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GPR176 is in the G protein-coupled receptor family and are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters.
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Bovine, Dog, Bat, Horse, Stickleback, Zebrafish (100%).
GPR176 exists in different glycosylated forms.
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR176 (G protein-coupled receptor 176), also known as HB-954, GPR or Gm1012, is a 515 amino acid multi-pass membrane protein belonging to the G-protein coupled receptor 1 family. Expressed in brain and spleen, with trace expression in kidney, GPR176 functions as an orphan receptor that is thought to play a role in signaling events throughout the cell. Containing four N-glycosylation sites, seven transmembrane domains and a large C-terminal cytosolic domain, GPR176 is encoded by a gene mapping to human chromosome 15q14.
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Protein Aliases: G-protein coupled receptor 176; G-protein coupled receptor AGR9; HB-954; HB954; probable G-protein coupled receptor 176
Gene Aliases: Agr9; Gm1012; GPR176; HB-954
UniProt ID: (Human) Q14439, (Mouse) Q80WT4
Entrez Gene ID: (Human) 11245, (Mouse) 381413
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