Product References
Dysregulated Gln-Glu-α-ketoglutarate axis impairs maternal decidualization and increases the risk of recurrent spontaneous miscarriage.
Cell reports. Medicine
Tang L,Xu XH,Xu S,Liu Z,He Q,Li W,Sun J,Shuai W,Mao J,Zhao JY,Jin L
Tue May 16 00:00:00 EDT 2023
A prognostic risk model, tumor immune environment modulation, and drug prediction of ferroptosis and amino acid metabolism-related genes in hepatocellular carcinoma.
Human cell
Ji L,Zhang Q,Cao Y,Liu L
Mon May 01 00:00:00 EDT 2023
The delta subunit of the GABAA receptor is necessary for the GPT2-promoted breast cancer metastasis.
Theranostics
Li N,Xu X,Liu D,Gao J,Gao Y,Wu X,Sheng H,Li Q,Mi J
Tue Mar 21 00:00:00 EDT 2023
The delta subunit of the GABAA receptor is necessary for the GPT2-promoted breast cancer metastasis.
Theranostics
Li N,Xu X,Liu D,Gao J,Gao Y,Wu X,Sheng H,Li Q,Mi J
Tue Mar 21 00:00:00 EDT 2023
The delta subunit of the GABAA receptor is necessary for the GPT2-promoted breast cancer metastasis.
Theranostics
Li N,Xu X,Liu D,Gao J,Gao Y,Wu X,Sheng H,Li Q,Mi J
Tue Mar 21 00:00:00 EDT 2023
The delta subunit of the GABAA receptor is necessary for the GPT2-promoted breast cancer metastasis.
Theranostics
Li N,Xu X,Liu D,Gao J,Gao Y,Wu X,Sheng H,Li Q,Mi J
Tue Mar 21 00:00:00 EDT 2023
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.
EMBO molecular medicine
Southwell N,Primiano G,Nadkarni V,Attarwala N,Beattie E,Miller D,Alam S,Liparulo I,Shurubor YI,Valentino ML,Carelli V,Servidei S,Gross SS,Manfredi G,Chen Q,D'Aurelio M
Mon Jul 10 00:00:00 EDT 2023
SPTBN1 abrogates renal clear cell carcinoma progression via glycolysis reprogramming in a GPT2-dependent manner.
Journal of translational medicine
Wu J,Miao C,Wang Y,Wang S,Wang Z,Liu Y,Wang X,Wang Z
Fri Dec 16 00:00:00 EST 2022
SPTBN1 abrogates renal clear cell carcinoma progression via glycolysis reprogramming in a GPT2-dependent manner.
Journal of translational medicine
Wu J,Miao C,Wang Y,Wang S,Wang Z,Liu Y,Wang X,Wang Z
Fri Dec 16 00:00:00 EST 2022
Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2.
Cell reports
Cicatiello AG,Sagliocchi S,Nappi A,Di Cicco E,Miro C,Murolo M,Stornaiuolo M,Dentice M
Tue Mar 22 00:00:00 EDT 2022
Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2.
Cell reports
Cicatiello AG,Sagliocchi S,Nappi A,Di Cicco E,Miro C,Murolo M,Stornaiuolo M,Dentice M
Tue Feb 22 00:00:00 EST 2022
Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2.
Cell reports
Cicatiello AG,Sagliocchi S,Nappi A,Di Cicco E,Miro C,Murolo M,Stornaiuolo M,Dentice M
Tue Feb 22 00:00:00 EST 2022
Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2.
Cell reports
Cicatiello AG,Sagliocchi S,Nappi A,Di Cicco E,Miro C,Murolo M,Stornaiuolo M,Dentice M
Tue Feb 22 00:00:00 EST 2022
GPT2 Is Induced by Hypoxia-Inducible Factor (HIF)-2 and Promotes Glioblastoma Growth.
Cells
Zhang B,Chen Y,Bao L,Luo W
Sat Aug 20 00:00:00 EDT 2022
Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma.
Cancer research
Zhang B,Peng H,Zhou M,Bao L,Wang C,Cai F,Zhang H,Wang JE,Niu Y,Chen Y,Wang Y,Hatanpaa KJ,Copland JA,DeBerardinis RJ,Wang Y,Luo W
Tue Jul 05 00:00:00 EDT 2022
A Novel Ferroptosis-Based Molecular Signature Associated with Biochemical Recurrence-Free Survival and Tumor Immune Microenvironment of Prostate Cancer.
