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Product Details
25079-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GNE Fusion Protein Ag18689 (376-722 aa encoded by BC121179)
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SIDLQEPLQ KKFCFPPVKE NISQDIDHIL ETLSALAVDL GGTNLRVAIV SMKGEIVKKY TQFNPKTYEE RINLILQMCV EAAAEAVKLN CRILGVGIST GGRVNPREGI VLHSTKLIQE WNSVDLRTPL SDTLHLPVWV DNDGNCAALA ERKFGQGKGL ENFVTLITGT GIGGGIIHQH ELIHGSSFCA AELGHLVVSL DGPDCSCGSH GCIEAYASGM ALQREAKKLH DEDLLLVEGM SVPKDEAVGA LHLIQAAKLG NAKAQSILRT AGTALGLGVV NILHTMNPSL VILSGVLASH YIHIVKDVIR QQALSSVQDV DVVVSDLVDP ALLGAASMVL DYTTRRIY (376-722 aa encoded by BC121179)
Target Information
GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; N-acylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
Gene Aliases: DMRV; GLCNE; GNE; IBM2; NM; Uae1
UniProt ID: (Human) Q9Y223
Entrez Gene ID: (Human) 10020
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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