Product References
Limited impact of fingolimod treatment during the initial weeks of ART in SIV-infected rhesus macaques.
Nature communications
Pino M,Pagliuzza A,Pampena MB,Deleage C,Viox EG,Nguyen K,Shim I,Zhang A,Harper JL,Samer S,King CT,Cervasi B,Gill KP,Ehnert S,Jean SM,Freeman ML,Lifson JD,Kulpa D,Betts MR,Chomont N,Lederman MM,Paiardini M
Published figure using Granzyme B monoclonal antibody (Product # GRB17) in Flow Cytometry
Sat Aug 27 00:00:00 EDT 2022
Immune profile analysis of peripheral blood and tumors of lung cancer patients treated with immune checkpoint inhibitors.
Translational lung cancer research
Ichiki Y,Fukuyama T,Ueno M,Kanasaki Y,Goto H,Takahashi M,Mikami S,Kobayashi N,Nakanishi K,Hayashi S,Ishida T
GRB17 was used in Flow cytometry/Cell sorting to analyze the association between the immune-related molecular expression in peripheral blood mononuclear cells (PBMCs) and lung cancer tissues, and the effects of ICI monotherapy.
Tue Nov 01 00:00:00 EDT 2022
Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
Cell
Hoang TN,Pino M,Boddapati AK,Viox EG,Starke CE,Upadhyay AA,Gumber S,Nekorchuk M,Busman-Sahay K,Strongin Z,Harper JL,Tharp GK,Pellegrini KL,Kirejczyk S,Zandi K,Tao S,Horton TR,Beagle EN,Mahar EA,Lee MYH,Cohen J,Jean SM,Wood JS,Connor-Stroud F,Stammen RL,Delmas OM,Wang S,Cooney KA,Sayegh MN,Wang L,Filev PD,Weiskopf D,Silvestri G,Waggoner J,Piantadosi A,Kasturi SP,Al-Shakhshir H,Ribeiro SP,Sekaly RP,Levit RD,Estes JD,Vanderford TH,Schinazi RF,Bosinger SE,Paiardini M
GRB17 was used in Flow cytometry/Cell sorting to investigate the immunologic and virologic efficacy of baricitinib in a rhesus macaque model of SARS-CoV-2 infection.
Thu Jan 21 00:00:00 EST 2021
Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
Cell
Hoang TN,Pino M,Boddapati AK,Viox EG,Starke CE,Upadhyay AA,Gumber S,Nekorchuk M,Busman-Sahay K,Strongin Z,Harper JL,Tharp GK,Pellegrini KL,Kirejczyk S,Zandi K,Tao S,Horton TR,Beagle EN,Mahar EA,Lee MYH,Cohen J,Jean SM,Wood JS,Connor-Stroud F,Stammen RL,Delmas OM,Wang S,Cooney KA,Sayegh MN,Wang L,Filev PD,Weiskopf D,Silvestri G,Waggoner J,Piantadosi A,Kasturi SP,Al-Shakhshir H,Ribeiro SP,Sekaly RP,Levit RD,Estes JD,Vanderford TH,Schinazi RF,Bosinger SE,Paiardini M
GRB17 was used in Flow cytometry/Cell sorting to investigate the immunologic and virologic efficacy of baricitinib in a rhesus macaque model of SARS-CoV-2 infection.
Thu Jan 21 00:00:00 EST 2021
A Personalized Neoantigen Vaccine in Combination with Platinum-Based Chemotherapy Induces a T-Cell Response Coinciding with a Complete Response in Endometrial Carcinoma.
Cancers
Harari A,Sarivalasis A,de Jonge K,Thierry AC,Huber F,Boudousquie C,Rossier L,Orcurto A,Imbimbo M,Baumgaertner P,Bassani-Sternberg M,Kandalaft LE
GRB17 was used in Flow Cytometry to show the feasibility of generating a personalized dendritic cell vaccine pulsed with peptide neoantigens in a patient with pMMR, p53-mutated, and serous endometrial adenocarcinoma.
Thu Nov 18 00:00:00 EST 2021
Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas.
Journal for immunotherapy of cancer
Judge SJ,Darrow MA,Thorpe SW,Gingrich AA,O'Donnell EF,Bellini AR,Sturgill IR,Vick LV,Dunai C,Stoffel KM,Lyu Y,Chen S,Cho M,Rebhun RB,Monjazeb AM,Murphy WJ,Canter RJ
GRB17 was used in Flow cytometry/Cell sorting to assess the effects of interleukin 15 (IL-15) stimulation on both NK and T cell activation and TIGIT upregulation. Finally, we evaluated cytotoxic effects of IL-15 combined with TIGIT blockade using a novel anti-TIGIT antibody.
Sun Nov 01 00:00:00 EDT 2020
Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas.
