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Product Details
GPCR56-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken from large extracellular loop of the human GPCR56 protein. Peptide was conjugated to Keyhole Limpet Haemocyanin (KLH).
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
GPR56 is a member of the G protein-coupled receptor family. The protein contains 7 transmembrane domains and a mucin-like domain in the N-terminal region. The gene is implicated in the regulation of brain cortical patterning. The protein binds specifically to transglutaminase 2 in the extracellular space. Expression of this gene is downregulated in melanoma cell lines, and overexpression of this gene can suppress tumor growth and metastasis. Mutations in this gene result in bilateral frontoparietal polymicrogyria. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 7-transmembrane protein with no EGF-like N-terminal domains-1; Adhesion G-protein coupled receptor G1; Cyt28; DKFZp781L1398; G protein-coupled receptor 56; G-protein coupled receptor 56; Protein TM7XN1; secretin receptor; Serpentine receptor cyt28; testicular tissue protein Li 77
Gene Aliases: ADGRG1; BFPP; BPPR; Cyt28; GPR56; TM7LN4; TM7XN1; UNQ540/PRO1083
UniProt ID: (Human) Q9Y653, (Mouse) Q8K209
Entrez Gene ID: (Human) 9289, (Mouse) 14766, (Rat) 260326
angiogenesis
cell adhesion
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
Rho protein signal transduction
cell-cell signaling
brain development
negative regulation of cell proliferation
vascular endothelial growth factor production
cell migration
cerebral cortex regionalization
cerebral cortex radial glia guided migration
layer formation in cerebral cortex
positive regulation of Rho protein signal transduction
positive regulation of cell adhesion
protein kinase C signaling
positive regulation of neural precursor cell proliferation
negative regulation of neuron migration
signal transduction
multicellular organism development
nervous system development
cell differentiation
Performance Guarantee
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