Invitrogen

GPR30 Polyclonal Antibody

View all (46) GPR30 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-87717

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 307-375 of human GPER1 (NP_0014961)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.84 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804365

Product Specific Information

Immunogen sequence: HIVNLAAFSN SCLNPLIYSF LGETFRDKLR LYIEQKTNLP ALNRFCHAAL KAVIPDSTEQ SDVRFSSAV

Positive Samples: Mouse brain, Mouse heart, Rat brain; Cellular Location: Basolateral cell membrane, Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle membrane, Early endosome, Endoplasmic reticulum membrane, Golgi apparatus, Golgi apparatus membrane, Mitochondrion membrane, Multi-pass membrane protein, Nucleus, Recycling endosome, axon, cytoskeleton, dendrite, dendritic spine membrane, perinuclear region, postsynaptic cell membrane, postsynaptic density, synapse, trans-Golgi network

Target Information

This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: Chemoattractant receptor-like 2; chemokine receptor-like 2; constitutively expressed peptide-like receptor; constitutively expressed peptide-like receptor like; FEG-1; Flow-induced endothelial G-protein coupled receptor 1; G protein-coupled estrogen receptor 1; G protein-coupled receptor 30; G-protein coupled estrogen receptor 1; G-protein coupled receptor 30; G-protein coupled receptor 41; GPCR-Br; heptahelix receptor; IL8-related receptor DRY12; leucine rich protein in GPR30 3'UTR; LYGPR; Lymphocyte-derived G-protein coupled receptor; Membrane estrogen receptor; mER

View more View less

Gene Aliases: 6330420K13Rik; CEPR; Ceprl; CMKRL2; DRY12; FEG-1; GPCR-Br; GPER; GPER1; GPR30; GPR41; LERGU; LERGU2; LyGPR; mER

View more View less

UniProt ID: (Human) Q99527, (Rat) O08878, (Mouse) Q8BMP4

View more View less

Entrez Gene ID: (Human) 2852, (Rat) 171104, (Mouse) 76854

View more View less

Function(s)
chromatin binding G-protein coupled receptor activity steroid binding protein binding drug binding mineralocorticoid receptor activity estrogen receptor activity steroid hormone binding steroid hormone receptor activity hormone binding signal transducer activity G-protein coupled receptor
Process(es)
positive regulation of protein phosphorylation positive regulation of neurotransmitter secretion negative regulation of leukocyte activation inflammatory response cell cycle G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway positive regulation of gene expression negative regulation of gene expression negative regulation of cell cycle process positive regulation of phosphatidylinositol 3-kinase signaling neuronal action potential apoptotic chromosome condensation nuclear fragmentation involved in apoptotic nuclear change positive regulation of cell migration intracellular steroid hormone receptor signaling pathway positive regulation of cAMP biosynthetic process mineralocorticoid receptor signaling pathway positive regulation of insulin secretion positive regulation of inositol trisphosphate biosynthetic process positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process steroid hormone mediated signaling pathway positive regulation of MAPK cascade innate immune response negative regulation of fat cell differentiation positive regulation of epidermal growth factor receptor signaling pathway positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of vasodilation positive regulation of transcription from RNA polymerase II promoter negative regulation of inflammatory response positive regulation of neurogenesis negative regulation of DNA metabolic process negative regulation of lipid biosynthetic process positive regulation of release of sequestered calcium ion into cytosol regulation of cytosolic calcium ion concentration negative regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of uterine smooth muscle contraction negative regulation of cell cycle arrest cellular response to glucose stimulus cellular response to tumor necrosis factor cellular response to peptide hormone stimulus cellular response to mineralocorticoid stimulus cellular response to estradiol stimulus positive regulation of establishment of protein localization to plasma membrane positive regulation of release of cytochrome c from mitochondria negative regulation of vascular smooth muscle cell proliferation positive regulation of endothelial cell apoptotic process positive regulation of cardiac vascular smooth muscle cell differentiation positive regulation of extrinsic apoptotic signaling pathway immune system process transcription from RNA polymerase II promoter apoptotic process signal transduction nervous system development cell differentiation
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support