Journal for immunotherapy of cancer
Judge SJ,Darrow MA,Thorpe SW,Gingrich AA,O'Donnell EF,Bellini AR,Sturgill IR,Vick LV,Dunai C,Stoffel KM,Lyu Y,Chen S,Cho M,Rebhun RB,Monjazeb AM,Murphy WJ,Canter RJ
GRB17 was used in Flow cytometry/Cell sorting to assess the effects of interleukin 15 (IL-15) stimulation on both NK and T cell activation and TIGIT upregulation. Finally, we evaluated cytotoxic effects of IL-15 combined with TIGIT blockade using a novel anti-TIGIT antibody.
Sun Nov 01 00:00:00 EDT 2020
Deciphering the Mechanisms of Improved Immunogenicity of Hypochlorous Acid-Treated Antigens in Anti-Cancer Dendritic Cell-Based Vaccines.
Vaccines
Graciotti M,Marino F,Pak H,Baumgaertner P,Thierry AC,Chiffelle J,Perez MAS,Zoete V,Harari A,Bassani-Sternberg M,Kandalaft LE
GRB17 was used in Flow cytometry/Cell sorting to map modifications and alterations introduced by HOCl treatment using a human melanoma cell line as a model system.
Tue Jun 02 00:00:00 EDT 2020
Deciphering the Mechanisms of Improved Immunogenicity of Hypochlorous Acid-Treated Antigens in Anti-Cancer Dendritic Cell-Based Vaccines.
Vaccines
Graciotti M,Marino F,Pak H,Baumgaertner P,Thierry AC,Chiffelle J,Perez MAS,Zoete V,Harari A,Bassani-Sternberg M,Kandalaft LE
GRB17 was used in Flow cytometry/Cell sorting to map modifications and alterations introduced by HOCl treatment using a human melanoma cell line as a model system.
Tue Jun 02 00:00:00 EDT 2020
Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
bioRxiv : the preprint server for biology
Hoang TN,Pino M,Boddapati AK,Viox EG,Starke CE,Upadhyay AA,Gumber S,Busman-Sahay K,Strongin Z,Harper JL,Tharp GK,Pellegrini KL,Kirejczyk S,Zandi K,Tao S,Horton TR,Beagle EN,Mahar EA,Lee MY,Cohen J,Jean SM,Wood JS,Connor-Stroud F,Stammen RL,Delmas OM,Wang S,Cooney KA,Sayegh MN,Wang L,Weiskopf D,Filev PD,Waggoner J,Piantadosi A,Kasturi SP,Al-Shakhshir H,Ribeiro SP,Sekaly RP,Levit RD,Estes JD,Vanderford TH,Schinazi RF,Bosinger SE,Paiardini M
GRB17 was used in Flow cytometry/Cell sorting to investigate the immunologic and virologic efficacy of baricitinib in a rhesus macaque model of SARS-CoV-2 infection.
Wed Sep 16 00:00:00 EDT 2020
Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
bioRxiv : the preprint server for biology
Hoang TN,Pino M,Boddapati AK,Viox EG,Starke CE,Upadhyay AA,Gumber S,Busman-Sahay K,Strongin Z,Harper JL,Tharp GK,Pellegrini KL,Kirejczyk S,Zandi K,Tao S,Horton TR,Beagle EN,Mahar EA,Lee MY,Cohen J,Jean SM,Wood JS,Connor-Stroud F,Stammen RL,Delmas OM,Wang S,Cooney KA,Sayegh MN,Wang L,Weiskopf D,Filev PD,Waggoner J,Piantadosi A,Kasturi SP,Al-Shakhshir H,Ribeiro SP,Sekaly RP,Levit RD,Estes JD,Vanderford TH,Schinazi RF,Bosinger SE,Paiardini M
GRB17 was used in Flow cytometry/Cell sorting to investigate the immunologic and virologic efficacy of baricitinib in a rhesus macaque model of SARS-CoV-2 infection.
Wed Sep 16 00:00:00 EDT 2020
The Effectiveness of Checkpoint Inhibitor Combinations and Administration Timing Can Be Measured by Granzyme B PET Imaging.
Clinical cancer research : an official journal of the American Association for Cancer Research
Larimer BM,Bloch E,Nesti S,Austin EE,Wehrenberg-Klee E,Boland G,Mahmood U
GRB17 was used in Flow cytometry/Cell sorting to provide evidence that GZP PET imaging may be useful for rapid assessment of therapeutic efficacy in the context of clinical trials for both novel drugs as well as dosing regimens.
Fri Feb 15 00:00:00 EST 2019
50-Gy Stereotactic Body Radiation Therapy to the Dominant Intraprostatic Nodule: Results From a Phase 1a/b Trial.
International journal of radiation oncology, biology, physics
Herrera FG,Valerio M,Berthold D,Tawadros T,Meuwly JY,Vallet V,Baumgartner P,Thierry AC,De Bari B,Jichlinski P,Kandalaft L,Coukos G,Harari A,Bourhis J
GRB17 was used in Flow cytometry/Cell sorting to show stereotactic irradiation induced antigen-specific immune responses in a subset of patients.
Fri Feb 01 00:00:00 EST 2019
Differential Effect of Mucosal NKp44+ Innate Lymphoid Cells and Δγ Cells on Simian Immunodeficiency Virus Infection Outcome in Rhesus Macaques.
