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GIPR Antibody (PA5-97255) in IHC (P)
Immunohistochemistry analysis of GIPR in paraffin-embedded rat brain. Samples were incubated with GIPR Polyclonal antibody (Product # PA5-97255) using a dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-97255
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 22-138 of human GIPR (NP_0001551)
Conjugate
Form
Liquid
Concentration
0.66 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2809057
Product Specific Information
Immunogen sequence: RAETGSKGQT AGELYQRWER YRRECQETLA AAEPPSGLAC NGSFDMYVCW DYAAPNATAR ASCPWYLPWH HHVAAGFVLR QCGSDGQWGL WRDHTQCENP EKNEAFLDQR LILERLQ; Positive Samples: K-562, Mouse liver, Rat heart, Rat brain; Cellular Location: Cell membrane, Multi-pass membrane protein
Target Information
GIPR encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: gastric inhibitory peptide receptor; Gastric inhibitory polypeptide receptor; GIP receptor; GIP-R; Glucose-dependent insulinotropic polypeptide receptor
Gene Aliases: GIP-R; Gippr; GIPR; Gm1081; Gm160; PGQTL2; RATGIPPR
UniProt ID: (Human) P48546, (Mouse) Q0P543, (Rat) P43219
Entrez Gene ID: (Human) 2696, (Mouse) 381853, (Rat) 25024
desensitization of G-protein coupled receptor protein signaling pathway
generation of precursor metabolites and energy
cell surface receptor signaling pathway
activation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
response to nutrient
response to glucose
endocrine pancreas development
positive regulation of insulin secretion
gastric inhibitory peptide signaling pathway
response to axon injury
regulation of insulin secretion
response to calcium ion
response to fatty acid
signal transduction
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
positive regulation of cAMP biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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