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GPX7 Polyclonal Antibody

GPX7 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GPX7 Antibody (13501-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using (Product # 13501-1-AP) (GPX7 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Product Image Gallery

Product Details

13501-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Chicken, Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GPX7 Fusion Protein Ag4328 (58-187 aa encoded by BC032788)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GFTDQHYRA LQQLQRDLGP HHFNVLAFPC NQFGQQEPDS NKEIESFARR TYSVSFPMFS KIAVTGTGAH PAFKYLAQTS GKEPTWNFWK YLVAPDGKVV GAWDPTVSVE EVRPQITALV RKLILLKRED L (58-187 aa encoded by BC032788)

Target Information

Human GPX 7 is believed to be a member of the glutathione peroxidase family of proteins. These proteins play important roles in cellular defense mechanisms against oxidative damage. This is accomplished by catalyzing the reduction of hydroperoxides and hydrogen peroxide through the reducing substrate, glutathione.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A glycometabolic gene signature associating with immune infiltration and chemosensitivity and predicting the prognosis of patients with osteosarcoma.

Frontiers in medicine

Wang F,Yang K,Pan R,Xiang Y,Xiong Z,Li P,Li K,Sun H

Mon Jun 12 00:00:00 EDT 2023

GPX7 Facilitates BMSCs Osteoblastogenesis via ER Stress and mTOR Pathway.

Journal of cellular and molecular medicine

Hu X,Li B,Wu F,Liu X,Liu M,Wang C,Shi Y,Ye L

Mon Nov 01 00:00:00 EDT 2021

GPX7 Facilitates BMSCs Osteoblastogenesis via ER Stress and mTOR Pathway.

Journal of cellular and molecular medicine

Hu X,Li B,Wu F,Liu X,Liu M,Wang C,Shi Y,Ye L

Mon Nov 01 00:00:00 EDT 2021

GPX7 Facilitates BMSCs Osteoblastogenesis via ER Stress and mTOR Pathway.

Journal of cellular and molecular medicine

Hu X,Li B,Wu F,Liu X,Liu M,Wang C,Shi Y,Ye L

Mon Nov 01 00:00:00 EDT 2021

GPX7 Facilitates BMSCs Osteoblastogenesis via ER Stress and mTOR Pathway.

Journal of cellular and molecular medicine

Hu X,Li B,Wu F,Liu X,Liu M,Wang C,Shi Y,Ye L

Mon Nov 01 00:00:00 EDT 2021

GPX7 Is Targeted by miR-29b and GPX7 Knockdown Enhances Ferroptosis Induced by Erastin in Glioma.

Frontiers in oncology

Zhou Y,Wu H,Wang F,Xu L,Yan Y,Tong X,Yan H

Sun May 01 00:00:00 EDT 2022

GPX7 Is Targeted by miR-29b and GPX7 Knockdown Enhances Ferroptosis Induced by Erastin in Glioma.

Frontiers in oncology

Zhou Y,Wu H,Wang F,Xu L,Yan Y,Tong X,Yan H

Sun May 01 00:00:00 EDT 2022

GPx7 ameliorates non-alcoholic steatohepatitis by regulating oxidative stress.

BMB reports

Kim HJ,Lee Y,Fang S,Kim W,Kim HJ,Kim JW

Mon Jun 01 00:00:00 EDT 2020

The development of antioxidant system in the intestinal tract of broiler chickens.

Poultry science

Tang D,Wu J,Jiao H,Wang X,Zhao J,Lin H

Fri Feb 01 00:00:00 EST 2019

The development of antioxidant system in the intestinal tract of broiler chickens.

Poultry science

Tang D,Wu J,Jiao H,Wang X,Zhao J,Lin H

Fri Feb 01 00:00:00 EST 2019

Abrogation of glutathione peroxidase-1 drives EMT and chemoresistance in pancreatic cancer by activating ROS-mediated Akt/GSK3β/Snail signaling.

