 00:00:00 EDT 2005
The S. pombe Cdc14-like phosphatase Clp1p regulates chromosome biorientation and interacts with Aurora kinase.
Developmental cell
Trautmann S,Rajagopalan S,McCollum D
A-11120 was used in immunoprecipitation to report that Clp1p/Flp1p localizes to kinetochores in prometaphase and functions in chromosome segregation
Mon Nov 01 00:00:00 EST 2004
The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate.
Developmental biology
Wilm B,James RG,Schultheiss TM,Hogan BL
A-11120 was used in immunohistochemistry to report that Foxc1 and Foxc2 contribute to the specification of mesoderm to paraxial versus intermediate fates
Thu Jul 01 00:00:00 EDT 2004
Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter.
Developmental biology
Rowan S,Cepko CL
A-11120 was used in immunohistochemistry - frozen section to examine Chx10 regulation and function
Thu Jul 15 00:00:00 EDT 2004
CD4 receptor localized to non-raft membrane microdomains supports HIV-1 entry. Identification of a novel raft localization marker in CD4.
The Journal of biological chemistry
Popik W,Alce TM
A-11120 was used in immunoprecipitation to assess the support of HIV-1 entry by CD4 receptor localized to non-raft membrane microdomains as a novel raft localization marker in CD4
Fri Jan 02 00:00:00 EST 2004
Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling.
The Journal of biological chemistry
Schrantz N,da Silva Correia J,Fowler B,Ge Q,Sun Z,Bokoch GM
A-11120 was used in Immunoprecipitation to investigate the biochemical basis for inhibition of androgen receptor signalling by PAK6.
Fri Jan 16 00:00:00 EST 2004
Ligand-selective dissociation of activation and internalization of the parathyroid hormone (PTH) receptor: conditional efficacy of PTH peptide fragments.
Endocrinology
Sneddon WB,Magyar CE,Willick GE,Syme CA,Galbiati F,Bisello A,Friedman PA
A-11120 was used in Immunoprecipitation to investigate parathyroid hormone and associated receptors signalling responses.
Tue Jun 01 00:00:00 EDT 2004
Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant.
Nature cell biology
Weimann JM,Johansson CB,Trejo A,Blau HM
A-11120 was used in immunohistochemistry - frozen section to demonstrate that bone-marrow-derived cells contribute to adult mouse Purkinje neurons through cell fusion
Sat Nov 01 00:00:00 EST 2003
Regulation of eIF2alpha phosphorylation by different functions that act during discrete phases in the herpes simplex virus type 1 life cycle.
Journal of virology
Mulvey M,Poppers J,Sternberg D,Mohr I
A-11120 was used in western blot to test if Us11 of herpes simplex virus type 1 regulates late translation.
Wed Oct 01 00:00:00 EDT 2003
Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK).
The Journal of biological chemistry
Takemoto-Kimura S,Terai H,Takamoto M,Ohmae S,Kikumura S,Segi E,Arakawa Y,Furuyashiki T,Narumiya S,Bito H
A-11120 was used in Western Blotting to elucidate a novel mechanism by which neuronal Ca2+/calmodulin-dependent protein kinase activity could be targeted to specific membrane compartments.
Fri May 16 00:00:00 EDT 2003
Folding of the striated muscle myosin motor domain.
The Journal of biological chemistry
Chow D,Srikakulam R,Chen Y,Winkelmann DA
A-11120 was used to study folding of the myosin motor domain
Fri Sep 27 00:00:00 EDT 2002
Restriction of secretory granule motion near the plasma membrane of chromaffin cells.
The Journal of cell biology
Johns LM,Levitan ES,Shelden EA,Holz RW,Axelrod D
A-11120 was used in immunocytochemistry to observe the motion and distribution of secretory granules near the plasma membrane of living bovine chromaffin cells
Mon Apr 02 00:00:00 EDT 2001
Yop1p, the yeast homolog of the polyposis locus protein 1, interacts with Yip1p and negatively regulates cell growth.
The Journal of biological chemistry
Calero M,Whittaker GR,Collins RN
A-11120 was used in Immunocytochemistry to identify a Yip1p-associated protein.
Fri Apr 13 00:00:00 EDT 2001
Semaphorin 3A is a chemoattractant for cortical apical dendrites.
Nature
Polleux F,Morrow T,Ghosh A
A-11120 was used in immunohistochemistry to report a chemoattractive effect of Sema3A on apical dendrite
Thu Apr 06 00:00:00 EDT 2000
