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Invitrogen
GLT-1 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 4
GLT-1 Antibody (PA5-19706) in WB
Western blot was performed using Anti-GLT-1 Polyclonal Antibody (Product # PA5-19706) and a 55 kDa band corresponding to GLT-1 was observed in Mouse Brain, Rat Brain and Mouse Cerebellum when compared to other tissue extracts tested which are reported to be low. Tissue extracts (30 µg lysate) of Mouse Kidney (Lane 1), Mouse Lung (Lane 2), Rat Kidney (Lane 3), Rat Lung (Lane 4), Mouse Brain (Lane 5), Rat Brain (Lane 6) and Mouse Cerebellum (Lane 7) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved... View More
Product Details
PA5-19706
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 550 to the C-terminus of Rat Glutamate Transporter 1 (EAAT2).
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10980198
Product Specific Information
This antibody is predicted to react with human based on sequence homology.
Target Information
Excitatory amino acid transporter 2 (EAAT2) is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis (ALS.) Alternatively spliced transcript variants of this gene have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EAAT2 variant mEAAT2/5UT5; Excitatory amino acid transporter 2; glial high affinity glutamate transporter; GLT-1; GLT1a; GLT1b; GLT1c; GLUT-R; glutamate transporter 1c; high affinity glucose transporter; OTTHUMP00000165209; OTTHUMP00000165210; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2; solute carrier family 1, member 2
Gene Aliases: 1700091C19Rik; 2900019G14Rik; AI159670; Eaat2; Glt; GLT-1; GLT1; MGLT1; Slc1a2
UniProt ID: (Mouse) P43006, (Rat) P31596
Entrez Gene ID: (Mouse) 20511, (Rat) 29482
transport
dicarboxylic acid transport
nervous system development
visual behavior
response to light stimulus
response to wounding
multicellular organism aging
L-glutamate transport
telencephalon development
adult behavior
cellular response to extracellular stimulus
multicellular organism growth
sodium ion transmembrane transport
response to drug
response to amino acid
positive regulation of glucose import
L-glutamate import
D-aspartate import
L-glutamate transmembrane transport
neurotransmitter transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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