Journal of immunology (Baltimore, Md. : 1950)
Rahman MA,Ko EJ,Enyindah-Asonye G,Helmold Hait S,Hogge C,Hunegnaw R,Venzon DJ,Hoang T,Robert-Guroff M
GRB17 was used in Flow cytometry/Cell sorting to investigate NK cell and innate lymphoid cell (ILC) dynamics and function in rhesus macaque rectal tissue and blood following mucosal priming with replicating adenovirus (Ad)-SIV recombinants, systemic boosting with SIV envelope protein, and subsequent repeated low-dose intravaginal SIV exposures.
Fri Nov 01 00:00:00 EDT 2019
Circulating CD56bright NK cells inversely correlate with survival of melanoma patients.
Scientific reports
de Jonge K,Ebering A,Nassiri S,Maby-El Hajjami H,Ouertatani-Sakouhi H,Baumgaertner P,Speiser DE
GRB17 was used in Flow cytometry/Cell sorting to characterise natural killer cells from peripheral blood obtained from late stage melanoma patients.
Thu Mar 14 00:00:00 EDT 2019
PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy.
The Journal of clinical investigation
Zamarin D,Ricca JM,Sadekova S,Oseledchyk A,Yu Y,Blumenschein WM,Wong J,Gigoux M,Merghoub T,Wolchok JD
GRB17 was used in Flow cytometry/Cell sorting to use human tumour histocultures and syngeneic tumour models treated with Newcastle disease virus to identify immune targets upregulated by OV treatment.
Mon Apr 02 00:00:00 EDT 2018
Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.
Molecular therapy : the journal of the American Society of Gene Therapy
Ricca JM,Oseledchyk A,Walther T,Liu C,Mangarin L,Merghoub T,Wolchok JD,Zamarin D
GRB17 was used in Flow cytometry/Cell sorting to study the effects of pre-existing anti-viral immunity on therapeutic efficacy in syngeneic mouse tumour models.
Wed Apr 04 00:00:00 EDT 2018
PD-1 Blockade Unleashes Effector Potential of Both High- and Low-Affinity Tumor-Infiltrating T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Martínez-Usatorre A,Donda A,Zehn D,Romero P
GRB17 was used in Flow cytometry/Cell sorting to show that αPD-1 treatment enhances tumor control of high- and low-affinity ligand-expressing tumors, suggesting that combination of high-affinity peripheral priming by altered peptide ligands and checkpoint blockade may enable tumor control upon low-affinity Ag recognition in the tumor.
Sun Jul 15 00:00:00 EDT 2018
Lysis-independent potentiation of immune checkpoint blockade by oncolytic virus.
Oncotarget
Oseledchyk A,Ricca JM,Gigoux M,Ko B,Redelman-Sidi G,Walther T,Liu C,Iyer G,Merghoub T,Wolchok JD,Zamarin D
GRB17 was used in Flow cytometry/Cell sorting to study the immunogenic potential of an oncolytic virus in bladder cancer where existing immune checkpoint blockade has shown suboptimal response rates.
Tue Jun 19 00:00:00 EDT 2018
Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155.
Cell reports
Stelekati E,Chen Z,Manne S,Kurachi M,Ali MA,Lewy K,Cai Z,Nzingha K,McLane LM,Hope JL,Fike AJ,Katsikis PD,Wherry EJ
GRB17 was used in Flow cytometry/Cell sorting to identify microRNA-155 as a key regulator of sustained exhausted T cell responses during chronic lymphocytic choriomeningitis virus infection.
Tue May 15 00:00:00 EDT 2018
miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb.
Cell reports
Chen Z,Stelekati E,Kurachi M,Yu S,Cai Z,Manne S,Khan O,Yang X,Wherry EJ
GRB17 was used in Flow cytometry/Cell sorting to identify a key role for miR-150 in memory CD8 T cell differentiation, through a c-Myb controlled survival circuit.
Tue Sep 12 00:00:00 EDT 2017
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Nature communications
Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP
GRB17 was used in Flow cytometry/Cell sorting to highlight that intratumoral immunomodulation with an oncolytic virus expressing a rationally selected ligand can be an effective strategy to drive systemic efficacy of immune checkpoint blockade.
Mon Feb 13 00:00:00 EST 2017
IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo.
Scientific reports
Kritikou JS,Dahlberg CI,Baptista MA,Wagner AK,Banerjee PP,Gwalani LA,Poli C,Panda SK,Kärre K,Kaech SM,Wermeling F,Andersson J,Orange JS,Brauner H,Westerberg LS
Published figure using Granzyme B monoclonal antibody (Product # GRB17) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
A CD8α(-) subpopulation of macaque circulatory natural killer cells can mediate both antibody-dependent and antibody-independent cytotoxic activities.
Immunology
Vargas-Inchaustegui DA,Demberg T,Robert-Guroff M
GRB17 was used in Flow cytometry/Cell sorting to show that about 35% of macaque CD8α(-) cells represent a novel, functional population of circulatory NK cells that possesses cytotoxic potential and is capable of mediating anti-viral immune responses.
Tue Nov 01 00:00:00 EDT 2011