Frontiers in cell and developmental biology
Ke ZB,You Q,Sun JB,Zhu JM,Li XD,Chen DN,Su L,Zheng QS,Wei Y,Xue XY,Xu N
Tue Jan 25 00:00:00 EST 2022
Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma.
Theranostics
Zhang X,Yu K,Ma L,Qian Z,Tian X,Miao Y,Niu Y,Xu X,Guo S,Yang Y,Wang Z,Xue X,Gu C,Fang W,Sun J,Yu Y,Wang J
Thu Jul 29 00:00:00 EDT 2021
Exosome-transmitted microRNA-133b inhibited bladder cancer proliferation by upregulating dual-specificity protein phosphatase 1.
Cancer medicine
Cai X,Qu L,Yang J,Xu J,Sun L,Wei X,Qu X,Bai T,Guo Z,Zhu Y
Sat Aug 01 00:00:00 EDT 2020
Deactivation of Glutaminolysis Sensitizes PIK3CA-Mutated Colorectal Cancer Cells to Aspirin-Induced Growth Inhibition.
Cancers
Boku S,Watanabe M,Sukeno M,Yaoi T,Hirota K,Iizuka-Ohashi M,Itoh K,Sakai T
Thu Apr 30 00:00:00 EDT 2020
Enhanced glutamine utilization mediated by SLC1A5 and GPT2 is an essential metabolic feature of colorectal signet ring cell carcinoma with therapeutic potential.
Annals of translational medicine
Wang R,Xiang W,Xu Y,Han L,Li Q,Dai W,Cai G
Sun Mar 01 00:00:00 EST 2020
Enhanced glutamine utilization mediated by SLC1A5 and GPT2 is an essential metabolic feature of colorectal signet ring cell carcinoma with therapeutic potential.
Annals of translational medicine
Wang R,Xiang W,Xu Y,Han L,Li Q,Dai W,Cai G
Sun Mar 01 00:00:00 EST 2020
Mitochondrial GPT2 plays a pivotal role in metabolic adaptation to the perturbation of mitochondrial glutamine metabolism.
Oncogene
Kim M,Gwak J,Hwang S,Yang S,Jeong SM
Sat Jun 01 00:00:00 EDT 2019
T Cell Activation Depends on Extracellular Alanine.
Cell reports
Ron-Harel N,Ghergurovich JM,Notarangelo G,LaFleur MW,Tsubosaka Y,Sharpe AH,Rabinowitz JD,Haigis MC
Tue Sep 17 00:00:00 EDT 2019
Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.
American journal of respiratory cell and molecular biology
Hamanaka RB,O'Leary EM,Witt LJ,Tian Y,Gökalp GA,Meliton AY,Dulin NO,Mutlu GM
Fri Nov 01 00:00:00 EDT 2019
Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation.
Molecular oncology
Hong R,Zhang W,Xia X,Zhang K,Wang Y,Wu M,Fan J,Li J,Xia W,Xu F,Chen J,Wang S,Zhan Q
Mon Apr 01 00:00:00 EDT 2019
Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.
Cell research
Cai WF,Zhang C,Wu YQ,Zhuang G,Ye Z,Zhang CS,Lin SC
Wed Aug 01 00:00:00 EDT 2018
Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.
Cell research
Cai WF,Zhang C,Wu YQ,Zhuang G,Ye Z,Zhang CS,Lin SC
Wed Aug 01 00:00:00 EDT 2018
Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner.
Nature communications
Wang YQ,Wang HL,Xu J,Tan J,Fu LN,Wang JL,Zou TH,Sun DF,Gao QY,Chen YX,Fang JY
Wed Feb 07 00:00:00 EST 2018
Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner.
Nature communications
Wang YQ,Wang HL,Xu J,Tan J,Fu LN,Wang JL,Zou TH,Sun DF,Gao QY,Chen YX,Fang JY
Wed Feb 07 00:00:00 EST 2018
Metabolic consequences of HIF silencing in a triple negative human breast cancer xenograft.
Oncotarget
Bharti SK,Mironchik Y,Wildes F,Penet MF,Goggins E,Krishnamachary B,Bhujwalla ZM
Fri Mar 16 00:00:00 EDT 2018
Metabolic consequences of HIF silencing in a triple negative human breast cancer xenograft.