Oncogene

Meng Q,Shi S,Liang C,Liang D,Hua J,Zhang B,Xu J,Yu X

Thu Nov 01 00:00:00 EDT 2018

Abrogation of glutathione peroxidase-1 drives EMT and chemoresistance in pancreatic cancer by activating ROS-mediated Akt/GSK3β/Snail signaling.

Oncogene

Meng Q,Shi S,Liang C,Liang D,Hua J,Zhang B,Xu J,Yu X

Thu Nov 01 00:00:00 EDT 2018

Glutathione peroxidase 7 suppresses cancer cell growth and is hypermethylated in gastric cancer.

Oncotarget

Chen Z,Hu T,Zhu S,Mukaisho K,El-Rifai W,Peng DF

Tue Aug 15 00:00:00 EDT 2017

Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma.

Gut

Peng D,Hu T,Soutto M,Belkhiri A,Zaika A,El-Rifai W

Tue Apr 01 00:00:00 EDT 2014

Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma.

Gut

Peng D,Hu T,Soutto M,Belkhiri A,Zaika A,El-Rifai W

Tue Apr 01 00:00:00 EDT 2014

GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum.

Free radical biology & medicine

Ramming T,Hansen HG,Nagata K,Ellgaard L,Appenzeller-Herzog C

Thu May 01 00:00:00 EDT 2014

Loss of glutathione peroxidase 7 promotes TNF-α-induced NF-κB activation in Barrett's carcinogenesis.

Carcinogenesis

Peng DF,Hu TL,Soutto M,Belkhiri A,El-Rifai W

Tue Jul 01 00:00:00 EDT 2014

Loss of glutathione peroxidase 7 promotes TNF-α-induced NF-κB activation in Barrett's carcinogenesis.

Carcinogenesis

Peng DF,Hu TL,Soutto M,Belkhiri A,El-Rifai W

Tue Jul 01 00:00:00 EDT 2014

Glutathione Peroxidase 7 Suppresses Bile Salt-Induced Expression of Pro-Inflammatory Cytokines in Barrett's Carcinogenesis.

Journal of Cancer

Peng DF,Hu TL,Soutto M,Belkhiri A,El-Rifai W

Wed Jun 25 00:00:00 EDT 2014

Glutathione Peroxidase 7 Suppresses Bile Salt-Induced Expression of Pro-Inflammatory Cytokines in Barrett's Carcinogenesis.

Journal of Cancer

Peng DF,Hu TL,Soutto M,Belkhiri A,El-Rifai W

Wed Jun 25 00:00:00 EDT 2014

Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.

EMBO molecular medicine

Chang YC,Yu YH,Shew JY,Lee WJ,Hwang JJ,Chen YH,Chen YR,Wei PC,Chuang LM,Lee WH

Thu Aug 01 00:00:00 EDT 2013

Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.

EMBO molecular medicine

Chang YC,Yu YH,Shew JY,Lee WJ,Hwang JJ,Chen YH,Chen YR,Wei PC,Chuang LM,Lee WH

Thu Aug 01 00:00:00 EDT 2013

Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells.

Gut

Peng D,Belkhiri A,Hu T,Chaturvedi R,Asim M,Wilson KT,Zaika A,El-Rifai W

Sat Sep 01 00:00:00 EDT 2012

Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells.

Gut

Peng D,Belkhiri A,Hu T,Chaturvedi R,Asim M,Wilson KT,Zaika A,El-Rifai W

Sat Sep 01 00:00:00 EDT 2012

Bioinformatics

Protein Aliases: CL683; FLJ14777; glutathione peroxidase 6; Glutathione peroxidase 7; GPx-7; HGNC:4559; non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase

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Gene Aliases: CL683; GPx-7; GPX6; GPX7; GSHPx-7; NPGPx; UNQ469/PRO828

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UniProt ID: (Human) Q96SL4

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Entrez Gene ID: (Human) 2882

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Function(s)

catalase activity peroxidase activity glutathione peroxidase activity protein binding peroxidase

Process(es)

response to reactive oxygen species oxidation-reduction process cellular oxidant detoxification

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GPX7 Polyclonal Antibody

GPX7 Antibody (13501-1-AP) in IHC (P)

Product Details

13501-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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