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The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date.
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Protein Aliases: B47; Epidermal growth factor receptor GRB-7; GRB7 adapter protein; growth factor receptor binding protein GRB7; Growth factor receptor-bound protein 7; Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7); OTTHUMP00000164352
Gene Aliases: GRB7; mKIAA4028
UniProt ID: (Human) Q14451, (Mouse) Q03160, (Rat) Q9QZC5
Entrez Gene ID: (Human) 2886, (Mouse) 14786, (Rat) 84427
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