Oncotarget
Bharti SK,Mironchik Y,Wildes F,Penet MF,Goggins E,Krishnamachary B,Bhujwalla ZM
Fri Mar 16 00:00:00 EDT 2018
Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations.
Cell metabolism
Chen Q,Kirk K,Shurubor YI,Zhao D,Arreguin AJ,Shahi I,Valsecchi F,Primiano G,Calder EL,Carelli V,Denton TT,Beal MF,Gross SS,Manfredi G,D'Aurelio M
Tue May 01 00:00:00 EDT 2018
Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling.
Theranostics
Cao Y,Lin SH,Wang Y,Chin YE,Kang L,Mi J
Mon Apr 30 00:00:00 EDT 2018
Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling.
Theranostics
Cao Y,Lin SH,Wang Y,Chin YE,Kang L,Mi J
Mon Apr 30 00:00:00 EDT 2018
Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling.
Theranostics
Cao Y,Lin SH,Wang Y,Chin YE,Kang L,Mi J
Mon Apr 30 00:00:00 EDT 2018
Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling.
Theranostics
Cao Y,Lin SH,Wang Y,Chin YE,Kang L,Mi J
Mon Apr 30 00:00:00 EDT 2018
Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features.
Proceedings of the National Academy of Sciences of the United States of America
Ouyang Q,Nakayama T,Baytas O,Davidson SM,Yang C,Schmidt M,Lizarraga SB,Mishra S,Ei-Quessny M,Niaz S,Gul Butt M,Imran Murtaza S,Javed A,Chaudhry HR,Vaughan DJ,Hill RS,Partlow JN,Yoo SY,Lam AT,Nasir R,Al-Saffar M,Barkovich AJ,Schwede M,Nagpal S,Rajab A,DeBerardinis RJ,Housman DE,Mochida GH,Morrow EM
Tue Sep 20 00:00:00 EDT 2016
Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features.
Proceedings of the National Academy of Sciences of the United States of America
Ouyang Q,Nakayama T,Baytas O,Davidson SM,Yang C,Schmidt M,Lizarraga SB,Mishra S,Ei-Quessny M,Niaz S,Gul Butt M,Imran Murtaza S,Javed A,Chaudhry HR,Vaughan DJ,Hill RS,Partlow JN,Yoo SY,Lam AT,Nasir R,Al-Saffar M,Barkovich AJ,Schwede M,Nagpal S,Rajab A,DeBerardinis RJ,Housman DE,Mochida GH,Morrow EM
Tue Sep 20 00:00:00 EDT 2016
Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features.
Proceedings of the National Academy of Sciences of the United States of America
Ouyang Q,Nakayama T,Baytas O,Davidson SM,Yang C,Schmidt M,Lizarraga SB,Mishra S,Ei-Quessny M,Niaz S,Gul Butt M,Imran Murtaza S,Javed A,Chaudhry HR,Vaughan DJ,Hill RS,Partlow JN,Yoo SY,Lam AT,Nasir R,Al-Saffar M,Barkovich AJ,Schwede M,Nagpal S,Rajab A,DeBerardinis RJ,Housman DE,Mochida GH,Morrow EM
Tue Sep 20 00:00:00 EDT 2016
Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features.
Proceedings of the National Academy of Sciences of the United States of America
Ouyang Q,Nakayama T,Baytas O,Davidson SM,Yang C,Schmidt M,Lizarraga SB,Mishra S,Ei-Quessny M,Niaz S,Gul Butt M,Imran Murtaza S,Javed A,Chaudhry HR,Vaughan DJ,Hill RS,Partlow JN,Yoo SY,Lam AT,Nasir R,Al-Saffar M,Barkovich AJ,Schwede M,Nagpal S,Rajab A,DeBerardinis RJ,Housman DE,Mochida GH,Morrow EM
Tue Sep 20 00:00:00 EDT 2016
Transcriptomic and metabolic analyses reveal salvage pathways in creatine-deficient AGAT(-/-) mice.
Amino acids
Stockebrand M,Nejad AS,Neu A,Kharbanda KK,Sauter K,Schillemeit S,Isbrandt D,Choe CU
Mon Aug 01 00:00:00 EDT 2016
Transcriptomic and metabolic analyses reveal salvage pathways in creatine-deficient AGAT(-/-) mice.
Amino acids
Stockebrand M,Nejad AS,Neu A,Kharbanda KK,Sauter K,Schillemeit S,Isbrandt D,Choe CU
Mon Aug 01 00:00:00 EDT 2016
