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The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size. Originally thought to be liver-specific, this protein has been found in other tissues as well. At least one transcribed pseudogene has been found for this gene.
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Protein Aliases: breast cell glutaminase; GLS; glutaminase 2 (liver, mitochondrial); glutaminase GA; glutaminase I; Glutaminase liver isoform, mitochondrial; L hL L-glutaminase; L hLGA; L-glutaminase; L-glutamine amidohydrolase; LGA; liver mitochondrial glutaminase; phosphate-activated glutaminase; phosphate-dependent glutaminase
Gene Aliases: A330074B06Rik; AI195532; GA; GLS; GLS2; hLGA; Kiaa4146; LGA
UniProt ID: (Human) Q9UI32, (Rat) P28492, (Mouse) Q571F8
Entrez Gene ID: (Human) 27165, (Rat) 192268, (Mouse) 216456
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