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Product Details
H00002737-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2C9
Immunogen
GLI3 (NP_000159, 1 a.a. approximately 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MEAQSHSSTT TEKKKVENSI VKCSTRTDVS EKAVASSTTS NEDESPGQTY HRERRNAITM QPQNVQGLSK VSEEPSTSSD ERASLIKKEI HGSLPHVAEP SVPYRGTVFA
Target Information
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GLI-Kruppel family member GLI3; GLI3 form of 190 kDa; GLI3 full-length protein; GLI3-190; GLI3FL; glioma-associated oncogene family zinc finger 3; oncogene GLI3; Transcriptional activator GLI3; zinc finger protein GLI3
Gene Aliases: ACLS; GCPS; GLI3; GLI3-190; GLI3FL; PAP-A; PAPA; PAPA1; PAPB; PHS; PPDIV
UniProt ID: (Human) P10071
Entrez Gene ID: (Human) 2737
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
histone acetyltransferase binding
histone deacetylase binding
metal ion binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
metanephros development
branching involved in ureteric bud morphogenesis
in utero embryonic development
positive regulation of neuroblast proliferation
transcription from RNA polymerase II promoter
smoothened signaling pathway
axon guidance
hindgut morphogenesis
heart development
negative regulation of cell proliferation
anterior/posterior pattern specification
proximal/distal pattern formation
protein processing
optic nerve morphogenesis
hippocampus development
smoothened signaling pathway involved in ventral spinal cord interneuron specification
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
forebrain dorsal/ventral pattern formation
layer formation in cerebral cortex
forebrain radial glial cell differentiation
lateral ganglionic eminence cell proliferation
melanocyte differentiation
lung development
positive regulation of chondrocyte differentiation
T cell differentiation in thymus
limb morphogenesis
wound healing
positive regulation of protein import into nucleus
odontogenesis of dentin-containing tooth
embryonic digit morphogenesis
negative regulation of apoptotic process
nose morphogenesis
tongue development
response to estrogen
negative thymic T cell selection
negative regulation of neuron differentiation
positive regulation of osteoblast differentiation
negative regulation of smoothened signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of alpha-beta T cell differentiation
negative regulation of alpha-beta T cell differentiation
embryonic digestive tract morphogenesis
embryonic digestive tract development
developmental growth
camera-type eye morphogenesis
embryonic skeletal system morphogenesis
oligodendrocyte differentiation
palate development
frontal suture morphogenesis
lambdoid suture morphogenesis
sagittal suture morphogenesis
mammary gland specification
smoothened signaling pathway involved in dorsal/ventral neural tube patterning
artery development
anterior semicircular canal development
lateral semicircular canal development
cell differentiation involved in kidney development
thymocyte apoptotic process
negative regulation of canonical Wnt signaling pathway
regulation of bone development
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